Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
Open accessAbstract
Dysregulation of insulin action is most often considered in the context of impaired glucose homeostasis, with the defining feature of diabetes mellitus being elevated blood glucose concentration. Complications arising from the hyperglycemia accompanying frank diabetes are well known and epidemiological studies point to higher risk toward development of metabolic disease in persons with impaired glucose tolerance. Although the central role of proper blood sugar control in maintaining metabolic health is well established, recent developments have begun to shed light on associations between compromised insulin action [obesity, prediabetes, and type 2 diabetes mellitus (T2DM)] and altered intermediary metabolism of fats and amino acids. For amino acids, changes in blood concentrations of select essential amino acids and their derivatives, in particular BCAA, sulfur amino acids, tyrosine, and phenylalanine, are apparent with obesity and insulin resistance, often before the onset of clinically diagnosed T2DM. This review provides an overview of these changes and places recent observations from metabolomics research into the context of historical reports in the areas of biochemistry and nutritional biology. Based on this synthesis, a model is proposed that links the FFA-rich environment of obesity/insulin resistance and T2DM with diminution of BCAA catabolic enzyme activity, changes in methionine oxidation and cysteine/cystine generation, and tissue redox balance (NADH/NAD+).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BCAAs have recently been demonstrated to accumulate in the context of obesity and insulin resistance.
“BCAAs have recently been demonstrated to accumulate in the context of obesity and insulin resistance (Adams, 2011; Newgard et al., 2009; Wang et al., 2011), though the mechanisms leading to this metabolic phenotype (i.e., higher intake, decreased catabolism) are not yet clear.”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Adams, 2011
Mpc inhibition may potentiate oxidation of BCAAs or other amino acids that accumulate in the context of insulin resistance.
“Mpc inhibition may potentiate oxidation of BCAAs or other amino acids that accumulate in the context of insulin resistance (Adams, 2011; Newgard et al., 2009; Wang et al., 2011).”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Adams, 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165 · see citing works
Metabolite profiles and the risk of developing diabetes
Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S., Rhee, E. P., McCabe, E., Lewis, G. D., Fox, C. S., Jacques, P. F., Fernandez, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2307 · Cited by 3,143 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works
Regulation of adiposity by dietary calcium
Zemel, M. B., Shi, H., Greer, B. P., DiRienzo, D. B., & Zemel, P. C. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1132 · Cited by 968 · see citing works
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887 · see citing works
Plasma Amino Acid Levels and Insulin Secretion in Obesity
Felig, P., Marliss, E., & Cahill, G. F. (1969) · New England Journal of Medicine · doi:10.1056/nejm196910092811503 · Cited by 812 · see citing works
Morino, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25151 · Cited by 811 · see citing works
Gall, W. E., Beebe, K. D., Lawton, K. A., Adam, K., Mitchell, M. W., Nakhle, P. J., Ryals, J. A., Milburn, M. V., Nannipieri, M., Camastra, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010883 · Cited by 702 · see citing works
Adams, S. H., Hoppel, C. L., Lok, K. H., Zhao, L., Wong, S. W., Minkler, P. E., Hwang, D. H., Newman, J. W., & Garvey, W. T. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103754 · Cited by 598 · see citing works
Branched-Chain Amino Acids: Enzyme and Substrate Regulation
Brosnan, J. T., & Brosnan, M. E. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.207s · Cited by 577 · see citing works
Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works
D'Antona, G., Ragni, M., Cardile, A., Tedesco, L., Dossena, M., Bruttini, F., Caliaro, F., Corsetti, G., Bottinelli, R., Carruba, M. O., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.016 · Cited by 568 · see citing works
Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway
Tremblay, F., & Marette, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106703200 · Cited by 536 · see citing works
Zhang, Y., Guo, K., LeBlanc, R. E., Loh, D., Schwartz, G. J., & Yu, Y. (2007) · Diabetes · doi:10.2337/db07-0123 · Cited by 532 · see citing works
She, P., Horn, C. V., Reid, T., Hutson, S. M., Cooney, R. N., & Lynch, C. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00134.2007 · Cited by 504 · see citing works
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
Holness, M. J., & Sugden, M. C. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311143 · Cited by 479 · see citing works
Tai, E. S., Tan, M. L. S., Stevens, R. D., Low, Y.-L., Muehlbauer, M. J., Goh, D. L. M., Ilkayeva, O., Wenner, B. R., Bain, J. R., Lee, J. J. M., et al. (2010) · Diabetologia · doi:10.1007/s00125-009-1637-8 · Cited by 471 · see citing works
Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes · doi:10.2337/db06-0783 · Cited by 453 · see citing works
Fiehn, O., Garvey, W. T., Newman, J. W. I., Lok, K. H., Hoppel, C. L., & Adams, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015234 · Cited by 418 · see citing works
A molecular model of human branched-chain amino acid metabolism
Suryawan, A., Hawes, J. W., Harris, R. A., Shimomura, Y., Jenkins, A. E., & Hutson, S. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.1.72 · Cited by 414 · see citing works
Huffman, K. M., Shah, S. H., Stevens, R. D., Bain, J. R., Muehlbauer, M., Slentz, C. A., Tanner, C. J., Kuchibhatla, M., Houmard, J. A., Newgard, C. B., et al. (2009) · Diabetes Care · doi:10.2337/dc08-2075 · Cited by 410 · see citing works
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
Salek, R. M., Maguire, M. L., Bentley, E., Rubtsov, D. V., Hough, T., Cheeseman, M. T., Nunez, D. J., Sweatman, B. C., Haselden, J. N., Cox, R., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00194.2006 · Cited by 405 · see citing works
An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
Gannon, M. C., Nuttall, F. Q., Saeed, A., Jordan, K., & Hoover, H. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.734 · Cited by 404 · see citing works
Tzatsos, A., & Kandror, K. V. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.63-76.2006 · Cited by 399 · see citing works
Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.50 · Cited by 399 · see citing works
Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels
Herman, M. A., She, P., Peroni, O. D., Lynch, C. J., & Kahn, B. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075184 · Cited by 395 · see citing works
Laferrère, B., Reilly, D., Arias, S., Swerdlow, N. J., Gorroochurn, P., Bawa, B., Bose, M., Teixeira, J. A., Stevens, R. D., Wenner, B. R., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002043 · Cited by 385 · see citing works
Pettit, F. H., Yeaman, S. J., & Reed, L. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.4881 · Cited by 282 · see citing works
Body composition phenotypes in pathways to obesity and the metabolic syndrome
