Novel HDL-directed pharmacotherapeutic strategies
Open accessAbstract
The burden of atherothrombotic cardiovascular disease remains high despite currently available optimum medical therapy. To address this substantial residual risk, the development of novel therapies that attempt to harness the atheroprotective functions of HDL is a major goal. These functions include the critical role of HDL in reverse cholesterol transport, and its anti-inflammatory, antithrombotic, and antioxidant activities. Discoveries in the past decade have shed light on the complex metabolic and antiatherosclerotic pathways of HDL. These insights have fueled the development of HDL-targeted drugs, which can be classified among four different therapeutic approaches: directly augmenting apolipoprotein A-I (apo A-I) levels, such as with apo A-I infusions and upregulators of endogenous apo A-I production; indirectly augmenting apo A-I and HDL-cholesterol levels, such as through inhibition of cholesteryl ester transfer protein or endothelial lipase, or through activation of the high-affinity niacin receptor GPR109A; mimicking the functionality of apo A-I with apo A-I mimetic peptides; and enhancing steps in the reverse cholesterol transport pathway, such as via activation of the liver X receptor or of lecithin-cholesterol acyltransferase.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Direct infusions with recombinant HDL particles and augmenting APOA1 levels are the most promising strategies among approaches of modulating HDL.
“Among the various approaches of modulating HDL, direct infusions with recombinant HDL (rHDL) particles and augmenting APOA1 levels have been shown to be the most promising strategies54.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Optimal Medical Therapy with or without PCI for Stable Coronary Disease
Boden, W. E., O'Rourke, R. A., Teo, K. K., Hartigan, P. M., Maron, D. J., Kostuk, W. J., Knudtson, M., Dada, M., Casperson, P., Harris, C. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070829 · Cited by 4,699 · see citing works
Effects of torcetrapib in patients at high risk for coronary events
Barter, P. J., Caulfield, M., Eriksson, M., Grundy, S. M., Kastelein, J. J. P., Komajda, M., Lopez-Sendon, J., Mosca, L., Tardif, J.-C., Waters, D. D., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706628 · Cited by 3,139 · see citing works
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Brown, B. G., Ganz, P., Vogel, R. A., Crowe, T., Howard, G., Cooper, C. J., Brodie, B. R., et al. (2004) · JAMA · doi:10.1001/jama.291.9.1071 · Cited by 2,358 · see citing works
Brown, B. G., Zhao, X.-Q., Chait, A., Fisher, L. D., Cheung, M. C., Morse, J. S., Dowdy, A. A., Marino, E. K., Bolson, E. L., Alaupovic, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011090 · Cited by 1,979 · see citing works
A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805796 · Cited by 1,939 · see citing works
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824 · see citing works
Nissen, S. E., Tsunoda, T., Tuzcu, E. M., Schoenhagen, P., Cooper, C. J., Yasin, M., Eaton, G. M., Lauer, M. A., Sheldon, W. S., Grines, C. L., et al. (2003) · JAMA · doi:10.1001/jama.290.17.2292 · Cited by 1,707 · see citing works
Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,693 · see citing works
Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,428 · see citing works
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394 · see citing works
Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor
Costet, P., Luo, Y., Wang, N., & Tall, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003337200 · Cited by 981 · see citing works
Jukema, J., Bruschke, A. V., van Boven, A. J., Reiber, J., Bal, E., Zwinderman, A., Jansen, H., Boerma, G., van Rappard, F. M., & Kong, L. I. (1995) · Circulation · doi:10.1161/01.cir.91.10.2528 · Cited by 911 · see citing works
Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2
Taylor, A. J., Sullenberger, L. E., Lee, H. J., Lee, J. K., & Grace, K. A. (2004) · Circulation · doi:10.1161/01.cir.0000148955.19792.8d · Cited by 889 · see citing works
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Tunaru, S., Kero, J. T., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., & Offermanns, S. (2003) · Nature Medicine · doi:10.1038/nm824 · Cited by 794 · see citing works
Badimón, J. J., Badimón, L., & Fuster, V. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114558 · Cited by 764 · see citing works
High-Density Lipoprotein Subfractions - What the Clinicians Need to Know
Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Cardiology · doi:10.1159/000346463 · Cited by 749 · see citing works
Safety of anacetrapib in patients with or at high risk for coronary heart disease
Cannon, C. P., Shah, S., Dansky, H. M., Davidson, M., Brinton, E. A., Gotto, A. M., Stepanavage, M., Liu, S. X., Gibbons, P., Ashraf, T. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1009744 · Cited by 749 · see citing works
Influence of nicotinic acid on serum cholesterol in man
Altschul, R., Hoffer, A., & Stephen, J. D. (1955) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(55)90070-9 · Cited by 726 · see citing works
Tardif, J. (2007) · JAMA · doi:10.1001/jama.297.15.jpc70004 · Cited by 724 · see citing works
Navab, M., Ananthramaiah, G. M., Reddy, S. T., Lenten, B. J. V., Ansell, B. J., Fonarow, G. C., Vahabzadeh, K., Hama, S. Y., Hough, G., Kamranpour, N., et al. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400001-jlr200 · Cited by 687 · see citing works
Molecular regulation of HDL metabolism and function: implications for novel therapies
Rader, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30163 · Cited by 603 · see citing works
Self-citationMolecular Identification of High and Low Affinity Receptors for Nicotinic Acid
