Serial Changes in Glucose Utilization and Insulin and Growth Hormone Secretion in Acute Cerebrovascular Disease
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Serial studies were made of glucose utilization and insulin and growth hormone secretion following intravenous glucose tolerance tests given to 16 patients during recovery from acute cerebrovascular disease. Three groups of patients were identified based on the pattern of change of glucose utilization during the first month of convalescence. A small group showed a persistent defective insulin response to glucose and appeared to have had pre-existing unrecognized adult-onset diabetes mellitus. The two other groups showed either an immediate suppression of glucose utilization or delayed development of glucose intolerance associated with an increase in total insulin secretion. Both of these responses returned to normal by the end of the fourth week. Growth hormone secretion correlated with the severity of the stroke. Alterations in glucose metabolism and insulin secretion seem to occur in most patients following recovery from stroke and undoubtedly reflect transient hormonal or metabolic changes related to either acute stress or tissue injury, depending on the interval after the onset of the vascular episode.
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Insulin sensitivity may be transiently impaired after a stroke.
“Because insulin sensitivity may be transiently impaired after a stroke,21 the screening blood test was conducted at least 14 days after the index event.”
From Pioglitazone after Ischemic Stroke or Transient Ischemic Attack (2016) · cites this paper as [21]
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Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
Kernan, W. N., Viscoli, C. M., Furie, K. L., Young, L. H., Inzucchi, S. E., Gorman, M., Guarino, P. D., Lovejoy, A. M., Peduzzi, P. N., Conwit, R., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506930 · Cited by 1,127 · see citing works
Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke
Kernan, W. N., Inzucchi, S. E., Viscoli, C. M., Brass, L. M., Bravata, D. M., Shulman, G. I., McVeety, J. C., & Horwitz, R. I. (2003) · Neurology · doi:10.1212/01.wnl.0000063318.66140.a3 · Cited by 126 · see citing works
Young, L. H., Viscoli, C. M., Curtis, J. P., Inzucchi, S. E., Schwartz, G. G., Lovejoy, A. M., Furie, K. L., Gorman, M. J., Conwit, R., Abbott, J. D., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024863 · Cited by 66 · see citing works
Viscoli, C. M., Brass, L. M., Carolei, A., Conwit, R., Ford, G. A., Furie, K. L., Gorman, M., Guarino, P. D., Inzucchi, S. E., Lovejoy, A. M., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.07.016 · Cited by 50 · see citing works
- Authors
- Huff, T. A., Lebovitz, H. E., HEYMAN, A., & Davis, L.
- Affiliations
- Augusta University (US)
- Duke University (US)
- Venue
- Stroke
- Published
- 1972-09
- Volume
- 3
- Issue
- 5
- Pages
- 543-552
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2150076094
- Cited by
- 10
- References
- 14
- Citations by year
- 2024: 2 · 2021: 1 · 2017: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- acute cerebrovascular disease, stroke recovery, glucose utilization, insulin secretion, growth hormone secretion, glucose tolerance test, impaired glucose tolerance, adult-onset diabetes mellitus, stroke severity
- MeSH terms
- Insulin Secretion, Acute Disease, Adult, Aged, Catecholamines, Intracranial Embolism and Thrombosis, Cerebral Hemorrhage, Cerebrovascular Disorders, Diabetes Mellitus, Diabetic Angiopathies, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Growth Hormone, Diabetes Complications
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