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Cited by 59Coffee research and impactsBlood Pressure and Hypertension StudiesAlcohol Consumption and Health Effects

Coffee Consumption in Hypertensive Men in Older Middle-Age and the Risk of Stroke

Hakim, Amy A., Ross, G.Webster, Curb, J.David, Rodriguez, Beatriz L., Burchfiel, Cecil M., Sharp, Dan S., Yano, Katsuhiko, Abbott, Robert D.·1998·Journal of Clinical Epidemiology
DOI 10.1016/s0895-4356(98)00023-7
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Abstract

Objective To examine the association between coffee consumption and the development of stroke in men at high risk for cardiovascular disease.Methods Coffee intake was observed from 1965 to 1968 in a cohort of men enrolled in the Honolulu Heart Program with follow-up for incident stroke over a 25-year period. Subjects were 499 hypertensive men (having systolic or diastolic blood pressures at or above 140 and 90 mm Hg, respectively) in older middle-age (55 to 68 years) when follow-up began. Past and current cigarette smokers were excluded from follow-up.Results In the course of follow-up, 76 men developed a stroke. After age-adjustment, risk of thromboembolic stroke increased significantly with increases in coffee consumption (P = 0.002). No relationships were observed with hemorrhagic stroke. When adjusted for other factors, the risk of thromboembolic stroke was more than doubled for men who consumed three cups of coffee per day as compared to nondrinkers of coffee (RR = 2.1; 95% CI = 1.2-3.7).Conclusions Although in need of further confirmation, consumption of coffee appears to be positively associated with an increased risk of thromboembolic stroke in hypertensive men in older middle-age. Findings suggest that it may be prudent to advise older middle-aged men with hypertension who consume large amounts of coffee to consider reducing their coffee intake.

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  • Another study found that coffee consumption was associated with an increased risk of ischemic stroke among hypertensive men who reported no previous or current smoking.

    “and another study found that coffee consumption was associated with an increased risk of ischemic stroke among hypertensive men who reported no previous or current smoking.24”

    From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [24]

  • There have been discrepant findings on the association between habitual coffee intake and ischemic stroke.

    “There have been discrepant findings on the association between habitual coffee intake and ischemic stroke.”

    From Coffee and acute ischemic stroke onset: The Stroke Onset Study (2010) · cites this paper as [24]

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Authors
Hakim, A. A., Ross, G. W., Curb, J. D., Rodriguez, B. L., Burchfiel, C. M., Sharp, D. S., Yano, K., & Abbott, R. D.
Affiliations
  • University of Minnesota (US)
  • University of Hawaiʻi at Mānoa (US)
  • National Heart, Lung, and Blood Institute (US)
  • Kuakini Medical Center (US)
Corresponding author
Abbott, Robert D.
ORCID
Venue
Journal of Clinical Epidemiology
Publisher
Elsevier BV
Published
1998-06
Volume
51
Issue
6
Pages
487-494
ISSN
0895-4356 (ISSN-L)
DOI
10.1016/s0895-4356(98)00023-7
OpenAlex
W2052515260
Cited by
59
References
51
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Clinical Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc005102-027)
  • National Heart, Lung, and Blood Institute (N01 HC 05102)
  • National Center for Research Resources (P20 RR/AI 11091)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
coffee consumption, stroke, thromboembolic stroke, hemorrhagic stroke, hypertension, cardiovascular risk, Honolulu Heart Program, dietary risk factors
MeSH terms
Aged, Cardiovascular Diseases, Intracranial Embolism and Thrombosis, Coffee, Hawaii, Humans, Hypertension, Male, Middle Aged, Risk, Risk Factors, Cohort Studies

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