The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation
Open accessAbstract
Objective— The balance between apoptosis susceptibility and efferocytosis of macrophages is central to plaque remodeling and inflammation. LRP-1 and its ligand, apolipoprotein E, have been implicated in efferocytosis and apoptosis in some cell types. We investigated the involvement of the macrophage LRP-1/apolipoprotein E axis in controlling plaque apoptosis and efferocytosis. Method and Results— LRP-1 −/− macrophages displayed nearly 2-fold more TUNEL positivity compared to wild-type cells in the presence of DMEM alone or with either lipopolysaccharide or oxidized low-density lipoprotein. The survival kinase, phosphorylated Akt, was barely detectable in LRP-1 −/− cells, causing decreased phosphorylated Bad and increased cleaved caspase-3. Regardless of the apoptotic stimulation and degree of cell death, LRP-1 −/− macrophages displayed enhanced inflammation with increased IL-1β, IL-6, and tumor necrosis factor-α expression. Efferocytosis of apoptotic macrophages was reduced by 60% in LRP-1 −/− vs wild-type macrophages despite increased apolipoprotein E expression by both LRP-1 −/− phagocytes and wild-type apoptotic cells. Compared to wild-type macrophage lesions, LRP-1 −/− lesions had 5.7-fold more necrotic core with more dead cells not associated with macrophages. Conclusion— Macrophage LRP-1 deficiency increases cell death and inflammation by impairing phosphorylated Akt activation and efferocytosis. Increased apolipoprotein E expression in LRP-1 −/− macrophages suggests that the LRP-1/apolipoprotein E axis regulates the balance between apoptosis and efferocytosis, thereby preventing necrotic core formation.
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“We previously reported that apoE-LRP1 interactions in macrophages control the rate of apoE secretion ( 51 ).”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [51]
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“Consistent with the role of defective efferocytosis in contributing to atherosclerosis progression, loss of LRP1 in haematopoietic cells increases atherosclerotic lesion area and necrotic core size in athero-prone mice fed a high-fat diet199,200.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [199]
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Cites
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,651
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases
Rüegg, U. T., & Gillian, B. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90263-0 · Cited by 904
Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis
Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509
Herz, J., Clouthier, D. E., & Hammer, R. E. (1992) · Cell · doi:10.1016/0092-8674(92)90511-a · Cited by 497
Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455
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- 10.1161/circ.99.19.2571 · DOI
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Alavi, M. S., Soheili, V., & Roohbakhsh, A. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176302 · Cited by 18
Georges, A. B., & Bouatia‐Naji, N. (2022) · Clinical Science · doi:10.1042/cs20210990 · Cited by 16
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Potì, F., Scalera, E., Feuerborn, R., Fischer, J., Arndt, L., Varga, G., Pardali, E., Seidl, M. D., Fobker, M., Liebisch, G., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.158127 · Cited by 15
Rentsendorj, A., Raedschelders, K., Fuchs, D.-T. S., Sheyn, J., Vaibhav, V., Porritt, R. A., Shi, H., Dagvadorj, J., Germano, J. D. F., Koronyo, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155935 · Cited by 16
Efferocytosis and Bone Dynamics
Batoon, L., Hawse, J. R., McCauley, L. K., Weivoda, M. M., & Roca, H. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00878-y · Cited by 16
sLRP1 (Soluble Low-Density Lipoprotein Receptor-Related Protein 1)
Chen, J., Pi, S., Yu, C. J., Shi, H., Liu, Y., Guo, X. Q., Zhou, L., Li, Y., He, H., Xia, Y., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314350 · Cited by 15
Lee, R. H., & Vázquez, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124584 · Cited by 14
Rafatian, N., Karunakaran, D., Rayner, K. J., Leenen, F. H. H., Milne, R. W., & Whitman, S. C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00618.2012 · Cited by 14
Vázquez, G., Solanki, S. A., Dube, P., Smedlund, K., & Ampem, P. T. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-26974-0_9 · Cited by 14
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Shu, L.-X., Cao, L.-L., Guo, X., Wang, Z., & Wang, S. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02439-3 · Cited by 16
Tano, J.-Y., Lee, R. H., & Vázquez, G. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.09.038 · Cited by 12
