AMP-activated protein kinase conducts the ischemic stress response orchestra

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,666 · see citing works

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650 · see citing works

Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000261924.76669.36 · Cited by 1,505 · see citing works

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264 · see citing works

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Towler, M. C., & Hardie, D. G. (2007) · Circulation Research · doi:10.1161/01.res.0000256090.42690.05 · Cited by 1,248 · see citing works

Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart

Hein, S., Arnon, E., Sawa Kostin, D., Schönburg, M., Elsässer, A., Polyakova, V. O., Bauer, E., Klövekorn, W., & Schaper, J. (2003) · Circulation · doi:10.1161/01.cir.0000051865.66123.b7 · Cited by 1,100 · see citing works

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

Fryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,030 · see citing works

The Molecular Basis of Skeletal Muscle Atrophy

Jackman, R. W., & Kandarian, S. C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00579.2003 · Cited by 1,008 · see citing works

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994 · see citing works

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Cool, B. L., Zinker, B. A., Chiou, W. J. H., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A. L., Gagné, G. D., Iyengar, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.005 · Cited by 932 · see citing works

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

Marsin, A.-S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., den Berghe, G. V., Carling, D., & Hue, L. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00742-9 · Cited by 818 · see citing works

AMP-Activated Protein Kinase – Development of the Energy Sensor Concept

Hardie, D. G., Hawley, S. A., & Scott, J. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108944 · Cited by 813 · see citing works

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes · doi:10.2337/diab.47.8.1369 · Cited by 774 · see citing works

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738 · see citing works

Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

Gollob, M. H., Green, M. S., Tang, A. S.-L., Gollob, T., Karibe, A., Hassan, A.-S., Ahmad, F., Lozado, R., Shah, G., Fananapazir, L., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106143442403 · Cited by 671 · see citing works

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 660 · see citing works

Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy

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The regulation of AMP-activated protein kinase by phosphorylation

STEIN, S. C., Woods, A., Jones, N. A., DAVISON, M. D., & Carling, D. (2000) · Biochemical Journal · doi:10.1042/bj3450437 · Cited by 605 · see citing works

The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis

Crow, M. T., Mani, K. M., Nam, Y., & Kitsis, R. N. (2004) · Circulation Research · doi:10.1161/01.res.0000148632.35500.d9 · Cited by 584 · see citing works

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Kudo, N., Barr, A., Barr, R. L., Desai, S. S., & Lopaschuk, G. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17513 · Cited by 565 · see citing works

Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR

Russell, R. R., Bergeron, R., Shulman, G. I., & Young, L. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h643 · Cited by 553 · see citing works

AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer

Motoshima, H., Goldstein, B. J., Igata, M., & Araki, E. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108324 · Cited by 529 · see citing works

Autophagy in chronically ischemic myocardium

Yan, L., Vatner, D. E., Kim, S., Ge, H., Masurekar, M. R., Massover, W. H., Yang, G., Matsui, Y., Sadoshima, J., & Vatner, S. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506843102 · Cited by 497 · see citing works

Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase

Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 473 · see citing works

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Arad, M., Benson, D. W., Pérez‐Atayde, A. R., McKenna, W. J., Sparks, E. A., Kanter, R. J., McGarry, K., Seidman, J. G., & Seidman, C. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14571 · Cited by 460 · see citing works

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., & Hardie, D. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27186 · Cited by 441 · see citing works

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Arad, M., Benson, D. W., Pérez‐Atayde, A. R., McKenna, W. J., Sparks, E. A., Kanter, R. J., McGarry, K., Seidman, J. G., & Seidman, C. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214571 · Cited by 441 · see citing works

Role of apoptosis in reperfusion injury.