Dulloo, A. G., Jacquet, J., Solinas, G., Montani, J.-P., & Schutz, Y. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.234 · Cited by 268 · see citing works
Macotela, Y., Emanuelli, B., Bång, A. M., Espinoza, D., Boucher, J., Beebe, K. D., Gall, W., & Kahn, C. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021187 · Cited by 263 · see citing works
Increased Fructose Concentrations in Blood and Urine in Patients With Diabetes
Kawasaki, T., Akanuma, H., & Yamanouchi, T. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.353 · Cited by 253 · see citing works
Li, X., Xu, Z., Lu, X., Yang, X., Yin, P., Kong, H., Yu, Y. Q., & Xu, G. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.11.058 · Cited by 248 · see citing works
Lu, G., Sun, H., She, P., Youn, J.-Y., Warburton, S., Ping, P., Vondriska, T. M., Cai, H. “., Lynch, C. J., & Wang, Y. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38151 · Cited by 226 · see citing works
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism
Goodman, M. N., Larsen, P. R., Kaplan, M. M., Aoki, T. T., Young, V. R., & Ruderman, N. B. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.239.4.e277 · Cited by 223 · see citing works
Plasma Amino Acid Levels and Insulin Secretion in Obesity
Felig, P. (1970) · Laboratory Medicine · doi:10.1093/labmed/1.9.39 · Cited by 213 · see citing works
Insulin Resistance of Protein Metabolism in Type 2 Diabetes
Pereira, S., Marliss, E. B., Morais, J. A., Chevalier, S., & Gougeon, R. (2007) · Diabetes · doi:10.2337/db07-0887 · Cited by 198 · see citing works
Larsen, R. N., Mann, N. J., Maclean, E., & Shaw, J. E. (2011) · Diabetologia · doi:10.1007/s00125-010-2027-y · Cited by 197 · see citing works
Regulation of branched-chain α-ketoacid dehydrogenase kinase
Paxton, R., & Harris, R. A. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90361-8 · Cited by 179 · see citing works
Elshorbagy, A. K., Nurk, E., Gjesdal, C. G., Tell, G. S., Ueland, P. M., Nygard, O. K., Tverdal, A., Vollset, S. E., & Refsum, H. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.738 · Cited by 178 · see citing works
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
Sears, D. D., Hsiao, G., Hsiao, A., Yu, J., Courtney, C. H., Ofrecio, J. M., Chapman, J., & Subramaniam, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903032106 · Cited by 177 · see citing works
Influence of dietary deprivations on plasma concentration of free amino acids of man.
Adibi, S. A. (1968) · Journal of Applied Physiology · doi:10.1152/jappl.1968.25.1.52 · Cited by 176 · see citing works
Brinkworth, G. D., Noakes, M., Parker, B., Foster, P., & Clifton, P. M. (2004) · Diabetologia · doi:10.1007/s00125-004-1511-7 · Cited by 175 · see citing works
Guillet, C., Delcourt, I., Rance, M., Giraudet, C., Walrand, S., Bedu, M., Duché, P., & Boirie, Y. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2216 · Cited by 175 · see citing works
Coinduction of Rat Liver Branched Chain α-Keto Acid Dehydrogenase Activities
Wohlhueter, R. M., & Harper, A. E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63165-5 · Cited by 169 · see citing works
El-Khairy, L., Ueland, P. M., Nygard, O. K., Refsum, H. M., & Vollset, S. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1016 · Cited by 163 · see citing works
Pyruvate Dehydrogenase, Substrate Specificity and Product Inhibition
Bremmer, J. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00559.x · Cited by 161 · see citing works
High Dietary Calcium Reduces Body Fat Content, Digestibility of Fat, and Serum Vitamin D in Rats
Papakonstantinou, E., Flatt, W. P., Huth, P. J., & Harris, R. B. S. (2003) · Obesity Research · doi:10.1038/oby.2003.52 · Cited by 159 · see citing works
Effects of oral hypoglycemic agents and diet on protein metabolism in type 2 diabetes.
Gougeon, R., Styhler, K., Morais, J. A., Jones, P. J. H., & Marliss, E. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.1 · Cited by 156 · see citing works
Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes
Doi, M., Yamaoka, I., Fukunaga, T., & Nakayama, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.039 · Cited by 155 · see citing works
Wijekoon, E. P., Skinner, C., Brosnan, M. E., & Brosnan, J. T. (2004) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y04-067 · Cited by 154 · see citing works
Zemel, M. B., Sun, X., Sobhani, T., & Wilson, B. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28468 · Cited by 148 · see citing works
Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes
Halvatsiotis, P., Short, K. R., Bigelow, M. L., & Nair, K. S. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2395 · Cited by 143 · see citing works
Sweatt, A. J., Wood, M., Suryawan, A., Wallin, R., Willingham, M. C., & Hutson, S. M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00276.2003 · Cited by 140 · see citing works
Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator
Feng, X., Chen, Y., Zhao, J., Tang, C., Jiang, Z., & Geng, B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.059 · Cited by 130 · see citing works
Sargrad, K. R., Homko, C. J., Mozzoli, M. A., & Boden, G. H. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.01.009 · Cited by 129 · see citing works
Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes
Menge, B. A., Schrader, H., Ritter, P. R., Ellrichmann, M., Uhl, W. H., Schmidt, W. E., & Meier, J. J. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.08.001 · Cited by 126 · see citing works
Shimomura, Y., Obayashi, M., Murakami, T., & Harris, R. A. (2001) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200109000-00013 · Cited by 126 · see citing works
Inverse relationship of leucine flux and oxidation to free fatty acid availability in vivo.
Tessari, P., Nissen, S., Miles, J. M., & Haymond, M. W. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112339 · Cited by 109 · see citing works
Homocysteine metabolism in diabetes
Wijekoon, E. P., Brosnan, M. E., & Brosnan, J. T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351175 · Cited by 108 · see citing works
Smith, A. J., & Strang, L. B. (1958) · Archives of Disease in Childhood · doi:10.1136/adc.33.168.109 · Cited by 107 · see citing works
A Novel Branched-chain Amino Acid Metabolon
Islam, M. M., Wallin, R., Wynn, R. M., Conway, M., Fujii, H., Mobley, J. A., Chuang, D. T., & Hutson, S. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700198200 · Cited by 107 · see citing works
WILLIAMSON, J. R., Wałajtys-Rode, E., & Coll, K. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86514-6 · Cited by 104 · see citing works
Partial purification and properties of branched-chain 2-oxo acid dehydrogenase of ox liver
Parker, P. J., & Randle, P. J. (1978) · Biochemical Journal · doi:10.1042/bj1710751 · Cited by 102 · see citing works
Gillim, S. E., Paxton, R., Cook, G. A., & Harris, R. A. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(83)80119-3 · Cited by 98 · see citing works
Determinants of Whole-Body Protein Metabolism in Subjects With and Without Type 2 Diabetes
Gougeon, R., Morais, J. A., Chevalier, S., Pereira, S., Lamarche, M., & Marliss, E. B. (2007) · Diabetes Care · doi:10.2337/dc07-1268 · Cited by 97 · see citing works
Guo, K., Yu, Y., Hou, J., & Zhang, Y. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-57 · Cited by 95 · see citing works
How does ethnicity affect the association between obesity and diabetes?
