α1AMP-activated protein kinase mediates vascular protective effects of exercise
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OBJECTIVE: We investigated whether AMP-activated protein kinase (AMPK) may be involved in the signaling processes leading to exercise-mediated vascular protection. METHODS AND RESULTS: The effects of voluntary exercise on AMPK activity, endothelial NO synthase expression and phosphorylation, vascular reactive oxygen species formation, and cell senescence were tested in α1AMPK knockout and corresponding wild-type mice. Exercise significantly improved endothelial function, and increased plasma nitrite production in wild-type mice, associated with an activation of aortic AMPK assessed by its phosphorylation at threonine 172. In addition, regular physical activity resulted in an upregulation of endothelial NO synthase protein, serine 1177 endothelial NO synthase phosphorylation, and an increase of circulating Tie-2(+)Sca-1(+)Flk-1(+) myeloid progenitor cells. All these changes were absent after α1AMPK deletion. In addition, exercise increased the expression of important regulators of the antioxidative defense including heme oxygenase-1 and peroxisome proliferator-activated receptor γ coactivator 1α, decreased aortic reactive oxygen species levels, and prevented endothelial cell senescence in an α1AMPK-dependent manner. CONCLUSIONS: Intact α1AMPK signaling is required for the signaling events leading to the manifestation of vascular protective effects during exercise. Pharmacological AMPK activation might be a novel approach in the near future to simulate the beneficial vascular effects of physical activity.
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The reduction in P16, P53, and Chk2 protein levels and the increase in TRF2 and TERT mRNA expression in the vasculature of young wild-type mice induced by an 8-wk voluntary wheel running exercise intervention were attenuated in α1AMPK knockout mice.
“In relation to senescence, they found that the reduction in P16, P53, and Chk2 protein levels and the increase in TRF2 and TERT mRNA expression in the vasculature of young wild-type mice induced by an 8-wk voluntary wheel running exercise intervention were attenuated in α1AMPK knockout mice (51).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [51]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works
Asahara, T., Masuda, H., Takahashi, T., Kalka, C., Pastore, C., Silver, M., Kearne, M., Magner, M., & Isner, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.3.221 · Cited by 3,249 · see citing works
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709 · see citing works
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650 · see citing works
Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340 · see citing works
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
Towler, M. C., & Hardie, D. G. (2007) · Circulation Research · doi:10.1161/01.res.0000256090.42690.05 · Cited by 1,248 · see citing works
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works
Hambrecht, R., Adams, V., Erbs, S., Linke, A. H.-P., Kränkel, N., Shu, Y., Baither, Y., Gielen, S., Thiele, H., Gummert, J. F., et al. (2003) · Circulation · doi:10.1161/01.cir.0000074229.93804.5c · Cited by 941 · see citing works
Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858 · see citing works
AMP‐activated protein kinase phosphorylation of endothelial NO synthase
Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works
Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773 · see citing works
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586 · see citing works
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585 · see citing works
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556 · see citing works
Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553 · see citing works
Self-citationRegulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training
Fukai, T., Siegfried, M. R., Ushio‐Fukai, M., Cheng, Y. C., Kojda, G., & Harrison, D. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9551 · Cited by 552 · see citing works
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
Potente, M., Urbich, C., Sasaki, K., Hofmann, W. K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R. A., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23126 · Cited by 527 · see citing works
Shear Stress Mediates Endothelial Adaptations to Exercise Training in Humans
Tinken, T. M., Thijssen, D. H. J., Hopkins, N. D., Dawson, E. A., Cable, N. T., & GREEN, D. J. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.146282 · Cited by 496 · see citing works
Strehlow, K., Werner, N., Berweiler, J., Link, A., Dirnagl, U., Priller, J., Laufs, K., Ghaeni, L., Milošević, M., Böhm, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000077911.81151.30 · Cited by 454 · see citing works
Seeger, F. H., Tonn, T., Krzossok, N., Zeiher, A. M., & Dimmeler, S. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl509 · Cited by 387 · see citing works
