CoChat
Sign Up
Cited by 94Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlVagus Nerve Stimulation Research

Altered Sympathetic Nervous Reactivity and Norepinephrine Transporter Expression in Patients With Postural Tachycardia Syndrome

Lambert, Elisabeth, Eikelis, Nina, Esler, Murray, Dawood, Tye, Schlaich, Markus, Bayles, Richard, Socratous, Flora, Agrotis, Alex +3 more·2008·Circulation: Arrhythmia and Electrophysiology
DOI 10.1161/circep.107.750471
Open this paper in CoChat — free account

Abstract

Background— Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET). Methods and Results— We examined sympathetic nervous system responses to head-up tilt by combining NE plasma kinetics measurements and muscle sympathetic nerve activity recordings and by quantifying NET protein content in peripheral sympathetic nerves in patients with POTS compared with that in controls. POTS patients had an elevated heart rate during supine rest (81�2 bpm versus 66�2 bpm in healthy subjects [HS], P <0.01). Head-up tilt to 40� induced a greater rise in heart rate in patients with POTS (+24�4 bpm versus +13�2 bpm in HS, P <0.001). During rest in the supine position, muscle sympathetic nerve activity, arterial NE concentration, and whole-body NE spillover to plasma were similar in both groups. Muscle sympathetic nerve activity response to head-up tilt was greater in the POTS group (+29�3 bursts/min in patients with POTS and +13�2 bursts/min in HS, P <0.001), but the NE spillover rise was similar in both groups (51% in the POTS subjects and 50% in the HS). Western blot analysis of NET protein extracted from forearm vein biopsies in patients with POTS and HS demonstrated a decrease in the expression of NET protein in patients with POTS. Conclusion— Patients with POTS exhibit a decrease in NET protein in their peripheral sympathetic nerves. Paradoxically, whole-body NE spillover to plasma during rest in the supine position and in response to head-up tilt is not altered despite excessive nerve firing rate in response to the head-up tilt.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/circep.107.750471

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Some POTS patients may have decreased expression of NET protein, leading to a functional NET deficiency.

    “Lambert et al. have reported that some POTS patients may have decreased expression of NET protein, leading to a functional NET deficiency [55].”

    From Postural tachycardia syndrome: beyond orthostatic intolerance (2015) · cites this paper as [55]

  • Impaired neuronal noradrenaline reuptake, as a solitary identified abnormality in patients with postural tachycardia syndrome, is not associated with heart disease or reduced longevity.

    “Impaired neuronal noradrenaline reuptake, as a solitary identified abnormality in patients with the postural tachycardia syndrome, 70,82 is not associated with heart disease or reduced longevity.”

    From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [82]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 31 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Fouad FM, Tadena-Thome L, Bravo EL, Tarazi RC. Idiopathic hypo- volemia. Ann Intern Med. 1986;104:298 -303.

Cited by

Sorted by citations

Related

Authors
Lambert, E., Eikelis, N., Esler, M., Dawood, T., Schlaich, M., Bayles, R., Socratous, F., Agrotis, A., Jennings, G., Lambert, G., & Vaddadi, G.
Affiliations
From the Human Neurotransmitter Laboratory (E.L., N.E., M.E., T.D., M.S., R.B., F.S., G.L., G.V.) and Cell Biology Laboratory (A.A.), Baker Heart Research Institute (G.J.), Melbourne, Victoria, Australia.
ORCID
Venue
Circulation: Arrhythmia and Electrophysiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-06
Volume
1
Issue
2
Pages
103-109
ISSN
  • 1941-3084 (ISSN-L)
  • 1941-3149
DOI
10.1161/circep.107.750471
OpenAlex
W2123559447
Cited by
94
References
31
Citations by year
2026: 2 · 2025: 5 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 6
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Arrhythmia and Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council (225108)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
postural orthostatic tachycardia syndrome, sympathetic nervous system, norepinephrine transporter, norepinephrine spillover, muscle sympathetic nerve activity, head-up tilt, autonomic dysfunction
MeSH terms
Adult, Female, Forearm, Heart Rate, Humans, Male, Norepinephrine, Peripheral Nerves, Posture, Sympathetic Nervous System, Veins, Blotting, Western, Down-Regulation, Supine Position, Muscle, Skeletal, Norepinephrine Plasma Membrane Transport Proteins, Postural Orthostatic Tachycardia Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review