Díaz, V. A., Mainous, A. G., Baker, R., Carnemolla, M. A., & Majeed, A. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02244.x · Cited by 88 · see citing works
Pyridine Nucleotide Redox Abnormalities in Diabetes
Ido, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1630 · Cited by 83 · see citing works
Dietary Whey Protein Lowers the Risk for Metabolic Disease in Mice Fed a High-Fat Diet,
Shertzer, H. G., Woods, S., Krishan, M., Genter, M. B., & Pearson, K. J. (2011) · Journal of Nutrition · doi:10.3945/jn.110.133736 · Cited by 83 · see citing works
Hinault, C., Mothe‐Satney, I., Gautier, N., Lawrence, J., & Obberghen, E. V. (2004) · The FASEB Journal · doi:10.1096/fj.03-1409fje · Cited by 80 · see citing works
Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
Hsiao, G., Chapman, J., Ofrecio, J. M., Wilkes, J. J., Resnik, J. L., Thapar, D., Subramaniam, S., & Sears, D. D. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2010 · Cited by 80 · see citing works
Cellular localization and characterization of bovine liver branched-chain α-keto acid dehydrogenases
Johnson, W. A., Connelly, J. L., & Glynn, M. T. (1972) · Biochemistry · doi:10.1021/bi00760a036 · Cited by 77 · see citing works
Regulation of Branched-Chain α-Keto Acid Dehydrogenase Kinase Expression in Rat Liver
Harris, R. A., Kobayashi, R., Murakami, T., & Shimomura, Y. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.841s · Cited by 71 · see citing works
Gougeon, R., Pencharz, P. B., & Sigal, R. J. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.3.861 · Cited by 67 · see citing works
Mammalian α-Keto Acid Dehydrogenase Complexes
Kanzaki, T., Hayakawa, T., HAMADA, M., Fukuyoshi, Y., & Koike, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91827-2 · Cited by 67 · see citing works
Differential effects of insulin resistance on leucine and glucose kinetics in obesity
Caballero, B. H., & Wurtman, R. J. (1991) · Metabolism · doi:10.1016/0026-0495(91)90192-y · Cited by 67 · see citing works
Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms
Kobayashi, R., Murakami, T., Obayashi, M., Nakai, N., Jaskiewicz, J. A., Fujiwara, Y., Shimomura, Y., & Harris, R. A. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00472-1 · Cited by 66 · see citing works
Leucine Metabolism in Type II Diabetes Mellitus
Staten, M. A., Matthews, D. E., & Bier, D. M. (1986) · Diabetes · doi:10.2337/diab.35.11.1249 · Cited by 66 · see citing works
Leucine and isoleucine activate skeletal muscle branched-chain alpha-keto acid dehydrogenase in vivo
Aftring, R. P., Block, K. P., & Buse, M. G. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.5.e599 · Cited by 65 · see citing works
The Association of Plasma Cysteine and γ‐Glutamyltransferase With BMI and Obesity
Elshorbagy, A. K., Refsum, H., Smith, A. D., & Graham, I. M. (2009) · Obesity · doi:10.1038/oby.2008.671 · Cited by 65 · see citing works
Kuzuya, T., Katano, Y., Nakano, I., Hirooka, Y., Ito, A., Ishigami, M., Hayashi, K., Honda, T., Goto, H., Fujita, Y., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.167 · Cited by 65 · see citing works
Effect of NIDDM on the Kinetics of Whole-Body Protein Metabolism
Gougeon, R., Pencharz, P. B., & Marliss, E. B. (1994) · Diabetes · doi:10.2337/diab.43.2.318 · Cited by 64 · see citing works
Paxton, R., Ścisłowski, P. W. D., Davis, E. J., & Harris, R. A. (1986) · Biochemical Journal · doi:10.1042/bj2340295 · Cited by 63 · see citing works
Zeng, M., Liang, Y., Li, H., Wang, M., Wang, B., Chen, X., Zhou, N., Cao, D., & Wu, J. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.01.002 · Cited by 63 · see citing works
Jacobs, R. L., Stead, L. M., Brosnan, M. E., & Brosnan, J. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107553200 · Cited by 62 · see citing works
Effect of the LoBAG 30 diet on blood glucose control in people with type 2 diabetes
Nuttall, F. Q., Schweim, K., Hoover, H., & Gannon, M. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507819155 · Cited by 60 · see citing works
Lowell, B. B., & Goodman, M. N. (1987) · Diabetes · doi:10.2337/diab.36.1.14 · Cited by 58 · see citing works
High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice
Pilvi, T. K., Korpela, R., Huttunen, M. M., Vapaatalo, H., & Mervaala, E. M. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764760 · Cited by 57 · see citing works
El-Khairy, L., Vollset, S. E., Refsum, H., & Ueland, P. M. (2003) · Clinical Chemistry · doi:10.1373/49.1.113 · Cited by 56 · see citing works
Korsheninnikova, E., van der Zon, G. C. M., Voshol, P. J., Janssen, G. M. C., Havekes, L. M., Grefhorst, A., Kuipers, F., Reijngoud, D., Romijn, J. A., Ouwens, D. M., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0439-5 · Cited by 55 · see citing works
JONES, S. M. A., & Yeaman, S. J. (1986) · Biochemical Journal · doi:10.1042/bj2370621 · Cited by 54 · see citing works
Noatsch, A., Petzke, K. J., Millrose, M. K., & Klaus, S. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0155-2 · Cited by 52 · see citing works
Insulin effect on leucine kinetics in type 2 diabetes mellitus.
Halvatsiotis, P., Turk, D., Alzaid, A., Dinneen, S. F., Rizza, R. A., & Nair, K. S. (2002) · PubMed · Cited by 51 · see citing works
Protein and energy metabolism in starvation reconsidered.
