Nrf2-Mediated Dichotomy in the Vascular System: Mechanistic and Therapeutic Perspective

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Role of Oxidative Modifications in Atherosclerosis

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Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,158 · see citing works

The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews · doi:10.1152/physrev.00023.2017 · Cited by 1,968 · see citing works

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

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Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Durham, A. L., Speer, M. Y., Scatena, M., Giachelli, C. M., & Shanahan, C. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy010 · Cited by 1,131 · see citing works

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G. L., Chin, M. P., Christ‐Schmidt, H., Goldsberry, A., Houser, M. T., Krauth, M., Heerspink, H. J. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306033 · Cited by 1,041 · see citing works

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S., Kensler, T. W., Yamamoto, M. P., Petrache, I., Tuder, R. M., & Biswal, S. S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21146 · Cited by 993 · see citing works

SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759 · see citing works

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene · doi:10.1038/onc.2012.388 · Cited by 657 · see citing works

Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

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Impact of Oxidative Stress on the Heart and Vasculature

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Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

Pan, H., Xue, C., Auerbach, B. J., Fan, J., Bashore, A. C., Cui, J. G., Yang, D. Y., Trignano, S. B., Liu, W., Shi, J., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.048378 · Cited by 623 · see citing works

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

Robledinos-Antón, N., Fernández-Ginés, R., Manda, G., & Cuadrado, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9372182 · Cited by 608 · see citing works

Endothelial fluid shear stress sensing in vascular health and disease

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NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Zhang, Y., Murugesan, P., Huang, K., & Cai, H. “. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0260-8 · Cited by 546 · see citing works

Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway

Miao, W., Hu, L., Scrivens, P. J., & Batist, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412081200 · Cited by 541 · see citing works

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

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Redox Signaling in Cardiac Physiology and Pathology

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Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

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Nrf2 at the heart of oxidative stress and cardiac protection

Chen, Q. M., & Maltagliati, A. J. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00041.2017 · Cited by 474 · see citing works

Is oxidative stress a therapeutic target in cardiovascular disease?

Münzel, T., Gori, T., Bruno, R. M., & Taddei, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq396 · Cited by 470 · see citing works

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

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Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages

Ishii, T., Itoh, K., Ruiz, E., Leake, D. S., Unoki‐Kubota, H., Yamamoto, M. P., & Mann, G. E. (2004) · Circulation Research · doi:10.1161/01.res.0000119171.44657.45 · Cited by 400 · see citing works

Canonical and non-canonical mechanisms of Nrf2 activation

Silva‐Islas, C. A., & Maldonado, P. D. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.06.013 · Cited by 393 · see citing works

The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation

Nioi, P., Nguyen, T., Sherratt, P. J., & Pickett, C. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10895-10906.2005 · Cited by 383 · see citing works

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3386 · Cited by 382 · see citing works

Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution

Niemann, B., Rohrbach, S., Miller, M. R., Newby, D. E., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.043 · Cited by 354 · see citing works

Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2

Köhle, C., & Bock, K. W. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.009 · Cited by 346 · see citing works

Role of Oxidative Stress in the Pathogenesis of Abdominal Aortic Aneurysms

McCormick, M. L., Gavrila, D., & Weintraub, N. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000257552.94483.14 · Cited by 337 · see citing works

Nrf2‐deficient mice are highly susceptible to cigarette smoke‐induced emphysema

Iizuka, T., Ishii, Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A. E., Homma, S., Nomura, A., et al. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00905.x · Cited by 336 · see citing works

Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells

Chen, X.-L., Varner, S. E., Rao, A. S., Grey, J. Y., Thomas, S., Cook, C. K., Wasserman, M. A., Medford, R. M., Jaiswal, A. K., & Kunsch, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203161200 · Cited by 333 · see citing works

