Cited by 130Cholesterol and Lipid MetabolismLipid metabolism and disordersLipoproteins and Cardiovascular Health

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Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans

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Calabresi, Laura, Baldassarre, Damiano, Castelnuovo, Samuela, Conca, Paola, Bocchi, Letizia, Candini, Chiara, Frigerio, Beatrice, Amato, Mauro, Sirtori, Cesare R., Alessandrini, Paola, Arca, Marcello, Boscutti, Giuliano, Cattin, Luigi, Gesualdo, Loreto, Sampietro, Tiziana, Vaudo, Gaetano, Veglia, Fabrizio, Calandra, Sebastiano, Franceschini, Guido·2009·Circulation

DOI 10.1161/circulationaha.108.848143

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Abstract

Background— Mutations in the LCAT gene cause lecithin:cholesterol acyltransferase (LCAT) deficiency, a very rare metabolic disorder with 2 hypoalphalipoproteinemia syndromes: classic familial LCAT deficiency (Online Mendelian Inheritance in Man No. 245900), characterized by complete lack of enzyme activity, and fish-eye disease (Online Mendelian Inheritance in Man No. 136120), with a partially defective enzyme. Theoretically, hypoalphalipoproteinemia cases with LCAT deficiency should be at increased cardiovascular risk because of high-density lipoprotein deficiency and defective reverse cholesterol transport. Methods and Results— The extent of preclinical atherosclerosis was assessed in 40 carriers of LCAT gene mutations from 13 Italian families and 80 healthy controls by measuring carotid intima-media thickness (IMT). The average and maximum IMT values in the carriers were 0.07 and 0.21 mm smaller than in controls ( P =0.0003 and P =0.0027), respectively. Moreover, the inheritance of a mutated LCAT genotype had a remarkable gene-dose–dependent effect in reducing carotid IMT ( P =0.0003 for average IMT; P =0.001 for maximum IMT). Finally, no significant difference in carotid IMT was found between carriers of LCAT gene mutations that cause total or partial LCAT deficiency (ie, familial LCAT deficiency or fish-eye disease). Conclusions— Genetically determined low LCAT activity in Italian families is not associated with enhanced preclinical atherosclerosis despite low high-density lipoprotein cholesterol levels. This finding challenges the notion that LCAT is required for effective atheroprotection and suggests that elevating LCAT expression or activity is not a promising therapeutic strategy to reduce cardiovascular risk.

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STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Statistical methods for assessing agreement between two methods of clinical measurement
Bland, J. M., & Altman, D. G. (2010) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2009.10.001 · Cited by 5,220
Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults
O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400103 · Cited by 4,685
Use of Carotid Ultrasound to Identify Subclinical Vascular Disease and Evaluate Cardiovascular Disease Risk: A Consensus Statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force Endorsed by the Society for Vascular Medicine
Stein, J. H., Korcarz, C. E., Hurst, R. T., Lonn, E., Kendall, C. B., Mohler, E. R., Najjar, S. S., Rembold, C. M., & Post, W. S. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.11.011 · Cited by 2,454
The plasma lecithin:cholesterol acyltransferase reaction
Glomset, J. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43114-1 · Cited by 2,396
The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis
Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J. T., & Rothblat, G. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800088-jlr200 · Cited by 597
Macrophage Reverse Cholesterol Transport
Cuchel, M., & Rader, D. J. (2006) · Circulation · doi:10.1161/circulationaha.104.475715 · Cited by 536
Lecithin cholesterol acyltransferase
Jonas, A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00153-0 · Cited by 477
The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes
Kuivenhoven, J. A., Pritchard, H., Hill, J. S., Frohlich, J., Assmann, G., & Kastelein, J. J. P. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37433-2 · Cited by 364

Show all 33 references

Research works printed but not linked: 4

10.1161/atvb.22.2.317 · DOI
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10.1161/atvb.15.11.1819 · DOI