Eefting, F., Rensing, B., Wigman, J., Pannekoek, W., Liu, W.-M., Cramer, M., Lips, D., & Doevendans, P. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.023 · Cited by 439 · see citing works

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

Salt, I. P., Celler, J. W., Hawley, S. A., Prescott, A. R., Woods, A., Carling, D., & Hardie, D. G. (1998) · Biochemical Journal · doi:10.1042/bj3340177 · Cited by 437 · see citing works

AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

Polekhina, G., Gupta, A., Michell, B. J., van Denderen, B., Murthy, S., Feil, S. C., Jennings, I. G., Campbell, D. J., Witters, L. A., Parker, M. W., et al. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00292-6 · Cited by 423 · see citing works

Purification and characterization of the AMP‐activated protein kinase

Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418 · see citing works

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G., & Sutherland, C. D. (2000) · Diabetes · doi:10.2337/diabetes.49.6.896 · Cited by 391 · see citing works

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 386 · see citing works

AMP-Activated Protein Kinase in the Heart

Arad, M., Seidman, C. E., & Seidman, J. G. (2007) · Circulation Research · doi:10.1161/01.res.0000258446.23525.37 · Cited by 356 · see citing works

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

Browne, G. J., Finn, S. G., & Proud, C. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309773200 · Cited by 353 · see citing works

AMP-Activated Protein Kinase Protects Cardiomyocytes against Hypoxic Injury through Attenuation of Endoplasmic Reticulum Stress

Terai, K., Hiramoto, Y., Masaki, M., Sugiyama, S., Kuroda, T., Hori, M., Kawase, I., & Hirota, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9554-9575.2005 · Cited by 351 · see citing works

AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation

Chen, Z., McConell, G. K., Michell, B. J., Snow, R. J., Canny, B. J., & Kemp, B. E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1202 · Cited by 342 · see citing works

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress

Nagata, D., Mogi, M., & Walsh, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300643200 · Cited by 331 · see citing works

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

Chan, A. Y. M., Soltys, C.-L. M., Young, M. E., Proud, C. G., & Dyck, J. R. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403528200 · Cited by 331 · see citing works

Transgenic Mice Overexpressing Mutant PRKAG2 Define the Cause of Wolff-Parkinson-White Syndrome in Glycogen Storage Cardiomyopathy

Arad, M., Moskowitz, I. P. G., Patel, V. V., Ahmad, F., Pérez‐Atayde, A. R., Sawyer, D. B., Walter, M., Li, G. H., Burgon, P. G., Maguire, C. T., et al. (2003) · Circulation · doi:10.1161/01.cir.0000075270.13497.2b · Cited by 323 · see citing works

Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

Luiken, J. J. F. P., Coort, S. L., Willems, J., Coumans, W. A., Bonen, A., Vusse, G. J., & Glatz, J. F. C. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1627 · Cited by 296 · see citing works

Novel PRKAG2 Mutation Responsible for the Genetic Syndrome of Ventricular Preexcitation and Conduction System Disease With Childhood Onset and Absence of Cardiac Hypertrophy

Gollob, M. H., Seger, J. J., Gollob, T. N., Tapscott, T., Gonzales, O., Bachinski, L. L., & Roberts, R. (2001) · Circulation · doi:10.1161/hc5001.102111 · Cited by 278 · see citing works

Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo

Sun, W., Lee, T., Zhu, M., Gu, C., Wang, Y., Zhu, Y., & Shyy, J. Y.-J. (2006) · Circulation · doi:10.1161/circulationaha.106.630194 · Cited by 264 · see citing works

Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle

Wojtaszewski, J. F. P., Jørgensen, S. B., Hellsten, Y., Hardie, D. G., & Richter, E. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.284 · Cited by 261 · see citing works

Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

Kudo, N., Gillespie, J. G., Kung, L., Witters, L. A., Schulz, R., Clanachan, A. S., & Lopaschuk, G. D. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00013-6 · Cited by 246 · see citing works

Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression

Igata, M., Motoshima, H., Tsuruzoe, K., Kojima, K., Matsumura, T., Kondo, T., Taguchi, T., Nakamaru, K., Yano, M., Kukidome, D., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000185823.73556.06 · Cited by 244 · see citing works

