Influence of Previous Heart Failure Hospitalization on Cardiovascular Events in Patients With Reduced and Preserved Ejection Fraction
Open accessAbstract
Background—: Hospitalization for acute heart failure (HF) is associated with high rates of subsequent mortality and readmission. We assessed the influence of the time interval between previous HF hospitalization and randomization in the Candesartan in Heart failure: Reduction in Mortality and morbidity (CHARM) trials on clinical outcomes in patients with both reduced and preserved ejection fraction. Methods and Results—: CHARM enrolled 7599 patients with New York Heart Association class II to IV HF, of whom 5426 had a history of previous HF hospitalization. Cox proportional hazards regression models were used to assess the association between time from previous HF hospitalization and randomization and the primary outcome of cardiovascular death or unplanned admission to hospital for the management of worsening HF during a median of 36.6 months. For patients with HF and reduced or preserved ejection fraction, rates of cardiovascular mortality and HF hospitalization were higher among patients with previous HF hospitalization than those without. The risk for mortality and hospitalization varied inversely with the time interval between hospitalization and randomization. Rates were higher for patients with HF and reduced ejection fraction within each category. Event rates for those with HF with preserved ejection fraction and a HF hospitalization in the 6 months before randomization were comparable with the rate in patients with HF and reduced ejection fraction with no previous HF hospitalization. Conclusions—: Rates of cardiovascular death or HF hospitalization are greatest in those who have been previously hospitalized for HF. Independent of EF, rates of death and readmission decline as time from HF hospitalization to trial enrollment increased. Recent HF hospitalization identifies a high-risk population for future clinical trials in HF and reduced ejection fraction and HF with preserved ejection fraction. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00634400.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hospitalization for heart failure has been regarded as a reliable surrogate of disease progression in heart failure.
“Although hospitalization for heart failure has been regarded as a reliable surrogate of disease progression in heart failure,9,10”
From Effect of Empagliflozin on the Clinical Stability of Patients With Heart Failure and a Reduced Ejection Fraction: The EMPEROR-Reduced Trial (2021) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994 · see citing works
Self-citationMcMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604 · see citing works
Self-citationLong-term trends in the incidence of and survival with heart failure
Levy, D., Kenchaiah, S., Larson, M. G., Benjamin, E. J., Kupka, M. J., Ho, K. K. L., Murabito, J. M., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020265 · Cited by 2,152 · see citing works
Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study
Bhatia, R. S., Tu, J. V., Lee, D. S., Austin, P. C., Fang, J., Haouzi, A., Gong, Y., & Liu, P. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051530 · Cited by 1,959 · see citing works
Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Held, P., McMurray, J. J. V., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,885 · see citing works
Self-citationGranger, C. B., McMurray, J. J., Yusuf, S., Held, P., Michelson, E. L., Olofsson, B., Östergren, J., Pfeffer, M. A., & Swedberg, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14284-5 · Cited by 1,686 · see citing works
Self-citationKonstam, M. A. (2007) · JAMA · doi:10.1001/jama.297.12.1319 · Cited by 1,628 · see citing works
Trends in Heart Failure Incidence and Survival in a Community-Based Population
Roger, V. L. (2004) · JAMA · doi:10.1001/jama.292.3.344 · Cited by 1,591 · see citing works
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction
Vasan, R. S., Larson, S., Benjamin, E. J., Evans, J. C., Reiss, C. K., & Levy, D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00118-7 · Cited by 1,331 · see citing works
Fonarow, G. C., Stough, W. G., Abraham, W. T., Albert, N. M., Gheorghiade, M., Greenberg, B., O’Connor, C. M., Sun, J. L., Yancy, C. W., & Young, J. B. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.064 · Cited by 1,092 · see citing works
McMurray, J. J. V., Östergren, J., Swedberg, K. B., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer (2003) · The Lancet · Cited by 1,043 · see citing works
Self-citationThe epidemiology of heart failure
Cowie, M., Mosterd, A., Wood, D. A., Deckers, J. W., Poole-Wilson, P. A., Sutton, G. C., & Grobbee, D. E. (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015223 · Cited by 1,031 · see citing works
Predictors of mortality and morbidity in patients with chronic heart failure
Pocock, S., Wang, D., Pfeffer, M. A., Yusuf, S., McMurray, J. J. V., Swedberg, K. B., Östergren, J., Michelson, E. L., Pieper, K. S., & Granger, C. B. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi555 · Cited by 972 · see citing works
Self-citationSystolic and Diastolic Heart Failure in the Community
Bursi, F., Weston, S. A., Redfield, M. M., Jacobsen, S. J., Pakhomov, S., Nkomo, V. T., Meverden, R. A., & Roger, V. L. (2006) · JAMA · doi:10.1001/jama.296.18.2209 · Cited by 891 · see citing works
Gheorghiade, M., Zannad, F. M., Sopko, G. S., Klein, L., Piña, I. L., Konstam, M. A., Massie, B. M., Roland, E., Targum, S. L., Collins, S. P., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.590091 · Cited by 788 · see citing works
