Cited by 807Cardiomyopathy and Myosin StudiesCardiovascular Effects of ExerciseViral Infections and Immunology Research

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2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

Ommen, Steve R., Ho, Carolyn Y., Asif, Irfan M., Balaji, Seshadri, Burke, Michael A., Day, Sharlene M., Dearani, Joseph A., Epps, Kelly C., Evanovich, Lauren, Ferrari, Victor A., Joglar, José A., Khan, Sadiya S., Kim, Jeffrey J., Kittleson, Michelle M., Krittanawong, Chayakrit, Martinez, Matthew W., Mital, Seema, Naidu, Srihari S., Saberi, Sara, Semsarian, Christopher, Times, Sabrina, Waldman, Cynthia Burstein·2024·Circulation

DOI 10.1161/cir.0000000000001250

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Abstract

AIM: The “2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy” provides recommendations to guide clinicians in the management of patients with hypertrophic cardiomyopathy. METHODS: A comprehensive literature search was conducted from September 14, 2022, to November 22, 2022, encompassing studies, reviews, and other evidence on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. Additional relevant studies, published through May 23, 2023, during the guideline writing process, were also considered by the writing committee and added to the evidence tables, where appropriate. STRUCTURE: Hypertrophic cardiomyopathy remains a common genetic heart disease reported in populations globally. Recommendations from the “2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy” have been updated with new evidence to guide clinicians.

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Impact of glucose metabolism on myocardial fibrosis and inflammation in hypertrophic cardiomyopathy: a cardiac MR study
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Stress Echocardiography for Assessment of Diastolic Function
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Challenges in clinical translation of cardiac magnetic resonance imaging radiomics in non-ischemic cardiomyopathy: a narrative review
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Recent Clinical Updates of Hypertrophic Cardiomyopathy and Future Therapeutic Strategies
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Efficacy and safety of myectomy and radiofrequency septal ablation for treating hypertrophic obstructive cardiomyopathy
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cMyBP-C in hypertrophic cardiomyopathy: gene therapy and small-molecule innovations
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Contemporary clinical characteristics and management patterns in hypertrophic cardiomyopathy: insights from baseline enrolment data in a nationwide prospective Japanese registry
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Using Genomics to Develop Personalized Cardiovascular Treatments
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Left Atrial Stiffness Is Increased in Pediatric Hypertrophic Cardiomyopathy and Offers Incremental Value in Predicting Major Adverse Cardiac Events in This Group
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Genotype-Phenotype Relationship in Hypertrophic Cardiomyopathy
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Scar architecture as a structural biomarker of ventricular arrhythmias and sudden cardiac death in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance study
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Fully Automated Plane Prescription in Cardiac MRI : A Prospective Cohort Study
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Efficacy and Safety of Aficamten in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy: Study Design and Rationale of CEDAR-HCM
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Natural History of Asymptomatic Phenotypically Mild HCM
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Long-term clinical outcomes after alcohol septal ablation for hypertrophic obstructive cardiomyopathy in Japan: a retrospective study
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Detection of late gadolinium enhancement in patients with hypertrophic cardiomyopathy using machine learning
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Hypertrophic Cardiomyopathy: New Clinical and Therapeutic Perspectives of an “Old” Genetic Myocardial Disease
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Understanding Sex Differences in Hypertrophic Cardiomyopathy Surgery: Insights From a Decade‐Long Cohort Study From China
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Update on Imaging in Hypertrophic Cardiomyopathy
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Cardiotoxicity Associated with Venlafaxine—Defining Features in a Series of Five Cases and a Call for Proactive Monitoring
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Temporal Patterns of Holter-Detected Arrhythmias in Hypertrophic Cardiomyopathy Patients Treated with Mavacamten
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Circulating microRNAs in predicting fibrosis in hypertrophic cardiomyopathy: A systematic review
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Great debate: artificial intelligence will replace much of what cardiologists do
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Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis
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Differences in Healthcare Resource Use and Cost by Pharmacotherapy Among Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy: Real-World Analysis of Claims Data
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Stop Dreaming: Mavacamten REMS Data Are Here
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Echocardiographic Diagnosis of Hypertrophic Cardiomyopathy by Machine Learning
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The role of endothelin and its receptors in cardiomyopathy: From molecular mechanisms to therapeutic insights
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Feasibility of an Individualized Exercise Training Program for Children with Hypertrophic Cardiomyopathy
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Metabolic alterations in human hypertrophic cardiomyopathy
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Unveiling the Masquerading of Myocardial Bridging in Cardiovascular Diseases
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Redefining Left Ventricular Systolic Dysfunction in Hypertrophic Cardiomyopathy
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Yield on Reinterpretation of Genetic Variants in Pediatric Cardiomyopathy
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Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial
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A New Era in the Management of Hypertrophic Cardiomyopathy
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What Should a Clinical Cardiologist Know About Cardiogenetics?
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Post-mortem genetic testing: Role in sudden cardiac death in the young
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Transapical beating-heart approach is advantageous for surgical septal reduction therapy in pediatrics
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Multimodality imaging in hypertrophic cardiomyopathy
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Cardiac magnetic resonance-derived left atrial strain restratifies patients with hypertrophic cardiomyopathy at low-risk of sudden cardiac death
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From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce
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Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis
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Hypertrophic Cardiomyopathy and Risk of Out-of-Hospital Cardiac Arrest
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Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy
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Implications of primary bradycardia in patients with hypertrophic cardiomyopathy
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Association of neighborhood median income to outcomes in hypertrophic cardiomyopathy
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A Practical Approach to Multimodality Imaging in Hypertrophic Cardiomyopathy
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Clinical management and healthcare resource utilization among patients with obstructive hypertrophic cardiomyopathy in Spain: a real-world study
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Cardiac Magnetic Resonance in Heart Failure: Diagnostic and Prognostic Assessments
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Medical Malpractice Claims for Sports Cardiology Cases Among Young Athletes
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Mavacamten in Symptomatic Patients Resistant to Previous Advanced Therapy for Obstructive Hypertrophic Cardiomyopathy
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Astragalus Polysaccharide Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β1/Smad3 Signal Pathway
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Systolic anterior motion-mediated mitral regurgitation and surgical management in hypertrophic obstructive cardiomyopathy
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Optimal Medical Therapy Versus Septal Reduction Therapy
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Exercise Stress Echocardiography: A Dynamic Assessment for an Evolving Landscape
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Major adverse cardiovascular events after modified morrow surgery in hypertrophic obstructive cardiomyopathy: A 12-year cohort study
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Advanced Computed Tomography and Magnetic Resonance Imaging in Ischemic and Nonischemic Cardiomyopathies
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Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM
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The Role of Cardiac Magnetic Resonance Imaging in the Management of Hypertrophic Cardiomyopathy
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Favorable cardiac remodeling in response to treatment in obstructive hypertrophic cardiomyopathy: a current appraisal
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Hypertrophic Cardiomyopathy and Phenocopies: New Therapies for Old Diseases—Current Evidence and Future Perspectives
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Prognostic Value of Coronary Angiography‐Derived Index of Microvascular Resistance in Patients With Hypertrophic Cardiomyopathy
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VO2 Max in Clinical Cardiology: Clinical Applications, Evidence Gaps, and Future Directions
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High rate of seroeligibility among MYBPC3-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 MYBPC3 gene therapy
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Hypertrophic Cardiomyopathy: Current Perspectives
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RASopathy and Sudden Cardiac Death: A Literature Review
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Mechanisms of metabolic transition in hypertrophic cardiomyopathy
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Transapical Beating-Heart Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy After Failed Septal Reduction Therapy
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Quantitative myocardial blood flow and perfusion reserve with exercise cardiovascular magnetic resonance
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Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy: from Pathophysiology To Real World Data
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Functional and structural cardiac remodelling in farmed Atlantic salmon (Salmo salar)
Halvorsen, P. S., Mahat, S., Becker, V., Kavaliauskiene, S., Sørgaard, T. M. G., Morgenroth, D., Strøm, M., Louch, W. E., Johansen, I. B., & Frisk, M. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743496 · Cited by 3