Fate and state of vascular smooth muscle cells in atherosclerosis

Miano, J. M., Fisher, E. A., & Majesky, M. W. (2021) · Circulation · doi:10.1161/circulationaha.120.049922 · Cited by 318 · see citing works

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

Leung, L., Kwong, M., Hou, S., Lee, C., & Chan, J. Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308439200 · Cited by 299 · see citing works

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

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Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., & Yamamoto, M. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01191-13 · Cited by 265 · see citing works

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

Cuadrado, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.029 · Cited by 265 · see citing works

Flow Shear Stress and Atherosclerosis: A Matter of Site Specificity

Nigro, P., Abe, J., & Berk, B. C. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3679 · Cited by 263 · see citing works

Beyond repression of Nrf2: An update on Keap1

Kopacz, A., Klóska, D., Forman, H. J., Józkowicz, A., & Grochot‐Przeczek, A. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.023 · Cited by 262 · see citing works

Glutathione Peroxidase 2, the Major Cigarette Smoke–Inducible Isoform of GPX in Lungs, Is Regulated by Nrf2

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O., Brigelius‐Flohé, R., Kensler, T. W., Yamamoto, M. P., & Biswal, S. S. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0325oc · Cited by 248 · see citing works

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

Zakkar, M., der Heiden, K. V., Luong, L. A., Chaudhury, H., Cuhlmann, S., Hamdulay, S., Krams, R., Edirisinghe, I., Rahman, I., Carlsen, H., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.193375 · Cited by 248 · see citing works

Biomechanical Forces in Atherosclerosis-Resistant Vascular Regions Regulate Endothelial Redox Balance via Phosphoinositol 3-Kinase/Akt-Dependent Activation of Nrf2

Dai, G., Vaughn, S., Zhang, Y., Wang, E. T., García‐Cardeña, G., & Gimbrone, M. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.152942 · Cited by 245 · see citing works

Basic Biology of Oxidative Stress and the Cardiovascular System

Sack, M. N., Fyhrquist, F., Saijonmaa, O. J., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.034 · Cited by 243 · see citing works

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

Maher, J. M., & Yamamoto, M. P. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.011 · Cited by 231 · see citing works

A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway

Zhang, Y., & Gordon, G. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.885.3.7 · Cited by 231 · see citing works

Differential Responses of the Nrf2-Keap1 System to Laminar and Oscillatory Shear Stresses in Endothelial Cells

Hosoya, T., Maruyama, A., Kang, M.-I., Kawatani, Y., Shibata, T., Uchida, K., Itoh, K., & Yamamoto, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502551200 · Cited by 227 · see citing works

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

Rojo, A. I., Medina‐Campos, O. N., Rada, P., Zúñiga-Toalá, A., López-Gazcón, A., Espada, S., Pedraza‐Chaverrí, J., & Cuadrado, A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.003 · Cited by 195 · see citing works

Targeting Mechanosensitive Transcription Factors in Atherosclerosis

Niu, N., Xu, S., Xu, Y., Little, P. J., & Jin, Z. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.02.004 · Cited by 188 · see citing works

Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway

Cheng, X., Siow, R. C. M., & Mann, G. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3283 · Cited by 181 · see citing works

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

Sussan, T. E., Jun, J. C., Thimmulappa, R. K., Bedja, D., Antero, M. F., Gabrielson, K. L., Polotsky, V. Y., & Biswal, S. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003791 · Cited by 179 · see citing works

Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2

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NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

Barajas, B., Che, N., Yin, F., Rowshanrad, A., Orozco, L. D., Gong, K., Wang, X., Castellani, L. W., Reue, K., Lusis, A. J., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210906 · Cited by 169 · see citing works

Targeting the Nrf2 pathway against cardiovascular disease

Li, J., Ichikawa, T., Janicki, J. S., & Cui, T. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903025762 · Cited by 168 · see citing works

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

Ma, W., Sun, X., Zhu, Y., & Liu, N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.033 · Cited by 164 · see citing works

Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation

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Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice

Bendall, J. K., Rinze, R., Adlam, D., Tatham, A. L., de Bono, J., & Channon, K. M. (2007) · Circulation Research · doi:10.1161/01.res.0000263381.83835.7b · Cited by 157 · see citing works

Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury

Herring, B. P., Hoggatt, A. M., Burlak, C., & Offermanns, S. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-21 · Cited by 140 · see citing works

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

Prasad, S., Sajja, R. K., Kaisar, M. A., Park, J. H., Villalba, H., Liles, T., Abbruscato, T. J., & Cucullo, L. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.007 · Cited by 140 · see citing works

Panax notoginseng Saponins Protect Cerebral Microvascular Endothelial Cells against Oxygen-Glucose Deprivation/Reperfusion-Induced Barrier Dysfunction via Activation of PI3K/Akt/Nrf2 Antioxidant Signaling Pathway

Hu, S., Wu, Y., Zhao, B., Hu, H., Zhu, B., Sun, Z., Li, P., & Du, S. (2018) · Molecules · doi:10.3390/molecules23112781 · Cited by 137 · see citing works

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

Song, H., Xu, T., Feng, X., Lai, Y., Yang, Y., Zheng, H., He, X. F., Wei, G., Liao, W., Liao, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102832 · Cited by 137 · see citing works

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

Wakabayashi, N., Skoko, J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01408-13 · Cited by 133 · see citing works

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Zang, H., Wu, W., Qi, L., Tan, W., Nagarkatti, P. S., Nagarkatti, M., Wang, X., & Cui, T. (2020) · Diabetes · doi:10.2337/db19-1176 · Cited by 115 · see citing works

Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway

Feng, Z., Wang, C., Jin, Y., Meng, Q., Wu, J., & Sun, H. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1961823 · Cited by 114 · see citing works

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

Wei, Y., Gong, J., Thimmulappa, R. K., Kośmider, B., Biswal, S. S., & Duh, E. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309276110 · Cited by 113 · see citing works

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

Kim, J.-H., Yu, S., Chen, J. D., & Kong, A.-N. T. (2012) · Oncogene · doi:10.1038/onc.2012.59 · Cited by 110 · see citing works

Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress

Alonso-Piñero, J. A., González-Rovira, A., Sánchez-Gomar, I., Moreno, J. A., & Durán-Ruiz, M. C. (2021) · Antioxidants · doi:10.3390/antiox10091463 · Cited by 110 · see citing works

Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs

Choi, E. S., Yoon, J. J., Han, B. H., Jeong, D. H., Lee, Y. J., Kang, D. G., & Lee, H. S. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.022 · Cited by 104 · see citing works

Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation

Aghagolzadeh, P., Radpour, R., Bachtler, M., van Goor, H., Smith, E. R., Lister, A., Odermatt, A., Feelisch, M., & Pasch, A. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.012 · Cited by 103 · see citing works

Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt

Wang, X., Chen, L., Wang, T., Jiang, X., Zhang, H., Li, P., Lv, B., & Gao, X. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.06.010 · Cited by 102 · see citing works

Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)

Tian, W., de la Vega, M. R., Schmidlin, C. J., Ooi, A., & Zhang, D. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000428 · Cited by 101 · see citing works

Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the <i>Nrf3</i> Locus

Derjuga, A., Gourley, T. S., Holm, T. M., Heng, H. H. Q., Shivdasani, R. A., Ahmed, R., Andrews, N. C., & Blank, V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3286-3294.2004 · Cited by 100 · see citing works

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

Mylroie, H., Dumont, O., Bauer, A., Thornton, C. C., Mackey, J., Calay, D., Hamdulay, S., Choo, J. R. E., Boyle, J. J., Samarel, A. M., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv131 · Cited by 100 · see citing works