Henry, C. J., Rivers, J. P. W., & Payne, P. (1988) · PubMed · Cited by 51 · see citing works
Dairy Protein Attenuates Weight Gain in Obese Rats Better Than Whey or Casein Alone
Eller, L. K., & Reimer, R. A. (2009) · Obesity · doi:10.1038/oby.2009.300 · Cited by 49 · see citing works
Jakobs, C., Solem, E., Ek, J., Halvorsen, K., & Jellum, E. (1977) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)81324-9 · Cited by 49 · see citing works
Dietary calcium attenuation of body fat gain during high-fat feeding in mice
Parra, P., Bruni, G., Palou, A., & Serra, F. A. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.01.009 · Cited by 48 · see citing works
Doisaki, M., Katano, Y., Nakano, I., Hirooka, Y., Ito, A., Ishigami, M., Hayashi, K., Goto, H., Fujita, Y., Kadota, Y., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.004 · Cited by 43 · see citing works
High blood ketone body concentration in Type 2 non-insulin dependent diabetic patients
Avogaro, A., Crepaldi, C., Miola, M., Maran, A., Pengo, V., Tiengo, A., & Prato, S. D. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349844 · Cited by 43 · see citing works
Identification of a novel PP2C-type mitochondrial phosphatase
Joshi, M., Jeoung, N. H., Popov, K. M., & Harris, R. A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.108 · Cited by 42 · see citing works
Gougeon, R., Marliss, E., Jones, P., Pencharz, P. B., & Morais, J. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800577 · Cited by 41 · see citing works
Hinault, C., OBBERGHEN, E. V., & Mothe‐Satney, I. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.008 · Cited by 39 · see citing works
Mechanism of Activation of Branched-Chain α-Keto Acid Dehydrogenase Complex by Exercise
Xu, M. Q., Nagasaki, M., Obayashi, M., Sato, Y., Tamura, T., & Shimomura, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5647 · Cited by 38 · see citing works
Obayashi, M., Sato, Y., Harris, R. A., & Shimomura, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02149-4 · Cited by 36 · see citing works
Block, K. P., Soemitro, S., Heywood, B. W., & Harper, A. E. (1985) · Journal of Nutrition · doi:10.1093/jn/115.12.1550 · Cited by 35 · see citing works
Gannon, M. C., Hoover, H., & Nuttall, F. Q. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-64 · Cited by 34 · see citing works
Activation of rat liver branched-chain 2-oxo acid dehydrogenase in vivo by glucagon and adrenaline
Block, K. P., Heywood, B. W., Buse, M. G., & Harper, A. E. (1985) · Biochemical Journal · doi:10.1042/bj2320593 · Cited by 34 · see citing works
Insulin increases branched-chain α-ketoacid dehydrogenase kinase expression in Clone 9 rat cells
Nellis, M. M., Doering, C. B., Kasinski, A. L., & Danner, D. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00133.2002 · Cited by 32 · see citing works
Khatra, B. S., Chawla, R. K., Wadsworth, A. D., & Rudman, D. (1977) · Journal of Nutrition · doi:10.1093/jn/107.8.1528 · Cited by 31 · see citing works
α-Ketoacid dehydrogenase complexes and respiratory fuel utilisation in diabetes
Randle, P. J. (1985) · Diabetologia · doi:10.1007/bf00281981 · Cited by 31 · see citing works
Hargrove, J. L. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77830-2 · Cited by 29 · see citing works
Hargrove, J. L., & Wichman, R. D. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48243-9 · Cited by 27 · see citing works
Paul, H. S., Liu, W., & Adibi, S. A. (1996) · Biochemical Journal · doi:10.1042/bj3170411 · Cited by 27 · see citing works
Papet, I., Lezebot, N., BARRÉ, F., Arnal, M., & Harper, A. E. (1988) · British Journal Of Nutrition · doi:10.1079/bjn19880057 · Cited by 25 · see citing works
Dixon, J. L., & Harper, A. E. (1984) · Journal of Nutrition · doi:10.1093/jn/114.6.1025 · Cited by 25 · see citing works
Disturbance of methyl group metabolism in alloxan-diabetic sheep.
Gp, X., & Snoswell, A. (1985) · PubMed · Cited by 24 · see citing works
Glass, A. R., Bongiovanni, R., Smith, C. E., & Boehm, T. M. (1981) · Metabolism · doi:10.1016/0026-0495(81)90134-7 · Cited by 23 · see citing works
Crowell, P. L., Block, K., Repa, J. J., Torres, N., Nawabi, M., Buse, M., & Harper, A. E. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.2.313 · Cited by 22 · see citing works
Bajotto, G., Murakami, T., Nagasaki, M., Sato, Y., & Shimomura, Y. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.029 · Cited by 22 · see citing works
Kinetic characterization of branched chain ketoacid dehydrogenase
Boyer, B., & Odessey, R. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90321-9 · Cited by 22 · see citing works
Sloger, M. S., Scholfield, L. G., & Reynolds, R. D. (1978) · Journal of Nutrition · doi:10.1093/jn/108.8.1355 · Cited by 21 · see citing works
Hargrove, J. L., Trotter, J. F., Ashline, H. C., & Krishnamurti, P. V. (1989) · Metabolism · doi:10.1016/0026-0495(89)90105-4 · Cited by 21 · see citing works
JONES, S. M. A., & Yeaman, S. J. (1986) · Biochemical Journal · doi:10.1042/bj2360209 · Cited by 20 · see citing works
Okuda, Y., Kawai, K., Murayama, Y., & Yamashita, K. (1987) · Endocrinologia Japonica · doi:10.1507/endocrj1954.34.415 · Cited by 19 · see citing works
Characterization of α-Ketobutyrate Metabolism in Rat Tissues: Effects of Dietary Protein and Fasting
Steele, R. D., WEBER, H., & Patterson, J. I. (1984) · Journal of Nutrition · doi:10.1093/jn/114.4.701 · Cited by 18 · see citing works
Diurnal variation in glucose and leucine metabolism in non-insulin-dependent diabetes
Umpleby, A. M., Scobie, I. N., Boroujerdi, M. A., Carson, E. R., & Sönksen, P. H. (1990) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(90)90014-k · Cited by 17 · see citing works
Kettelhut, Í. D. C., Foss, M. C., & Migliorini, R. H. (1985) · Metabolism · doi:10.1016/0026-0495(85)90063-0 · Cited by 17 · see citing works
Buckley, W., & Milligan, L. P. (1978) · Biochemical Journal · doi:10.1042/bj1760449 · Cited by 15 · see citing works