Wise, A., Foord, S. M., Fraser, N. J., Barnes, A. A., Elshourbagy, N. A., Eilert, M. M., Ignar, D. M., Murdock, P. R., Steplewski, K. M., Green, A. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210695200 · Cited by 540 · see citing works
A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
Okamoto, H., Yonemori, F., Wakitani, K., Minowa, T., Maeda, K., & Shinkai, H. (2000) · Nature · doi:10.1038/35018119 · Cited by 532 · see citing works
Yoshikawa, T., Shimano, H., Amemiya-Kudo, M., Yahagi, N., Hasty, A. H., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.2991-3000.2001 · Cited by 526 · see citing works
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
Brunham, L. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27352 · Cited by 519 · see citing works
Waters, D., Higginson, L., Gladstone, P., Kimball, B., May, M. L. L., Boccuzzi, S., & Lésperance, J. (1994) · Circulation · doi:10.1161/01.cir.89.3.959 · Cited by 512 · see citing works
Grefhorst, A., Elzinga, B. M., Voshol, P. J., Plösch, T., Kok, T., Bloks, V. W., van der Sluijs, F. H., Havekes, L. M., Romijn, J. A., Verkade, H. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204887200 · Cited by 502 · see citing works
A novel endothelial-derived lipase that modulates HDL metabolism
Jaye, M., Lynch, K. J., Krawiec, J. A., Marchadier, D. H. L., Maugeais, C., Doan, K. N., South, V., Amin, D., Perrone, M. H., & Rader, D. J. (1999) · Nature Genetics · doi:10.1038/7766 · Cited by 499 · see citing works
Self-citationThompson, A. (2008) · JAMA · doi:10.1001/jama.299.23.2777 · Cited by 494 · see citing works
Efficacy and Safety of a Novel Cholesteryl Ester Transfer Protein Inhibitor, JTT-705, in Humans
de Grooth, G. J., Kuivenhoven, J. A., Stalenhoef, A. F. H., Graaf, J. D., Zwinderman, A. H., Posma, J. L., van Tol, A., & Kastelein, J. J. P. (2002) · Circulation · doi:10.1161/01.cir.0000015857.31889.7b · Cited by 454 · see citing works
Bots, M. L., Visseren, F. L. J., Evans, G. W., Riley, W. A., Revkin, J. H., Tegeler, C. H., Shear, C. L., Duggan, W. T., Vicari, R. M., Grobbee, D. E., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61088-5 · Cited by 453 · see citing works
Zhang, Y., Zanotti, I., Reilly, M. P., Glick, J. M., Rothblat, G. H., & Rader, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000086981.09834.e0 · Cited by 435 · see citing works
Self-citationHigh Density Lipoprotein Metabolism in Man
Blum, C. B., Levy, R. I., Eisenberg, S., Hall, M., Goebel, R. H., & Berman, M. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108833 · Cited by 406 · see citing works
Navab, M., Anantharamaiah, G. M., Hama, S. Y., Garber, D. W., Chaddha, M., Hough, G., Lallone, R. L., & Fogelman, A. M. (2002) · Circulation · doi:10.1161/hc0302.103711 · Cited by 400 · see citing works
Shah, P. K., Yano, J., Reyes, O. S., Chyu, K., Kaul, S., Bisgaier, C. L., Drake, S., & Cercek, B. (2001) · Circulation · doi:10.1161/hc2501.092494 · Cited by 381 · see citing works
Ordovás, J. M., Cupples, L. A., Corella, D., Otvos, J. D., Osgood, D. P., Martinez, A. A., Lahoz, C., Coltell, Ó., Wilson, P. W. F., & Schaefer, E. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.5.1323 · Cited by 379 · see citing works
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice
Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., & Gustafsson, J.-Α. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9794 · Cited by 364 · see citing works
Cardiovascular Status of Carriers of the Apolipoprotein A-I Milano Mutant
Sirtori, C. R., Calabresi, L., Franceschini, G., Baldassarre, D., Amato, M., Johansson, J., Salvetti, M., Monteduro, C., Zulli, R., Muiesan, M. L., et al. (2001) · Circulation · doi:10.1161/01.cir.103.15.1949 · Cited by 321 · see citing works
Rittershaus, C. W., MILLER, D. P., Thomas, L. J., Picard, M. D., Honan, C. M., Emmett, C. D., Pettey, C. L., Adari, H. Y., Hammond, R. A., Beattie, D. T., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2106 · Cited by 308 · see citing works
Endothelial lipase is a major determinant of HDL level
Ishida, T., Choi, S. Y., Kundu, R. K., Hirata, K., Rubin, E. M., Cooper, A. D., & Quertermous, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16306 · Cited by 306 · see citing works
Schaap, F. G., Rensen, P. C. N., Voshol, P. J., Vrins, C. L. J., van der Vliet, H. N., Chamuleau, R. A. F. M., Havekes, L. M., Groen, A. K., & van Dijk, K. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403240200 · Cited by 300 · see citing works
Nicholls, S. J., Dusting, G. J., Cutri, B., Bao, S., Drummond, G. R., Rye, K., & Barter, P. J. (2005) · Circulation · doi:10.1161/01.cir.0000159351.95399.50 · Cited by 294 · see citing works
Matsuura, F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27602 · Cited by 293 · see citing works
Bloedon, L. T., Dunbar, R. L., Duffy, D., Pinell-Salles, P., Norris, R., DeGroot, B. J., Movva, R., Navab, M., Fogelman, A. M., & Rader, D. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.p800003-jlr200 · Cited by 290 · see citing works
Self-citationForrest, M. J., Bloomfield, D. M., Briscoe, R. J., Brown, P. N., Cumiskey, A., Ehrhart, J., Hershey, J. C., Keller, W. J., Ma, X., McPherson, H. E., et al. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.229 · Cited by 288 · see citing works
Bradley, M. N., Hong, C., Chen, M., Joseph, S. B., Wilpitz, D. C., Wang, X., Lusis, A. J., Collins, A., Hseuh, W. A., Collins, J. L., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31909 · Cited by 277 · see citing works
Krishna, R., Anderson, M. S., Bergman, A. J., Jin, B., Fallon, M. S., Côté, J., Rosko, K., Chavez-Eng, C. M., Lutz, R., Bloomfield, D. M., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61813-3 · Cited by 275 · see citing works