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Janać, J., Zeljković, A., Jelić‐Ivanović, Z., Dimitrijevic-Sreckovic, V. S., Miljković, M., Stefanović, A., Munjas, J., Vekić, J., Kotur‐Stevuljević, J., & Spasojević‐Kalimanovska, V. (2019) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563219853596 · Cited by 19
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Role of Lecithin
Ahsan, L., Ossoli, A., Freeman, L. A., Vaisman, B. L., Amar, M. J., Shamburek, R. D., & Remaley, A. T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407867-3.00007-x · Cited by 19
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Tanaka, S., Yasuda, T., Ishida, T., Fujioka, Y., Tsujino, T., Miki, T., & Hirata, K. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301297 · Cited by 17
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Ng, D., Burnett, J. R., Bell, D. A., Hegele, R. A., & Hooper, A. J. (2018) · Pathology · doi:10.1016/j.pathol.2018.11.005 · Cited by 18
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The beneficial effects of HDL-C on atherosclerosis: rationale and clinical results
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Semenkovich, C. F., Goldberg, A. C., & Goldberg, I. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00037-x · Cited by 14
Characteristic, polymorphism and expression distribution of LCAT gene in a Mongolian gerbil model for hyperlipidemia
Liu, Y. H., Wu, J. S., Wang, Z. Y., Chen, Y., Ying, H. Z., & Xu, N. Y. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.07.011 · Cited by 8
A woman with low HDL cholesterol and corneal opacity
Lucchi, T. A., Calabresi, L., Pinto, A. F., Benetti, E., Arosio, B., Simonelli, S., Ratiglia, R., & Vergani, C. (2011) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0712-6 · Cited by 7
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März, W., Grammer, T. B., Delgado, G., & Kleber, M. E. (2017) · Herz · doi:10.1007/s00059-017-4578-x · Cited by 7
Genetic variation in HDL-related genes and the association with cardiovascular disease: HDL particles as chameleons of lipoprotein metabolism
Kronenberg, F. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02403.x · Cited by 6
HDL and endothelial protection: examining evidence from HDL inherited disorders
Gomaraschi, M., Ossoli, A., Vitali, C., & Calabresi, L. (2013) · Clinical Lipidology · doi:10.2217/clp.13.30 · Cited by 6
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Miyata, M., Kuroda, M., Miyoshi, J., Kirinashizawa, M., Nagasawa, R., Yamamoto, M., Akasaki, Y., Utatsu, K., Maezawa, Y., Yokote, K., et al. (2024) · Journal of clinical lipidology · doi:10.1016/j.jacl.2024.09.013 · Cited by 5
Enzymatic Targets in Atherosclerosis
VG, F. E. T., & AV, R. C. G. (2015) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000176 · Cited by 5
Genetic LCAT Deficiency: Molecular Diagnosis, Plasma Lipids, and Atherosclerosis
Calabresi, L., & Franceschini, G. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1059-2_11 · Cited by 5
Self-citation

Authors: Calabresi, L., Baldassarre, D., Castelnuovo, S., Conca, P., Bocchi, L., Candini, C., Frigerio, B., Amato, M., Sirtori, C. R., Alessandrini, P., Arca, M., Boscutti, G., Cattin, L., Gesualdo, L., Sampietro, T., Vaudo, G., Veglia, F., Calandra, S., & Franceschini, G.
Affiliations: University of Foggia (IT)
ORCID: Calabresi, Laura
Baldassarre, Damiano
Castelnuovo, Samuela
Bocchi, Letizia
Frigerio, Beatrice
Amato, Mauro
Sirtori, Cesare R.
Arca, Marcello
Gesualdo, Loreto
Vaudo, Gaetano
Veglia, Fabrizio
Calandra, Sebastiano
Franceschini, Guido
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-08-18
Volume: 120
Issue: 7
Pages: 628-635
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.108.848143
OpenAlex: W2030554449
Cited by: 130
References: 33
Citations by year: 2026: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 13 · 2014: 14 · 2013: 9 · 2012: 9
FWCI: 16.13
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: LCAT deficiency, lecithin:cholesterol acyltransferase, carotid intima-media thickness, preclinical atherosclerosis, atheroprotection, fish eye disease, familial LCAT deficiency, HDL cholesterol, reverse cholesterol transport, cardiovascular risk
MeSH terms: Adult, Alleles, Carotid Arteries, Diagnosis, Differential, Female, Humans, Italy, Phosphatidylcholine-Sterol O-Acyltransferase, Lecithin Cholesterol Acyltransferase Deficiency, Cholesterol, HDL, Male, Middle Aged, Mutation, Risk Factors, Ultrasonography, Case-Control Studies, Tunica Intima, Tunica Media, Atherosclerosis

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Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans

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