The receptor for advanced glycation end‐products (RAGE) directly binds to ERK by a D‐domain‐like docking site
Abstract
The receptor for advanced glycation end‐products (RAGE)‐mediated cellular activation through the mitogen‐activated protein kinase (MAPK) cascade, activation of NF‐κB and Rho family small G‐proteins, cdc42/Rac, is implicated in the pathogenesis of inflammatory disorders and tumor growth/metastasis. However, the precise molecular mechanisms for the initiation of cell signaling by RAGE remain to be elucidated. In this study, proteins which directly bind to the cytoplasmic C‐terminus of RAGE were purified from rat lung extracts using an affinity chromatography technique and identified to be extracellular signal‐regulated protein kinase‐1 and ‐2 (ERK‐1/2). Their interactions were confirmed by immunoprecipitation of ERK‐1/2 from RAGE‐expressing HT1080 cell extracts with anti‐RAGE antibody. Furthermore, the augmentation of kinase activity of RAGE‐bound ERK upon the stimulation of cells with amphoterin was demonstrated by determining the phosphorylation level of myelin basic protein, an ERK substrate. In vitro binding studies using a series of C‐terminal deletion mutants of human RAGE revealed the importance of the membrane‐proximal cytoplasmic region of RAGE for the direct ERK–RAGE interaction. This region contained a sequence similar to the D‐domain, a ERK docking site which is conserved in some ERK substrates including MAPK‐interacting kinase‐1/2, mitogen‐ and stress‐activated protein kinase‐1, and ribosomal S6 kinase. These data suggest that ERK may play a role in RAGE signaling through direct interaction with RAGE.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ERK directly interacts with the cytoplasmic tail of RAGE.
“The protein contains no obvious signalling domains90, although extracellular signal-regulated kinase (eRK) was shown to directly interact with the cytoplasmic tail of RAGe97.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [97]
Cites
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
Donato, R. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00046-2 · Cited by 1,580 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217 · see citing works
The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039 · see citing works
Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor
Schlessinger, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00966-2 · Cited by 995 · see citing works
Apoptosis signaling by death receptors
Schulze‐Osthoff, K., Ferrari, D., Łoś, M., Wesselborg, S., & Peter, M. E. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540439.x · Cited by 981 · see citing works
Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896 · see citing works
Schmidt, A. M., Vianna, M., Gerlach, M. L., Brett, J., Ryan, J., Kao, J. J., Esposito, C., Hegarty, H. M., Hurley, W. L., & Clauss, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42137-0 · Cited by 833 · see citing works
Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB
Bierhaus, A., Schiekofer, S., Schwaninger, M., Andrassy, M., Humpert, P. M., Chen, J., Hong, M., Luther, T., Henle, T., Klöting, I., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2792 · Cited by 826 · see citing works
A conserved docking motif in MAP kinases common to substrates, activators and regulators
Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816 · see citing works
Lander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17810 · Cited by 813 · see citing works
Huttunen, H. J., Fages, C., & Rauvala, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19919 · Cited by 629 · see citing works
Huttunen, H. J., Kuja‐Panula, J., Sorci, G., Agneletti, A. L., Donato, R., & Rauvala, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006993200 · Cited by 578 · see citing works
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S.-I., Sakurai, S., Takasawa, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11771 · Cited by 475 · see citing works
Integrating the MAP kinase signal into the G1 phase cell cycle machinery
Roovers, K., & Assoian, R. K. (2000) · BioEssays · doi:10.1002/1521-1878(200009)22:9 · Cited by 469 · see citing works
Docking domains and substrate-specificity determination for MAP kinases
Sharrocks, A. D., Yang, S.-H., & Galanis, A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01627-3 · Cited by 442 · see citing works
Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 427 · see citing works
Tanaka, N., Yonekura, H., Yamagishi, S., Fujimori, H., Yamamoto, Y., & Yamamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001235200 · Cited by 425 · see citing works
