The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Stroke-Induced Neurogenesis in Aged Brain
Abstract
Background and Purpose— Stroke induced by middle cerebral artery occlusion (MCAO) triggers increased neurogenesis in the damaged striatum and nondamaged hippocampus of young adult rodents. We explored whether stroke influences neurogenesis similarly in the aged brain. Methods— Young adult (3 months) and old (15 months) rats were subjected to 1 hour of MCAO, and new cells were labeled by intraperitoneal injection of 5-bromo-2′-deoxyuridine 5′-monophosphate (BrdU), a marker for dividing cells, for 2 weeks thereafter. Animals were euthanized at 7 weeks after the insult, and neurogenesis was assessed immunocytochemically with antibodies against BrdU and neuronal markers with epifluorescence or confocal microscopy. Results— Young and old rats exhibited the same increased numbers of new striatal neurons after stroke, despite basal cell proliferation in the subventricular zone being reduced in the aged brain. In contrast, both the number of stroke-generated granule cells and basal neurogenesis in the dentate subgranular zone were lower in old compared with young animals. Also, the ability of newly formed cells to differentiate into neurons was impaired in the aged dentate gyrus. Conclusions— Basal neurogenesis is impaired in the subgranular and subventricular zones of aged animals, but both regions react to stroke with increased formation of new neurons. The magnitude of striatal neurogenesis after stroke is similar in young and old animals, indicating that this potential mechanism for self-repair also operates in the aged brain.
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“The numbers of proliferating neural pre cursor cells in the subventricular zone and subgranular layer were lower in the brain tissue of 15-month-old rats than in that of 3-month-old rats, both under normal physiological and ischaemic conditions.78”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [78]
In the citing paper
“Although the de novo generation of neurons in the ischaemic striatum was very similar in both groups, neurogenesis was decreased in the dentate gyrus of 15-month-old rats when exposed to focal cerebral ischemia.78”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [78]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Self-citationInflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Self-citationTransient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,540
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150
Jin, K., Minami, M., Lan, J. Q., Mao, X. O., Parmentier‐Batteur, S., Simon, R. P., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081011098 · Cited by 1,061
Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002) · Annals of Neurology · doi:10.1002/ana.10393 · Cited by 1,020
Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999
Experimental studies of ischemic brain edema
Koizumi, J.-I., Yoshida, Y., Nakazawa, T., & Ooneda, G. (1986) · Nosotchu · doi:10.3995/jstroke.8.1 · Cited by 996
Tanapat, P., Hastings, N. B., Reeves, A. J., & Gould, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05792.1999 · Cited by 994
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Finkbeiner, S. M., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80395-5 · Cited by 959
Kempermann, G., Gast, D., & Gage, F. H. (2002) · Annals of Neurology · doi:10.1002/ana.10262 · Cited by 889
Gender-Linked Brain Injury in Experimental Stroke
Alkayed, N. J., Harukuni, I., Kimes, A. S., London, E. D., Traystman, R. J., & Hurn, P. D. (1998) · Stroke · doi:10.1161/01.str.29.1.159 · Cited by 754
Restoring production of hippocampal neurons in old age
Cameron, H. A., & McKay, R. D. G. (1999) · Nature Neuroscience · doi:10.1038/13197 · Cited by 710
Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
Jin, K., Sun, Y., Xie, L., Peel, A. L., Mao, X. O., Parmentier‐Batteur, S., & Greenberg, D. A. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00159-3 · Cited by 526
Jin, K., Sun, Y., Xie, L., Batteur, S., Mao, X. O., Smelick, C., Logvinova, A., & Greenberg, D. A. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00046.x · Cited by 396
Neurogenesis by Progenitor Cells in the Ischemic Adult Rat Hippocampus
Yagita, Y., Kitagawa, K., Ohtsuki, T., 高沢健一郎, Miyata, T., Okano, H., Hori, M., & Matsumoto, M. (2001) · Stroke · doi:10.1161/01.str.32.8.1890 · Cited by 343
Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00090-3 · Cited by 318
Arvidsson, A., Kokaia, Z., & Lindvall, O. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01611.x · Cited by 314
Self-citationKoizumi, J. (1986) · Medical Entomology and Zoology · Cited by 292
Kokaia, Z., Zhao, Q., Kokaia, M., Elmér, E., Metsis, M., Smith, M.-L., Siesjö, B. K., & Lindvall, O. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1085 · Cited by 252
Self-citationEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia
Teramoto, T., Qiu, J., Plumier, J.-C., & Moskowitz, M. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17170 · Cited by 227
EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia
Teramoto, T., Qiu, J., Plumier, J.-C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317170 · Cited by 194
Nácher, J., Alonso‐Llosà, G., Rosell, D. R., & McEwen, B. S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00096-9 · Cited by 182
Zhu, D. Y., Lau, L. W., Liu, S. H., Wei, J., & Lu, Y. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401063101 · Cited by 178
Ischemia‐induced neurogenesis is preserved but reduced in the aged rodent brain
Jin, K., Minami, M., Xie, L., Sun, Y., Mao, X. O., Wang, Y., Simon, R. P., & Greenberg, D. A. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00131.x · Cited by 121
Cell death in regenerating populations of neurons in BDNF mutant mice
Linnarsson, S., Willson, C. A., & Ernfors, P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00295-8 · Cited by 121
Ekdahl, C. T., Mohapel, P., Elmér, E., & Lindvall, O. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01713.x · Cited by 106
Self-citationShetty, A. K., Rao, M. S. R., Hattiangady, B., Zaman, V., & Shetty, G. A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20302 · Cited by 97
Spatial Cognitive Performance after Chronic Focal Cerebral Ischemia in Rats
Yonemori, F., Yamaguchi, T. F., Yamada, H., & Tamura, A. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199905000-00002 · Cited by 78
Asanuma, M., Nishibayashi, S., Iwata, E., Kondo, Y., Nakanishi, T., Gómez‐Vargas, M., & Ogawa, N. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00098-8 · Cited by 67
Decker, L., Picard-Riéra, N., Lachapelle, F., & Evercooren, A. B. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10411 · Cited by 62
Sato, K., Hayashi, T., Sasaki, C., Iwai, M., Li, F., Manabe, Y., Seki, T., & Abe, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03137-7 · Cited by 38
Dowson, J. H. (1985) · Experimental Gerontology · doi:10.1016/0531-5565(85)90013-0 · Cited by 15
The nursing student loan program: its history and present status.
Bc, B. (1986) · PubMed · Cited by 3
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Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943
Lee, J. S., Hong, J. M., Moon, G. J., Lee, P. H., Ahn, Y. H., & Bang, O. Y. (2010) · Stem Cells · doi:10.1002/stem.430 · Cited by 775
Stem cells in human neurodegenerative disorders — time for clinical translation?
Lindvall, O., & Kokaia, Z. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40543 · Cited by 629
Self-citationWhitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05886.x · Cited by 384
Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333
Metadata
- Authors
- Darsalia, V., Heldmann, U., Lindvall, O., & Kokaia, Z.
- Affiliations
- Skåne University Hospital (SE)
- Venue
- Stroke
- Published
- 2005-08
- Volume
- 36
- Issue
- 8
- Pages
- 1790-1795
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2167181354
- Cited by
- 240
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 13 · 2012: 19
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- brain aging, middle cerebral artery occlusion, striatum, dentate gyrus, subventricular zone, subgranular zone, basal cell proliferation, neuronal differentiation, hippocampus, BrdU labeling
- MeSH terms
- Aging, Animals, Brain, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cerebral Arteries, Female, Hippocampus, Immunohistochemistry, Injections, Intraperitoneal, Ischemia, Microscopy, Fluorescence, Neurons, Stem Cells, Time Factors, Rats, Wistar, Microscopy, Confocal, Dentate Gyrus, Ki-67 Antigen, Infarction, Middle Cerebral Artery, Stroke, Cell Proliferation, Rats
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