The DOI matches its Crossref record; 151 of the 152 references it cites were found in a registry or an index.
Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk
Open accessAbstract
Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.
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“| Lipid Metabolism | Affects cholesterol, linked to cardiovascular disease. | High | Adults | Long-term cardiovascular effects | [228] |”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [228]
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“adults and the elderly are more vulnerable to metabolic, cardiovascular, and bone diseases.”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [228]
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“| Cardiovascular Health | Linked to hypertension but not coronary heart disease. | Moderate | Adults | Long-term cardiovascular issues | [228] |”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [228]
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Cites
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
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Half-Lives of PFOS, PFHxS and PFOA after End of Exposure to Contaminated Drinking Water
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Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
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Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats
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Items 101–103 of 103
Zhou, K., Zheng, Y., Zhao, M., Zhou, Y., Han, J., Zhang, Z., Wang, Y., Qu, H., Pang, M., & Zhu, C. (2026) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2026.10.001
Mariner, H., & D’Souza, M. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44037-3.00818-6
Lu, Y., Li, J., Chen, X., Li, Z., Gong, Y., 汝少国, & Wang, W. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129369
Metadata
- Authors
- Schlezinger, J. J., & Gokce, N.
- Affiliations
- Boston University (US)
- Venue
- Circulation Research
- Published
- 2024-04-26
- Volume
- 134
- Issue
- 9
- Pages
- 1136-1159
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC11047059
- OpenAlex
- W4395447637
- Cited by
- 103
- References
- 152
- Citations by year
- 2026: 49 · 2025: 42 · 2024: 12
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL142650)
- National Institute of Environmental Health Sciences (R21ES034939)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
- Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
- Keywords
- per- and polyfluoroalkyl substances, PFAS, cardiovascular risk, dyslipidemia, obesity, impaired glucose tolerance, hypertension, hyperuricemia, atherosclerosis, vascular disease, environmental toxins, screening guidelines
- MeSH terms
- Animals, Cardiovascular Diseases, Environmental Exposure, Fluorocarbons, Humans, Risk Factors, Dyslipidemias
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