Schmidt, A. M., Hasu, M., Popov, D., Zhang, J. H., Chen, J., Yan, S. D., Brett, J., Cao, R. Y., Kuwabara, K., & Costache, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8807 · Cited by 327 · see citing works
Yeh, C.-H., Sturgis, L., Haidacher, J., Zhang, X.-N., Sherwood, S. J., Bjercke, R. J., Juhasz, O., Crow, M. T., Tilton, R. G., & Denner, L. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1495 · Cited by 326 · see citing works
Pulido, R., Zúñiga, Á., & Ullrich, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7337 · Cited by 320 · see citing works
Rage: A Novel Cellular Receptor for Advanced Glycation End Products
Schmidt, A. M., Hori, O., Cao, R. Y., Yan, S. D., Brett, J., Wautier, J., Ogawa, S., Kuwabara, K., Matsumoto, M., & Stern, D. (1996) · Diabetes · doi:10.2337/diab.45.3.s77 · Cited by 299 · see citing works
Smith, J. A., Poteet-Smith, C. E., Malarkey, K., & Sturgill, T. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2893 · Cited by 283 · see citing works
Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
Kerkhoff, C., Klempt, M., & Sorg, C. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00144-x · Cited by 277 · see citing works
Advanced Glycation End Products-driven Angiogenesis in Vitro
Yamagishi, S., Yonekura, H., Yamamoto, Y., Katsuno, K., Sato, F., Mita, I., O'OKA, H., Satozawa, N., Kawakami, T., Nomura, M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8723 · Cited by 274 · see citing works
Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes
Stern, D., Yan, S. D., Yan, S. D., & SCHMIDT, A. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00366-9 · Cited by 267 · see citing works
KSR modulates signal propagation within the MAPK cascade.
Therrien, M., Michaud, N. R., Rubin, G. M., & Morrison, D. K. (1996) · Genes & Development · doi:10.1101/gad.10.21.2684 · Cited by 257 · see citing works
Yang, S., Yates, P. R., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.710 · Cited by 255 · see citing works
HMG1 and 2: architectural DNA-binding proteins
Thomas, J. O. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290395 · Cited by 254 · see citing works
Merenmies, J. M., Pihlaskari, R., Laitinen, J., Wartiovaara, J., & Rauvala, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55361-8 · Cited by 242 · see citing works
MacKenzie, S. J., Baillie, G. S., McPhee, I., Bolger, G. B., & Houslay, M. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16609 · Cited by 237 · see citing works
Bierhaus, A., Illmer, T., Kasper, M. E., Luther, T., Quehenberger, P., Tritschler, H., Wahl, P. M., Ziegler, R., Müller, M., & Nawroth, P. P. (1997) · Circulation · doi:10.1161/01.cir.96.7.2262 · Cited by 220 · see citing works
Parkkinen, J., Raulo, E., Merenmies, J. M., Nolo, R. M., Kajander, E. O., Baumann, M., & Rauvala, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36575-5 · Cited by 216 · see citing works
Huttunen, H. J., Kuja‐Panula, J., & Rauvala, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202515200 · Cited by 173 · see citing works
A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1
Gavin, A.-C., & Nebreda, A. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80120-1 · Cited by 158 · see citing works
Zúñiga, Á., Torres, J., Úbeda, J., & Pulido, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21900 · Cited by 131 · see citing works
Srikrishna, G., Huttunen, H. J., Johansson, L., Weigle, B., Yamaguchi, Y., Rauvala, H., & Freeze, H. H. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00796.x · Cited by 130 · see citing works
Dual roles for HMGB1: DNA binding and cytokine
Czura, C. J., Wang, H., & Tracey, K. J. (2001) · Journal of Endotoxin Research · doi:10.1177/09680519010070041401 · Cited by 120 · see citing works
Katsuoka, F., Kawakami, Y., Arai, T., Imuta, H., Fujiwara, M., Kanma, H., & Yamashita, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7263 · Cited by 105 · see citing works
Structural and functional basis for hormone binding and receptor oligomerization
Wells, J. A. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90132-5 · Cited by 91 · see citing works
Molecular mechanisms of cytokine receptor activation
Grötzinger, J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00316-6 · Cited by 76 · see citing works
Regulation and proinflammatory properties of the chemotactic protein CP-10
Geczy, C. L. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(96)00096-1 · Cited by 32 · see citing works
Assoian, R. K. (2002) · Nature Cell Biology · doi:10.1038/ncb0802-e187 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490 · see citing works
