CoChat
Sign Up
Cited by 120Cardiovascular Syncope and Autonomic DisordersFibromyalgia and Chronic Fatigue Syndrome ResearchLong-Term Effects of COVID-19

Adolescent Fatigue, POTS, and Recovery: A Guide for Clinicians

Open access
Kizilbash, Sarah J., Ahrens, Shelley P., Bruce, Barbara K., Chelimsky, Gisela, Driscoll, Sherilyn W., Harbeck-Weber, Cynthia, Lloyd, Robin M., Mack, Kenneth J. +6 more·2014·Current Problems in Pediatric and Adolescent Health Care
DOI 10.1016/j.cppeds.2013.12.014PMC PMC5819886
Open this paper in CoChat — free account

Abstract

Many teenagers who struggle with chronic fatigue have symptoms suggestive of autonomic dysfunction that may include lightheadedness, headaches, palpitations, nausea, and abdominal pain. Inadequate sleep habits and psychological conditions can contribute to fatigue, as can concurrent medical conditions. One type of autonomic dysfunction, postural orthostatic tachycardia syndrome, is increasingly being identified in adolescents with its constellation of fatigue, orthostatic intolerance, and excessive postural tachycardia (more than 40 beats/min). A family-based approach to care with support from a multidisciplinary team can diagnose, treat, educate, and encourage patients. Full recovery is possible with multi-faceted treatment. The daily treatment plan should consist of increased fluid and salt intake, aerobic exercise, and regular sleep and meal schedules; some medications can be helpful. Psychological support is critical and often includes biobehavioral strategies and cognitive-behavioral therapy to help with symptom management. More intensive recovery plans can be implemented when necessary.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cppeds.2013.12.014

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • POTS patients often have numerous comorbidities including chronic fatigue, dizziness, syncope, migraines, functional GI disorders, chronic nausea, fibromyalgia, and joint hypermobility.

    “These are numerous and include chronic fatigue, dizziness, syncope, migraines, functional GI disorders, chronic nausea, fibromyalgia, and joint hypermobility among others(68).”

    From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [68]

    The POTS sections on typical presentations and GI physiology (page unavailable) describe fatigue, dizziness, nausea, migraine-like headaches, functional GI symptoms, and joint hypermobility; the recovery section also lists fainting among POTS symptoms. But the recovery section calls fibromyalgia a syndrome with features similar to POTS, not a frequent POTS comorbidity. The source also describes several listed items as symptoms rather than separate comorbid conditions. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 122

