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Cited by 170

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Associations of Plasma Kynurenines With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris

Open access
Pedersen, Eva Ringdal, Tuseth, Nora, Eussen, Simone J.P.M., Ueland, Per Magne, Strand, Elin, Svingen, Gard Frodahl Tveitevåg, Midttun, Øivind, Meyer, Klaus, Mellgren, Gunnar, Ulvik, Arve, Nordrehaug, Jan Erik, Nilsen, Dennis W., Nygård, Ottar·2015·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.114.304674
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Abstract

Objective—: Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-γ, has been related to cardiovascular disease progression and insulin resistance. We assessed downstream tryptophan metabolites of the kynurenine pathway as predictors of acute myocardial infarction in patients with suspected stable angina pectoris. Furthermore, we evaluated potential effect modifications according to diagnoses of pre-diabetes mellitus or diabetes mellitus. Approach and Results—: Blood samples were obtained from 4122 patients (median age, 62 years; 72% men) who underwent elective coronary angiography. During median follow-up of 56 months, 8.3% had acute myocardial infarction. Comparing the highest quartile to the lowest, for the total cohort, multivariable adjusted hazard ratios (95% confidence intervals) were 1.68 (1.21–2.34), 1.81 (1.33–2.48), 1.68 (1.21–2.32), and 1.48 (1.10–1.99) for kynurenic acid, hydroxykynurenine, anthranilic acid, and hydroxyanthranilic acid, respectively. The kynurenines correlated with phenotypes of the metabolic syndrome, and risk associations were generally stronger in subgroups classified with pre-diabetes mellitus or diabetes mellitus at inclusion ( P int ≤0.05). Evaluated in the total population, hydroxykynurenine and anthranilic acid provided statistically significant net reclassification improvements (0.21 [0.08–0.35] and 0.21 [0.07–0.35], respectively). Conclusions—: In patients with suspected stable angina pectoris, elevated levels of plasma kynurenines predicted increased risk of acute myocardial infarction, and risk estimates were generally stronger in subgroups with evidence of impaired glucose homeostasis. Future studies should aim to clarify roles of the kynurenine pathway in atherosclerosis and glucose metabolism.

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Metadata

Authors
Pedersen, E. R., Tuseth, N., Eussen, S. J. P. M., Ueland, P. M., Strand, E., Svingen, G. F. T., Midttun, Ø., Meyer, K., Mellgren, G., Ulvik, A., Nordrehaug, J. E., Nilsen, D. W., & Nygård, O.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-02
Volume
35
Issue
2
Pages
455-462
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.114.304674
OpenAlex
W2164335474
Cited by
170
References
5
FWCI
2.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Associations of Plasma Kynurenines With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris. https://app.cochat.ai/papers/10.1161/atvbaha.114.304674
The paper
Pedersen, E. R., Tuseth, N., Eussen, S. J. P. M., Ueland, P. M., Strand, E., Svingen, G. F. T., Midttun, Ø., Meyer, K., Mellgren, G., Ulvik, A., Nordrehaug, J. E., Nilsen, D. W., & Nygård, O. (2015). Associations of Plasma Kynurenines With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.114.304674

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.