HMGB1 and RAGE in Inflammation and Cancer
Sims, G. P., Rowe, D. C., Rietdijk, S. T., Herbst, R., & Coyle, A. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132603 · Cited by 1,436 · see citing works
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
Understanding RAGE, the receptor for advanced glycation end products
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297 · see citing works
Endogenous HMGB1 regulates autophagy
Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911078 · Cited by 951 · see citing works
Cellular signalling of the receptor for advanced glycation end products (RAGE)
Xie, J., Méndez, J. D., Méndez-Valenzuela, V., & Aguilar-Hernández, M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.013 · Cited by 515 · see citing works
Targeting RAGE Signaling in Inflammatory Disease
Hudson, B. I., & Lippman, M. E. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-041316-085215 · Cited by 511 · see citing works
Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06320.x · Cited by 521 · see citing works
Early Release of HMGB-1 from Neurons after the Onset of Brain Ischemia
Qiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., Salomone, S., & Moskowitz, M. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600582 · Cited by 405 · see citing works
The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature
Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.212217 · Cited by 381 · see citing works
Hansmann, G., de Jesus Perez, V. A., Alastalo, T.-P., Alvira, C. M., Guignabert, C., Bekker, J. M., Schellong, S., Urashima, T., Wang, L., Morrell, N. W., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32503 · Cited by 367 · see citing works
RAGE: a single receptor fits multiple ligands
Fritz, G. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.08.008 · Cited by 342 · see citing works
Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective
Bongarzone, S., Savickas, V., Luzi, F., & Gee, A. D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00058 · Cited by 313 · see citing works
RAGE: therapeutic target and biomarker of the inflammatory response—the evidence mounts
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409230 · Cited by 283 · see citing works
Arumugam, T., Simeone, D. M., Schmidt, A. M., & Logsdon, C. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310124200 · Cited by 269 · see citing works
Vincent, A. M., Perrone, L., Sullivan, K. A., Backus, C., Sastry, A. M., Lastoskie, C. M., & Feldman, E. L. (2006) · Endocrinology · doi:10.1210/en.2006-0073 · Cited by 258 · see citing works
Structural Basis for Ligand Recognition and Activation of RAGE
Koch, M., Chitayat, S., Dattilo, B. M., Schiefner, A., Diez, J., Chazin, W., & Fritz, G. (2010) · Structure · doi:10.1016/j.str.2010.05.017 · Cited by 245 · see citing works
The receptor RAGE: Bridging inflammation and cancer
Riehl, A., Németh, J., Angel, P. E., & Heß, J. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-12 · Cited by 236 · see citing works
Sakaguchi, M., Murata, H., Yamamoto, K.-I., Ono, T., Sakaguchi, Y. M., Motoyama, A., Hibino, T., Kataoka, K., & Huh, N.-H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023132 · Cited by 230 · see citing works
Oczypok, E. A., Perkins, T. N., & Oury, T. D. (2017) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2017.03.012 · Cited by 225 · see citing works
Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
Rouhiainen, A., Tumova, S., Valmu, L., Kalkkinen, N., & Rauvala, H. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306200 · Cited by 214 · see citing works
Basta, G., Lazzerini, G., Turco, S. D., Ratto, G. M., Schmidt, A. M., & Caterina, R. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000167522.48370.5e · Cited by 212 · see citing works
Commonality in chronic inflammatory diseases: periodontitis, diabetes, and coronary artery disease
Southerland, J. H., Taylor, G. W., MOSS, K. L., Beck, J. D., & Offenbacher, S. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00138.x · Cited by 204 · see citing works
Advanced glycation end products and diabetic foot disease
Huijberts, M. S., Schaper, N. C., & Schalkwijk, C. G. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.861 · Cited by 202 · see citing works
Dattilo, B. M., Fritz, G., Leclerc, E., Kooi, C. W. V., Heizmann, C. W., & Chazin, W. (2007) · Biochemistry · doi:10.1021/bi7003735 · Cited by 193 · see citing works
Rasheed, Z., Akhtar, N., & Haqqi, T. M. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq380 · Cited by 188 · see citing works
RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?