Hirano, K.-I., Yamashita, S., Nakajima, N., Arai, T., Maruyama, T., Yoshida, Y., Ishigami, M., Sakai, N., Kameda-Takemura, K., & Matsuzawa, Y. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1053 · Cited by 275 · see citing works
Shaw, J. A., Bobik, A., Murphy, A. J., Kanellakis, P., Blombery, P. A., Mukhamedova, N., Woollard, K. J., Lyon, S. M., Sviridov, D., & Dart, A. M. (2008) · Circulation Research · doi:10.1161/circresaha.108.182063 · Cited by 272 · see citing works
Beyond High-Density Lipoprotein Cholesterol Levels
deGoma, E. M., deGoma, R. L., & Rader, D. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.016 · Cited by 251 · see citing works
Self-citationShepherd, J., Packard, C. J., Patsch, J. R., Gotto, A. M., & Taunton, O. D. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109385 · Cited by 248 · see citing works
Bloomfield, D. M., Carlson, G. L., Sapre, A., Tribble, D. L., McKenney, J. M., Littlejohn, T. W., Sisk, C. M., Mitchel, Y., & Pasternak, R. C. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.09.022 · Cited by 242 · see citing works
Sugano, M., Makino, N., Sawada, S., Otsuka, S., Watanabe, M., Okamoto, H., Kamada, M., & Mizushima, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5033 · Cited by 241 · see citing works
Yvan‐Charvet, L., Kling, J., Pagler, T. A., Li, H., Hubbard, B. K., Fisher, T., Sparrow, C. P., Taggart, A. K. P., & Tall, A. R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207142 · Cited by 238 · see citing works
Shah, P. K., Nilsson, J. Å., Kaul, S., Fishbein, M. C., Ageland, H., Hamsten, A., Johansson, J., Karpe, F., & Cercek, B. (1998) · Circulation · doi:10.1161/01.cir.97.8.780 · Cited by 238 · see citing works
Bailey, D., Jahagirdar, R., Gordon, A., Hafiane, A., Campbell, S., Chatur, S., Wagner, G. S., Hansen, H. C., Chiacchia, F. S., Johansson, J., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.035 · Cited by 233 · see citing works
Hoeg, J. M., Santamarina-Fojo, S., Bérard, A. M., Cornhill, J. F., Herderick, E. E., Feldman, S. H., Haudenschild, C. C., Vaisman, B. L., Hoyt, R. F., Demosky, S. J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11448 · Cited by 230 · see citing works
Waksman, R., Torguson, R., Kent, K. M., Pichard, A. D., Suddath, W. O., Satler, L. F., Martin, B. D., Perlman, T. J., Maltais, J. B., Weissman, N. J., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.067 · Cited by 225 · see citing works
Föger, B., Chase, M. B., Amar, M. J., Vaisman, B. L., Shamburek, R. D., Paigen, B. J., Fruchart‐Najib, J., Paiz, J. A., Koch, C. A., Hoyt, R. F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36912 · Cited by 224 · see citing works
Villines, T. C., Stanek, E. J., Devine, P. J., Turco, M., Miller, M., Weissman, N. J., Griffen, L., & Taylor, A. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.017 · Cited by 223 · see citing works
Datta, G., Chaddha, M., Hama, S. Y., Navab, M., Fogelman, A. M., Garber, D. W., Mishra, V., Epand, R. M., Epand, R. F., Lund‐Katz, S., et al. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31599-6 · Cited by 222 · see citing works
Boekholdt, S. M., Kuivenhoven, J. A., Wareham, N. J., Peters, R. J. G., Jukema, J. W., Luben, R., Bingham, S. A., Day, N., Kastelein, J. J. P., & Khaw, K. (2004) · Circulation · doi:10.1161/01.cir.0000141730.65972.95 · Cited by 218 · see citing works
Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo
Jin, W., Millar, J. S., Broedl, U. C., Glick, J. M., & Rader, D. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16146 · Cited by 217 · see citing works
Self-citationHigh density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits.
Jj, B., Badimón, L., Galvez, A., Dische, R., & Fuster, V. (1989) · PubMed · Cited by 214 · see citing works
Nicholls, S. J., Tuzcu, E. M., Brennan, D. M., Tardif, J., & Nissen, S. E. (2008) · Circulation · doi:10.1161/circulationaha.108.790733 · Cited by 213 · see citing works
Patel, S., Drew, B. G., Nakhla, S., Duffy, S. J., Murphy, A. J., Barter, P. J., Rye, K., Chin-Dusting, J. P. F., Hoang, A., Sviridov, D., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.008 · Cited by 203 · see citing works
Yvan‐Charvet, L., Matsuura, F., Wang, N., Bamberger, M. J., Nguyen, T. T., Rinninger, F., Jiang, X., Shear, C. L., & Tall, A. R. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.138347 · Cited by 200 · see citing works
Calkin, A. C., Drew, B. G., Ono, A., Duffy, S. J., Gordon, M. V., Schoenwaelder, S. M., Sviridov, D., Cooper, M. E., Kingwell, B. A., & Jackson, S. P. (2009) · Circulation · doi:10.1161/circulationaha.109.870709 · Cited by 198 · see citing works
Hanson, J., Gille, A., Zwykiel, S., Lukasova, M., Clausen, B. E., Ahmed, K., Tunaru, S., Wirth, A., & Offermanns, S. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42273 · Cited by 197 · see citing works
Jin, F.-Y., Kamanna, V. S., & Kashyap, M. L. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2020 · Cited by 194 · see citing works
Lenten, B. J. V., Wagner, A. C., Jung, C., Ruchala, P. P., Waring, A. J., Lehrer, R. I., Watson, A. D., Hama, S. Y., Navab, M., Anantharamaiah, G. M., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800075-jlr200 · Cited by 194 · see citing works
Chiesa, G., Monteggia, E., Marchesi, M., Lorenzon, P., Laucello, M., Lorusso, V., Mario, C. D., Karvouni, E., Newton, R. S., Bisgaier, C. L., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000018422.31717.ee · Cited by 194 · see citing works
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
Edmondson, A. C., Brown, R., Kathiresan, S., Cupples, L. A., Demissie, S., Manning, A. K., Jensen, M. K., Rimm, E. B., Wang, J., Rodrigues, A., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37176 · Cited by 193 · see citing works