  1. [1]Ghandour RM Overpeck MD Huang ZJ Kogan MD Scheidt PC Headache, stomachache, backache, and morning fatigue among adolescent girls in the United States: associations with behavioral, sociodemographic, and environmental factors Arch Pediatr Adolesc Med 2004 158 8 797 803 15289254
  2. [2]ter Wolbeek M van Doornen LJ Kavelaars A Heijnen CJ Severe fatigue in adolescents: a common phenomenon? Pediatrics 2006 117 6 e1078 86 16740810
  3. [3]Rimes KA Goodman R Hotopf M Wessely S Meltzer H Chalder T Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study Pediatrics 2007 119 3 e603 9 17332180
  4. [5]Jones JF Nisenbaum R Solomon L Reyes M Reeves WC Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study J Adolesc Health 2004 35 1 34 40 15193572
  5. [6]Chalder T Goodman R Wessely S Hotopf M Meltzer H Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5–15 year olds: cross sectional study Br Med J 2003 327 7416 654 5 14500438 PMC196393
  6. [7]Buchwald D Umali P Umali J Kith P Pearlman T Komaroff AL Chronic fatigue and the chronic fatigue syndrome: prevalence in a Pacific Northwest health care system Ann Intern Med 1995 123 2 81 8 7778839
  7. [8]Reyes M Nisenbaum R Hoaglin DC Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas Arch Intern Med 2003 163 13 1530 6 12860574
  8. [9]ter Wolbeek M van Doornen LJ Kavelaars A Heijnen CJ Predictors of persistent and new-onset fatigue in adolescent girls Pediatrics 2008 121 3 e449 57 18310166
  9. [10]Siegel JM Why we sleep Sci Am 2003 289 5 92 7 14564818 PMC9059976
  10. [12]Beebe DW Cognitive, behavioral, and functional consequences of inadequate sleep in children and adolescents Pediatr Clin North Am 2011 58 3 649 65 21600347 PMC3100528
  11. [13]Carskadon MA Acebo C Regulation of sleepiness in adolescents: update, insights, and speculation Sleep 2002 25 6 606 14 12224839
  12. [15]Sadeh A Dahl RE Shahar G Rosenblat-Stein S Sleep and the transition to adolescence: a longitudinal study Sleep 2009 32 12 1602 9 20041596 PMC2786044
  13. [16]Jenni OG Achermann P Carskadon MA Homeostatic sleep regulation in adolescents Sleep 2005 28 11 1446 54 16335485
  14. [17]Punamaki RL Wallenius M Nygard CH Saarni L Rimpela A Use of information and communication technology (ICT) and perceived health in adolescence: the role of sleeping habits and waking-time tiredness J Adolesc 2007 30 4 569 85 16979753
  15. [20]Mindell JA Owens JA A Clinical Guide to Pediatric Sleep Diagnosis and Management of Sleep Problems 2nd Philadelphia Lippincott Williams & Wilkins 2010
  16. [21]ter Woolbeek M van Doornen LJ Kavelaars A Tersteeg-Kamperman MD Heijnen CJ Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study Brain Behav Immun 2011 25 6 1249 55 21549830
  17. [22]Smith MS Martin-Herz SP Womack WM Marsigan JL Comparative study of anxiety, depression, somatization, functional disability, and illness attribution in adolescents with chronic fatigue or migraine Pediatrics 2003 111 4 Pt 1 e376 81 12671155
  18. [24]Lane TJ Matthews DA Manu P The low yield of physical examinations and laboratory investigations of patients with chronic fatigue Am J Med Sci 1990 299 5 313 8 2337122
  19. [25]De Becker P Dendale P De Meirleir K Campine I Vandenborne K Hagers Y Autonomic testing in patients with chronic fatigue syndrome Am J Med 1998 105 3A 22S 6S 9790478
  20. [27]Lewis TA Lecture on vasovagal syncope and the carotid sinus mechanism Br Med J 1932 1 3723 873 6 20776843 PMC2520889
  21. [28]Pilgrim JA Stansfeld S Marmot M Low blood pressure, low mood? Br Med J 1992 304 6819 75 8 1737142 PMC1881007
  22. [29]Wessely S Nickson J Cox B Symptoms of low blood pressure: a population study Br Med J 1990 301 6748 362 5 2400856 PMC1679910
  23. [30]Rowe PC Bou-Holaigah I Kan JS Calkins H Is neurally mediated hypotension an unrecognised cause of chronic fatigue? Lancet 1995 345 8950 623 4 7898182
  24. [31]Wyller VB Helland IB Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: an exploratory study Biopsychosoc Med 2013 7 1 5 23388153 PMC3570350
  25. [32]Hurum H Sulheim D Thaulow E Wyller VB Elevated nocturnal blood pressure and heart rate in adolescent chronic fatigue syndrome Acta Paediatr 2011 100 2 289 92 21059182
  26. [33]Wyller VB Barbieri R Thaulow E Saul JP Enhanced vagal withdrawal during mild orthostatic stress in adolescents with chronic fatigue Ann Noninvasive Electrocardiol 2008 13 1 67 73 18234008 PMC6932180
  27. [34]Boneva RS Decker MJ Maloney EM Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study Auton Neurosci 2007 137 1-2 94 101 17851136
  28. [35]Montague TJ Marrie TJ Klassen GA Bewick DJ Horacek BM Cardiac function at rest and with exercise in the chronic fatigue syndrome Chest 1989 95 4 779 84 2924607
  29. [36]Lillestal K Bondevik H Neurasthenia in Norway 1880– 1920 Tidsskr Nor Laegeforen 2013 133 6 661 5 23552163
  30. [37]Wooley CF Jacob Mendez DaCosta: medical teacher, clinician, and clinical investigator Am J Cardiol 1982 50 5 1145 8 6753556
  31. [39]Fischer PR Brands CK Porter CJ High prevalence of orthostatic intolerance in adolescents in a general pediatric referral clinic Presented to the 16th International Symposium on the Autonomic Nervous System Los Cabos, Mexico October 7,2005