Yan, S. D., Bierhaus, A., Nawroth, P. P., & Stern, D. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1030 · Cited by 179 · see citing works
Regulation of osteoclast function and bone mass by RAGE
Zhou, Z., Immel, D., Xi, C.-X., Bierhaus, A., Feng, X., Mei, L., Nawroth, P., Stern, D. M., & Xiong, W.-C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051947 · Cited by 178 · see citing works
Amphoterin as an extracellular regulator of cell motility: from discovery to disease
Huttunen, H. J., & Rauvala, H. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01301.x · Cited by 173 · see citing works
Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging
Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.013 · Cited by 169 · see citing works
Xie, J., Burz, D. S., He, W., Bronstein, I. B., Lednev, I. K., & Shekhtman, A. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608888200 · Cited by 166 · see citing works
Suppression of Pro-inflammatory Adhesion Molecules by PPAR-δ in Human Vascular Endothelial Cells
Fan, Y., Wang, Y., Tang, Z., Zhang, H., Qin, X., Zhu, Y., Guan, Y., Wang, X., Staels, B., Chien, S., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149815 · Cited by 163 · see citing works
Advanced glycation endproducts: from precursors to RAGE: round and round we go
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2010) · Amino Acids · doi:10.1007/s00726-010-0773-2 · Cited by 158 · see citing works
Roles of the Receptor for Advanced Glycation Endproducts in Diabetes-Induced Vascular Injury
Yonekura, H., Yamamoto, Y., Sakurai, S., Watanabe, T., & Yamamoto, H. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cpj04005x · Cited by 147 · see citing works
Kaji, Y., Usui, T., Ishida, S., Yamashiro, K., Moore, T., Moore, J. E., Yamamoto, Y., Yamamoto, H., & Adamis, A. P. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0495 · Cited by 140 · see citing works
RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease
Alexiou, P., Chatzopoulou, M., Pegklidou, K., & Demopoulos, V. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791331086 · Cited by 138 · see citing works
Herold, K. C., Moser, B., Chen, Y., Zeng, S., Yan, S. F., Ramasamy, R., Emond, J. C., Clynes, R., & Schmidt, A. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206751 · Cited by 138 · see citing works
Site-Specific Blockade of RAGE-V<sub>d</sub>Prevents Amyloid-β Oligomer Neurotoxicity
Sturchler, E., Galichet, A., Weibel, M., Leclerc, E., & Heizmann, C. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4878-07.2008 · Cited by 136 · see citing works
Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling
Pedrazzi, M., Patrone, M., Passalacqua, M., Ranzato, E., Colamassaro, D., Sparatore, B., Pontremoli, S., & Melloni, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8525 · Cited by 132 · see citing works
Role of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126 · see citing works
Bopp, C., Bierhaus, A., Hofer, S., Bouchon, A., Nawroth, P. P., Martin, E., & Weigand, M. A. (2007) · Critical Care · doi:10.1186/cc6164 · Cited by 131 · see citing works
Protein–Protein Interactions in the Regulation of the Extracellular Signal-Regulated Kinase
Chuderland, D., & Seger, R. (2005) · Molecular Biotechnology · doi:10.1385/mb:29:1:57 · Cited by 127 · see citing works
Sorci, G., Riuzzi, F., Arcuri, C., Giambanco, I., & Donato, R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4880-4894.2004 · Cited by 125 · see citing works
Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction
Manigrasso, M. B., Pan, J., Rai, V., Zhang, J., Reverdatto, S., Quadri, N., DeVita, R. J., Ramasamy, R., Shekhtman, A. G., & Schmidt, A. M. (2016) · Scientific Reports · doi:10.1038/srep22450 · Cited by 121 · see citing works
Evaluation of rage isoforms, ligands, and signaling in the brain
Ding, Q., & Keller, J. N. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.08.006 · Cited by 119 · see citing works
