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Cited by 394

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall

Open access
Rao, Ravi M., Yang, Lin, Garcia-Cardena, Guillermo, Luscinskas, Francis W.·2007·Circulation Research
DOI 10.1161/circresaha.107.151860b
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Abstract

Inflammation is a fundamental process that protects organisms by removing or neutralizing injurious agents. A key event in the inflammatory response is the localized recruitment of various leukocyte subsets. Here we address the cellular and regulatory mechanisms of leukocyte recruitment to the vessel wall in cardiovascular disease and discuss our evolving understanding of the role of the vascular endothelium in this process. The vascular endothelium is the continuous single-cell lining of the cardiovascular system that forms a critical interface between the blood and its components on one side and the tissues and organs on the other. It is heterogeneous and has many synthetic and metabolic functions including secretion of platelet-derived growth factor, von Willebrand factor, prostacyclin, NO, endothelin-1, and chemokines and the expression of adhesion molecules. It also acts as a nonthrombogenic and selective permeable barrier. Endothelial cells also interact closely with the extracellular matrix and with adjacent cells including pericytes and smooth muscle cells within the vessel wall. A central question in vascular biology is the role of the endothelium in the initiation of inflammatory response, the extent of its “molecular conversations” with recruited leukocytes, and its influence on the extent and/or outcome of this response.

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Metadata

Authors
Rao, R. M., Yang, L., Garcia-Cardena, G., & Luscinskas, F. W.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-08-03
Volume
101
Issue
3
Pages
234-247
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.107.151860b
OpenAlex
W2099463369
Cited by
394
References
9
FWCI
18.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall. https://app.cochat.ai/papers/10.1161/circresaha.107.151860b
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Rao, R. M., Yang, L., Garcia-Cardena, G., & Luscinskas, F. W. (2007). Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall. Circulation Research. https://doi.org/10.1161/circresaha.107.151860b

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.