Robertson, D. A., Singh, B. M., & Nattrass, M. (1991) · PubMed · Cited by 14 · see citing works
Boyer, B. B., & Odessey, R. (1990) · Biochemical Journal · doi:10.1042/bj2710523 · Cited by 13 · see citing works
Vitamin B-6 requirement for irreversible inactivation of rat liver tyrosine aminotransferase
Reynolds, R. D. (1978) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(78)90442-3 · Cited by 13 · see citing works
Marchesini, G., Bianchi, G. P., Vilstrup, H., Capelli, M., Zoli, M., & Pisi, E. (1991) · Clinical Nutrition · doi:10.1016/0261-5614(91)90096-u · Cited by 13 · see citing works
Sex-specific differences in plasma branched-chain keto acid levels in obesity
SCHAUDER, P., Zavelberg, D., Langer, K., & Herbertz, L. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.1.58 · Cited by 13 · see citing works
Hu, H., Jaskiewicz, J. A., & Harris, R. A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90243-p · Cited by 12 · see citing works
Hoffer, L. J., Taveroff, A., & Hamadeh, M. J. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90291-8 · Cited by 11 · see citing works
Ubukata, E. (1990) · Annals of Nutrition and Metabolism · doi:10.1159/000177607 · Cited by 10 · see citing works
Borud, O., & Pettersen, J. E. (1982) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01799755 · Cited by 6 · see citing works
Okita, M., Watanabe, A., Shiota, T., & Nagashima, H. (1986) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.32.83 · Cited by 3 · see citing works
On the inhibition of α-oxobutyrate utilization by fatty acids in rat liver mitochondria
Ciman, M., Carignani, G., Alexandre, A., & Siliprandi, N. (1971) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(71)90229-5 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 143 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Branched-chain amino acids in metabolic signalling and insulin resistance
Lynch, C. J., & Adams, S. H. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.171 · Cited by 1,461 · see citing works
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441 · see citing works
The gut microbiota influences skeletal muscle mass and function in mice
Lahiri, S., Kim, H., Garcia-Perez, I., Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang, H., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5662 · Cited by 580 · see citing works
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471 · see citing works
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance
Gaggini, M., Carli, F., Rosso, C., Buzzigoli, E., Marietti, M., Latta, V. D., Ciociaro, D., Abate, M. L., Gambino, R., Cassader, M., et al. (2017) · Hepatology · doi:10.1002/hep.29465 · Cited by 467 · see citing works
The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
Yoon, M.-S. (2016) · Nutrients · doi:10.3390/nu8070405 · Cited by 395 · see citing works
Ferrannini, E., Natali, A., Camastra, S., Nannipieri, M., Mari, A., Adam, K., Milburn, M. V., Kastenmüller, G., Adamski, J., Tuomilehto, J., et al. (2012) · Diabetes · doi:10.2337/db12-0707 · Cited by 350 · see citing works
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks
Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 335 · see citing works
Lackey, D. E., Lynch, C. J., Olson, K. C., Mostaedi, R., Ali, M., Smith, W. H., Karpe, F., Humphreys, S. M., Bedinger, D., Dunn, T. N., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00630.2012 · Cited by 317 · see citing works
Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives
Milagro, F. I., Mansego, M. L., de Miguel, C., & Martínez, J. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.010 · Cited by 310 · see citing works
Vanweert, F., Schrauwen, P., & Esther Phielix, E. (2022) · Nutrition and Diabetes · doi:10.1038/s41387-022-00213-3 · Cited by 315 · see citing works
Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
Vacanti, N. M., Divakaruni, A. S., Green, C. R., Parker, S. J., Henry, R. R., Ciaraldi, T. P., Murphy, A. N., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.024 · Cited by 277 · see citing works
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
Li, H., Zhang, L., Li, J., Wu, Q., Qian, L., He, J., Ni, Y., Kovatcheva‐Datchary, P., Yuan, R. R., Liu, S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00988-y · Cited by 270 · see citing works
Prevotella copri increases fat accumulation in pigs fed with formula diets
Chen, C., Fang, S., Hong Kui, W. E. I., He, M., Fu, H., Xiong, X., Zhou, Y., Wu, J., Gao, J., Yang, H., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01110-0 · Cited by 237 · see citing works
Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts
Sansbury, B. E., DeMartino, A. M., Xie, Z., Brooks, A. C., Brainard, R. E., Watson, L. J., DeFilippis, A. P., Cummins, T. D., Harbeson, M. A., Brittian, K. R., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001151 · Cited by 234 · see citing works
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
Lake, A. D., Novák, P., Shipkova, P. A., Aranı́bar, N., Robertson, D. G., Reily, M. D., Lehman‐McKeeman, L. D., Vaillancourt, R. R., & Cherrington, N. J. (2014) · Amino Acids · doi:10.1007/s00726-014-1894-9 · Cited by 232 · see citing works
Rangel-Huerta, Ó. D., Pastor‐Villaescusa, B., & Gil, Á. (2019) · Metabolomics · doi:10.1007/s11306-019-1553-y · Cited by 224 · see citing works
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss
Piening, B., Zhou, W., Contrepois, K., Röst, H. L., Gu, G. J., Mishra, T., Hanson, B., Bautista, E. J., Leopold, S. R., Yeh, C. Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.013 · Cited by 210 · see citing works
Budhathoki, S., Sawada, N., Iwasaki, M., Yamaji, T., Goto, A., Kotemori, A., Ishihara, J., Takachi, R., Charvat, H., Mizoue, T., et al. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.2806 · Cited by 203 · see citing works
High dietary protein intake, reducing or eliciting insulin resistance?