Morrow, V. A., Foufelle, F., Connell, J., Petrie, J., Gould, G., & Salt, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212831200 · Cited by 384 · see citing works
Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall
Werner, C., Fürster, T., Widmann, T., Pöss, J., Roggia, C., Hanhoun, M., Scharhag, J., Büchner, N., Meyer, T., Kindermann, W., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.861005 · Cited by 380 · see citing works
Adams, V., Linke, A. H.-P., Kränkel, N., Erbs, S., Gielen, S., Möbius‐Winkler, S., Gummert, J. F., Mohr, F. W., Schuler, G. C., & Hambrecht, R. (2005) · Circulation · doi:10.1161/01.cir.0000154560.88933.7e · Cited by 337 · see citing works
Dernbach, E., Urbich, C., Brandes, R. P., Hofmann, W. K., Zeiher, A. M., & Dimmeler, S. (2004) · Blood · doi:10.1182/blood-2003-12-4103 · Cited by 331 · see citing works
Nagata, D., Mogi, M., & Walsh, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300643200 · Cited by 331 · see citing works
Wallerath, T., Witte, K. K., Schäfer, S. C., Schwarz, P. M., Prellwitz, W., Wohlfart, P., Kleinert, H., Lehr, H., Lemmer, B., & Förstermann, U. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13357 · Cited by 289 · see citing works
Detection of Superoxide in Vascular Tissue
Münzel, T. F., Afanasʹev, I. B., Kleschyov, A. L., & Harrison, D. G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034022.11764.ec · Cited by 281 · see citing works
Self-citationExercise Training and the Cardiovascular Consequences of Type 2 Diabetes and Hypertension
Stewart, K. J. (2002) · JAMA · doi:10.1001/jama.288.13.1622 · Cited by 257 · see citing works
Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212 · see citing works
Oelze, M. W., Daiber, A., Brandes, R. P., Hortmann, M., Wenzel, P., Hink, U., Schulz, E., Mollnau, H., von Sandersleben, A., Kleschyov, A. L., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000239207.82326.29 · Cited by 202 · see citing works
Self-citationNagata, D., Takeda, R., Sata, M., Satonaka, H., Suzuki, E., Nagano, T., & Hirata, Y. (2004) · Circulation · doi:10.1161/01.cir.0000136025.96811.76 · Cited by 198 · see citing works
Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012
Daiber, A., August, M., Baldus, S. E., Wendt, M., Oelze, M. W., Sydow, K., Kleschyov, A. L., & Münzel, T. F. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.012 · Cited by 184 · see citing works
Self-citationActivation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
Liu, X., Peyton, K. J., Shebib, A. R., Wang, H., Korthuis, R. J., & Durante, W. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2010 · Cited by 171 · see citing works
Schulz, E., Dopheide, J. F., Schuhmacher, S., Thomas, S. R., Chen, K., Daiber, A., Wenzel, P., Münzel, T. F., & Keaney, J. F. (2008) · Circulation · doi:10.1161/circulationaha.108.784289 · Cited by 150 · see citing works
Self-citationLee-Young, R. S., Griffee, S. R., Lynes, S. E., Bracy, D. P., Ayala, J. E., McGuinness, O. P., & Wasserman, D. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021048 · Cited by 145 · see citing works
Kojda, G., Cheng, Y. C., Burchfield, J. S., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.23.2839 · Cited by 143 · see citing works
Chrzczanowicz, J., Gawron-Skarbek, A., Zwolińska, A., de Graft‐Johnson, J., Krajewski, W. W., Król, M., Markowski, J., Kostka, T., & Nowak, D. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.062 · Cited by 124 · see citing works
Honold, J., Lehmann, R., Heeschen, C., Walter, D. H., Aßmus, B., Sasaki, K., Martin, H., Haendeler, J., Zeiher, A. M., & Dimmeler, S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000240248.55172.dd · Cited by 124 · see citing works
AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells
Li, X., Han, Y., Pang, W., Li, C., Xie, X., Shyy, J. Y.-J., & Zhu, Y. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.172452 · Cited by 113 · see citing works
The Exercise-Induced Oxidative Stress Paradox: The Effects of Physical Exercise Training
Leaf, D. A., Kleinman, M. T., Hamilton, M., & Deitrick, R. W. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40531-2 · Cited by 89 · see citing works
Lee, R. S., Ayala, J. E., Hunley, C. F., James, F. D., Bracy, D. P., Kang, L., & Wasserman, D. H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00004.2010 · Cited by 87 · see citing works
Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
Takabe, W., Warabi, E., & Noguchi, N. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3433 · Cited by 80 · see citing works
Dixit, M., Bess, E. N., Fißlthaler, B., Härtel, F. V., Noll, T., Busse, R., & Fleming, I. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm017 · Cited by 68 · see citing works
Sun, M.-W., Zhong, M., Gu, J. F., Feng-lei, Q., Gu, J.-Z., & Chen, H. (2008) · Hypertension Research · doi:10.1291/hypres.31.805 · Cited by 65 · see citing works
The Exercise-Induced Oxidative Stress Paradox: The Effects of Physical Exercise Training
