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Autophagy in Cardiovascular Aging
Abstract
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
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“Autophagy, a catabolic process that removes and digests damaged proteins and organelles, protects the cell against aging and disease.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
In the citing paper
“Because autophagy can remove damaged cell components that are associated with aging, this process, and particularly macrophagy, plays an important role in retarding aging and aging-related disease [128,129,130,131,132,133,134].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
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Metadata
- Authors
- Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G.
- Affiliations
- Medical University of Graz (AT)
- BioTechMed Graz, Austria (S.S., D.C.-G., F.M.)
- University of Graz (AT)
- Inserm (FR)
- Venue
- Circulation Research
- Published
- 2018-09-14
- Volume
- 123
- Issue
- 7
- Pages
- 803-824
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2890933287
- Cited by
- 239
- References
- 253
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 24 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 24 · 2018: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-17-CE14-0030, ANR-16-ECVD-0008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- autophagy, cardiovascular aging, longevity pathways, caloric restriction, caloric restriction mimetics, metformin, spermidine, rapamycin, cardioprotection, vascular health, age-related cardiovascular disease, dietary intervention, genetic models
- MeSH terms
- Age Factors, Aging, Animals, Autophagy, Cardiovascular Diseases, Cardiovascular System, Health Status, Humans, Longevity, Metformin, Risk Factors, Spermidine, Sirolimus, Caloric Restriction, Protective Factors
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