Rietman, A., Schwarz, J., Tomé, D., Kok, F. J., & Mensink, M. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.123 · Cited by 202 · see citing works
The Effect of n-3 Fatty Acids on Glucose Homeostasis and Insulin Sensitivity
Flachs, P., Rossmeisl, M., & Kopecký, J. (2014) · Physiological Research · doi:10.33549/physiolres.932715 · Cited by 183 · see citing works
Metabolomic profiles and childhood obesity
Perng, W., Gillman, M. W., Fleisch, A. F., Michalek, R. D., Watkins, S. M., ISGANAITIS, E. M., Patti, M., & Oken, E. (2014) · Obesity · doi:10.1002/oby.20901 · Cited by 181 · see citing works
Metabolic remodeling of white adipose tissue in obesity
Cummins, T. D., Holden, C. R., Sansbury, B. E., Gibb, A., Shah, J., Zafar, N., Tang, Y., Hellmann, J. L., Rai, S. N., Spite, M. R., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00271.2013 · Cited by 169 · see citing works
Pedersen, E., Tuseth, N., Eussen, S., Ueland, P., Strand, E., Svingen, G., Midttun, Ø., Meyer, K., Mellgren, G., Ulvik, A., et al. (2015) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304674 · Cited by 165 · see citing works
Yamakado, M., Nagao, K., Imaizumi, A., Tani, M., Toda, A., Tanaka, T., Jinzu, H., Miyano, H., Yamamoto, H., Daimon, T., et al. (2015) · Scientific Reports · doi:10.1038/srep11918 · Cited by 169 · see citing works
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes
Park, S., Sadanala, K. C., & Kim, E. K. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0126 · Cited by 168 · see citing works
Alderete, T. L., Jin, R., Walker, D. I., Valvi, D., Chen, Z., Jones, D. P., Peng, C., Gilliland, F. D., Berhane, K. T., Conti, D. V., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.02.047 · Cited by 162 · see citing works
Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism
Lerín, C., Goldfine, A. B., Boes, T., Liu, M., Kasif, S., Dreyfuss, J. M., Sousa‐Coelho, A. L. D., Daher, G., Manoli, I., Sysol, J. R., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.08.001 · Cited by 150 · see citing works
Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 149 · see citing works
Legault, J. T., Strittmatter, L., Tardif, J., Sharma, R., Vaillancourt, V. T., Aubut, C., Boucher, G., Clish, C. B., Cyr, D., Daneault, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.054 · Cited by 149 · see citing works
Pena, M. J., Heerspink, H. J. L., Hellemons, M. E., Friedrich, T., Dallmann, G., Lajer, M., Bakker, S. J. L., Gansevoort, R. T., Rossing, P. R., de Zeeuw, D., et al. (2014) · Diabetic Medicine · doi:10.1111/dme.12447 · Cited by 147 · see citing works
Branched-chain amino acid metabolism: from rare Mendelian diseases to more common disorders
Burrage, L. C., Nagamani, S. C. S., Campeau, P. M., & Lee, B. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu123 · Cited by 150 · see citing works
Mitochondrial function/dysfunction in white adipose tissue
Boudina, S., & Graham, T. E. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.081414 · Cited by 146 · see citing works
Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes
Gar, C., Rottenkolber, M., Prehn, C. P., Adamski, J., Seißler, J., & Lechner, A. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1414143 · Cited by 140 · see citing works
Defining meal requirements for protein to optimize metabolic roles of amino acids
Layman, D., Anthony, T., Rasmussen, B., Adams, S., Lynch, C., Brinkworth, G., & Davis, T. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.084053 · Cited by 141 · see citing works
α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance
Cobb, J. E., Eckhart, A. D., Motsinger‐Reif, A. A., Carr, B., Groop, L., & Ferrannini, E. (2016) · Diabetes Care · doi:10.2337/dc15-2752 · Cited by 135 · see citing works
Metabolic profiling of gestational diabetes in obese women during pregnancy
White, S. L., Pasupathy, D., Sattar, N. A., Nelson, S. M., Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P. I., & Poston, L. (2017) · Diabetologia · doi:10.1007/s00125-017-4380-6 · Cited by 131 · see citing works
Nagata, C., Nakamura, K., Wada, K., Tsuji, M., Tamai, Y., & Kawachi, T. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt112 · Cited by 133 · see citing works
Gaike, A. H., Paul, D., Bhute, S. S., Dhotre, D. P., Pande, P., Upadhyaya, S., Reddy, Y. B. S., Sampath, R., Ghosh, D., Chandraprabha, D., et al. (2020) · mSystems · doi:10.1128/msystems.00578-19 · Cited by 130 · see citing works
Serum and Adipose Tissue Amino Acid Homeostasis in the Metabolically Healthy Obese
Badoud, F., Lam, K. P., DiBattista, A., Perreault, M., Zulyniak, M. A., Cattrysse, B., Stephenson, S., Britz‐McKibbin, P., & Mutch, D. M. (2014) · Journal of Proteome Research · doi:10.1021/pr500416v · Cited by 129 · see citing works
Biswas, D., Duffley, L., & Pulinilkunnil, T. (2019) · The FASEB Journal · doi:10.1096/fj.201802842rr · Cited by 124 · see citing works
Metabolomic Biomarkers for Obesity in Humans: A Short Review
Rauschert, S., Uhl, O., Koletzko, B. V., & Hellmuth, C. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000365040 · Cited by 125 · see citing works
Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore
Belosludtsev, K. N., Belosludtseva, N. V., & Dubinin, M. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186559 · Cited by 122 · see citing works
Lian, K., Du, C., Liu, Y., Zhu, D., Yan, W., Zhang, H., Hong, Z., Liu, P., Zhang, L., Pei, H., et al. (2014) · Diabetes · doi:10.2337/db14-0312 · Cited by 119 · see citing works
Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes
Bakar, M. H. A., Sarmidi, M. R., Cheng, K., Khan, A. A., Suan, C. L., Huri, H. Z., & Yaakob, H. (2015) · Molecular BioSystems · doi:10.1039/c5mb00158g · Cited by 117 · see citing works
Hellmuth, C., Kirchberg, F. F., Lass, N., Harder, U., Peißner, W., Koletzko, B. V., & Reinehr, T. (2015) · Journal of Diabetes Research · doi:10.1155/2016/2108909 · Cited by 115 · see citing works
Metabolomics in diabetes, a review
Pallares-Méndez, R., Aguilar-Salinas, C. A., Cruz‐Bautista, I., & del Bosque‐Plata, L. (2016) · Annals of Medicine · doi:10.3109/07853890.2015.1137630 · Cited by 114 · see citing works
Gut Microbiome and Metabolome Profiles Associated with High-Fat Diet in Mice
Jo, J.-K., Seo, S.-H., Park, S.-E., Kim, H., Kim, E., Kim, J.-S., Pyo, J., Cho, K., Kwon, S.-J., Park, D.-H., et al. (2021) · Metabolites · doi:10.3390/metabo11080482 · Cited by 112 · see citing works
Leucine and Protein Metabolism in Obese Zucker Rats