Tsoporis, J. N., Izhar, S., Leong-Poi, H., Desjardins, J.-F., Huttunen, H. J., & Parker, T. G. (2010) · Circulation Research · doi:10.1161/circresaha.109.195834 · Cited by 118 · see citing works
Cassese, A., Esposito, I., Fiory, F., Barbagallo, A., Paturzo, F., Mirra, P., Ulianich, L., Giacco, F., Iadicicco, C., Lombardi, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801698200 · Cited by 116 · see citing works
Yu, X., Guo, C., Fisher, P. B., Subjeck, J. R., & Wang, X. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.004 · Cited by 116 · see citing works
Rouhiainen, A., Kuja‐Panula, J., Tumova, S., & Rauvala, H. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-230-8_15 · Cited by 112 · see citing works
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Gąsiorowski, K., Brokos, B., Echeverrı́a, V., Barreto, G. E., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0419-4 · Cited by 117 · see citing works
Yoshizaki, A., Komura, K., Iwata, Y., Ogawa, F., Hara, T., Muroi, E., Takenaka, M., Shimizu, K., Hasegawa, M., Fujimoto, M., et al. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9252-x · Cited by 111 · see citing works
RAGE: The Beneficial and Deleterious Effects by Diverse Mechanisms of Actions
Han, S.-H., Kim, Y. H., & Mook‐Jung, I. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0030-x · Cited by 109 · see citing works
Dietary AGEs as Exogenous Boosters of Inflammation
Garay‐Sevilla, M. E., Armando Rojas, R., Portero‐Otín, M., & Uribarri, J. (2021) · Nutrients · doi:10.3390/nu13082802 · Cited by 104 · see citing works
Nah, S., Choi, I.-Y., Yoo, B., Kim, Y., Moon, H., & Lee, C. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.090 · Cited by 102 · see citing works
Nah, S., Choi, I.-Y., Lee, C. K., Oh, J. S., Kim, Y. G., Moon, H., & Yoo, B. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/kem376 · Cited by 102 · see citing works
RAGE: a new frontier in chronic airways disease
Sukkar, M. B., Ullah, M. A., Gan, W. J., Wark, P. A. B., Chung, K. F., Hughes, J. M., Armour, C. L., & Phipps, S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01984.x · Cited by 98 · see citing works
Activation of the receptor for advanced glycation end products and consequences on health
Wautier, M., Guillausseau, P.-J., & Wautier, J. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.09.009 · Cited by 95 · see citing works
Businaro, R., Leone, S., Fabrizi, C., Sorci, G., Donato, R., Lauro, G. M., & Fumagalli, L. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20785 · Cited by 96 · see citing works
Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors
Kim, H. J., Jeong, M. S., & Jang, S. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136904 · Cited by 92 · see citing works
HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration
Bassi, R., Giussani, P., Anelli, V., Colleoni, T., Pedrazzi, M., Patrone, M., Viani, P., Sparatore, B., Melloni, E., & Riboni, L. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9488-y · Cited by 91 · see citing works
Spiekerkoetter, E. F., Guignabert, C., Pérez, V. D. J., Alastalo, T., Powers, J. M., Wang, L., Lawrie, A., Ambartsumian, N. S., Schmidt, A., Berryman, M. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.205120 · Cited by 91 · see citing works
Somensi, N., Brum, P. O., Ramos, V. D. M., Gasparotto, J., Zanotto‐Filho, A., Rostirolla, D. C., Morrone, M. D. S., Moreira, J. C. F., & Gelain, D. P. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480213 · Cited by 89 · see citing works
Participation of the Receptor for Advanced Glycation End Products in Efferocytosis
Friggeri, A., Banerjee, S., Biswas, S. K., de Freitas, A., Liu, G., Bierhaus, A., & Abraham, E. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004134 · Cited by 89 · see citing works
Șerban, A. I., Stanca, L., Geicu, O. I., Munteanu, M. C., & Dinischiotu, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152376 · Cited by 88 · see citing works
Alternative splicing of RAGE: roles in biology and disease