Solomon, S. D., Dobson, J., Pocock, S., Skali, H., McMurray, J. J. V., Granger, C. B., Yusuf, S., Swedberg, K., Young, J. B., Michelson, E. L., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.696906 · Cited by 681 · see citing works
Self-citationCurtis, J. P., Sokol, S. I., Wang, Y., Rathore, S. S., Ko, D. T., Jadbabaie, F., Portnay, E. L., Marshalko, S. J., Radford, M. J., & Krumholz, H. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00789-7 · Cited by 579 · see citing works
Gottdiener, J. S., McClelland, R. L., Marshall, R., Shemanski, L., Furberg, C. D., Kitzman, D. W., Cushman, M., Polak, J. F., Gardin, J. M., Gersh, B. J., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-8-200210150-00006 · Cited by 476 · see citing works
Lenzen, M. J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.006 · Cited by 369 · see citing works
Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials
Collins, R., & MacMahon, S. W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03651-5 · Cited by 337 · see citing works
Swedberg, K. B., Pfeffer, M. A., Granger, C. B., Held, P., McMurray, J. J. V., Ohlin, G., Olofsson, B., Östergren, J., & Yusuf, S. (1999) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(99)90013-1 · Cited by 294 · see citing works
Self-citationMurphy, S., Cannon, C., Wiviott, S., McCabe, C., & Braunwald, E. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.005 · Cited by 202 · see citing works
Chen, J., Hsieh, A., Dharmarajan, K., Masoudi, F. A., & Krumholz, H. M. (2013) · Circulation · doi:10.1161/circulationaha.113.003668 · Cited by 168 · see citing works
Kirk, V., Bay, M., Parner, J., et al. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.01.002 · Cited by 108 · see citing works
Heart failure with preserved left ventricular systolic function: a hospital cohort study
Berry, C. (2005) · Heart · doi:10.1136/hrt.2004.041996 · Cited by 100 · see citing works
Contemporary Prevalence and Correlates of Incident Heart Failure with Preserved Ejection Fraction
Gurwitz, J. H., Magid, D. J., Smith, D. H., Goldberg, R. J., McManus, D. D., Allen, L. A., Saczynski, J. S., Thorp, M. L., Hsu, G., Sung, S. H., et al. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.10.022 · Cited by 93 · see citing works
Varadarajan, P., & Pai, R. G. (2003) · Journal of Cardiac Failure · doi:10.1054/jcaf.2003.13 · Cited by 82 · see citing works
Tikkanen, M., Szarek, M., Fayyad, R., Holme, I., Cater, N., Faergeman, O., Kastelein, J., Olsson, A., Larsen, M., Lindahl, C., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.035 · Cited by 76 · see citing works
Long-Term Prognosis of Acute Pulmonary Oedema — An Ominous Outcome
Roguin, A., Behar, D. M., Ami, H. B., et al. (2000) · European Journal of Heart Failure · doi:10.1016/s1388-9842(00)00069-6 · Cited by 68 · see citing works
Admission to Hospitals With On-Site Cardiac Catheterization Facilities
Krumholz, H. M., Chen, J., Murillo, J. E., et al. (1998) · Circulation · doi:10.1161/01.cir.98.19.2010 · Cited by 68 · see citing works
McCullough, P. A., Khandelwal, A. K., McKinnon, J. E., et al. (2005) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2005.03731.x · Cited by 39 · see citing works
Heart Failure and Preserved Left Ventricular Function: Long Term Clinical Outcome
Gotsman, I., Zwas, D. R., Lotan, C., & Keren, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041022 · Cited by 19 · see citing works
Clinical Trials in Cardiovascular Medicine
Antman, E. M. (2001) · Circulation · doi:10.1161/01.cir.103.21.e101 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
Packer, M., Anker, S. D., Butler, J., Filippatos, G., Ferreira, J. P., Pocock, S. J., Carson, P., Anand, I., Doehner, W., Haass, M., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.051783 · Cited by 435 · see citing works
Patient selection in heart failure with preserved ejection fraction clinical trials
Kelly, J. P., Mentz, R. J., Mebazaa, A., Voors, A. A., Butler, J., Roessig, L., Fiuzat, M., Zannad, F., Pitt, B., O’Connor, C. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.043 · Cited by 139 · see citing works
Efficacy and safety of sacubitril/valsartan by dose level achieved in the PIONEER-HF trial
Berg, D. D., Braunwald, E., DeVore, A. D., Lala, A., Pinney, S. P., Duffy, C. I., Gurmu, Y., Velazquez, E. J., & Morrow, D. A. (2020) · JACC: Heart Failure · doi:10.1016/j.jchf.2020.06.008 · Cited by 36 · see citing works
- Authors
- Bello, N. A., Claggett, B., Desai, A. S., McMurray, J. J. V., Granger, C. B., Yusuf, S., Swedberg, K., Pfeffer, M. A., & Solomon, S. D.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Circulation: Heart Failure
- Published
- 2014-07
- Volume
- 7
- Issue
- 4
- Pages
- 590-595
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- PMC
- PMC4102617
- OpenAlex
- W2100947680
- Cited by
- 147
- References
- 34
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 18 · 2021: 28 · 2020: 21 · 2019: 13 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 1
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institutes of Health (5t32hl007374-41)
- National Heart, Lung, and Blood Institute (T32 HL007374-34., T32‐HL007374)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure hospitalization, reduced ejection fraction, preserved ejection fraction, cardiovascular mortality, heart failure readmission, CHARM trial, candesartan, inclusion and exclusion criteria, heart failure with preserved ejection fraction
- MeSH terms
- Aged, Angiotensin-Converting Enzyme Inhibitors, Benzimidazoles, Biphenyl Compounds, Echocardiography, Female, Follow-Up Studies, Heart Failure, Humans, Male, Prognosis, Retrospective Studies, Stroke Volume, Tetrazoles, Time Factors, United States, Survival Rate, Ventricular Function, Left, Outcome Assessment, Health Care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
