The DOI matches its Crossref record; 253 of the 253 references it cites were found in a registry or an index.
Autophagy in Cardiovascular Aging
Abstract
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
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In the citing paper
“Autophagy, a catabolic process that removes and digests damaged proteins and organelles, protects the cell against aging and disease.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
In the citing paper
“Because autophagy can remove damaged cell components that are associated with aging, this process, and particularly macrophagy, plays an important role in retarding aging and aging-related disease [128,129,130,131,132,133,134].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
Citations
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,890
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,192
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.052 · Cited by 3,791
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,532
Research works printed but not linked: 2
- Khavjou, O, Dunbar, SB, Whitsel, L, Nelson, S. Projected costs of informal caregiving for cardiovascular disease: 2015 – 2035 [abstract 16715]. Circulation. 2017;136(suppl 1):A16715 LP–A16715 LP.
- Sciarretta, S, Zhai, P, Volpe, M, Sadoshima, J. Trehalose, a natural dissacharide, reduces cardiac remodeling after myocardial infarction through autophagy activation [abstract 18096]. Circulation. 2012;126(suppl 21):A18096–A18096.
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Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
Abdellatif, M., Trummer-Herbst, V., Heberle, A. M., Humnig, A., Pendl, T., Durand, S., Cerrato, G., Hofer, S. J., Islam, M., Voglhuber, J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059863 · Cited by 108
Self-citationCaloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109
Self-citationThe mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94
Obesity accelerates cardiovascular ageing
Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73
Self-citationRuiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa132 · Cited by 67
Metadata
- Authors
- Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G.
- Affiliations
- Medical University of Graz (AT)
- BioTechMed Graz, Austria (S.S., D.C.-G., F.M.)
- University of Graz (AT)
- Inserm (FR)
- Venue
- Circulation Research
- Published
- 2018-09-14
- Volume
- 123
- Issue
- 7
- Pages
- 803-824
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2890933287
- Cited by
- 239
- References
- 253
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 24 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 24 · 2018: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-17-CE14-0030, ANR-16-ECVD-0008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- autophagy, cardiovascular aging, longevity pathways, caloric restriction, caloric restriction mimetics, metformin, spermidine, rapamycin, cardioprotection, vascular health, age-related cardiovascular disease, dietary intervention, genetic models
- MeSH terms
- Age Factors, Aging, Animals, Autophagy, Cardiovascular Diseases, Cardiovascular System, Health Status, Humans, Longevity, Metformin, Risk Factors, Spermidine, Sirolimus, Caloric Restriction, Protective Factors
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