LEAF, D. A., Kleinman, M. T., Hamilton, M., et al. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199905000-00005 · Cited by 40 · see citing works
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Steinbacher, P., & Eckl, P. (2015) · Biomolecules · doi:10.3390/biom5020356 · Cited by 416 · see citing works
Vion, A.-C., Kheloufi, M., Hammoutène, A., Poisson, J., Lasselin, J., Devue, C., Pic, I., Dupont, N., Busse, J., Stark, K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702223114 · Cited by 229 · see citing works
Self-citationRedox Regulation of Inflammation: Old Elements, a New Story
Lei, Y., Wang, K., Deng, L., Chen, Y., Nice, E. C., & Huang, C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21330 · Cited by 208 · see citing works
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Tauffenberger, A., & Magistretti, P. J. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03208-7 · Cited by 151 · see citing works
Is exercise a senolytic medicine? A systematic review
Chen, X., Yi, Z., Wong, G. T., Hasan, K. M. M., Kwan, J. S., Ma, A. C., & Chang, R. C. (2021) · Aging Cell · doi:10.1111/acel.13294 · Cited by 88 · see citing works
Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation
Vaibhav, K., Braun, M., Khan, M. B., Fatima, S., Saad, N., Shankar, A., Khan, Z. T., Harris, R. B. S., Yang, Q., Huo, Y., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171905 · Cited by 78 · see citing works
Morris, G., & Maes, M. H. J. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0628-x · Cited by 75 · see citing works
Zheng, Z., Wang, M., Cheng, C., Liu, D., Wu, L., Zhu, J., & Qian, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11096 · Cited by 74 · see citing works
Enkhjargal, B., Godo, S., Sawada, A., Nergui, S., Saito, H., Noda, K., Satoh, K., & Shimokawa, H. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303735 · Cited by 70 · see citing works
Hypoxia, AMPK activation and uterine artery vasoreactivity
Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69 · see citing works
Jansen, T., Kvandová, M., Daiber, A., Stamm, P., Frenis, K., Schulz, E., Münzel, T., & Kröller-Schön, S. (2020) · Antioxidants · doi:10.3390/antiox9060525 · Cited by 68 · see citing works
Self-citationBoa, B. C. S., Yudkin, J. S., van Hinsbergh, V. W. M., Bouskela, E., & Eringa, E. C. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13732 · Cited by 64 · see citing works
Exercise Counters the Age-Related Accumulation of Senescent Cells
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Self-citationLiu, D., Ding, Z., Wu, M., Xu, W., Qian, M., Du, Q., Zhang, L., Cui, Y., Zheng, J., Chang, H., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.01.017 · Cited by 36 · see citing works
Sheldon, R. D., Laughlin, M. H., & Rector, R. S. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01275.2013 · Cited by 33 · see citing works
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Kvandová, M., Rajlic, S., Stamm, P., Schmal, I., Mihaliková, D., Kuntić, M., Jiménez, M. T. B., Hahad, O., Kollárová, M., Ubbens, H., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad075 · Cited by 28 · see citing works
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Targeting senescent cells for vascular aging and related diseases
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- Authors
- Kröller-Schön, S., Jansen, T., Hauptmann, F., Schüler, A., Heeren, T., Hausding, M., Oelze, M., Viollet, B., Keaney, J. F., Wenzel, P., Daiber, A., Münzel, T., & Schulz, E.
- Affiliations
- From the Department of Cardiology, II. Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany (S.K-S., T.J., F.H., T.H., M.H., M.O., P.W., A.D., T.M., E.S.); Inserm U1016, Institut Cochin (B.V.); Cnrs, UMR8104 (B.V.); Univ Paris Descartes (B.V.), Paris, France; Division of Cardiovascular Medicine, UMass Medical School, Worcester, MA (J.F.K.); Center for Thrombosis and Hemostasis (S.K-S., P.W.) and the Department of Haematology (A.S.), III. Medizinische Klinik und Poliklinik,...
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2012-07
- Volume
- 32
- Issue
- 7
- Pages
- 1632-1641
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC3873341
- OpenAlex
- W2105591192
- Cited by
- 38
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Stiftung Mainzer Herz
- Bundesministerium für Bildung und Forschung (BMBF 01EO1003, 01EO1003)
- Deutsche Herzstiftung
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL098407, R01HL092122)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- AMPK, physical activity, vascular protection, endothelial function, endothelial nitric oxide synthase, reactive oxygen species, endothelial cell senescence, myeloid progenitor cells, heme oxygenase-1, PGC-1α, nitrite, AMPK activation
- MeSH terms
- Adenosine Triphosphate, Animals, Endothelium, Vascular, Male, Mice, Inbred C57BL, Nitrites, Physical Conditioning, Animal, Regeneration, Signal Transduction, Cellular Senescence, Oxidative Stress, Mice, Nitric Oxide Synthase Type III, AMP-Activated Protein Kinases
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