Regular Physical Activity and Risk of Atrial Fibrillation: A Systematic Review and Meta-analysis
Abstract
Background Although previous studies have suggested that competitive athletes have a higher risk of atrial fibrillation than the general population, limited and inconsistent data are available on the association between regular physical activity and the risk of atrial fibrillation. Methods and results A systematic, comprehensive literature search was performed using MEDLINE, EMBASE, and COCHRANE until 2011. Extracted data from the eligible studies were meta-analyzed using fixed effects model. Four studies, which included 95 526 subjects, were eligible for meta-analysis. For all of the studies included, the extreme groups (ie, maximum versus minimal amount of physical activity) were used for the current analyses. The total number of participants belonging to the extreme groups was 43 672. The pooled odds ratio (95% confidence interval) for atrial fibrillation among regular exercisers was 1.08 (0.97-1.21). Conclusions Our data do not support a statistically significant association between regular physical activity and increased incidence of atrial fibrillation.
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Regular exercise of low or moderate intensity serves as a preventive strategy for cardiovascular disease and AF, while higher-intensity endurance exercise may lead to AF.
“Regular exercise of either low or moderate intensity seems serve as a preventive strategy for cardiovascular disease and AF, while higher-intensity endurance exercise may lead to AF [6,7,8,12,13,14,15,16,17,18,19,20,21].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [16]
A 2 to 10 times higher frequency of AF has been shown in high-intensity endurance athletes compared to individuals who do not exercise.
“Many retrospective observational studies and meta-analyses have estimated a 2 to 10 times higher frequency of AF in high-intensity endurance athletes compared to individuals who do not exercise [6,7,8,12,13,14,15,16,17].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [16]
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- Authors
- Ofman, P., Khawaja, O., Rahilly-Tierney, C. R., Peralta, A., Hoffmeister, P., Reynolds, M. R., Gaziano, J. M., & Djousse, L.
- Affiliations
- Brigham and Women's Hospital (US)
- From the Division of Cardiology, VA Boston Healthcare System, Harvard Medical School, Boston, MA (P.O., A.P., P.H., M.R.R., J.M.G.); Division of Aging, Department of Medicine (P.O., C.R.R.-T., J.M.G., L.D.); Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (C.R.R.-T., J.M.G.); Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) (P.O., C.R.R.-T., J.M.G., L.D.) and Geriatric Research, Education, and Clinical Center (GRECC), VA...
- Venue
- Circulation: Arrhythmia and Electrophysiology
- Published
- 2013-04
- Volume
- 6
- Issue
- 2
- Pages
- 252-256
- ISSN
- 1941-3084 (ISSN-L)
- 1941-3149
- OpenAlex
- W2163826963
- Cited by
- 96
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 15 · 2015: 19 · 2014: 14 · 2013: 1
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Arrhythmia and Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- atrial fibrillation, physical activity, competitive athletes, atrial fibrillation risk
- MeSH terms
- Atrial Fibrillation, Humans, Motor Activity, Risk Factors, Global Health, Incidence, Odds Ratio, Risk Assessment
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