Self-citationSasso, G. L., Murzilli, S., Salvatore, L., D’Errico, I., Petruzzelli, M., Conca, P., Jiang, Z., Calabresi, L., Parini, P., & Moschetta, A. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.07.002 · Cited by 189 · see citing works
Ameli, S., Hultgårdh‐Nilsson, A., Cercek, B., Shah, P. K., Forrester, J. S., Ageland, H., & Nilsson, J. (1994) · Circulation · doi:10.1161/01.cir.90.4.1935 · Cited by 184 · see citing works
Badellino, K. O., Wolfe, M. L., Reilly, M. P., & Rader, D. J. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030022 · Cited by 173 · see citing works
Self-citationMertens, A. C., Verhamme, P. B., Bielicki, J. K., Phillips, M. C., Quarck, R. A., Verreth, W., Stengel, D., Ninio, E., Navab, M., Mackness, B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000056523.08033.9f · Cited by 172 · see citing works
Kuivenhoven, J. A., de Grooth, G. J., Kawamura, H., Klerkx, A. H. E. M., Wilhelm, F. E., Trip, M. D., & Kastelein, J. J. P. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.064 · Cited by 170 · see citing works
Morehouse, L. A., Sugarman, E. D., Bourassa, P.-A. K., Sand, T. M., Zimetti, F., Gao, F., Rothblat, G. H., & Milici, A. J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600332-jlr200 · Cited by 169 · see citing works
Compromised LCAT Function Is Associated With Increased Atherosclerosis
Hovingh, G. K., Hutten, B. A., Holleboom, A. G., Petersen, W., Rol, P., Stalenhoef, A. F. H., Zwinderman, A. H., de Groot, E., Kastelein, J. J. P., & Kuivenhoven, J. A. (2005) · Circulation · doi:10.1161/circulationaha.105.540427 · Cited by 165 · see citing works
Niesor, E. J., Magg, C., Ogawa, N., Okamoto, H., von der Mark, E., Matile, H., Schmid, G., Clerc, R. G., Chaput, E., Blum‐Kaelin, D., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m008706 · Cited by 151 · see citing works
Lamon‐Fava, S., Diffenderfer, M. R., Barrett, P. H. R., Buchsbaum, A., Nyaku, M. K., Horvath, K. V., Asztalos, B. F., Otokozawa, S., Ai, M., Matthan, N. R., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164541 · Cited by 149 · see citing works
Brousseau, M. E., O’Connor, J. J., Ordovás, J. M., Collins, D. E., Otvos, J. D., Massov, T., McNamara, J. R., Bloomfield, H. E., Robins, S. J., & Schaefer, E. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000024566.57589.2e · Cited by 149 · see citing works
Tanigawa, H., Billheimer, J. T., Tohyama, J., Zhang, Y., Rothblat, G. H., & Rader, D. J. (2007) · Circulation · doi:10.1161/circulationaha.107.704254 · Cited by 149 · see citing works
Self-citationLund, E. G., Peterson, L. B., Adams, A. D., Lam, M.-H. N., Burton, C. A., Chin, J., Guo, Q., Huang, S., Latham, M., Lopez, J. C., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.11.004 · Cited by 148 · see citing works
Liver X Receptor (LXR)-β Regulation in LXRα-Deficient Mice: Implications for Therapeutic Targeting
Quinet, E. M., Savio, D. A., Halpern, A. R., Chen, L., Schuster, G. U., Gustafsson, J.-Å., Basso, M. D., & Nambi, P. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022608 · Cited by 148 · see citing works
Navab, M., Anantharamaiah, G. M., Hama, S. Y., Hough, G., Reddy, S. T., Frank, J. S., Garber, D. W., Handattu, S. P., & Fogelman, A. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000167412.98221.1a · Cited by 146 · see citing works
Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor
Inaba, T., Matsuda, M., Shimamura, M., Takei, N., Terasaka, N., Ando, Y., Yasumo, H., Koishi, R., Makishima, M., & Shimomura, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213202200 · Cited by 138 · see citing works
Yasuda, T., Grillot, D., Billheimer, J. T., Briand, F., Delerive, P., Huet, S., & Rader, D. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.195693 · Cited by 138 · see citing works
Self-citationRigamonti, E., Helin, L., Lestavel, S., Mutka, A., Lepore, M., Fontaine, C., Bouhlel, M. A., Bultel, S., Fruchart, J., Ikonen, E., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000184678.43488.9f · Cited by 132 · see citing works
Li, X., Chyu, K., Faria‐Neto, J. R., Yano, J., Nathwani, N., Ferreira, C., Dimayuga, P. C., Cercek, B., Kaul, S., & Shah, P. K. (2004) · Circulation · doi:10.1161/01.cir.0000142857.79401.69 · Cited by 131 · see citing works
Calabresi, L., Baldassarre, D., Castelnuovo, S., Conca, P., Bocchi, L., Candini, C., Frigerio, B., Amato, M., Sirtori, C. R., Alessandrini, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.818143 · Cited by 130 · see citing works
Calabresi, L., Baldassarre, D., Castelnuovo, S., Conca, P., Bocchi, L., Candini, C., Frigerio, B., Amato, M., Sirtori, C. R., Alessandrini, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.848143 · Cited by 130 · see citing works
Dimayuga, P. C., Zhu, J., Oguchi, S., Chyu, K., Xu, X.-O. H., Yano, J., Shah, P. K., Nilsson, J. Å., & Cercek, B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1278 · Cited by 129 · see citing works
Ishigami, M., Yamashita, S., Sakai, N., Aral, T., Hirano, K., Hiraoka, H., Kameda-Takemura, K., & Matsuzawa, Y. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124516 · Cited by 128 · see citing works
Lerch, P. G., Förtsch, V., Hodler, G., & Bolli, R. (1996) · Vox Sanguinis · doi:10.1046/j.1423-0410.1996.7130155.x · Cited by 128 · see citing works
Bielicki, J. K., Zhang, H., Cortez, Y., Zheng, Y. Y., Narayanaswami, V., Patel, A., Johansson, J., & Azhar, S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003665 · Cited by 126 · see citing works
Borggreve, S. E., Hillege, H. L., Wolffenbuttel, B. H. R., de Jong, P. E., Zuurman, M. W., van der Steege, G., van Tol, A., & Dullaart, R. P. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2322 · Cited by 121 · see citing works
石神, 眞. (1996) · Medical Entomology and Zoology · doi:10.11501/3119662 · Cited by 120 · see citing works
Illuminating HDL — Is It Still a Viable Therapeutic Target?
