Macrophage heterogeneity and tissue lipids
Open accessAbstract
Macrophages are present as resident cells in adipose tissue, and blood monocytes are recruited in increased numbers to sites of lipid accumulation in atherosclerosis, a modified form of inflammation in the arterial wall. Recent findings reported by 3 separate groups in this issue of the JCI provide evidence for distinct monocyte subsets, differential chemokine receptor usage, and phenotypic modulation of macrophages in murine models of genetic and high-fat diet-induced disease (see the related articles beginning on pages 175, 185, and 195). These studies raise prospects for selective therapeutic targets to ameliorate macrophage hyperinflammatory responses, while sparing host defense and repair mechanisms.
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LPS at 1 μg/ml stimulates pro-inflammatory cytokine expression in macrophages in vitro.
“This concentration was chosen because it has been shown to stimulate pro-inflammatory cytokine expression in macrophages in vitro.31,32”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [32]
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- Authors
- Gordon, S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Gordon, Siamon
- ORCID
- Gordon, Siamon
- Venue
- Journal of Clinical Investigation
- Published
- 2007-01-02
- Volume
- 117
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1716225
- OpenAlex
- W2147367043
- Cited by
- 207
- References
- 16
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 9 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 16 · 2013: 21 · 2012: 15
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation
- University of Oxford
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- macrophage heterogeneity, tissue lipids, adipose tissue macrophages, monocyte recruitment, atherosclerosis, chemokine receptors, monocyte subsets, high-fat diet, hyperinflammation, therapeutic target
- MeSH terms
- Adipose Tissue, Animals, Disease Models, Animal, Fetal Blood, Humans, Lipids, Macrophage Activation, Macrophages, Monocytes
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