Low-Flow Ischemia Leads to Translocation of Canine Heart GLUT-4 and GLUT-1 Glucose Transporters to the Sarcolemma In Vivo

Young, L. H., Ren-fu, Y., Russell, R. R., Hu, X., Caplan, M. J., Ren, J., Shulman, G. I., & Sinusas, A. J. (1997) · Circulation · doi:10.1161/01.cir.95.2.415 · Cited by 237 · see citing works

AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart

Li, J., Miller, E. J., Ninomiya‐Tsuji, J., Russell, R. R., & Young, L. H. (2005) · Circulation Research · doi:10.1161/01.res.0000187458.77026.10 · Cited by 234 · see citing works

Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis

Tian, R., & Abel, E. D. (2001) · Circulation · doi:10.1161/01.cir.103.24.2961 · Cited by 233 · see citing works

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A., Dutta, A., Prescott, A. R., Vanoverschelde, J., Ashworth, A., Jovanović, A., Alessi, D. R., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2005 · Cited by 221 · see citing works

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

Saha, A. K., Avilucea, P. R., Ye, J.-M., Assifi, M. M., Kraegen, E. W., & Ruderman, N. B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.120 · Cited by 218 · see citing works

Glucose Metabolism and Energy Homeostasis in Mouse Hearts Overexpressing Dominant Negative α2 Subunit of AMP-activated Protein Kinase

Xing, Y., Musi, N., FUJII, N. L., Zou, L., Luptak, I., Hirshman, M. F., Goodyear, L. J., & Tian, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303521200 · Cited by 213 · see citing works

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K.-L., Dong, L. Q., & Liu, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700098200 · Cited by 210 · see citing works

Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells

Dagher, Z., Ruderman, N. B., Tornheim, K., & Ido, Y. (2001) · Circulation Research · doi:10.1161/hh1201.092998 · Cited by 209 · see citing works

AMP-Activated Protein Kinase Inhibits Angiotensin II–Stimulated Vascular Smooth Muscle Cell Proliferation

Nagata, D., Takeda, R., Sata, M., Satonaka, H., Suzuki, E., Nagano, T., & Hirata, Y. (2004) · Circulation · doi:10.1161/01.cir.0000136025.96811.76 · Cited by 198 · see citing works

Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle

Li, J., Hu, X., Selvakumar, P., Russell, R. R., Cushman, S. W., Holman, G. D., & Young, L. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2004 · Cited by 197 · see citing works

Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome

Murphy, R. T., Mogensen, J., McGarry, K., Bahl, A., Evans, A. L., Osman, E., Syrris, P., Gorman, G. S., Farrell, M., Holton, J. L., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.053 · Cited by 179 · see citing works

Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise

Coven, D. L., Hu, X., Cong, L., Bergeron, R., Shulman, G. I., Hardie, D. G., & Young, L. H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00171.2003 · Cited by 174 · see citing works

AMP-Activated Protein Kinase: A Key Stress Signaling Pathway in the Heart

Young, L. H., Li, J., Baron, S. J., & Russell, R. R. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.04.005 · Cited by 166 · see citing works

Bateman domains and adenosine derivatives form a binding contract

Kemp, B. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20846 · Cited by 165 · see citing works

AMP-activated protein kinase: a key system mediating metabolic responses to exercise

HARDIE, D. G. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000106171.38299.64 · Cited by 165 · see citing works

Effects of Acadesine on Myocardial Infarction, Stroke, and Death Following Surgery A Meta-analysis of the 5 International Randomized Trials

Mangano, D. T. (1997) · JAMA · doi:10.1001/jama.1997.03540280063035 · Cited by 156 · see citing works

Transgenic Mouse Model of Ventricular Preexcitation and Atrioventricular Reentrant Tachycardia Induced by an AMP-Activated Protein Kinase Loss-of-Function Mutation Responsible for Wolff-Parkinson-White Syndrome

Sidhu, J. S., Rajawat, Y. S., Rami, T. G., Gollob, M. H., Wang, Z., Yuan, R., Marian, A. J., DeMayo, F. J., Weilbaecher, D., Taffet, G. E., et al. (2004) · Circulation · doi:10.1161/01.cir.0000151291.32974.d5 · Cited by 145 · see citing works

Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.