She, P., Olson, K. C., Kadota, Y., Inukai, A., Shimomura, Y., Hoppel, C. L., Adams, S. H., Kawamata, Y., Matsumoto, H., Sakai, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059443 · Cited by 109 · see citing works
Monnerie, S., Comte, B., Ziegler, D., Morais, J. A., Pujos‐Guillot, E., & Gaudreau, P. (2020) · Scientific Reports · doi:10.1038/s41598-019-56909-7 · Cited by 109 · see citing works
Yousri, N. A., Mook-Kanamori, D. O., Selim, M. M. E.-D., Takiddin, A. H., Al-Homsi, H., Al-Mahmoud, K. A. S., Karoly, E. D., Krumsiek, J., Thinh, K., Neumaier, U., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3636-2 · Cited by 106 · see citing works
Sunny, N. E., Kalavalapalli, S., Bril, F., Garrett, T. J., Nautiyal, M., Mathew, J. T., Williams, C. M., & Cusi, K. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2015 · Cited by 106 · see citing works
Plasma-free amino acid profiles are predictors of cancer and diabetes development
Bi, X., & Henry, C. J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2016.55 · Cited by 106 · see citing works
Obesity and diabetes related plasma amino acid alterations
Zhou, Y., Qiu, L., Xiao, Q., Wang, Y., Meng, X., Xu, R. H., Wang, S., & Na, R. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.05.045 · Cited by 105 · see citing works
Exploratory metabolomics of metabolic syndrome: A status report
Lent-Schochet, D., McLaughlin, M. J., Ramakrishnan, N., & Jialal, I. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i1.23 · Cited by 105 · see citing works
Stanciu, S. M., Rusu, E., Miricescu, D., Radu, A. C., Axinia, B., Vrabie, A.-M., Ionescu, R. F., Jinga, M., & Sîrbu, C. A. (2023) · Metabolites · doi:10.3390/metabo13010087 · Cited by 113 · see citing works
Effect of Insulin Sensitizer Therapy on Amino Acids and Their Metabolites
Irving, B. A., Carter, R. E., Soop, M., Weymiller, A., Syed, H., Karakelides, H., Bhagra, S., Short, K. R., Tatpati, L. L., Barazzoni, R., et al. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.008 · Cited by 98 · see citing works
Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes
Tulipani, S., Palau‐Rodriguez, M., Miñarro, A., Cardona, F., Marco‐Ramell, A., Žonja, B., de Alda, M. L., Muñoz‐Garach, A., Sánchez‐Pla, Á., Tinahones, F. J., et al. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.10.005 · Cited by 97 · see citing works
Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster
Heinrichsen, E. T., Zhang, H., Robinson, J. E., Ngo, J. T., Diop, S. B., Bodmer, R., Joiner, W. J., Metallo, C. M., & Haddad, G. G. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.003 · Cited by 97 · see citing works
Liu, Y., Turdi, S., Park, T., Morris, N. J., Deshaies, Y., Xu, A., & Sweeney, G. (2012) · Diabetes · doi:10.2337/db12-0687 · Cited by 97 · see citing works
Asghari, G., Farhadnejad, H., Teymoori, F., Mirmiran, P., Tohidi, M., & Azizi, F. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12639 · Cited by 97 · see citing works
Abnormal circulating amino acid profiles in multiple metabolic disorders
Okekunle, A. P., Li, Y., Liu, L., Du, S., Wu, X., Chen, Y., Li, Y., Qi, J., Sun, C., & Feng, R. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.07.023 · Cited by 94 · see citing works
Leucine in Obesity: Therapeutic Prospects
Yao, K., Duan, Y., Li, F., Tan, B., Hou, Y., Wu, G., & Yin, Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.004 · Cited by 89 · see citing works
Su, X., Magkos, F., Zhou, D., Eagon, J. C., Fabbrini, E., Okunade, A. L., & Klein, S. (2014) · Obesity · doi:10.1002/oby.20923 · Cited by 90 · see citing works
Vanweert, F., Neinast, M. D., Erazo‐Tapia, E., van de Weijer, T., Joris Hoeks, J., Schrauwen‐Hinderling, V. B., Blair, M. C., Bornstein, M. R., Hesselink, M. K. C., Schrauwen, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31249-9 · Cited by 87 · see citing works
Hu, X., Thakur, K., Chen, G.-H., Hu, F., Zhang, J., Zhang, H.-B., & Wei, Z. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01766 · Cited by 86 · see citing works
Potential Role of Branched-Chain Amino Acid Catabolism in Regulating Fat Oxidation
Kainulainen, H., Hulmi, J. J., & Kujala, U. M. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a4e6b6 · Cited by 84 · see citing works
Freudenberg, A., Petzke, K. J., & Klaus, S. (2012) · Amino Acids · doi:10.1007/s00726-012-1363-2 · Cited by 84 · see citing works
Yamaguchi, N., Mahbub, M., Takahashi, H., Hase, R., Ishimaru, Y., Sunagawa, H., Amano, H., Kobayashi‐Miura, M., Kanda, H., Fujita, Y., et al. (2017) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-017-0642-7 · Cited by 83 · see citing works
The relationship between BMI and metabolomic profiles: a focus on amino acids
Morris, C., O'Grada, C., Ryan, M., Roche, H. M., Gibney, M. J., Gibney, E. R., & Brennan, L. (2012) · Proceedings of the Nutrition Society · doi:10.1017/s0029665112000699 · Cited by 81 · see citing works
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population
Zaghlool, S. B., Halama, A., Stephan, N., Guðmundsdóttir, V., Gudnason, V. G., Jennings, L. L., Thangam, M., Ahlqvist, E., Malik, R. A., Albagha, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34754-z · Cited by 80 · see citing works
Tricò, D., Prinsen, H., Giannini, C., de Graaf, R. A., Juchem, C., Li, F., Caprio, S., Santoro, N., & Herzog, R. I. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00475 · Cited by 81 · see citing works
Metabolomic Profiling of Amino Acids and β-Cell Function Relative to Insulin Sensitivity in Youth
Michaliszyn, S. F., Sjaarda, L. A., Mihalik, S. J., Lee, S., Bacha, F. F., Chace, D. H., Jesús, V. R. D., Vockley, J. E., & Arslanian, S. A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2170 · Cited by 80 · see citing works
Changes in the serum metabolite profile in obese children with weight loss
Reinehr, T., Wolters, B., Knop, C., Lass, N., Hellmuth, C., Harder, U., Peißner, W., Wahl, S., Grallert, H., Adamski, J., et al. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0698-8 · Cited by 78 · see citing works
Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H. L., Gao, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900665rr · Cited by 75 · see citing works
Piccolo, B. D., Comerford, K. B., Karakas, S. E., Knotts, T. A., Fiehn, O., & Adams, S. H. (2015) · Journal of Nutrition · doi:10.3945/jn.114.203943 · Cited by 74 · see citing works
O’Brien, A., Loftus, R. M., Pisarska, M. M., Tobin, L. M., Bergin, R., Wood, N., Foley, C., Mat, A., Tinley, F. C., Bannan, C., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801600 · Cited by 70 · see citing works