Rader, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejme0707210 · Cited by 119 · see citing works
Self-citationApolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages
Smythies, L. E., White, C. R., Maheshwari, A., Palgunachari, M. N., Anantharamaiah, G. M., Chaddha, M., Kurundkar, A., & Datta, G. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00467.2009 · Cited by 117 · see citing works
Increased Cholesterol Efflux Potential of Sera From ApoA-I Milano Carriers and Transgenic Mice
Franceschini, G., Calabresi, L., Chiesa, G., Parolini, C., Sirtori, C. R., Canavesi, M., & Bernini, F. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.5.1257 · Cited by 117 · see citing works
Anantharamaiah, G. M., Mishra, V., Garber, D. W., Datta, G., Handattu, S. P., Palgunachari, M. N., Chaddha, M., Navab, M., Reddy, S. T., Segrest, J. P., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700010-jlr200 · Cited by 115 · see citing works
Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial
Stein, E. A., Roth, E. M., Rhyne, J. M., Burgess, T., Kallend, D. G., & Robinson, J. G. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp601 · Cited by 109 · see citing works
Endothelial Lipase Is Increased In Vivo by Inflammation in Humans
Badellino, K. O., Wolfe, M. L., Reilly, M. P., & Rader, D. J. (2008) · Circulation · doi:10.1161/circulationaha.107.707349 · Cited by 107 · see citing works
Self-citationSantamarina-Fojo, S., Lambert, G. C., Hoeg, J. M., & Brewer, H. B. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200006000-00007 · Cited by 104 · see citing works
Barter, P. J. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.09.014 · Cited by 101 · see citing works
Biochemical characterization of cholesteryl ester transfer protein inhibitors
Ranalletta, M., Bierilo, K. K., Chen, Y., Milot, D. P., Chen, Q., Tung, E. C., Houde, C., Elowe, N. H., Garcia-Calvo, M. M., Porter, G., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007468 · Cited by 97 · see citing works
Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors
Richman, J. G., Kanemitsu-Parks, M., Gaidarov, I., Cameron, J. S., Griffin, P. S., Zheng, H., Guerra, N. C., Cham, L., Maciejewski-Lenoir, D., Behan, D. P., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701866200 · Cited by 97 · see citing works
Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo
Sacks, F. M., Rudel, L. L., Conner, A. P., Akeefe, H., Kostner, G. M., Baki, T. T., Rothblat, G. H., de la Llera-Moya, M., Asztalos, B. F., Perlman, T. J., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800622-jlr200 · Cited by 96 · see citing works
Jäkel, H., Nowak, M., Moitrot, E., Dehondt, H., Hum, D. W., Pennacchio, L. A., Fruchart‐Najib, J., & Fruchart, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404744200 · Cited by 93 · see citing works
Fiévet, C., & Staels, B. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.026 · Cited by 92 · see citing works
Parolini, C., Marchesi, M., Lorenzon, P., Castano, M., Balconi, E., Miragoli, L., Chaabane, L., Morisetti, A., Lorusso, V., Martin, B. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.010 · Cited by 91 · see citing works
Dullaart, R. P. F., Perton, F. G., van der Klauw, M. M., Hillege, H. L., & Sluiter, W. J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.07.042 · Cited by 91 · see citing works
Structural characterisation of the mouse nuclear oxysterol receptor genes LXRα and LXRβ
Alberti, S., Steffensen, K. R., & Gustafsson, J.-Α. (2000) · Gene · doi:10.1016/s0378-1119(99)00555-7 · Cited by 91 · see citing works
Cannon, C. P., Dansky, H. M., Davidson, M. H., Gotto, A. M., Brinton, E. A., Gould, A. L., Stepanavage, M. E., Liu, S. X., Shah, S., Rubino, J., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.028 · Cited by 90 · see citing works
Tanigawa, H., Billheimer, J. T., Tohyama, J.-I., Fuki, I. V., Ng, D. S., Rothblat, G. H., & Rader, D. J. (2009) · Circulation · doi:10.1161/circulationaha.108.825109 · Cited by 90 · see citing works
Self-citationChoi, S. Y., Hirata, K., Ishida, T., Quertermous, T., & Cooper, A. D. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200011-jlr200 · Cited by 90 · see citing works
Apolipoprotein A-I mimetic peptides
Lenten, B. J. V., Wagner, A. C., Anantharamaiah, G. M., Navab, M., Reddy, S. T., Buga, G. M., & Fogelman, A. M. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0008-8 · Cited by 87 · see citing works
Brown, R., Lagor, W. R., Sankaranaravanan, S., Yasuda, T., Quertermous, T., Rothblat, G. H., & Rader, D. J. (2010) · Circulation Research · doi:10.1161/circresaha.110.219188 · Cited by 86 · see citing works
Self-citationStructure/Function Relationships of Apolipoprotein A-I Mimetic Peptides
D’Souza, W., Stonik, J. A., Murphy, A. J., Demosky, S. J., Sethi, A. A., Moore, X. L., Chin-Dusting, J. P. F., Remaley, A. T., & Sviridov, D. (2010) · Circulation Research · doi:10.1161/circresaha.110.216507 · Cited by 80 · see citing works
Borggreve, S. E., Hillege, H. L., Dallinga‐Thie, G. M., de Jong, P. E., Wolffenbuttel, B. H. R., Grobbee, D. E., van Tol, A., Dullaart, R. P. F., & on behalf of the PREVEND Study Group (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm062 · Cited by 78 · see citing works
Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent
Lebherz, C., Sanmiguel, J. C., Wilson, J. M., & Rader, D. J. (2007) · Cardiovascular Diabetology · doi:10.1186/1475-2840-6-15 · Cited by 72 · see citing works
Self-citationMaccubbin, D., Koren, M. J., Davidson, M., Gavish, D., Pasternak, R. C., Macdonell, G., Mallick, M., Sisk, C. M., Paolini, J. F., & Mitchel, Y. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.02.047 · Cited by 71 · see citing works
Holleboom, A. G., Kuivenhoven, J. A., Vergeer, M., Hovingh, G. K., van Miert, J. N. I., Wareham, N. J., Kastelein, J. J. P., Khaw, K., & Boekholdt, S. M. (2009) · Journal of Lipid Research · doi:10.1194/p900038-jlr200 · Cited by 64 · see citing works
The Pharmacology and Off-Target Effects of Some Cholesterol Ester Transfer Protein Inhibitors
Vergeer, M., & Stroes, E. S. G. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.09.017 · Cited by 63 · see citing works
Lerch, P. G., Förtsch, V., Hodler, G., et al. (1996) · Vox Sanguinis · doi:10.1159/000462047 · Cited by 62 · see citing works
Lai, E., Waters, M. G., Tata, J. R., Radziszewski, W., Perevozskaya, I. T., Zheng, W., Wenning, L. A., Connolly, D. T., Semple, G., Johnson‐Levonas, A. O., et al. (2008) · Journal of clinical lipidology · doi:10.1016/j.jacl.2008.08.445 · Cited by 56 · see citing works
Macrophage Reverse Cholesterol Transport in Mice Expressing ApoA-I Milano
Alexander, E. T., Weibel, G. L., Joshi, M. R., Vedhachalam, C., de la Llera-Moya, M., Rothblat, G. H., Phillips, M. C., & Rader, D. J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191379 · Cited by 55 · see citing works
Self-citationWang, L., Sharifi, B. G., Pan, T., Song, L., Yukht, A., & Shah, P. K. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.040 · Cited by 54 · see citing works
Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors
Goodman, K. B., Bury, M. J., Cheung, M., Cichy-Knight, M. A., Dowdell, S. E., Dunn, A. K., Lee, D. M., Lieby, J. A., Moore, M. L., Scherzer, D. A., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.11.033 · Cited by 53 · see citing works
Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets
Rader, D. J. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.08.008 · Cited by 53 · see citing works
Self-citationQi, G., Long, J., Yang, X., Liu, W., Wu, J., Xiuyun, Z., & Jingjing, L. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000161402.91456.70 · Cited by 52 · see citing works
Weibel, G. L., Alexander, E. T., Joshi, M. R., Rader, D. J., Lund‐Katz, S., Phillips, M. C., & Rothblat, G. H. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.148403 · Cited by 48 · see citing works
Self-citationTang, N., Wang, L., Yang, L., Zhou, B., Gu, H., Sun, Q., Cong, R.-H., Zhu, H., & Wang, B. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700399-jlr200 · Cited by 47 · see citing works
Parolini, C., Chiesa, G., Gong, E., Caligari, S., Cortese-Krott, M. M., Koga, T., Forte, T. M., & Rubin, E. M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.008 · Cited by 46 · see citing works
Causes of Interscan Variability of Coronary Artery Calcium Measurements at Electron-Beam CT
Lü, B., Budoff, M. J., Zhuang, N., Child, J., Bakhsheshi, H., Carson, S., & Mao, S. (2002) · Academic Radiology · doi:10.1016/s1076-6332(03)80310-0 · Cited by 45 · see citing works
Emerging high-density lipoprotein infusion therapies: Fulfilling the promise of epidemiology?
