The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Morphological and Functional Characteristics of Patent Foramen Ovale and Their Embolic Implications
Abstract
Background and Purpose —Transesophageal echocardiography (TEE) has detected a high prevalence of patent foramen ovale (PFO) in stroke patients, but the clinical implications of the distinctive characteristics of this patency are still a matter of debate. Methods —We studied 350 patients with acute ischemic stroke or transient ischemic attack (TIA) within 1 week of admission. Of these, 101 (29%) were identified by contrast TEE to have a PFO; 86 patients (25%) were cryptogenic stroke patients, and 163 were excluded because of the presence of a definite or possible arterial or clinical evidence of a source of emboli or small-vessel disease. Thirteen PFO subjects without a history of embolism were designated as the control group. All PFO and cryptogenic stroke patients were followed up by neurological visits. Results —Compared with controls, PFO patients with acute stroke or TIA more frequently presented with a right-to-left shunt at rest and a higher membrane mobility ( P <0.05). Patients with these characteristics were considered to be at high risk. During a median follow-up period of 31 months (range, 4 to 58 months), 8 PFO and 18 cryptogenic stroke patients experienced recurrent cerebrovascular events. The cumulative estimate of risk of cerebrovascular event recurrence at 3 years was 4.3% (95% confidence interval [CI], 0% to 10.2%) for “low-risk” PFO patients, 12.5% (95% CI, 0% to 26.1%) for “high-risk” PFO patients, and 16.3% (95% CI, 7.2% to 25.4%) for cryptogenic stroke patients (high-risk PFO versus low-risk PFO, P =0.05). Conclusions —The association of right-to-left shunting at rest and high membrane mobility, as detected by contrast TEE, seems to identify PFO patients with cerebrovascular ischemic events who are at higher risk for recurrent brain embolism.
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Citations
Cites
Prevalence of Patent Foramen Ovale in Patients with Stroke
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Atherosclerotic Disease of the Aortic Arch and the Risk of Ischemic Stroke
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Patent Foramen Ovale as a Risk Factor for Cryptogenic Stroke
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A Classification and Outline of Cerebrovascular Diseases II
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Cited by
Sacco, R. L., Adams, R., Albers, G., Alberts, M. J., Benavente, O., Furie, K., Goldstein, L. B., Gorelick, P., Halperin, J., Harbaugh, R., et al. (2006) · Stroke · doi:10.1161/01.str.0000199147.30016.74 · Cited by 1,873
Mas, J.-L., Arquizan, C., Lamy, C., Zuber, M., Cabanes, L., Derumeaux, G., & Coste, J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011503 · Cited by 1,361
Patent Foramen Ovale and Stroke
Homma, S., & Sacco, R. L. (2005) · Circulation · doi:10.1161/circulationaha.104.524371 · Cited by 435
Khairy, P., O'Donnell, C. P., & Landzberg, M. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-9-200311040-00010 · Cited by 388
Contemporary Management of Patent Foramen Ovale
Meier, B., & Lock, J. E. (2003) · Circulation · doi:10.1161/01.cir.0000046073.34261.c1 · Cited by 256
Metadata
- Authors
- De Castro, S., Cartoni, D., Fiorelli, M., Rasura, M., Anzini, A., Zanette, E. M., Beccia, M., Colonnese, C., Fedele, F., Fieschi, C., & Pandian, N. G.
- Venue
- Stroke
- Published
- 2000-10
- Volume
- 31
- Issue
- 10
- Pages
- 2407-2413
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2089933125
- Cited by
- 379
- References
- 21
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Castro, S., Cartoni, D., Fiorelli, M., Rasura, M., Anzini, A., Zanette, E. M., Beccia, M., Colonnese, C., Fedele, F., Fieschi, C., & Pandian, N. G. (2000). Morphological and Functional Characteristics of Patent Foramen Ovale and Their Embolic Implications. Stroke. https://doi.org/10.1161/01.str.31.10.2407
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