Neurovascular Dysfunction in Vascular Dementia, Alzheimer's and Atherosclerosis

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Atherosclerosis

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Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

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Pericytes regulate the blood–brain barrier

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Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

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The immune system in atherosclerosis

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Stroke

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Atherosclerosis: current pathogenesis and therapeutic options

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Pericytes are required for blood–brain barrier integrity during embryogenesis

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

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Capillary pericytes regulate cerebral blood flow in health and disease

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The Pathobiology of Vascular Dementia

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High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Alzheimer's disease

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ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

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Establishment and Dysfunction of the Blood-Brain Barrier

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Oxidative Stress and Vascular Disease

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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The Response-to-Retention Hypothesis of Early Atherogenesis

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Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications

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Brain magnetic resonance imaging with contrast-dependent oxygenation

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Imaging Calcium in Neurons

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Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

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Basic Neurochemistry???Molecular, Cellular, and Medical Aspects

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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

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Fast-spiking, parvalbumin ⁺ GABAergic interneurons: From cellular design to microcircuit function

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Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field

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Expanded dynamic range of fluorescent indicators for Ca ²⁺ by circularly permuted yellow fluorescent proteins

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Principles of two-photon excitation microscopy and its applications to neuroscience

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Overview of Functional Magnetic Resonance Imaging

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Recent insights into the cellular biology of atherosclerosis

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Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

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Central nervous system pericytes in health and disease

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T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.

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Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

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Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

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Circulation and Energy Metabolism of the Brain

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Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

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Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

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Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

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Animal Models of Atherosclerosis

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Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

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Cortical GABA Interneurons in Neurovascular Coupling: Relays for Subcortical Vasoactive Pathways

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Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

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Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

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Structure of apolipoprotein B-100 in low density lipoproteins

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Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging

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Next-generation probes, particles, and proteins for neural interfacing

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Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

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Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

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The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2

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Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

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Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain

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Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

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Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

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Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow

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Mouse models of Alzheimer's disease

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Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

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Invasion of brain microvascular endothelial cells by group B streptococci

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Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse Brain

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Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology

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Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow, and intracellular calcium dynamics

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Do the <i>Apoe</i> ^{<i>−/−</i>} and <i>Ldlr</i> ^{<i>−/–</i>} Mice Yield the Same Insight on Atherogenesis?

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Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy

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Induction of Sustained Hypercholesterolemia by Single Adeno-Associated Virus–Mediated Gene Transfer of Mutant hPCSK9

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Rapid stimulus-evoked astrocyte Ca 2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo

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Light controls cerebral blood flow in naive animals

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Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

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ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

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IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

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Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

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Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II–Induced Abdominal Aortic Aneurysms in C57BL/6 Mice—Brief Report

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A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging

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Cerebral Small Vessel Disease and Arterial Stiffness: Tsunami Effect in the Brain

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Tonic Local Brain Blood Flow Control by Astrocytes Independent of Phasic Neurovascular Coupling

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Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases

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Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review

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Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain

Wang, X., Padawer-Curry, J. A., Bice, A. R., Kim, B., Rosenthal, Z. P., Lee, J., Goyal, M. S., Macauley, S. L., & Bauer, A. Q. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114723 · Cited by 21 · see citing works

Biophysics of Blood Circulation in Vascular Dementia and Alzheimer’s Disease

Volobuev, A. N., & Иванович, Р. П. (2019) · Bulletin of Science and Practice · doi:10.33619/2414-2948/41/08 · Cited by 18 · see citing works

Does protracted radon exposure play a role in the development of dementia?

Zhang, Y., Lü, L., Chen, C., Field, R. W., D’Alton, M. E., & He, K. (2022) · Environmental Research · doi:10.1016/j.envres.2022.112980 · Cited by 18 · see citing works

Immune Response at the Crossroads of Atherosclerosis and Alzheimer's Disease

Stahr, N. A., & Galkina, E. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.870144 · Cited by 18 · see citing works

Towards a better diagnosis and treatment of dementia: Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia

Vollhardt, A., Frölich, L., Stockbauer, A., Danek, A., Schmitz, C., & Wahl, A.-S. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106845 · Cited by 17 · see citing works

Revealing the Modular Similarities and Differences Among Alzheimer’s Disease, Vascular Dementia, and Parkinson’s Disease in Genomic Networks

Chen, Y., Liu, Q., Liu, J., Wei, P., Li, B., Wang, N., Liu, Z., & Wang, Z. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08670-2 · Cited by 17 · see citing works

Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia

Shabir, O., Moll, T., Matuszyk, M. M., Eyre, B., Dake, M. D., Berwick, J., & Francis, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111361 · Cited by 17 · see citing works

Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease

Saavedra, J., Nascimento, M., Liz, M. A., & Cardoso, I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1036123 · Cited by 16 · see citing works

Oral anticoagulants: A plausible new treatment for Alzheimer's disease?