Tardif, J. (2010) · Journal of clinical lipidology · doi:10.1016/j.jacl.2010.08.018 · Cited by 43 · see citing works
Jensen, M. K., Rimm, E. B., Mukamal, K. J., Edmondson, A. C., Rader, D. J., Vogel, U. B., Tjønneland, A. M., Sørensen, T. I. A., Schmidt, E. B., & Overvad, K. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp145 · Cited by 39 · see citing works
Self-citationVergeer, M., Cohn, D. M., Boekholdt, S. M., Sandhu, M. S., Prins, H. M., Ricketts, S. L., Wareham, N. J., Kastelein, J. J. P., Khaw, K., Kamphuisen, P. W., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.04.004 · Cited by 38 · see citing works
Seeing red: flushing out instigators of niacin-associated skin toxicity
Dunbar, R. L., & Gelfand, J. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44098 · Cited by 38 · see citing works
Serial quantitative coronary angiography and coronary events
Mack, W. J., Xiang, M., Selzer, R. H., & Hodis, H. N. (2000) · American Heart Journal · doi:10.1067/mhj.2000.105702 · Cited by 37 · see citing works
Xie, Q., Zhao, S., & Li, F. (2010) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.220.223 · Cited by 35 · see citing works
Song, X. S., Fischer, P. A., Chen, X., Burton, C. A., & Wang, J. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.637 · Cited by 30 · see citing works
L-4F Alters Hyperlipidemic (But Not Healthy) Mouse Plasma to Reduce Platelet Aggregation
Buga, G. M., Navab, M., Imaizumi, S., Reddy, S. T., Yekta, B., Hough, G., Chanslor, S., Anantharamaiah, G. M., & Fogelman, A. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.200162 · Cited by 29 · see citing works
Lecithin: Cholesterol Acyltransferase and Atherosclerosis
Rader, D. J. (2009) · Circulation · doi:10.1161/circulationaha.109.881979 · Cited by 22 · see citing works
Self-citationCholesteryl Ester Transfer Protein (CETP) Inhibitors: Is There Life After Torcetrapib?
Neeli, H., & Rader, D. J. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.06.005 · Cited by 19 · see citing works
Self-citationOxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids
Ruchala, P. P., Navab, M., Jung, C., Hama-Levy, S., Micewicz, E. D., Luong, H. T., Reyles, J. E., Sharma, S. K., Waring, A. J., Fogelman, A. M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010181 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
HDL and cardiovascular disease
Rader, D. J., & Hovingh, G. K. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61217-4 · Cited by 870 · see citing works
Self-citationInhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, K. J., Esau, C. C., Hussain, F. N., McDaniel, A. L., Marshall, S. M., van Gils, J. M., Ray, T. D., Sheedy, F. J., Goedeke, L., Liu, X., et al. (2011) · Nature · doi:10.1038/nature10486 · Cited by 706 · see citing works
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Wang, H. H., Garruti, G., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.5495 · Cited by 297 · see citing works
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex
Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67478 · Cited by 269 · see citing works
KONES, R. J. (2011) · Drug Design Development and Therapy · doi:10.2147/dddt.s14934 · Cited by 257 · see citing works
ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation
Westerterp, M., Bochem, A. E., Yvan‐Charvet, L., Murphy, A. J., Wang, N., & Tall, A. R. (2014) · Circulation Research · doi:10.1161/circresaha.114.300738 · Cited by 257 · see citing works
The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects
Zamanian-Daryoush, M., Lindner, D. J., Tallant, T. C., Wang, Z., Buffa, J. A., Klipfell, E., Parker, Y., Hatala, D. A., Parsons‐Wingerter, P. A., Rayman, P. A., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.468967 · Cited by 245 · see citing works
Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer
Georgila, K., Vyrla, D., & Drakos, E. (2019) · Cancers · doi:10.3390/cancers11081097 · Cited by 226 · see citing works
Besler, C., Lüscher, T. F., & Landmesser, U. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200224 · Cited by 219 · see citing works
RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
McLure, K. G., Gesner, E. M., Tsujikawa, L. M., Kharenko, O. A., Attwell, S., Campeau, E., Wasiak, S., Stein, A. J., White, A., Fontano, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083190 · Cited by 199 · see citing works
High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk
Hafiane, A., & Genest, J. J. (2015) · BBA Clinical · doi:10.1016/j.bbacli.2015.01.005 · Cited by 195 · see citing works
Decrease in Irisin in Patients with Chronic Kidney Disease
Wen, M., Wang, C., Lin, S., & Hung, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064025 · Cited by 192 · see citing works
High Density Lipoprotein and it’s Dysfunction
Eren, E., Yilmaz, N., & Aydin, O. (2012) · The Open Biochemistry Journal · doi:10.2174/1874091x01206010078 · Cited by 170 · see citing works
Recent Highlights of ATVB Atherosclerosis
Lu, H. S., & Daugherty, A. (2015) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305380 · Cited by 76 · see citing works
High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential
Jomard, A., & Osto, E. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00039 · Cited by 143 · see citing works
Vascular disease and dementias: Paradigm shifts to drive research in new directions
Kling, M. A., Trojanowski, J. Q., Wolk, D. A., Lee, V. M. ‐., & Arnold, S. E. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.02.007 · Cited by 132 · see citing works
Lameijer, M., Binderup, T., van Leent, M. M. T., Senders, M. L., Fay, F., Malkus, J., Sánchez-Gaytán, B. L., Teunissen, A. J. P., Karakatsanis, N. A., Robson, P. M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0221-2 · Cited by 133 · see citing works
Detection and treatment of atherosclerosis using nanoparticles
Zhang, J., Zu, Y., Dhanasekara, C. S., Li, J., Wu, D., Fan, Z., & Wang, S. F. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1412 · Cited by 131 · see citing works
Inflammation alters HDL composition and function: Implications for HDL-raising therapies
Marsche, G., Säemann, M. D., Heinemann, Á., & Holzer, M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.001 · Cited by 130 · see citing works
Diditchenko, S., Gille, A., Pragst, I., Stadler, D., Waelchli, M., Hamilton, R., Leis, A. P., & Wright, S. D. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301981 · Cited by 128 · see citing works
