Risk Factor Differences for Aortic Versus Coronary Calcified Atherosclerosis: The Multiethnic Study of Atherosclerosis
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Objective— The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors. Methods and Results— We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r 2 values for the quantitative analyses were both much higher for AAC than for CAC. Conclusion— AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.
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Vascular calcification is a late event in the atherosclerotic process.
“Vascular calcification is a late event in the atherosclerotic process (36)”
From Triglycerides and residual atherosclerotic risk (2021) · cites this paper as [36]
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- [25]Jensky NE Laughlin GA Criqui MH Aboyans V Wong ND Detrano R Allison MA The epidemiology of abdominal aortic diameter: the Multi-Ethnic Study of Atherosclerosis Presented at the American Heart Association Arteriosclerosis, Thrombosis, and Vascular Biology Conference San Francisco, CA April 10, 2010 Available at: http://aha.scientificposters.com/atvb/epsWelcome.cfm
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Self-citationAortoiliac calcification correlates with 5-year survival after abdominal aortic aneurysm repair
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Walking and Calcified Atherosclerotic Plaque in the Coronary Arteries
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Self-citationProgression of arterial calcifications: what, where, and in whom?
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Systemic arterial calcium burden in patients with chronic limb-threatening ischemia
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Objective Methods to Assess Aorto-Iliac Calcifications: A Systematic Review
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Peripheral Artery Disease and Aortic Disease
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Self-citationAbdominal aortic calcification among gastroenterological and transplant surgery
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Morphomic calcification score from clinical CT scans: A proxy for coronary artery calcium
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Distribution of Abdominal Aortic Calcium by Computed Tomography
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Contre le curage lombo-aortique dans le cancer de l’ovaire après 70ans
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Self-citation
- Authors
- Criqui, M. H., Kamineni, A., Allison, M. A., Ix, J. H., Carr, J. J., Cushman, M., Detrano, R., Post, W., & Wong, N. D.
- Affiliations
- University of Vermont (US)
- ORCID
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2010-11
- Volume
- 30
- Issue
- 11
- Pages
- 2289-2296
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC2959146
- OpenAlex
- W2104983570
- Cited by
- 82
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc95164-17-0-1, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, n01hc95166-21-0-1, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, n01hc95163-22-0-1, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC-95160, N01-HC095169, N01 HC-95168, N01 HC95167, (N01-HC-95163, N01 HC-95161, N01 HC95165, N01HC95164, HL72403, N01-HC-095159, R01HL072403, N01‐HC‐95166, R21HL091217, HL091217, N01 HC-95162, N01 HC95169)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- coronary artery calcium, cardiovascular risk factors, cigarette smoking, dyslipidemia, hypertension, sex differences, phosphorus, novel risk factors, atherosclerosis imaging
- MeSH terms
- Aged, Aged, 80 and over, Aorta, Abdominal, Aortic Diseases, Calcinosis, Cardiovascular Diseases, Coronary Artery Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Regression Analysis, Risk Factors, Tomography, X-Ray Computed, Cohort Studies, Risk Assessment, Atherosclerosis
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