Horakova, O., Medříková, D., van Schothorst, E. M., Bunschoten, A., Flachs, P., Kůs, V., Kuda, O., Bardová, K., Janovská, P., Hensler, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043764 · Cited by 70 · see citing works
Metabolomic analyses for atherosclerosis, diabetes, and obesity
Du, F., Virtue, A. T., Wang, H., & Yang, X. (2013) · Biomarker Research · doi:10.1186/2050-7771-1-17 · Cited by 70 · see citing works
Zhao, X. Y., Gang, X., Liu, Y., Sun, C., Han, Q., & Wang, G. (2016) · Journal of Diabetes Research · doi:10.1155/2016/8160545 · Cited by 70 · see citing works
Zhang, L., Su, S., Zhu, K. Y., Guo, J., Guo, S., Qian, D., Ouyang, Z., & Duan, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108675 · Cited by 70 · see citing works
Coco, L. D., Vergara, D., Matteis, S. D., Mensa’, E., Sabbatinelli, J., Prattichizzo, F., Bonfigli, A. R., Storci, G., Bravaccini, S., Pirini, F., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050720 · Cited by 68 · see citing works
Boulangé, C. L., Claus, S. P., Chou, C. J., Collino, S., Montoliu, I., Kochhar, S., Holmes, E. C., Rezzi, S., Nicholson, J. K., Dumas, M., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr400051s · Cited by 69 · see citing works
Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults
Bagheri, M., Djazayery, A., Farzadfar, F., Qi, L., Yekaninejad, M. S., Aslibekyan, S. W., Chamari, M., Hassani, H., Koletzko, B. V., & Uhl, O. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1037-0 · Cited by 68 · see citing works
Relationship between the lipidome, inflammatory markers and insulin resistance
Wallace, M., Morris, C., O’Grada, C. M., Ryan, M., Dillon, E., Coleman, E., Gibney, E. R., Gibney, M. J., Roche, H. M., & Brennan, L. (2014) · Molecular BioSystems · doi:10.1039/c3mb70529c · Cited by 68 · see citing works
Newsome, S. D., Feeser, K. L., Bradley, C. J., Wolf, C., Takacs‐Vesbach, C. D., & Fogel, M. L. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2995 · Cited by 67 · see citing works
Wen, J.-J., Li, M., Gao, H., Hu, J., Nie, Q., Chen, H., Zhang, Y.-L., Xie, M., & Nie, S. (2021) · Food & Function · doi:10.1039/d0fo02600j · Cited by 68 · see citing works
Sailer, M., Dahlhoff, C., Giesbertz, P., Eidens, M. K., de Wit, N. J. W., Rubio‐Aliaga, I., Boekschoten, M. V., Müller, M. M., & Daniel, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063950 · Cited by 66 · see citing works
Habitual sleep and human plasma metabolomics
Xiao, Q., Derkach, A., Moore, S. C., Zheng, W., Shu, X., Gu, F., Caporaso, N. E., Sampson, J. N., & Matthews, C. E. (2017) · Metabolomics · doi:10.1007/s11306-017-1205-z · Cited by 63 · see citing works
Insulin resistance and normal thyroid hormone levels: prospective study and metabolomic analysis
Ferrannini, E., Iervasi, G., Cobb, J. E., Ndreu, R., & Nannipieri, M. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2016 · Cited by 64 · see citing works
Kawanaka, M., Nishino, K., Oka, T., Urata, N., Nakamura, J., Suehiro, M., Kawamoto, H., Chiba, Y., & Yamada, G. (2015) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s79100 · Cited by 62 · see citing works
Mastrangelo, A., Martos‐Moreno, G. Á., Garcı́a, A., Barrios, V., Rupérez, F. J., Chowen, J. A., Barbas, C., & Argente, J. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.92 · Cited by 62 · see citing works
The relationship between aerobic fitness level and metabolic profiles in healthy adults
Morris, C., Grada, C. O., Ryan, M., Roche, H. M., VITO, G. D., Gibney, M. J., Gibney, E. R., & Brennan, L. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200629 · Cited by 61 · see citing works
Moghei, M., Tavajohi‐Fini, P., Beatty, B., & Adegoke, O. A. J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2016 · Cited by 60 · see citing works
Hernández‐Álvarez, M. I., Díaz‐Ramos, A., Berdasco, M., Cobb, J. E., Planet, E., Cooper, D., Pazderska, A., Wanic, K., O’Hanlon, D., Gómez, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14120-6 · Cited by 60 · see citing works
Integrated omics analysis reveals the alteration of gut microbe–metabolites in obese adults
Li, R., Huang, X., Xiao, L., Su, M., Lai, K. P., & Chen, J. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa165 · Cited by 59 · see citing works
Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans
Elshorbagy, A. K., Jernerén, F., Basta, M., Basta, C., Turner, C., Khaled, M. A. T. M., & Refsum, H. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1237-6 · Cited by 59 · see citing works
Paul, H., Collins, K., Nicolucci, A. C., Urbanski, S., Hart, D. A., Vogel, H. J., & Reimer, R. A. (2019) · The FASEB Journal · doi:10.1096/fj.201801551r · Cited by 49 · see citing works
Amino acid transporters as modulators of glucose homeostasis
Bröer, S. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.11.004 · Cited by 58 · see citing works
Zhang, J., Light, A. R., Hoppel, C. L., Campbell, C., Chandler, C., Burnett, D. J., Souza, E. C., Casazza, G., Hughen, R. W., Keim, N., et al. (2016) · Experimental Physiology · doi:10.1113/ep086019 · Cited by 54 · see citing works
- Authors
- Adams, S. H.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Adams, Sean H.
- ORCID
- Adams, Sean H.
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 2
- Issue
- 6
- Pages
- 445-456
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC3226382
- OpenAlex
- W1995187187
- Cited by
- 394
- References
- 143
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 27 · 2023: 22 · 2022: 31 · 2021: 28 · 2020: 21 · 2019: 29 · 2018: 22 · 2017: 34 · 2016: 27 · 2015: 34 · 2014: 44 · 2013: 22 · 2012: 12
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (5306‐51530‐019‐00, 5306‐51530‐019)
- National Institutes of Health
- Agricultural Research Service (5306‐51530‐019‐00)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078328-02S, R01DK078328)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- obesity, insulin resistance, type 2 diabetes, prediabetes, branched-chain amino acids, sulfur-containing amino acids, methionine oxidation, redox homeostasis, free fatty acids, metabolomics, impaired glucose tolerance
- MeSH terms
- Amino Acids, Sulfur, Transaminases, Animals, Cysteine, Cystine, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Methionine, Models, Biological, Obesity, Oxidation-Reduction, Phenylalanine, Tyrosine, Oxidative Stress, Amino Acids, Aromatic, 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