Nishino, Y., Miura, T., Miki, T., Sakamoto, J., Nakamura, Y., Ikeda, Y., Kobayashi, H., & Shimamoto, K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.022 · Cited by 144 · see citing works

Insulin inhibition of 5′ adenosine monophosphate—activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation

Gamble, J., & Lopaschuk, G. D. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90229-8 · Cited by 139 · see citing works

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

Ruderman, N. B., Cacicedo, J. M., Itani, S. I., Yagihashi, N., Saha, A. K., Ye, J. M., Chen, K., Zou, M., Carling, D., Boden, G., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310202 · Cited by 138 · see citing works

AMP‐activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP‐sensitive K+ channels

Sukhodub, A., Jovanović, S., Du, Q., Budas, G. R., Clelland, A. K., Shen, M., Sakamoto, K., Tian, R., & Jovanović, A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20862 · Cited by 136 · see citing works

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer

Carretero, J., Medina, P. P., Blanco, R., Smit, L., Tang, M., Roncador, G., Maestre, L., Conde, E., López‐Ríos, F., Clevers, H. C., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209951 · Cited by 136 · see citing works

Loss of Lipoprotein Lipase-derived Fatty Acids Leads to Increased Cardiac Glucose Metabolism and Heart Dysfunction

Augustus, A. S., Buchanan, J., Park, T., Hirata, K., Noh, H. L., Sun, J., Homma, S., D'Armiento, J. M., Abel, E. D., & Goldberg, I. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509890200 · Cited by 128 · see citing works

Insulin antagonizes AMP‐activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides

Beauloye, C., Marsin, A.-S., Bertrand, L., Krause, U., Hardie, D. G., Vanoverschelde, J., & Hue, L. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02788-0 · Cited by 122 · see citing works

Myocardial Ischemia and Increased Heart Work Modulate the Phosphorylation State of Eukaryotic Elongation Factor-2

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Insulin and Contraction Stimulate Exocytosis, but Increased AMP-activated Protein Kinase Activity Resulting from Oxidative Metabolism Stress Slows Endocytosis of GLUT4 in Cardiomyocytes

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Effects of acadesine on myocardial infarction, stroke, and death following surgery. A meta-analysis of the 5 international randomized trials. The Multicenter Study of Perioperative Ischemia (McSPI) Research Group

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Neither LKB1 Nor AMPK Are the Direct Targets of Metformin

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Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart

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Insulin and Ischemia Stimulate Glycolysis by Acting on the Same Targets Through Different and Opposing Signaling Pathways

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Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage

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The Relationship between AMP-activated Protein Kinase Activity and AMP Concentration in the Isolated Perfused Rat Heart

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Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow

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The metabolic “switch” AMPK regulates cardiac heparin-releasable lipoprotein lipase

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AMP-activated protein kinase: the guardian of cardiac energy status

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Increased α2 Subunit–Associated AMPK Activity and PRKAG2 Cardiomyopathy

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Characterization of the role of γ2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

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Functional role of AMP‐activated protein kinase in the heart during exercise

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Dual cardiac contractile effects of the α2-AMPK deletion in low-flow ischemia and reperfusion

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Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart

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LKB1 Kinase: Master and Commander of Metabolism and Polarity

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N488I Mutation of the γ2-Subunit Results in Bidirectional Changes in AMP-Activated Protein Kinase Activity

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Apoptosis and the heart: a decade of progress

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AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

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Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase

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AMPK, Mitochondrial Function, and Cardiovascular Disease

