Cited by 240Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsNeonatal and fetal brain pathology

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Stroke-Induced Neurogenesis in Aged Brain

Darsalia, Vladimer, Heldmann, Ursula, Lindvall, Olle, Kokaia, Zaal·2005·Stroke

DOI 10.1161/01.str.0000173151.36031.be

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Abstract

Background and Purpose— Stroke induced by middle cerebral artery occlusion (MCAO) triggers increased neurogenesis in the damaged striatum and nondamaged hippocampus of young adult rodents. We explored whether stroke influences neurogenesis similarly in the aged brain. Methods— Young adult (3 months) and old (15 months) rats were subjected to 1 hour of MCAO, and new cells were labeled by intraperitoneal injection of 5-bromo-2′-deoxyuridine 5′-monophosphate (BrdU), a marker for dividing cells, for 2 weeks thereafter. Animals were euthanized at 7 weeks after the insult, and neurogenesis was assessed immunocytochemically with antibodies against BrdU and neuronal markers with epifluorescence or confocal microscopy. Results— Young and old rats exhibited the same increased numbers of new striatal neurons after stroke, despite basal cell proliferation in the subventricular zone being reduced in the aged brain. In contrast, both the number of stroke-generated granule cells and basal neurogenesis in the dentate subgranular zone were lower in old compared with young animals. Also, the ability of newly formed cells to differentiate into neurons was impaired in the aged dentate gyrus. Conclusions— Basal neurogenesis is impaired in the subgranular and subventricular zones of aged animals, but both regions react to stroke with increased formation of new neurons. The magnitude of striatal neurogenesis after stroke is similar in young and old animals, indicating that this potential mechanism for self-repair also operates in the aged brain.

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Authors: Darsalia, V., Heldmann, U., Lindvall, O., & Kokaia, Z.
Affiliations: Skåne University Hospital (SE)
ORCID: Darsalia, Vladimer
Lindvall, Olle
Kokaia, Zaal
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-08
Volume: 36
Issue: 8
Pages: 1790-1795
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000173151.36031.be
OpenAlex: W2167181354
Cited by: 240
References: 35
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 13 · 2012: 19
FWCI: 3.94
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Vetenskapsrådet
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords: brain aging, middle cerebral artery occlusion, striatum, dentate gyrus, subventricular zone, subgranular zone, basal cell proliferation, neuronal differentiation, hippocampus, BrdU labeling
MeSH terms: Aging, Animals, Brain, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cerebral Arteries, Female, Hippocampus, Immunohistochemistry, Injections, Intraperitoneal, Ischemia, Microscopy, Fluorescence, Neurons, Stem Cells, Time Factors, Rats, Wistar, Microscopy, Confocal, Dentate Gyrus, Ki-67 Antigen, Infarction, Middle Cerebral Artery, Stroke, Cell Proliferation, Rats

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