  32. [40]Kuntz NL Patwari PP Laboratory evaluation of pediatric autonomic disorders Semin Pediatr Neurol 2013 20 1 35 43 23465773
  33. [41]Skinner JE Driscoll SW Porter CJ Orthostatic heart rate and blood pressure and heart rate in adolescents: reference ranges J Child Neurol 2010 25 10 1210 5 20197269
  34. [42]Singer W Sletten D Opfer Gehrking T Brands CK Fischer PR Low PA Postural tachycardia in children and adolescents: what is normal? J Pediatr 2012 160 2 222 6 21996154 PMC3258321
  35. [43]Nicklander KK Carlson PJ Urrutia RA Camilleri M Low PA A screen of candidate genes and influence of beta 2-adrenergic receptor genotypes in postural tachycardia syndrome Auton Neurosci 2005 120 1-2 97 103 15946904
  36. [45]Garland EM Hahn MK Ketch TP Genetic basis of clinical catecholamine disorders Ann N Y Acad Sci 2002 971 506 14 12438171
  37. [46]Jarjour IT Postural tachycardia syndrome in children and adolescents Semin Pediatr Neurol 2013 20 1 18 26 23465770
  38. [47]Rowell LB Human Cardiovascular Control New York, NY Oxford University Press 1993
  39. [49]Ocon AJ Medow MS Taneja I Clarke D Stewart JM Decreased upright cerebral blood flow and cerebral autoregulation in normocapnic postural tachycardia syndrome Am J Physiol Heart Circ Physiol 2009 297 2 H664 73 19502561 PMC2724195
  40. [51]Fu Q Witkowski S Okazaki K Levine BD Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress Am J Physiol Regul Integr Comp Physiol 2005 289 1 R109 16 15761188
  41. [52]Schadt JC Ludbrook J Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals Am J Physiol 1991 260 2 Pt 2 H305 18 1671735
  42. [54]McDonald C Frith J Newton JL Single centre experience of ivabradine in postural orthostatic tachycardia syndrome Europace 2011 13 3 427 30 21062792 PMC3043639
  43. [57]Stewart JM Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects Circulation 2002 105 19 2274 81 12010910
  44. [59]Klein CM Vernino S Lennon VA The spectrum of autoimmune autonomic neuropathies Ann Neurol 2003 53 6 752 8 12783421
  45. [60]Chen L Wang L Sun J Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome Circ J 2011 75 4 927 31 21301135
  46. [62]Bonyhay I Freeman R Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome Circulation 2004 110 20 3193 8 15533861
  47. [63]Donnelly J Lucas SJ Thomas KN Galvin SD Ainslie PN Profound hyperventilation and development of periodic breathing during exceptional orthostatic stress in a 21-year-old man Respir Physiol Neurobiol 2011 177 1 66 70 21371574
  48. [65]Zanzinger J Czachurski J Seller H Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo Circ Res 1994 75 6 1073 7 7955145
  49. [66]Storgaard T Nedergaard OA Prejunctional modulation by angiotensins of noradrenaline release from sympathetic neurons in isolated rabbit aorta Naunyn Schmiedebergs Arch Pharmacol 1997 356 6 706 11 9453455
  50. [67]Head GA Role of AT1 receptors in the central control of sympathetic vasomotor function Clin Exp Pharmacol Physiol 1996 3 suppl S93 8 8993846
  51. [68]Hu ZW Shi XY Okazaki M Hoffman BB Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells Am J Physiol 1995 268 3 Pt 2 H1006 14 7900855
  52. [69]Campese VM Ye S Zhong H Yanamadala V Ye Z Chiu J Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity Am J Physiol Heart Circ Physiol 2004 287 2 H695 703 15277201
  53. [70]Wolin MS Interactions of oxidants with vascular signaling systems Arterioscler Thromb Vasc Biol 2000 20 6 1430 42 10845855
  54. [71]Landmesser U Dikalov S Price SR Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension J Clin Invest 2003 111 8 1201 9 12697739 PMC152929
  55. [77]Blomqvist CG Buckey JC Gaffney FA Lane LD Levine BD Watenpaugh DE Mechanisms of post-flight orthostatic intolerance J Gravit Physiol 1994 1 1 122 4 11538739
  56. [78]Meck JV Dreyer SA Warren LE Long-duration head-down bed rest: project overview, vital signs, and fluid balance Aviat Space Environ Med 2009 80 5 Suppl A1 8 19476163
  57. [79]Arbeille P Kerbeci P Mattar L Shoemaker JK Hughson R Insufficient flow reduction during LBNP in both splanchnic and lower limb areas is associated with orthostatic intolerance after bedrest Am J Physiol Heart Circ Physiol 2008 295 5 H1846 54 18757480
  58. [80]Ojha A Chelimsky TC Chelimsky G Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome J Pediatr 2011 158 1 20 3 20723911
  59. [81]Sandroni P Opfer-Gehrking TL McPhee BR Low PA Postural tachycardia syndrome: clinical features and followup study Mayo Clin Proc 1999 74 11 1106 10 10560597
  60. [82]Camilleri M Fealey RD Idiopathic autonomic denervation in eight patients presenting with functional gastrointestinal disease. A causal association? Dig Dis Sci 1990 35 5 609 16 2331954
  61. [83]Chelimsky G Boyle JT Tusing L Chelimsky TC Autonomic abnormalities in children with functional abdominal pain: coincidence or etiology? J Pediatr Gastroenterol Nutr 2001 33 1 47 53 11479407
  62. [84]Sullivan SD Hanauer J Rowe PC Barron DF Darbari A Oliva-Hemker M Gastrointestinal symptoms associated with orthostatic intolerance J Pediatr Gastroenterol Nutr 2005 40 4 425 8 15795588
