The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Hyperpolarized 13 C Metabolic MRI of the Human Heart: Initial Experience
Open accessAbstract
Rationale: Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. Objective: To demonstrate the first hyperpolarized 13 C metabolic magnetic resonance imaging of the human heart. Methods and Results: Four healthy subjects underwent conventional proton cardiac magnetic resonance imaging followed by 13 C imaging and spectroscopic acquisition immediately after intravenous administration of a 0.1 mmol/kg dose of hyperpolarized [1- 13 C]pyruvate. All subjects tolerated the procedure well with no adverse effects reported ≤1 month post procedure. The [1- 13 C]pyruvate signal appeared within the chambers but not within the muscle. Imaging of the downstream metabolites showed 13 C-bicarbonate signal mainly confined to the left ventricular myocardium, whereas the [1- 13 C]lactate signal appeared both within the chambers and in the myocardium. The mean 13 C image signal:noise ratio was 115 for [1- 13 C]pyruvate, 56 for 13 C-bicarbonate, and 53 for [1- 13 C]lactate. Conclusions: These results represent the first 13 C images of the human heart. The appearance of 13 C-bicarbonate signal after administration of hyperpolarized [1- 13 C]pyruvate was readily detected in this healthy cohort (n=4). This shows that assessment of pyruvate metabolism in vivo in humans is feasible using current technology. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02648009.
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Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
Ardenkjær-Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., & Golman, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733835100 · Cited by 2,861
Cardiac Metabolism in Heart Failure: Implications Beyond ATP Production
Doenst, T., Nguyen, T. D., & Abel, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300376 · Cited by 1,111
Metabolic Mechanisms in Heart Failure
Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 521
Adaptation and Maladaptation of the Heart in Diabetes: Part I: General Concepts
Taegtmeyer, H., McNulty, P., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 521
Mazumder, P. K., O’Neill, B. T., Roberts, M. W., Buchanan, J., Yun, U. J., Cooksey, R. C., Boudina, S., & Abel, E. D. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2366 · Cited by 437
Hyperpolarized 13 C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
Merritt, M. E., Harrison, C., Storey, C., Jeffrey, F. M., Sherry, A. D., & Malloy, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706235104 · Cited by 278
Energy Metabolism in the Normal and Failing Heart: Potential for Therapeutic Interventions
Stanley, W. C., & Chandler, M. P. (2002) · Heart Failure Reviews · doi:10.1023/a:1015320423577 · Cited by 271
Schroeder, M. A., Cochlin, L. E., Heather, L. C., Clarke, K., Radda, G. K., & Tyler, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805953105 · Cited by 246
Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI
Golman, K., Petersson, J. S., Magnusson, P., Johansson, E., Åkeson, P., Chai, C., Hansson, G., & Månsson, S. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21460 · Cited by 216
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McGarrah, R. W., Crown, S. B., Zhang, G.-F., Shah, S. H., & Newgard, C. B. (2018) · Circulation Research · doi:10.1161/circresaha.117.311002 · Cited by 423
Granlund, K. L., Tee, S.-S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.024 · Cited by 138
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Metadata
- Authors
- Cunningham, C. H., Lau, J. Y. C., Chen, A. P., Geraghty, B. J., Perks, W. J., Roifman, I., Wright, G. A., & Connelly, K. A.
- Venue
- Circulation Research
- Published
- 2016-11-11
- Volume
- 119
- Issue
- 11
- Pages
- 1177-1182
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2520679741
- Cited by
- 364
- References
- 17
- FWCI
- 21.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cunningham, C. H., Lau, J. Y. C., Chen, A. P., Geraghty, B. J., Perks, W. J., Roifman, I., Wright, G. A., & Connelly, K. A. (2016). Hyperpolarized 13 C Metabolic MRI of the Human Heart: Initial Experience. Circulation Research. https://doi.org/10.1161/circresaha.116.309769
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