A role for Rab27b in NF-E2-dependent pathways of platelet formation

Tiwari, S., Italiano, J. E., Barral, D. C., Mules, E. H., Novak, E. K., Swank, R. T., Seabra, M. C., & Shivdasani, R. A. (2003) · Blood · doi:10.1182/blood-2003-03-0977 · Cited by 98 · see citing works

Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production

Wei, R., Enaka, M., & Muragaki, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-46824-2 · Cited by 98 · see citing works

Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif

Li, W., Jain, M. R., Chen, C., Yue, X., Hebbar, V., Zhou, R., & Kong, A.-N. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410601200 · Cited by 95 · see citing works

Crucial role of nrf3 in smooth muscle cell differentiation from stem cells

Pepe, A. E., Xiao, Q., Zampetaki, A., Zhang, Z., Kobayashi, A., Hu, Y., & Xu, Q. (2010) · Circulation Research · doi:10.1161/circresaha.109.211417 · Cited by 94 · see citing works

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

Pan, B., Zhang, H., Cui, T., & Wang, X. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.10.003 · Cited by 93 · see citing works

The Dark Side of Nrf2 in the Heart

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Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract

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Redox-Sensitive Transcription Factor Nrf2 Regulates Vascular Smooth Muscle Cell Migration and Neointimal Hyperplasia

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Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway

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Nrf2 as an Endothelial Mechanosensitive Transcription Factor

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ROS-Nrf2 pathway mediates the development of TGF-β1-induced epithelial-mesenchymal transition through the activation of Notch signaling

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Astragaloside IV Protects Against Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Endothelial Cell Injury by Reducing Oxidative Stress and Inflammation

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Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

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Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

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SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling

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An overview of the mechanisms and novel roles of Nrf2 in cardiovascular diseases

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Mechanism Analysis of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide from Isochrysis zhanjiangensis Microalgae for Suppressing Vascular Injury in Human Umbilical Vein Endothelial Cells

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MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway

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The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway

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Lipoxin A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis

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Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE −/− Mice

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MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2

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Sestrin2 increases in aortas and plasma from aortic dissection patients and alleviates angiotensin II-induced smooth muscle cell apoptosis via the Nrf2 pathway

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Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway

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Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway

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Antiatherogenic Effect of Resveratrol Attributed to Decreased Expression of ICAM-1 (Intercellular Adhesion Molecule-1)

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Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells

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Irisin attenuates oxidized low‐density lipoprotein impaired angiogenesis through AKT/mTOR/S6K1/Nrf2 pathway

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Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation

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Ginkgo Biloba Leaf Extract Attenuates Atherosclerosis in Streptozotocin-Induced Diabetic ApoE-/- Mice by Inhibiting Endoplasmic Reticulum Stress via Restoration of Autophagy through the mTOR Signaling Pathway

Tian, J., Popal, M. S., Liu, Y., Gao, R., Lyu, S., Chen, K., & Liu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8134678 · Cited by 55 · see citing works

Activation of M3AChR (Type 3 Muscarinic Acetylcholine Receptor) and Nrf2 (Nuclear Factor Erythroid 2–Related Factor 2) Signaling by Choline Alleviates Vascular Smooth Muscle Cell Phenotypic Switching and Vascular Remodeling

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Theaflavin alleviates oxidative injury and atherosclerosis progress via activating microRNA ‐24‐mediated Nrf2/ HO ‐1 signal

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Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf2 signalling pathways

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Cinnamaldehyde protects against oxidative stress and inhibits the TNF‑α‑induced inflammatory response in human umbilical vein endothelial cells

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Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia

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Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

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Inhibition of neointimal formation by trans‐resveratrol: Role of phosphatidyl inositol 3‐kinase‐dependent Nrf2 activation in heme oxygenase‐1 induction

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Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice

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Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival

Jiang, J., Dong, C., Zhai, L., Lou, J., Jin, J., Cheng, S., Chen, Z., Guo, X., Lin, D., Ding, J. H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.735530 · Cited by 48 · see citing works

Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia

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Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells

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Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

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Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1

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Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats

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Genetic elimination of Nrf2 aggravates secondary complications except for vasospasm after experimental subarachnoid hemorrhage in mice

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Salvianolic Acid B Inhibits Atherogenesis of Vascular Cells through Induction of Nrf2-dependent Heme Oxygenase-1

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Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase‐1

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Nuclear factor erythroid-2 related factor 2 Nrf2 -mediated protein quality control in cardiomyocytes

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Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts

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Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis

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Epigallocatechin-3-Gallate Ameliorates Angiotensin II-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells through the Activation of Nrf2/Caspase-3 Signaling

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Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2

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Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells

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Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells

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Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling

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Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2‐induced PSMB5 in endothelial cells

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Zedoarondiol Attenuates Endothelial Cells Injury Induced by Oxidized Low-Density Lipoprotein via Nrf2 Activation

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Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II‐challenged vascular endothelium

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Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway

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Farrerol Directly Targets GSK-3 β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries

Yan, C., Zhang, X., Miao, J., Yuan, H., Liu, E., Liang, T., & Li, Q. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5967434 · Cited by 34 · see citing works

Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene

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NRF2‐suppressed vascular calcification by regulating the antioxidant pathway in chronic kidney disease

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Eupatolide Inhibits PDGF‐induced Proliferation and Migration of Aortic Smooth Muscle Cells Through ROS‐dependent Heme Oxygenase‐1 Induction

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Erratum to “Ginkgo Biloba Leaf Extract Attenuates Atherosclerosis in Streptozotocin-Induced Diabetic ApoE-/- Mice by Inhibiting Endoplasmic Reticulum Stress via Restoration of Autophagy through the mTOR Signaling Pathway”

Tian, J., Popal, M. S., Liu, Y., Gao, R., Lyu, S., Chen, K., & Liu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3084083 · Cited by 32 · see citing works

Rosmarinic acid exerts an antagonistic effect on vascular calcification by regulating the Nrf2 signalling pathway

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Rice Bran Phenolic Compounds Regulate Genes Associated with Antioxidant and Anti-Inflammatory Activity in Human Umbilical Vein Endothelial Cells with Induced Oxidative Stress

Saji, N., Francis, N., BLANCHARD, C. L., Schwarz, L. J., & Santhakumar, A. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194715 · Cited by 31 · see citing works

A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction

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Lycopene inhibits cyclic strain‐induced endothelin‐1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase‐1 in human umbilical vein endothelial cells

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Simvastatin Treatment Upregulates HO‐1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2

Piechota-Polańczyk, A., Kopacz, A., Klóska, D., Zagrapan, B., Neumayer, C., Grochot‐Przeczek, A., Huk, I., Brostjan, C., Dulak, J., & Józkowicz, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2028936 · Cited by 30 · see citing works

Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress

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Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells

Hsu, C., Vo, T. T. T., Lee, C., Chen, Y., Lin, W., Cheng, J. H.-C., Vo, Q. C., & Lee, I. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114978 · Cited by 30 · see citing works

Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells

Li, H., Zhuang, W., Xiong, T., Park, W. S., Zhang, S., Zha, Y., Yao, J., Wang, F., Yang, Y., Chen, Y., et al. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.02.025 · Cited by 30 · see citing works

Xanthoangelol Prevents Ox-LDL–Induced Endothelial Cell Injury by Activating Nrf2/ARE Signaling

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Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity

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Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia

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Coenzyme Q10 inhibits intracranial aneurysm formation and progression in a mouse model

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Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects

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Autophagy Controls Nrf2-Mediated Dichotomy in Pressure Overloaded Hearts

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Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation

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A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway

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Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

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Diabetic neuropathy: A NRF2 disease?

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Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm

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Ferroptosis and its Potential Determinant Role in Myocardial Susceptibility to Ischemia/Reperfusion Injury in Diabetes

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Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging

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