The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism
Demetz, E., Schroll, A., Auer, K., Heim, C., Patsch, J. R., Eller, K., Theurl, M., Theurl, I., Theurl, M., Seifert, M., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.004 · Cited by 118 · see citing works
Tricoci, P., D’Andrea, D. M., Gurbel, P. A., Yao, Z., Cuchel, M., Winston, B., Schott, R. J., Weiss, R., Blazing, M. A., Cannon, L., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002171 · Cited by 115 · see citing works
High-Density Lipoprotein and Atherosclerosis: The Role of Antioxidant Activity
Bandeali, S. J., & Farmer, J. A. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0235-2 · Cited by 112 · see citing works
microRNAs in lipoprotein metabolism and cardiometabolic disorders
Rotllán, N., Price, N. L., Pati, P., Goedeke, L., & Fernandez-Hernando, C. F. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.025 · Cited by 111 · see citing works
Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials
Lukasova, M., Hanson, J., Tunaru, S., & Offermanns, S. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.08.002 · Cited by 110 · see citing works
Hypercholesterolemia links hematopoiesis with atherosclerosis
Soehnlein, O., & Świrski, F. K. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.10.008 · Cited by 102 · see citing works
Metabolic nuclear receptor signaling and the inflammatory acute phase response
Venteclef, N., Jakobsson, T., Steffensen, K. R., & Treuter, E. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.04.004 · Cited by 99 · see citing works
Hambruch, E., Miyazaki‐Anzai, S., Hahn, U. K., Matysik, S., Boettcher, A., Perović‐Ottstadt, S., Schlüter, T., Kinzel, O. D., Krol, H. D., Deuschle, U., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.196519 · Cited by 99 · see citing works
Crosstalk between reverse cholesterol transport and innate immunity
Azzam, K. M., & Fessler, M. B. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.02.001 · Cited by 96 · see citing works
A novel approach to oral apoA-I mimetic therapy
Chattopadhyay, A., Navab, M., Hough, G., Gao, F., Meriwether, D., Grijalva, V. R., Springstead, J. R., Palgnachari, M. N., Namiri‐Kalantari, R., Su, F., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033555 · Cited by 92 · see citing works
Regulation of ABCA1 functions by signaling pathways
Liu, Y., & Tang, C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.08.015 · Cited by 90 · see citing works
Cheng, A. M., Handa, P., Tateya, S., Schwartz, J., Tang, C., Mitra, P., Oram, J. F., Chait, A., & Kim, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033917 · Cited by 82 · see citing works
MicroRNAs regulate lipid metabolism in atherogenesis
Rayner, K. J., Fernández-Hernando, C., & Moore, K. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-10-0694 · Cited by 83 · see citing works
HDL, Atherosclerosis, and Emerging Therapies
Hafiane, A., & Genest, J. J. (2013) · Cholesterol · doi:10.1155/2013/891403 · Cited by 80 · see citing works
Approach to the Patient with Extremely Low HDL-Cholesterol
Rader, D. J., & deGoma, E. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2185 · Cited by 79 · see citing works
Self-citationThe role of monocytosis and neutrophilia in atherosclerosis
Chistiakov, D. A., Grechko, A. V., Myasoedova, V. A., Melnichenko, A. А., & Orekhov, A. N. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13462 · Cited by 74 · see citing works
Niacin, an old drug with a new twist
Song, W., & FitzGerald, G. A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r040592 · Cited by 69 · see citing works
Ma, X., Gao, X., Gong, Z., Wu, J., Tian, L., Zhang, C., Zhou, Y., Sun, Y., Hu, B., Qiu, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12203 · Cited by 69 · see citing works
Michos, E. D., Sibley, C. T., Baer, J., Blaha, M. J., & Blumenthal, R. S. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.045 · Cited by 68 · see citing works
Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis
Leman, L. J., Maryanoff, B. E., & Ghadiri, M. R. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4005847 · Cited by 68 · see citing works
Barylski, M., Toth, P. P., Nikolic, D., Banach, M., Rizzo, M., & Montalto, G. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.11.001 · Cited by 67 · see citing works
Atherosclerosis: lessons from LXR and the intestine
Bonamassa, B., & Moschetta, A. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.10.004 · Cited by 67 · see citing works
Eren, E., Yılmaz, N., & Aydın, Ö. (2013) · Cholesterol · doi:10.1155/2013/792090 · Cited by 68 · see citing works
Human Apolipoprotein A-II Protects Against Diet-Induced Atherosclerosis in Transgenic Rabbits
Wang, Y., Niimi, M., Nishijima, K., Waqar, A. B., Yu, Y., Koike, T., Kitajima, S., Liu, E., Inoue, T., Kohashi, M., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300445 · Cited by 67 · see citing works
Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits
Zhang, J., Niimi, M., Yang, D., Liang, J., Xu, J., Kimura, T., Mathew, A. V., Guo, Y., Fan, Y., Zhu, T., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309114 · Cited by 67 · see citing works
Donna, L. D., Iacopetta, D., Cappello, A. R., Gallucci, G., Martello, E., Fiorillo, M., Dolce, V., & Sindona, G. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.12.029 · Cited by 66 · see citing works
Micro-RNAs and High-Density Lipoprotein Metabolism
Canfrán‐Duque, A., Lin, C., Goedeke, L., Suárez, Y., & Fernandez-Hernando, C. F. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307028 · Cited by 64 · see citing works
Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis
Getz, G. S., & Reardon (2011) · Journal of Inflammation Research · doi:10.2147/jir.s12983 · Cited by 59 · see citing works
Reijnders, E., van der Laarse, A., Jukema, J. W., & Cobbaert, C. M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1264319 · Cited by 50 · see citing works
A modular approach toward producing nanotherapeutics targeting the innate immune system
van Leent, M. M. T., Meerwaldt, A. E., Berchouchi, A., Toner, Y. C., Burnett, M. E., Klein, E. D., Verschuur, A. V. D., Nauta, S. A., Munitz, J., Prévot, G., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe7853 · Cited by 50 · see citing works
