The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation
Open accessAbstract
Cardiovascular diseases represent the leading cause of global deaths and life years spent with a severe disability. Endothelial dysfunction and vascular oxidative stress are early precursors of atherosclerotic processes in the vascular wall, all of which are hallmarks in the development of cardiovascular diseases and predictors of future cardiovascular events. There is growing evidence that inflammatory processes represent a major trigger for endothelial dysfunction, vascular oxidative stress and atherosclerosis and clinical data identified inflammation as a cardiovascular risk factor on its own. AMP-activated protein kinase (AMPK) is a central enzyme of cellular energy balance and metabolism that has been shown to confer cardio-protection and antioxidant defense which thereby contributes to vascular health. Interestingly, AMPK is also redox-regulated itself. We have previously shown that AMPK largely contributes to a healthy endothelium, confers potent antioxidant effects and prevents arterial hypertension. Recently, we provided deep mechanistic insights into the role of AMPK in cardiovascular protection and redox homeostasis by studies on arterial hypertension in endothelial and myelomonocytic cell-specific AMPK knockout (Cadh5CrexAMPKfl/fl and LysMCrexAMPKfl/fl) mice. Using these cell-specific knockout mice, we revealed the potent anti-inflammatory properties of AMPK representing the molecular basis of the antihypertensive effects of AMPK. Here, we discuss our own findings in the context of literature data with respect to the anti-inflammatory and antioxidant effects of AMPK in the specific setting of arterial hypertension as well as cardiovascular diseases in general.
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AMPK has potent anti-inflammatory properties in hypertension.
“Recently, deep mechanistic studies into the cardiovascular protection of AMPK using endothelial or myelomonocytic cell-specific AMPK KO mice have revealed the potent anti-inflammatory properties of AMPK in hypertension [145].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [145]
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Self-citation
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AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works
- Authors
- Jansen, T., Kvandová, M., Daiber, A., Stamm, P., Frenis, K., Schulz, E., Münzel, T., & Kröller-Schön, S.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Allgemeines Krankenhaus Celle (DE)
- Center for Cardiology, Department of Cardiology 1—Molecular Cardiology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
- Corresponding author
- Daiber, Andreas
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-06-16
- Volume
- 9
- Issue
- 6
- Pages
- 525
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7346208
- OpenAlex
- W3034715300
- Cited by
- 68
- References
- 111
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 10 · 2023: 11 · 2022: 16 · 2021: 8 · 2020: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (SCHU 1486/4-1)
- Deutsches Zentrum für Herz-Kreislaufforschung (Partner Site Rhine-Main, Mainz, Germany)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- AMPK, antioxidant defense, vascular inflammation, endothelial dysfunction, vascular oxidative stress, atherosclerosis, hypertension, redox homeostasis, anti-inflammatory activity, cardioprotection, myelomonocytic cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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