  63. [85]Safder S Chelimsky TC O'Riordan MA Chelimsky G Gastric electrical activity becomes abnormal in the upright position in patients with postural tachycardia syndrome J Pediatr Gastroenterol Nutr 2010 51 3 314 8 20479685
  64. [86]Seligman WH Low DA Asahina M Mathias CJ Abnormal gastric myoelectrical activity in postural tachycardia syndrome Clin Auton Res 2013 23 2 73 80 23212662
  65. [88]Mack KJ Johnson JN Rowe PC Orthostatic intolerance and the headache patient Semin Pediatr Neurol 2010 17 2 109 16 20541103
  66. [89]Heyer GL Fedak EM Legros AL Symptoms predictive of postural tachycardia syndrome (POTS) in the adolescent headache patient Headache 2013 53 6 947 53 23574111
  67. [90]Khurana RK Eisenberg L Orthostatic and non-orthostatic headache in postural tachycardia syndrome Cephalalgia 2011 31 4 409 15 20819844
  68. [91]Khurana RK Coat-hanger ache in orthostatic hypotension Cephalalgia 2012 32 10 731 7 22711896
  69. [92]Anonymous McGraw-Hill Concise Dictionary of Modern Medicine McGraw-Hill Companies 2002
  70. [97]Winker R Barth A Bidmon D Endurance exercise training in orthostatic intolerance: a randomized, controlled trial Hypertension 2005 45 3 391 8 15699447
  71. [98]Ellingson LD Shields MR Stegner AJ Cook DB Physical activity, sustained sedentary behavior, and pain modulation in women with fibromyalgia J Pain 2012 13 2 195 206 22245361 PMC3272134
  72. [100]Eccleston C Malleson P Managing chronic pain in children and adolescents. We need to address the embarrassing lack of data for this common problem Br Med J 2003 326 7404 1408 9 12829527 PMC1126302
  73. [101]Lachapelle DL Lavoie S Boudreau A The meaning and process of pain acceptance. Perceptions of women living with arthritis and fibromyalgia Pain Res Manag 2008 13 3 201 10 18592056 PMC2671308
  74. [102]Woolf CJ Central sensitization: implications for the diagnosis and treatment of pain Pain 2011 152 3 Suppl S2 15 20961685 PMC3268359
  75. [103]Raj S The postural tachycardia syndrome: pathophysiology, diagnosis and management Indian Pacing Electrophysiol J 2006 6 2 84 99 16943900 PMC1501099
  76. [107]Benarroch EE Postural tachycardia syndrome: a heterogeneous and multifactorial disorder Mayo Clin Proc 2012 87 12 1214 25 23122672 PMC3547546
  77. [108]Antiel RM Caudill JS Burkhardt BE Brands CK Fischer PR Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance South Med J 2011 104 8 609 11 21886073
  78. [109]Freitas J Santos R Azevedo E Costa O Carvalho M de Freitas AF Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone Clin Auton Res 2000 10 5 293 9 11198485
  79. [110]Lai CC Fischer PR Brands CK Outcomes in adolescents with postural orthostatic tachycardia syndrome treated with midodrine and beta-blockers Pacing Clin Electrophysiol 2009 32 2 234 8 19170913
  80. [111]Abell TL Camilleri M Donohoe K Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine Am J Gastroenterol 2008 103 1 753 63 18028513
  81. [112]Pasricha PJ Colvin R Yates K Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying Clin Gastroenterol Hepatol 2011 9 7 567 76 21397732 PMC3123425
  82. [113]Sanger GJ Wang Y Hobson A Broad J Motilin: toward a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists Br J Pharmacol 2012 170 7 1323 32 PMC3838679 23189978
  83. [114]Mishra A Friedman HS Sinha AK The effects of erythromycin on the electrocardiogram Chest 1999 115 4 983 6 10208196
  84. [115]Di Lorenzo C Lucanto C Flores AF Idries S Hyman PE Effect of sequential erythromycin and octreotide on antroduodenal manometry J Pediatr Gastroenterol Nutr 1999 29 3 293 6 10467994
  85. [116]Savoye G Bouin M Labbé L Concomitant variations of gastric tone and duodenal motility in humans: results of a placebo-controlled study assessing octreotide and sumatriptan Scand J Gastroenterol 2006 41 5 536 43 16638695
  86. [117]Hoeldtke RD Bryner KD Hoeldtke ME Hobbs G Treatment of postural tachycardia syndrome: a comparison of octreotide and midodrine Clin Auton Res 2006 16 6 390 5 17036177
  87. [118]Bahar RJ Collins BS Steinmetz B Ament ME Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents J Pediatr 2008 152 5 685 9 18410774
  88. [119]Saps M Youssef N Miranda A Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders Gastroenterology 2009 137 4 1261 9 19596010 PMC2827243
  89. [120]Teitelbaum JE Arora R Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders J Pediatr Gastroenterol Nutr 2011 53 3 260 4 21865971
  90. [121]Rodriguez L Diaz J Nurko S Safety and efficacy of cyproheptadine for treating dyspeptic symptoms in children J Pediatr 2013 163 1 261 7 23419589 PMC3661691
  91. [122]O'Brien HL Kabbouche MA Hershey AD Treating pediatric migraine: an expert opinion Expert Opin Pharmacother 2012 13 7 959 66 22500646
  92. [123]Joyner MJ Masuki S POTS versus deconditioning: the same or different? Clin Auton Res 2008 18 6 300 7 18704621 PMC3770293
  93. [125]Brilla LR Stephens AB Knutzen KM Caine D Effect of strength training on orthostatic hypotension in older adults J Cardiopulm Rehab 1998 18 4 295 300 9702609