Kalea, A. Z. (2011) · Frontiers in bioscience · doi:10.2741/3884 · Cited by 86 · see citing works
Brodeur, M. R., Bouvet, C., Bouchard, S., Moreau, S., Chain, J. L., deBlois, D., & Moreau, P. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085922 · Cited by 85 · see citing works
Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain
Yan, W. X., Armishaw, C. J., Goyette, J., Yang, Z., Cai, H., Alewood, P. F., & Geczy, C. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710388200 · Cited by 85 · see citing works
Xu, D., Young, J. H.-W., Song, D., & Esko, J. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299685 · Cited by 86 · see citing works
Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction
Xu, D., Young, J. H.-W., Krahn, J. M., Song, D., Corbett, K. D., Chazin, W., Pedersen, L. C., & Esko, J. D. (2013) · ACS Chemical Biology · doi:10.1021/cb4001553 · Cited by 85 · see citing works
Hmgb1 Promotes Wound Healing of 3T3 Mouse Fibroblasts via Rage-Dependent ERK1/2 Activation
Ranzato, E., Patrone, M., Pedrazzi, M., & Burlando, B. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9077-0 · Cited by 83 · see citing works
Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
Kumar, V., Fleming, T. H., Terjung, S., Gorzelanny, C., Gebhardt, C., Agrawal, R., Mall, M. A., Ranzinger, J., Zeier, M. G., Madhusudhan, T., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx705 · Cited by 81 · see citing works
McClelland, A. C., Hruska, M., Coenen, A. J., Henkemeyer, M. J., & Dalva, M. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910644107 · Cited by 75 · see citing works
Younessi, P., & Yoonessi, A. (2011) · Europe PMC (PubMed Central) · Cited by 72 · see citing works
HMGb1 promotes scratch wound closure of HaCaT keratinocytes via ERK1/2 activation
Ranzato, E., Patrone, M., Pedrazzi, M., & Burlando, B. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0192-4 · Cited by 71 · see citing works
MAPK, β-amyloid and synaptic dysfunction: the role of RAGE
Origlia, N., Arancio, O., Domenici, L., & Yan, S. S. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.107 · Cited by 70 · see citing works
Receptor for advanced glycation end products (RAGE) in vascular and inflammatory diseases
Mahajan, N., & Dhawan, V. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.05.013 · Cited by 69 · see citing works
Giurdanella, G., Anfuso, C. D., Olivieri, M., Lupo, G., Caporarello, N., Eandi, C. M., Drago, F., Bucolo, C., & Salomone, S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.05.017 · Cited by 68 · see citing works
Mi, L., Zhang, Y., Xu, Y., Zheng, X., Zhang, X., Wang, Z., Xue, M., & Jin, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109005 · Cited by 68 · see citing works
Cell-Matrix Interactions and Matricrine Signaling in the Pathogenesis of Vascular Calcification
Ngai, D., Lino, M., & Bendeck, M. P. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00174 · Cited by 68 · see citing works
Toma, L., Stancu, C. S., & Sima, A. V. (2020) · Biomedicines · doi:10.3390/biomedicines9010018 · Cited by 64 · see citing works
Giurdanella, G., Lazzara, F., Caporarello, N., Lupo, G., Anfuso, C. D., Eandi, C. M., Leggio, G. M., Drago, F., Bucolo, C., & Salomone, S. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.130 · Cited by 58 · see citing works
Singh, H., & Agrawal, D. K. (2022) · Drug Development Research · doi:10.1002/ddr.21971 · Cited by 57 · see citing works
Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function
Jules, J., Maiguel, D. A., & Hudson, B. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078267 · Cited by 57 · see citing works
Src family kinases are necessary for cell migration induced by extracellular HMGB1
Palumbo, R., Marchis, F. D., Pusterla, T., Conti, A., Alessio, M., & Bianchi, M. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908581 · Cited by 56 · see citing works
Activation of ERK1/2 MAP kinases in Familial Amyloidotic Polyneuropathy
