Cited by 103Per- and polyfluoroalkyl substances researchFluorine in Organic ChemistrySynthesis and properties of polymers

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Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

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Schlezinger, Jennifer J., Gokce, Noyan·2024·Circulation Research

DOI 10.1161/circresaha.124.323697PMC PMC11047059

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Abstract

Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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Authors: Schlezinger, J. J., & Gokce, N.
Affiliations: Boston University (US)
ORCID: Schlezinger, Jennifer J.
Gokce, Noyan
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2024-04-26
Volume: 134
Issue: 9
Pages: 1136-1159
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.124.323697
PMC: PMC11047059
OpenAlex: W4395447637
Cited by: 103
References: 152
Citations by year: 2026: 49 · 2025: 42 · 2024: 12
FWCI: 3.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: U.S. Department of Defense
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL142650)
National Institute of Environmental Health Sciences (R21ES034939)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
Keywords: per- and polyfluoroalkyl substances, PFAS, cardiovascular risk, dyslipidemia, obesity, impaired glucose tolerance, hypertension, hyperuricemia, atherosclerosis, vascular disease, environmental toxins, screening guidelines
MeSH terms: Animals, Cardiovascular Diseases, Environmental Exposure, Fluorocarbons, Humans, Risk Factors, Dyslipidemias

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