The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Patent Foramen Ovale Size and Embolic Brain Imaging Findings Among Patients With Ischemic Stroke
Open accessAbstract
Background and Purpose —Although the cause of stroke among patients with patent foramen ovale (PFO) may be due to paradoxical cerebral embolism (PCE), this mechanism is often difficult to prove. The aim of our study was to evaluate the association between brain imaging findings suggestive of embolism and PFO among ischemic stroke patients. Methods —As part of the Northern Manhattan Stroke Study, 95 patients with first ischemic stroke over age 39 underwent transesophageal echocardiography (TEE) for evaluation of a cardiac source of embolism. The stroke subtype was determined by modified NINDS Stroke Data Bank criteria. Stroke subtype and MRI/CT imaging data were evaluated blind to the presence of a PFO. These findings were compared between two groups: patients with medium to large PFO (≥2 mm) and small (<2 mm) or no PFO. Results —Of the 95 patients who underwent TEE, 31 (33%) had a PFO. The frequency of PFO was significantly greater among patients with cryptogenic infarcts (19 of 42; 45%) compared with patients with determined cause of stroke (12 of 53, 23%; P =0.02). Medium to large PFOs were found more often among cryptogenic strokes than among infarcts of determined cause (26% versus 6%; P =0.04). Superficial infarcts occurred more often in the group with larger PFOs than in the group with small or no PFOs (50% versus 21%; P =0.02). Patients with medium or large PFOs more frequently had occipital and infratentorial strokes (57% versus 27%; P =0.02). Conclusions —Stroke patients with larger PFOs show more brain imaging features of embolic infarcts than those with small PFOs. Larger PFOs may be more likely to cause paradoxical embolization and may help explain the stroke mechanism among patients with no other definite cause.
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Citations
Cites
Prevalence of Patent Foramen Ovale in Patients with Stroke
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The Stroke Data Bank: design, methods, and baseline characteristics.
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PATENT FORAMEN OVALE IN YOUNG STROKE PATIENTS
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Self-citationTranscatheter closure of patent foramen ovale after presumed paradoxical embolism.
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Stroke recurrence in patients with patent foramen ovale: The Lausanne Study
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Self-citationRisk of patent foramen ovale for thromboembolic events in all age groups
de Belder, M. A., Tourikis, L., Leech, G., & Camm, A. J. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91228-v · Cited by 200
Testing the validity of the lacunar hypothesis: The Northern Manhattan Stroke Study experience
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Self-citation
Cited by
Sacco, R. L., Adams, R., Albers, G., Alberts, M. J., Benavente, O., Furie, K., Goldstein, L. B., Gorelick, P., Halperin, J., Harbaugh, R., et al. (2006) · Stroke · doi:10.1161/01.str.0000199147.30016.74 · Cited by 1,873
Self-citationMas, J.-L., Arquizan, C., Lamy, C., Zuber, M., Cabanes, L., Derumeaux, G., & Coste, J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011503 · Cited by 1,361
Interatrial septal abnormalities and stroke: A meta-analysis of case-control studies
Overell, J. R., Bone, I., & Lees, K. R. (2000) · Neurology · doi:10.1212/wnl.55.8.1172 · Cited by 936
Patent Foramen Ovale and Stroke
Homma, S., & Sacco, R. L. (2005) · Circulation · doi:10.1161/circulationaha.104.524371 · Cited by 435
Self-citationKhairy, P., O'Donnell, C. P., & Landzberg, M. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00010 · Cited by 388
Metadata
- Authors
- Steiner, M. M., Di Tullio, M. R., Rundek, T., Gan, R., Chen, X., Liguori, C., Brainin, M., Homma, S., & Sacco, R. L.
- Venue
- Stroke
- Published
- 1998-05
- Volume
- 29
- Issue
- 5
- Pages
- 944-948
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1977747781
- Cited by
- 360
- References
- 12
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Steiner, M. M., Di Tullio, M. R., Rundek, T., Gan, R., Chen, X., Liguori, C., Brainin, M., Homma, S., & Sacco, R. L. (1998). Patent Foramen Ovale Size and Embolic Brain Imaging Findings Among Patients With Ischemic Stroke. Stroke. https://doi.org/10.1161/01.str.29.5.944
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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