Time and the Metrics of Aging
Open accessAbstract
The study of aging relates to changes in physical and functional dimensions that occur over time in living organisms. Yet, a model that establishes the hierarchical relationship and interlaced time courses of molecular, phenotypic, and functional hierarchical domains of aging in humans has not been established. We propose that studying the mechanisms and consequences of aging through the lens of these hierarchical domains and their connections will provide clarity in semantics and enhance a translational perspective. The study of human aging would be most informative from a life course, longitudinal perspective, given that manifestations of aging are already detectable early in life at the molecular level, yet the phenotypic responses remain masked by compensatory/resiliency mechanisms. Understanding the nature of these mechanisms is paramount for developing interventions that reduce the burden of disease and disability in older persons.
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Aging is characterized by accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.
“Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [2]
With aging, resilience mechanisms become less effective at repairing or removing damage and preventing its deleterious effects on health.
“With aging, resilience mechanisms become less effective at repairing or removing damage and preventing its deleterious effects on health (2).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [2]
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- Authors
- Ferrucci, L., Levine, M. E., Kuo, P.-L., & Simonsick, E. M.
- Affiliations
- National Institute on Aging (US)
- Yale University (US)
- Johns Hopkins University (US)
- Venue
- Circulation Research
- Published
- 2018-09-14
- Volume
- 123
- Issue
- 7
- Pages
- 740-744
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC6205734
- OpenAlex
- W2892085335
- Cited by
- 303
- References
- 20
- Citations by year
- 2026: 55 · 2025: 61 · 2024: 48 · 2023: 37 · 2022: 35 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 1
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (Z01AG000015, R00AG052604, P30AG021342)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- aging, molecular aging, functional aging, life course, longitudinal aging study, compensatory mechanisms, resilience, aging interventions, older adults, disease burden
- MeSH terms
- Healthy Aging, Age Factors, Aging, Animals, Cardiovascular Diseases, Cardiovascular System, Gene Expression Regulation, Health Status, Humans, Life Expectancy, Phenotype, Risk Factors, Time Factors, Signal Transduction
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