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Cited by 532

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Retrospective Determination of the Area at Risk for Reperfused Acute Myocardial Infarction With T2-Weighted Cardiac Magnetic Resonance Imaging: Histopathological and Displacement Encoding With Stimulated Echoes (DENSE) Functional Validations

Open access
Aletras, Anthony H., Tilak, Gauri S., Natanzon, Alex, Hsu, Li-Yueh, Gonzalez, Felix M., Hoyt, Robert F., Arai, Andrew E.·2006·Circulation
DOI 10.1161/circulationaha.105.576025
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Abstract

Background— The aim of this study was to determine whether edema imaging by T2-weighted cardiac magnetic resonance (CMR) imaging could retrospectively delineate the area at risk in reperfused myocardial infarction. We hypothesized that the size of the area at risk during a transient occlusion would be similar to the T2-weighted hyperintense region observed 2 days later, that the T2-weighted hyperintense myocardium would show partial functional recovery after 2 months, and that the T2 abnormality would resolve over 2 months. Methods and Results— Seventeen dogs underwent a 90-minute coronary artery occlusion, followed by reperfusion. The area at risk, as measured with microspheres (9 animals), was comparable to the size of the hyperintense zone on T2-weighted images 2 days later (43.4±3.3% versus 43.0±3.4% of the left ventricle; P =NS), and the 2 measures correlated ( R =0.84). The infarcted zone was significantly smaller (23.1±3.7; both P <0.001). To test whether the hyperintense myocardium would exhibit partial functional recovery over time, 8 animals were imaged on day 2 and 2 months later. Systolic strain was mapped with displacement encoding with stimulated echoes. Edema, as detected by a hyperintense zone on T2-weighted images, resolved, and regional radial systolic strain partially improved from 4.9±0.7 to 13.1±1.5 ( P =0.001) over 2 months. Conclusions— These findings are consistent with the premise that the T2 abnormality depicts the area at risk, a zone of reversibly and irreversibly injured myocardium associated with reperfused subendocardial infarctions. The persistence of postischemic edema allows T2-weighted CMR to delineate the area at risk 2 days after reperfused myocardial infarction.

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Metadata

Authors
Aletras, A. H., Tilak, G. S., Natanzon, A., Hsu, L.-Y., Gonzalez, F. M., Hoyt, R. F., & Arai, A. E.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-04-18
Volume
113
Issue
15
Pages
1865-1870
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.105.576025
OpenAlex
W2060943395
Cited by
532
References
17
FWCI
26.70
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Retrospective Determination of the Area at Risk for Reperfused Acute Myocardial Infarction With T2-Weighted Cardiac Magnetic Resonance Imaging: Histopathological and Displacement Encoding With Stimulated Echoes (DENSE) Functional Validations. https://app.cochat.ai/papers/10.1161/circulationaha.105.576025
The paper
Aletras, A. H., Tilak, G. S., Natanzon, A., Hsu, L.-Y., Gonzalez, F. M., Hoyt, R. F., & Arai, A. E. (2006). Retrospective Determination of the Area at Risk for Reperfused Acute Myocardial Infarction With T2-Weighted Cardiac Magnetic Resonance Imaging: Histopathological and Displacement Encoding With Stimulated Echoes (DENSE) Functional Validations. Circulation. https://doi.org/10.1161/circulationaha.105.576025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.