Toribio‐Fernández, R., Cerón, C., Tristão‐Pereira, C., Fernandez‐Nueda, I., Pérez‐Castillo, A., Fernández‐Ferro, J., Moro, M. Á., Ibáñez, B., Fuster, V., & Cortés‐Canteli, M. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16032 · Cited by 16 · see citing works

Explainable deep learning approach for extracting cognitive features from hand-drawn images of intersecting pentagons

Tasaki, S., Kim, N., Truty, T., Zhang, A., Buchman, A. S., Lamar, M., & Bennett, D. A. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00904-w · Cited by 16 · see citing works

Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke

Srivastava, A., Srivastava, P., & Verma, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104480 · Cited by 16 · see citing works

The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis

Maliszewska‐Cyna, E., Vecchio, L. M., Thomason, L. A. M., Oore, J., Steinman, J., Joo, I. L., Dorr, A. E., McLaurin, J., Sled, J. G., Stefanovic, B., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117269 · Cited by 16 · see citing works

Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease

Gan, Q., Wong, A., Zhang, Z., Na, H., Tian, H., Tao, Q., Rajab, I. M., Potempa, L. A., & Qiu, W. Q. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12319 · Cited by 16 · see citing works

Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging

Daniel, J. M., Lindsey, S. H., Mostany, R., Schrader, L. A., & Zsombok, A. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101068 · Cited by 17 · see citing works

Cognitive Impairment, Chronic Kidney Disease, and 1-Year Mortality in Older Patients Discharged from Acute Care Hospital

Rosa, M. D., D’Alia, S., Guarasci, F., Soraci, L., Pierpaoli, E., Lenci, F., Ricci, M., Onder, G., Volpato, S., Ruggiero, C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072202 · Cited by 15 · see citing works

Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications

Deshpande, A., Zhang, L. Q., Balu, R., Yahyavi‐Firouz‐Abadi, N., Badjatia, N., Laksari, K., & Tahsili‐Fahadan, P. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251328537 · Cited by 14 · see citing works

Reduced neurovascular coupling is associated with increased cardiovascular risk without established cerebrovascular disease: A cross-sectional analysis in UK Biobank

Yang, S., & Webb, A. J. S. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241302172 · Cited by 14 · see citing works

Neurovascular dysfunctions in hypertensive disorders of pregnancy

Ijomone, O. K., Osahon, I. R., Okoh, C. O. A., Akingbade, G. T., & Ijomone, O. M. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00710-x · Cited by 14 · see citing works

The heart-brain crosstalk in age related cardiovascular and neurodegenerative diseases

Fahim, M. A., Yao, Y., Tipparaju, S. M., & Xuan, W. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00700-6 · Cited by 13 · see citing works

Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction

Tripathi, A., Pandey, V. K., Sharma, G., Sharma, A. R., Taufeeq, A., Jha, A. K., & Kim, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0322 · Cited by 13 · see citing works

Associations Between Diabetic Retinal Microvasculopathy and Neuronal Degeneration Assessed by Swept-Source OCT and OCT Angiography

Qiu, B., Zhao, L., Zhang, X., Wang, Y., Wang, Q., Nie, Y., Chen, X., & Cheung, C. Y.-L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.778283 · Cited by 13 · see citing works

Moyamoya disease: A human model for chronic hypoperfusion and intervention in Alzheimer's disease

Zou, X., Yuan, Y., Liao, Y., Jiang, C., Zhao, F., Ding, D., Gu, Y., Chen, L., Chu, Y., Hsu, Y., et al. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12285 · Cited by 12 · see citing works

Clinical Applications of PET Imaging in Alzheimer’s Disease

Patil, S., Ayubcha, C., Teichner, E. M., Subtirelu, R. C., Cho, J. H., Ghonim, M., Ghonim, M., Werner, T. J., Høilund‐Carlsen, P. F., Alavi, A., et al. (2024) · PET Clinics · doi:10.1016/j.cpet.2024.09.015 · Cited by 13 · see citing works