Monteiro, F. A., Sousa, M. M., Cardoso, I., do Amaral, B., Guimarães, A., & Saraiva, M. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03716.x · Cited by 57 · see citing works
Gasparotto, J., Ribeiro, C. T., Bortolin, R. C., Somensi, N., Rabelo, T. K., Kunzler, A., Souza, N. C., Pasquali, M. A. D. B., Moreira, J. C. F., & Gelain, D. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-09257-3 · Cited by 55 · see citing works
Vella, V., Lappano, R., Bonavita, E., Maggiolini, M., Clarke, R. B., Belfiore, A., & Francesco, E. M. D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad005 · Cited by 56 · see citing works
Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis
Yan, Z., Luo, H., Xie, B., Tian, T., Li, S., Chen, Z., Liu, J., Zhao, X., Zhang, L., Deng, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20577-3 · Cited by 54 · see citing works
AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression
Peng, Y., Kim, J.-M., Park, H.-S., Yang, A., Islam, C., Lakatta, E. G., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep18822 · Cited by 54 · see citing works
Shu, T., Zhu, Y., Wang, H., Lin, Y., Ma, Z., & Han, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018782 · Cited by 51 · see citing works
RAGE, glomerulosclerosis and proteinuria: Roles in podocytes and endothelial cells
D’Agati, V. D., Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.07.003 · Cited by 50 · see citing works
S100B actions on glial and neuronal cells in the developing brain: an overview
Hernández‐Ortega, K., Canul-Euan, A. A., Solis‐Paredes, J. M., Borboa-Olivares, H. J., Reyes-Muñoz, E., Estrada‐Gutiérrez, G., & Camacho‐Arroyo, I. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1425525 · Cited by 49 · see citing works
Korenaga, K., Micci, M., Taglialatela, G., & Pasricha, P. J. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00774.x · Cited by 48 · see citing works
Agassandian, M., Zhou, J., Tephly, L. A., Ryan, A. J., Carter, A. B., & Mallampalli, R. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412409200 · Cited by 45 · see citing works
Diabetic Vascular Disease: It's All the RAGE
Hudson, B. I., Wendt, T., Bucciarelli, L. G., Rong, L., Naka, Y., Yan, S. F., & Schmidt, A. M. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1588 · Cited by 45 · see citing works
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE
Ye, C., Li, H., Li, Y., Zhang, Y., Liu, G., Mi, H., Li, H., Xiao, Q., Niu, L., & Yu, X. (2022) · iScience · doi:10.1016/j.isci.2022.104872 · Cited by 43 · see citing works
Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway.
Gao, S., Andreeva, K., & Cooper, N. G. F. (2014) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Feng, W., Brown, R. E., Trung, C. D., Li, W., Wang, L., Khoury, T., Alrawi, S., Yao, J. C., Xia, K., & Tan, D. (2008) · PubMed · Cited by 41 · see citing works
Nguyen, N. B., Naik, V., & Speer, M. Y. (2012) · Cardiovascular Pathology · doi:10.1016/j.carpath.2012.06.007 · Cited by 40 · see citing works
- Authors
- Ishihara, K., Tsutsumi, K., Kawane, S., Nakajima, M., & Kasaoka, T.
- Affiliations
- Novartis (Japan) (JP)
- ORCID
- Nakajima, Motowo
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-08-06
- Volume
- 550
- Issue
- 1-3
- Pages
- 107-113
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1965497701
- Cited by
- 201
- References
- 47
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- receptor for advanced glycation end products, RAGE, ERK1/2, D domain, MAPK signaling, protein-protein interaction, myelin basic protein phosphorylation, amphoterin, RAGE signaling
- MeSH terms
- Receptor for Advanced Glycation End Products, Amino Acid Sequence, Animals, Binding Sites, Cell Extracts, Cells, Cultured, Cytoplasm, Myelin Basic Protein, Humans, Lung, Male, Phosphorylation, Receptors, Immunologic, Conserved Sequence, Rats, Wistar, Sequence Deletion, Protein Structure, Tertiary, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, HMGB1 Protein, Mitogen-Activated Protein Kinase 3, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review