Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

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Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

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BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN

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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

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Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease

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Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

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5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels: Effects on Vascular Tetrahydrobiopterin Availability and Endothelial Nitric Oxide Synthase Coupling

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Markers of Inflammation and Rapid Coronary Artery Disease Progression in Patients With Stable Angina Pectoris

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Neopterin measurement in clinical diagnosis

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Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present.

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Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS Coupling in Vivo

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Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production

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Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris

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Global Improvement of Vascular Function and Redox State With Low-Dose Folic Acid

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Tetrahydrobiopterin, but Not l -Arginine, Decreases NO Synthase Uncoupling in Cells Expressing High Levels of Endothelial NO Synthase

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Serum neopterin and complex stenosis morphology in patients with unstable angina

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GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation

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Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells

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GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats

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Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress

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Malfunction of Vascular Control in Lifestyle-Related Diseases: Endothelial Nitric Oxide (NO) Synthase/NO System in Atherosclerosis

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Determination of quinonoid dihydrobiopterin by high-performance liquid chromatography and electrochemical detection

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GTP cyclohydrolase I mRNA induction and tetrahydrobiopterin synthesis in human endothelial cells

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Bacterial Lipopolysaccharide Down-regulates Expression of GTP Cyclohydrolase I Feedback Regulatory Protein

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Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse

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GTP Cyclohydrolase I Is Coinduced in Hepatocytes Stimulated to Produce Nitric Oxide

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Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

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Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

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The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway

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Tetrahydrobiopterin in Cardiovascular Health and Disease

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Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

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Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

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Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

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Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production

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Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation

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TIME-DEPENDENT INHIBITION AND TETRAHYDROBIOPTERIN DEPLETION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE CAUSED BY CIGARETTES

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Abstract 322: Acute Inhibition of GTP Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

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Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase

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