The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Stroke-Induced Neurogenesis in Aged Brain
Abstract
Background and Purpose— Stroke induced by middle cerebral artery occlusion (MCAO) triggers increased neurogenesis in the damaged striatum and nondamaged hippocampus of young adult rodents. We explored whether stroke influences neurogenesis similarly in the aged brain. Methods— Young adult (3 months) and old (15 months) rats were subjected to 1 hour of MCAO, and new cells were labeled by intraperitoneal injection of 5-bromo-2′-deoxyuridine 5′-monophosphate (BrdU), a marker for dividing cells, for 2 weeks thereafter. Animals were euthanized at 7 weeks after the insult, and neurogenesis was assessed immunocytochemically with antibodies against BrdU and neuronal markers with epifluorescence or confocal microscopy. Results— Young and old rats exhibited the same increased numbers of new striatal neurons after stroke, despite basal cell proliferation in the subventricular zone being reduced in the aged brain. In contrast, both the number of stroke-generated granule cells and basal neurogenesis in the dentate subgranular zone were lower in old compared with young animals. Also, the ability of newly formed cells to differentiate into neurons was impaired in the aged dentate gyrus. Conclusions— Basal neurogenesis is impaired in the subgranular and subventricular zones of aged animals, but both regions react to stroke with increased formation of new neurons. The magnitude of striatal neurogenesis after stroke is similar in young and old animals, indicating that this potential mechanism for self-repair also operates in the aged brain.
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“The numbers of proliferating neural pre cursor cells in the subventricular zone and subgranular layer were lower in the brain tissue of 15-month-old rats than in that of 3-month-old rats, both under normal physiological and ischaemic conditions.78”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [78]
In the citing paper
“Although the de novo generation of neurons in the ischaemic striatum was very similar in both groups, neurogenesis was decreased in the dentate gyrus of 15-month-old rats when exposed to focal cerebral ischemia.78”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [78]
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Metadata
- Authors
- Darsalia, V., Heldmann, U., Lindvall, O., & Kokaia, Z.
- Affiliations
- Skåne University Hospital (SE)
- Venue
- Stroke
- Published
- 2005-08
- Volume
- 36
- Issue
- 8
- Pages
- 1790-1795
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2167181354
- Cited by
- 240
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 13 · 2012: 19
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- brain aging, middle cerebral artery occlusion, striatum, dentate gyrus, subventricular zone, subgranular zone, basal cell proliferation, neuronal differentiation, hippocampus, BrdU labeling
- MeSH terms
- Aging, Animals, Brain, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cerebral Arteries, Female, Hippocampus, Immunohistochemistry, Injections, Intraperitoneal, Ischemia, Microscopy, Fluorescence, Neurons, Stem Cells, Time Factors, Rats, Wistar, Microscopy, Confocal, Dentate Gyrus, Ki-67 Antigen, Infarction, Middle Cerebral Artery, Stroke, Cell Proliferation, Rats
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