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Tavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B., & Fazio, S. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049874 · Cited by 10
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Zhu, M., Shen, H., Wang, B., He, Y., Chen, J., Ren, J., Zhang, Z., & Xu, J. (2023) · Oncology Letters · doi:10.3892/ol.2023.14019 · Cited by 9
Au, D. T., Arai, A. L., Fondrie, W. E., Muratoglu, S. C., & Strickland, D. K. (2018) · Current Drug Targets · doi:10.2174/1389450119666180511162048 · Cited by 9
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Wang, Y., Fang, L., Zhai, C., Cai, J., Li, X., Zong, L., Geng, Y., Zhu, C., Sun, C., Dong, M., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70841 · Cited by 1
Molecular and Cellular Aspects of Atherosclerosis: Emerging Roles of TRPC Channels
Vázquez, G., Smedlund, K., Jean-Yves, K., & Lee, R. (2012) · InTech eBooks · doi:10.5772/29877 · Cited by 1
Kinner, L. B., Pawaria, S., & Binder, R. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_413 · Cited by 1
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Dorien, M., Meyer, G. R. Y. D., & Martinet, W. (2012) · InTech eBooks · doi:10.5772/25335
Building Clinical Trust in Automated Knowledge Acquisition
Shillabeer, A. G. (2008) · InTech eBooks · doi:10.5772/6408
Degnan, A. J., & Gillard, J. H. (2011) · Future Neurology · doi:10.2217/fnl.11.60
Fontaine, M. A. C. (2020) · doi:10.26481/dis.20200514mf
Kinner, L. B., Pawaria, S., & Binder, R. J. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_413-1
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Fredman, G., & Tabas, I. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_18
Igel, E., Jaeschke, A., Haller, A. M., Asman, M., Mattam, U., Alagarsamy, J., Krishnan, K. C., & Hui, D. Y. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111421
ward, R., Krishnan, S. S., Stavrovskaya, I. G., Sanchez-Gonzalez, D., Agudelo, C. W., Park, S. S., Mai, M., Cai, H., Martinez, J., Cox, K., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101042
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Casale, R., Chiabrando, G. A., & Ceschin, D. G. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1829891
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Zhou, Z., Han, T., Wu, H., Yekefenhazi, D., Ye, K., & Han, F. (2026) · Fishes · doi:10.3390/fishes11060320
Li, D., Huang, Y. N., Chen, X.-Q., Lp, Z., Gong, Q., Li, Q., Li, Y., Xu, Y., & Huang, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1886016
Ran, C., Sanches, C. D., Swedblom, J., Wellfelt, K., Antoniazzi, A., Lloyd, J. O., Olofsgård, F. J., Spulber, S. D., Waldenlind, E., Lantz, M., et al. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02485-x
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Zhao, Y., Wu, K., Wang, H., Xu, C., Wei, Q., Li, M., Yang, D., Chen, M., & Zhang, D. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154484
Lei, S., Sun, D., Zhang, Y., Guo, Y., Chen, Y., Jiang, W., Zhang, Z., Luo, C., Wang, Z., Sun, J., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.08.018
Self-citationSubramanian, M. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2026_361
Metadata
- Authors
- Yancey, P. G., Blakemore, J., Ding, L., Fan, D., Overton, C. D., Zhang, Y., Linton, M. F., & Fazio, S.
- Affiliations
- Vanderbilt University Medical Center (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2010-04
- Volume
- 30
- Issue
- 4
- Pages
- 787-795
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC2845445
- OpenAlex
- W2108626579
- Cited by
- 168
- References
- 59
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 12 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 14 · 2014: 6 · 2013: 8 · 2012: 10
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL057986, R01HL065709, HL57986, R01HL086988, HL 53989, R01HL065405, HL 65405, R01HL053989, HL65709)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK59637, U24DK059637)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- LRP1, apolipoprotein E, efferocytosis, macrophage apoptosis, Akt signaling, atherosclerosis, plaque inflammation, necrotic core, macrophage phagocytosis, oxidized LDL, lipopolysaccharide, caspase-3, Bad phosphorylation
- MeSH terms
- Animals, Apolipoproteins E, Cell Survival, Cells, Cultured, Enzyme Activation, Female, Inflammation, Lipopolysaccharides, Lipoproteins, LDL, Necrosis, Phagocytosis, Phosphorylation, Receptors, LDL, Tumor Necrosis Factor-alpha, Interleukin-6, Apoptosis, Macrophages, Peritoneal, Mice, Knockout, In Situ Nick-End Labeling, Tumor Suppressor Proteins, Low Density Lipoprotein Receptor-Related Protein-1, Atherosclerosis, Proto-Oncogene Proteins c-akt, Mice, Interleukin-1beta
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