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Age-dependent changes of glyoxalase I expression in human brain

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Untitled work

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Role of neuroinflammation in neurodegeneration development

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The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

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Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

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Methylglyoxal, the dark side of glycolysis

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The RAGE axis: A fundamental mechanism signaling danger to the vulnerable vasculature

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Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

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The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

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Oxidative stress and aging: Is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

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Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

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Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases

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Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

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The sour side of neurodegenerative disorders: the effects of protein glycation

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The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

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Proteome analysis of human substantia nigra in Parkinson's disease

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Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

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Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

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Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway

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Advanced glycation end products as biomarkers and gerontotoxins – A basis to explore methylglyoxal-lowering agents for Alzheimer’s disease?

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Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

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Nutrition and AGE‐ing: Focusing on Alzheimer’s Disease

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Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons

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Posttranslational Modification of Human Glyoxalase 1 Indicates Redox-Dependent Regulation

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AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration

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Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity

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Healthy brain aging: Interplay between reactive species, inflammation and energy supply

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A disease with a sweet tooth: exploring the Warburg effect in Alzheimer’s disease

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Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation

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Pathological Significance of Mitochondrial Glycation

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The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration

Derk, J., MacLean, M., Juranek, J., & Schmidt, A. M. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000421 · Cited by 96 · see citing works

Glutathione: An Old and Small Molecule with Great Functions and New Applications in the Brain and in Alzheimer's Disease

Haddad, M., Hervé, V., Ben Khedher, M. R., Rabanel, J.-M., & Ramassamy, C. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8129 · Cited by 68 · see citing works

High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons

Mastrocola, R., Nigro, D., Cento, A. S., Chiazza, F., Collino, M., & Aragno, M. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.005 · Cited by 67 · see citing works

Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer’s disease. Exploring the crossroad of eternal youth and premature aging

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Anti-glycative and anti-inflammatory effects of protocatechuic acid in brain of mice treated by d-galactose

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Diabetes exacerbates amyloid and neurovascular pathology in aging‐accelerated mice

Currais, A. J. M., Prior, M., Lo, D., Jolivalt, C. G., Schubert, D. A., & Maher, P. A. (2012) · Aging Cell · doi:10.1111/acel.12002 · Cited by 61 · see citing works

Anti-oxidative, anti-glycative and anti-apoptotic effects of oleanolic acid in brain of mice treated by d-galactose

Tsai, S.-J., & Yin, M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.018 · Cited by 61 · see citing works

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

Chiavarina, B., Nokin, M., Durieux, F., Bianchi, E., Turtoï, A., Peulen, O., Peixoto, P., Irigaray, P., Uchida, K., Belpomme, D., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2121 · Cited by 56 · see citing works

The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy

Aragonès, G., Rowan, S., Francisco, S. G., Whitcomb, E. A., Yang, W., Perini-Villanueva, G., Schalkwijk, C. G., Taylor, A., & Bejarano, E. (2021) · Cells · doi:10.3390/cells10081852 · Cited by 51 · see citing works

Reduced Ovarian Glyoxalase-I Activity by Dietary Glycotoxins and Androgen Excess: A Causative Link to Polycystic Ovarian Syndrome

Kandaraki, E., Chatzigeorgiou, A., Piperi, C., Palioura, E., Palimeri, S., Korkolopoulou, P. A., Koutsilieris, M., & Papavassiliou, A. G. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00293 · Cited by 51 · see citing works

Restoration of Glyoxalase Enzyme Activity Precludes Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease

More, S. S., Vartak, A. P., & Vince, R. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn3001679 · Cited by 55 · see citing works

Methylglyoxal Formation—Metabolic Routes and Consequences

Vašková, J., Sabolová, G., Pudelský, J., Palenčár, D., & Mičková, H. (2025) · Antioxidants · doi:10.3390/antiox14020212 · Cited by 54 · see citing works

Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal

Huang, X., Wang, F., Chen, W., Chen, Y., Wang, N., & von Maltzan, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.011 · Cited by 48 · see citing works

The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced proteomic changes in the mouse striatum

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The Role of Glyoxalase in Glycation and Carbonyl Stress Induced Metabolic Disorders

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Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain

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3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system

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Glyoxalase I Retards Renal Senescence

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Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles

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Targeting Inflammatory Pathways in Alzheimer’s Disease: A Focus on Natural Products and Phytomedicines

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Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule

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The Role of Vitamin D in Alzheimer’s Disease

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