Establishing a competing endogenous RNA (ceRNA)-immunoregulatory network associated with the progression of Alzheimer’s disease

Li, Y., Shi, H., Chen, T., Xue, J., Wang, C., Peng, M., & Si, G. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6762 · Cited by 12 · see citing works

Time–frequency cross-coupling between cortical low-frequency neuronal calcium oscillations and blood oxygen metabolism evoked by ultrasound stimulation

Su, Z., Yan, J., Ji, H., Liu, M., Zhang, X., Xiaoli Li, A., & Yuan, Y. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac370 · Cited by 12 · see citing works

Human-in-the-Loop Optimization of Transcranial Electrical Stimulation at the Point of Care: A Computational Perspective

Arora, Y., & Dutta, A. (2022) · Brain Sciences · doi:10.3390/brainsci12101294 · Cited by 11 · see citing works

VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion

Sun, R., Shang, J., Yan, X., Zhao, J., Wang, W., Wang, W., Li, W., Gao, C., Wang, F., Zhang, H., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221059 · Cited by 11 · see citing works

Orthostatic hypotension and cognitive impairment: Systematic review and meta-analysis of longitudinal studies

Duval, G. T., Raud, E., Gohier, H., Dramé, M., Tabué-Teguo, M., & Annweiler, C. (2023) · Maturitas · doi:10.1016/j.maturitas.2023.107866 · Cited by 11 · see citing works

Role of orphan G-protein coupled receptors in tissue ischemia: A comprehensive review

Bajestani, A. K., Alavi, M. S., Etemad, L., & Roohbakhsh, A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176762 · Cited by 11 · see citing works

Carotid Atherosclerotic Calcification Characteristics Relate to Post-stroke Cognitive Impairment

Wang, Y., Li, C., Ding, M., Lin, L., Li, P., Wang, Y., Dong, Q., Yang, Y., & Cui, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.682908 · Cited by 11 · see citing works

Effects of far infrared light on Alzheimer’s disease-transgenic mice

Fukui, K., Shunsuke, K., Kato, Y., & Kohno, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253320 · Cited by 11 · see citing works

Altered dorsal functional connectivity after post-weaning social isolation and resocialization in mice

Kim, G. S., Lee, H., & Jeong, Y. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118740 · Cited by 11 · see citing works

The Brain’s Microvascular Response to High Glycemia and to the Inhibition of Soluble Epoxide Hydrolase Is Sexually Dimorphic

Nuthikattu, S., Milenković, D., Norman, J., Rutledge, J. C., & Villablanca, A. C. (2022) · Nutrients · doi:10.3390/nu14173451 · Cited by 11 · see citing works

Human mini-brains for reconstituting central nervous system disorders

Kang, Y. J., Xue, Y., Shin, J. H., & Cho, H. (2023) · Lab on a Chip · doi:10.1039/d2lc00897a · Cited by 11 · see citing works

Magnesium ions and dementia

Xu, P., Cui, D., Jin, M., & Sun, L. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100094 · Cited by 11 · see citing works

SDMA as a marker and mediator in cerebrovascular disease

Riddell, A., Flynn, A., Bergugnat, H., Dowsett, L., & Miller, A. A. (2024) · Clinical Science · doi:10.1042/cs20241021 · Cited by 10 · see citing works

Fast-spiking parvalbumin-positive interneurons: new perspectives of treatment and future challenges in dementia

Zhang, X., Wu, M., Cheng, L., Cao, W., Liu, Z., Yang, S., & Kim, M. S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02756-6 · Cited by 11 · see citing works

How does alzheimer’s disease, atherosclerosis and comorbid alzheimer’s disease and atherosclerosis impact neurovascular function?

Eyre, B., Shabir, O., Lee, L., Francis, S., Howarth, C., & Berwick, J. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.069266 · Cited by 1 · see citing works

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works

Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,268 · see citing works

Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease

Zhu, W. M., Neuhaus, A. A., Beard, D. J., Sutherland, B. A., & DeLuca, G. C. (2022) · Brain · doi:10.1093/brain/awac174 · Cited by 136 · see citing works

Physiological Regulatory Mechanisms of Neurovascular Coupling and the Role of Its Dysfunction in Neurological Diseases

Wang, A., Li, J., Liu, H., & Yue, D. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin42796 · Cited by 1 · see citing works