  94. [126]Jeong SM Shibata S Levine BD Zhang R Exercise plus volume loading prevents orthostatic intolerance but not reduction in cerebral blood flow velocity after bed rest Am J Physiol Heart Circ Physiol 2012 302 2 H489 97 22081705
  95. [127]Hastings JL Krainski F Snell PG Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest J Appl Physiol 2012 112 10 1735 43 22345434 PMC3785184
  96. [129]Bement MK Exercise-induced hypoalgesia: an evidence-based review Sluka KA Mechanisms and Management of Pain for the Physical Therapist ed Seattle, WA IASP Press 2009 143 66
  97. [130]Busch AJ Barber KA Overend TJ Peloso PM Schachter CL Exercise for treating fibromyalgia syndrome Cochrane Database Syst Rev 2007 x0005B;CD003786] PMC12832165 17943797
  98. [131]Edmonds M McGuire H Price J Exercise therapy for chronic fatigue syndrome Cochrane Database Syst Rev 2004 [CD003200] 15266475
  99. [132]Stagg NJ Mata HP Ibrahim MM Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids Anesthesiology 2011 114 4 940 8 21386701 PMC6345518
  100. [133]World Health Organization Global recommendations on physical activity for health Geneva WHO Available at 〈 http://whqlibdoc.who.int/publications/2010/9789241599979_eng.pdf〉; 2010 Accessed 17.06.12 26180873
  101. [135]Tremblay MS Warburton DE Janssen I New Canadian physical activity guidelines Appl Physiol Nutr Metab 2011 36 1 36 46 21326376
  102. [137]Ganley KJ Paterno MV Miles C Health-related fitness in children and adolescents Pediatr Phys Ther 2011 23 3 208 20 21829112
  103. [138]American College of Sports Medicine ACSM’s Guidelines for Exercise Testing and Prescription 8th Philadelphia, PA Lippincott Williams & Wilkins 2010
  104. [141]Council on Sports Medicine and Fitness Strength training by children and adolescents Pediatrics 2008 121 4 835 40 18381549
  105. [142]Faigenbaum AD Kraemer WJ Blimkie CJ Youth resistance training: updated position statement paper from the National Strength and Conditioning Association J Strength Cond Res 2009 23 5 Suppl S60 79 19620931
  106. [143]Sugawara J Komine H Miyazawa T Imai T Fisher JP Ogoh S Impact of chronic exercise training on the blood pressure response to orthostatic stimulation J Appl Physiol 2012 112 11 1891 6 22422799
  107. [145]Ruiz JR Castro-Piñero J Artero EG Predictive validity of health-related fitness in youth: a systematic review Br J Sports Med 2009 43 12 909 23 19158130
  108. [146]Ekelund U Luan J Sherar LB Esliger DW Griew P Cooper A Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents J Am Med Assoc 2012 307 7 704 12 PMC3793121 22337681
  109. [147]Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents National Heart, Lung, and Blood Institute Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report Pediatrics 2011 128 Suppl 5 S213 56 22084329 PMC4536582
  110. [148]Ondrak KS McMurray RG Bangdiwala SI Harrell JS Influence of aerobic power and percent body fat on cardiovascular disease risk in youth J Adolesc Health 2007 41 2 146 52 17659218
  111. [149]Parikh T Stratton G Influence of intensity of physical activity on adiposity and cardiorespiratory fitness in 5–18 year olds Sports Med 2011 41 6 477 88 21615189
  112. [150]Vicente-Rodríguez G How does exercise affect bone development during growth? Sports Med 2006 36 7 561 9 16796394
  113. [151]Kohrt WM Bloomfield SA Little KD Nelson ME Yingling VR American College of Sports Medicine position stand: physical activity and bone health Med Sci Sports Exerc 2004 36 11 1985 96 15514517
  114. [154]Hillman CH Kamijo K Scudder M A review of chronic and acute physical activity participation on neuroelectric measures of brain health and cognition during childhood Prev Med 2011 52 5 S21 8 21281669 PMC3094734
  115. [155]Best JR Effects of physical activity on children's executive function: contributions of experimental research on aerobic exercise Dev Rev 2010 30 4 331 51 21818169 PMC3147174
  116. [158]Landry BW Driscoll SW Physical activity in children and adolescents PM R 2012 4 11 826 32 23174545
  117. [159]Gatchel RJ Okifuji A Evidence-based scientific data documenting the treatment and cost-effectiveness of comprehensive pain programs for chronic nonmalignant pain J Pain 2006 7 11 779 93 17074616
  118. [161]Maynard CS Amari A Wieczorek B Christensen JR Slifer KJ Interdisciplinary behavioral rehabilitation of pediatric pain-associated disability: retrospective review of an inpatient treatment protocol J Pediatr Psychol 2009 35 2 128 37 19465538
  119. [162]Palermo TM Cognitive–Behavioral Therapy for Chronic Pain in Children and Adolescents Oxford Oxford University Press 2012
  120. [164]Kritzberger CJ Antiel RM Wallace DP Predictors of functional disability in adolescents with orthostatic intolerance J Child Neurol 2011 23 5 593 8 21303761
  121. [165]Silverman AH Tarbell S Feeding and vomiting problems in pediatric populations Roberts RC Steele RG Handbook of Pediatric Psychology 4th Guilford Press New York 2009
  122. [166]Walker LS Garber J Greene JW Psychosocial correlates of recurrent childhood pain: a comparison of pediatric patients with recurrent abdominal pain, organic illness, and psychiatric disorders J Abnorm Psychol 1993 102 248 58 8315137

