Mitochondrial health, the epigenome and healthspan

How mitochondria produce reactive oxygen species

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Oxidative stress and diabetic complications

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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

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Mitochondrial formation of reactive oxygen species

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

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What is flux balance analysis?

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Animal mitochondrial genomes

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ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

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Autophagy and the Integrated Stress Response

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Mitochondria: In Sickness and in Health

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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DNA methylation landscapes: Provocative insights from epigenomics

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.014 · Cited by 2,875 · see citing works

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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Assessing mitochondrial dysfunction in cells

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Mitochondria and cancer

Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works

The history of cancer epigenetics

Feinberg, A. P., & Tycko, B. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1279 · Cited by 2,350 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Autophagosome formation: core machinery and adaptations

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Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084 · see citing works

Transposable elements: targets for early nutritional effects on epigenetic gene regulation

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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works

Mitochondrial DNA mutations in human disease

Taylor, R. W., & Turnbull, D. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1606 · Cited by 1,866 · see citing works

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735 · see citing works

Translocation of Proteins into Mitochondria

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Reactive Oxygen Species (Ros-Induced) Ros Release

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369 · see citing works

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

Martinou, J., & Youle, R. J. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.017 · Cited by 1,366 · see citing works

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341 · see citing works

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328 · see citing works

The growing landscape of lysine acetylation links metabolism and cell signalling

Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3841 · Cited by 1,324 · see citing works

Regulation of autophagy by ROS: physiology and pathology

Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

Yu, T., Robotham, J. L., & Yoon, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511154103 · Cited by 1,246 · see citing works

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

Understanding the control of metabolism

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

Rambold, A. S., Kostelecky, B., Elia, N., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107402108 · Cited by 1,144 · see citing works

Inflammation and cardiovascular disease mechanisms

Libby, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.456s · Cited by 1,095 · see citing works

Interplay between lipids and branched-chain amino acids in development of insulin resistance

Newgard, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.024 · Cited by 1,080 · see citing works

Epigenetic Modifications

Handy, D. E., Castro, R., & Loscalzo, J. (2011) · Circulation · doi:10.1161/circulationaha.110.956839 · Cited by 1,074 · see citing works

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works

Uniparental inheritance of mitochondrial and chloroplast genes: mechanisms and evolution.

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The Mediterranean Diet, its Components, and Cardiovascular Disease

Widmer, R. J., Flammer, A. J., Lerman, L. O., & Lerman, A. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.10.014 · Cited by 963 · see citing works

Influence of Metabolism on Epigenetics and Disease

Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920 · see citing works

Molecular mechanisms of diabetic cardiomyopathy

Bugger, H., & Abel, E. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3171-6 · Cited by 903 · see citing works

Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells

Rossignol, R., Gilkerson, R., Aggeler, R., Yamagata, K., Remington, S., & Capaldi, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1101 · Cited by 865 · see citing works

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1Preprint

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Mitochondrial protein import: from proteomics to functional mechanisms

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Metabolic Regulation of Epigenetics

Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699 · see citing works

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

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Mitochondrial DNA mutations in disease and aging

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Lysine succinylation and lysine malonylation in histones

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Mitochondrial Energetics in the Heart in Obesity-Related Diabetes

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban, D., Nye, E., Stamp, G. W., Wolhuter, K., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.006 · Cited by 585 · see citing works

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576 · see citing works

Decoding the Epigenetic Language of Neuronal Plasticity

Borrelli, E., Nestler, E. J., Allis, C. D., & Sassone‐Corsi, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.012 · Cited by 529 · see citing works

Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes

Aon, M. A., Cortassa, S., Marbán, E., & O'Rourke, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302673200 · Cited by 521 · see citing works

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

Berger, F., Lau, C., Dahlmann, M., & Ziegler, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508660200 · Cited by 508 · see citing works

Energetics, epigenetics, mitochondrial genetics

Wallace, D. C., & Fan, W. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.09.006 · Cited by 507 · see citing works

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

Chen, Y., Liu, Y., & Dorn, G. W. (2011) · Circulation Research · doi:10.1161/circresaha.111.258723 · Cited by 506 · see citing works

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

Dominguez-Salas, P., Moore, S. E., Baker, M. S., Bergen, A. W., Cox, S. E., Dyer, R. A., Fulford, A. J., Guan, Y., Laritsky, E., Silver, M. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4746 · Cited by 506 · see citing works

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

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Regulation of autophagy by cytosolic acetyl-coenzyme A

Mariño, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.016 · Cited by 500 · see citing works

Redox Signaling in Cardiac Physiology and Pathology

Burgoyne, J. R., Mongue‐Din, H., Eaton, P., & Shah, A. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.255216 · Cited by 483 · see citing works

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

Song, M., Mihara, K., Chen, Y., Scorrano, L., & Dorn, G. W. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.011 · Cited by 482 · see citing works

Integration of cellular bioenergetics with mitochondrial quality control and autophagy

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Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

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Essential role for autophagy in life span extension

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Calorie restriction and sirtuins revisited

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Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart

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NAD ⁺ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439 · see citing works

Epigenetics at the Epicenter of Modern Medicine

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Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition

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Decoding Neural Circuits that Control Compulsive Sucrose Seeking

Nieh, E. H., Matthews, G. A., Allsop, S. A., Presbrey, K. N., Leppla, C. A., Wichmann, R., Neve, R., Wildes, C. P., & Tye, K. M. (2015) · Cell · doi:10.1016/j.cell.2015.01.003 · Cited by 402 · see citing works

Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations

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Redox-optimized ROS balance: A unifying hypothesis

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Food intake patterns and 25-year mortality from coronary heart disease: Cross-cultural correlations in the Seven Countries Study

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Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells.

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Aphid polyphenisms: trans-generational developmental regulation through viviparity

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Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine

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The role of the mitochondrial permeability transition pore in heart disease

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The mitochondrial origin of postischemic arrhythmias

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Potential Importance of Leucine in Treatment of Obesity and the Metabolic Syndrome

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Exercise-induced maximal metabolic rate scales with muscle aerobic capacity

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The metabolic regulation of aging

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Connecting threads: epigenetics and metabolism

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Epigenetics and Metabolism

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Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

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How mitochondrial dynamism orchestrates mitophagy

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Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol

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mTOR signaling in cellular and organismal energetics

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Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

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Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

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Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

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