Authors: Ommen, S. R., Ho, C. Y., Asif, I. M., Balaji, S., Burke, M. A., Day, S. M., Dearani, J. A., Epps, K. C., Evanovich, L., Ferrari, V. A., Joglar, J. A., Khan, S. S., Kim, J. J., Kittleson, M. M., Krittanawong, C., Martinez, M. W., Mital, S., Naidu, S. S., Saberi, S., Semsarian, C., Times, S., & Waldman, C. B.
Affiliations: American Medical Society for Sports Medicine (US)
HRS representative.
Lay stakeholder representative.
AHA/ACC Joint Committee on Clinical Practice Guidelines liaison.
American Hospital Association (US)
PACES representative.
Joint ACC/AHA staff representative.
ORCID: Ommen, Steve R.
Ho, Carolyn Y.
Asif, Irfan M.
Balaji, Seshadri
Burke, Michael A.
Day, Sharlene M.
Dearani, Joseph A.
Ferrari, Victor A.
Joglar, José A.
Khan, Sadiya S.
Kim, Jeffrey J.
Kittleson, Michelle M.
Krittanawong, Chayakrit
Martinez, Matthew W.
Mital, Seema
Naidu, Srihari S.
Saberi, Sara
Semsarian, Christopher
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2024-06-04
Volume: 149
Issue: 23
Pages: e1239-e1311
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001250
OpenAlex: W4396750647
Cited by: 807
References: 514
Citations by year: 2026: 353 · 2025: 372 · 2024: 82
FWCI: 226.55
Type: journal article
Language: en
Update notices: correction (2024-08-19)
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Keywords: hypertrophic cardiomyopathy, disease management, inherited heart disease, diagnosis, treatment guidelines, American Heart Association, American College of Cardiology, American Society of Echocardiography
MeSH terms: American Heart Association, Cardiology, Cardiomyopathy, Hypertrophic, Humans, United States, Disease Management

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2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

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