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Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

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Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart

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Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury

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Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart

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AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin

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Early Beneficial Effects of Bone Marrow-Derived Mesenchymal Stem Cells Overexpressing Akt on Cardiac Metabolism After Myocardial Infarction

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Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

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Nitrite Reduction and Cardiovascular Protection

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Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems

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LKB1 Knockout Mouse Develops Spontaneous Atrial Fibrillation and Provides Mechanistic Insights Into Human Disease Process

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Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling

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AMP‐activated protein kinase: a core signalling pathway in the heart

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Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion

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Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

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Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

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The Fire Within: Cardiac Inflammatory Signaling in Health and Disease

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Activated protein C protects against myocardial ischemic/reperfusion injury through AMP‐activated protein kinase signaling

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AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia

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The Role of Proteomics in Clinical Cardiovascular Biomarker Discovery

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Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?

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AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing

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Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia

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Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice

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Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms

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AMP-Activated Protein Kinase

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Atorvastatin prevents mesenchymal stem cells from hypoxia and serum-free injury through activating amp-activated protein kinase

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Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action

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A newly synthetic chromium complex—Chromium (d-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport

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Mitochondrial sirtuins in the heart

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When Hypothermia Meets Hypotension and Hyperglycemia: The Diverse Effects of Adenosine 5′-Monophosphate on Cerebral Ischemia in Rats

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Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart

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Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient

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GH-Releasing Hormone Induces Cardioprotection in Isolated Male Rat Heart via Activation of RISK and SAFE Pathways

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Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart

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Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells

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Salidroside exerts protective effects against chronic hypoxia-induced pulmonary arterial hypertension via AMPKα1-dependent pathways.

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Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome

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Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes

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A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell

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Organ Protective Mechanisms Common to Extremes of Physiology: A Window through Hibernation Biology

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AMPK in myocardial infarction and diabetes: the yin/yang effect

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Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia/reperfusion injury

Gottlieb, R. A., & Pourpirali, S. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.011 · Cited by 30 · see citing works

Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I

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Increase of macrophage migration inhibitory factor (MIF) expression in cardiomyocytes during chronic hypoxia

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The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet

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Triptolide induces apoptosis through the calcium/calmodulin‑dependent protein kinase kinaseβ/AMP‑activated protein kinase signaling pathway in non‑small cell lung cancer cells

Ren, T., Tang, Y., Wang, M., Wang, H., Liu, Y., Qian, X., Chang, C., & Chen, M. (2020) · Oncology Reports · doi:10.3892/or.2020.7763 · Cited by 22 · see citing works

Nitrite Confers Preconditioning and Cytoprotection After Ischemia/Reperfusion Injury Through the Modulation of Mitochondrial Function

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The Modulation of Cardiac Contractile Function by the Pharmacological and Toxicological Effects of Urocortin2

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Protective Effect of Natural Antioxidants on Heart Against Ischemia-Reperfusion Damage

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Adiponectin enhances bone marrow mesenchymal stem cell resistance to flow shear stress through AMP-activated protein kinase signaling

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Involvement of Adenosine Monophosphate-Activated Protein Kinase in Morphine-induced Cardioprotection

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Macrophage migration inhibitory factor deficiency augments cardiac dysfunction in Type 1 diabetic murine cardiomyocytes

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A Crystallized View of AMPK Activation

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Transient activation of P38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK

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Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation

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Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling

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Sevoflurane preconditioning protects from posttransplant injury in mouse lung transplantation

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Supplementation with the Prebiotic High-Esterified Pectin Improves Blood Pressure and Cardiovascular Risk Biomarker Profile, Counteracting Metabolic Malprogramming

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Cardiac β‐adrenergic responsiveness of obese Zucker rats: The role of AMPK

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Statins: Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins

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J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK/SREBP-1 pathway

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Modulation of cardiac cAMP signaling by AMPK and its adjustments in pressure overload-induced myocardial dysfunction in rat and mouse

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