Cited by

Sorted by citations

Authors
Kizilbash, S. J., Ahrens, S. P., Bruce, B. K., Chelimsky, G., Driscoll, S. W., Harbeck-Weber, C., Lloyd, R. M., Mack, K. J., Nelson, D. E., Ninis, N., Pianosi, P. T., Stewart, J. M., Weiss, K. E., & Fischer, P. R.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Current Problems in Pediatric and Adolescent Health Care
Publisher
Elsevier BV
Published
2014-05
Volume
44
Issue
5
Pages
108-133
ISSN
  • 1538-3199 (ISSN-L)
  • 1538-5442
DOI
10.1016/j.cppeds.2013.12.014
PMC
PMC5819886
OpenAlex
W2002273400
Cited by
120
References
36
Citations by year
2026: 4 · 2025: 12 · 2024: 11 · 2023: 4 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 8 · 2015: 9
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Current problems in pediatric and adolescent health care (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL074873)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Keywords
postural orthostatic tachycardia syndrome, autonomic dysfunction, orthostatic intolerance, family-based care, multidisciplinary treatment, sleep habits, psychological support, cognitive behavioral therapy, aerobic exercise, symptom management, recovery
MeSH terms
Adolescent, Autonomic Nervous System, Dizziness, Female, Humans, Male, Risk Factors, Syncope, Exercise, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Practice Guidelines as Topic, Orthostatic Intolerance, Postural Orthostatic Tachycardia Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review