Functional Characterization of Newly-Discovered Mutations in Human SR-BI
Chadwick, A. C., & Sahoo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045660 · Cited by 49 · see citing works
Creatine kinase, energy reserve, and hypertension: from bench to bedside
Brewster, L. M. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.07.15 · Cited by 49 · see citing works
Fat lowers fat: Purified phospholipids as emerging therapies for dyslipidemia
Sahebkar, A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.013 · Cited by 46 · see citing works
Rationale for cholesteryl ester transfer protein inhibition
Hewing, B., & Fisher, E. A. A. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328353ef1d · Cited by 45 · see citing works
Lipid Metabolism and Emerging Targets for Lipid-Lowering Therapy
Gaudet, D., Drouin‐Chartier, J., & Couture, P. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.12.019 · Cited by 43 · see citing works
Favari, E., Thomas, M. J., & Sorci‐Thomas, M. G. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000573 · Cited by 42 · see citing works
Genetic variants in CETP increase risk of intracerebral hemorrhage
Anderson, C. D., Falcone, G. J., Phuah, C., Radmanesh, F., Brouwers, H. B., Battey, T. W. K., Biffi, A., Peloso, G. M., Liu, D. J., Ayres, A. M., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24780 · Cited by 40 · see citing works
Kilogram-Lab-Scale Oxindole Synthesis via Palladium-Catalyzed C–H Functionalization
Kiser, E. J., Magano, J., Shine, R. J., & Chen, M. H. (2011) · Organic Process Research & Development · doi:10.1021/op200332p · Cited by 39 · see citing works
Dietary approaches to improving atheroprotective HDL functions
Andersen, C. J., & Fernández, M. L. (2013) · Food & Function · doi:10.1039/c3fo60207a · Cited by 37 · see citing works
Tian, G.-P., Tang, Y., He, P., Lv, Y.-C., Ouyang, X.-P., Zhao, G., Tang, S., Wu, J., Wang, J., Peng, J., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.109 · Cited by 36 · see citing works
Novel Therapies Focused on the High-Density Lipoprotein Particle
van Capelleveen, J. C., Brewer, H. B., Kastelein, J. J. P., & Hovingh, G. K. (2014) · Circulation Research · doi:10.1161/circresaha.114.301804 · Cited by 34 · see citing works
Patel, H., Ding, B., Ernst, K., Shen, L., Yuan, W., Tang, J., Drake, L. R., Kang, J., Li, Y., Chen, Z., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s179837 · Cited by 34 · see citing works
Wang, C., Nishijima, K., Kitajima, S., Niimi, M., Yan, H., Chen, Y., Ning, B., Matsuhisa, F., Liu, E., Zhang, J., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309139 · Cited by 34 · see citing works
Ng, D. S., Wong, N. C. W., & Hegele, R. A. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.238 · Cited by 33 · see citing works
Wang, H. H., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_8 · Cited by 33 · see citing works
HDL-C: clinical equipoise and vascular endothelial function
Campbell, S., & Genest, J. J. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.13.17 · Cited by 30 · see citing works
Current guidelines for high-density lipoprotein cholesterol in therapy and future directions
Michos, E. D., Subedi, B. H., Joshi, P. H., Jones, S. R., Martin, S. S., & Blaha, M. J. (2014) · Vascular Health and Risk Management · doi:10.2147/vhrm.s45648 · Cited by 30 · see citing works
Holy, E. W., Besler, C., Reiner, M. F., Camici, G. G., Manz, J., Beer, J. H., Lüscher, T. F., Landmesser, U., & Tanner, F. C. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-09-0775 · Cited by 30 · see citing works
Li, R., & Chao, H. (2011) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000106 · Cited by 29 · see citing works
Peng, X., Wu, Y., Zhu, Y., Huang, R.-D., Lu, Q., & Lin, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139417 · Cited by 28 · see citing works
ApoE controls the interface linking lipids and inflammation in atherosclerosis
Weber, C., & Soehnlein, O. (2011) · Journal of Clinical Investigation · doi:10.1172/jci60457 · Cited by 26 · see citing works
Proteomic Study on Usnic-Acid-Induced Hepatotoxicity in Rats
Liu, Q., Zhao, X., Lu, X., Fan, X., & Wáng, Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2046834 · Cited by 26 · see citing works
The Roles of Fatty Acids and Apolipoproteins in the Kidneys
Pan, X. (2022) · Metabolites · doi:10.3390/metabo12050462 · Cited by 27 · see citing works
Karamat, F. A., Oudman, I., Haan, Y. C., Kuilenburg, A. B. P., Leen, R., Danser, J., Leijten, F. P. J., Ris‐Stalpers, C., van Montfrans, G. A., Clark, J. F., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001090 · Cited by 24 · see citing works
Dysfunctional HDL: the journey from savior to slayer
Serban, C., Muntean, D. M., Mikhailids, D. P., Toth, P. P., & Banach, M. (2014) · Clinical Lipidology · doi:10.2217/clp.13.83 · Cited by 23 · see citing works
Kaul, S., Xu, H., Zabalawi, M., Maruko, E. C., Fulp, B. E., Bluemn, T., Brzoza‐Lewis, K. L., Gerelus, M., Weerasekera, R., Kallinger, R., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.004401 · Cited by 23 · see citing works
The role of HDL in plaque stabilization and regression
Feig, J. E., Feig, J. L., & Dangas, G. (2016) · Coronary Artery Disease · doi:10.1097/mca.0000000000000408 · Cited by 24 · see citing works
Mascarenhas‐Melo, F., Sereno, J., Teixeira‐Lemos, E., Marado, D., Palavra, F., Pinto, R. M. A., Rocha‐Pereira, P., Teixeira, F. J., & Reis, F. (2013) · Mediators of Inflammation · doi:10.1155/2013/612038 · Cited by 22 · see citing works
Anticipatory Role of High Density Lipoprotein and Endothelial Dysfunction: An Overview
Eren, E., Yılmaz, N., Aydın, Ö., & Elli̇dağ, H. Y. (2014) · The Open Biochemistry Journal · doi:10.2174/1874091x01408010100 · Cited by 21 · see citing works
Spotlight on HDL biology: new insights in metabolism, function, and translation
Rader, D. J. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu164 · Cited by 21 · see citing works
Self-citationSun, S., Dean, R., Jia, Q., Zenova, A., Zhong, J., Grayson, C., Xie, C., Lindgren, A., Samra, P., Sojo, L. E., et al. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.10.023 · Cited by 20 · see citing works
Reducing vascular events risk in patients with dyslipidaemia: an update for clinicians
Hermans, M. P., & Fruchart, J. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311413952 · Cited by 20 · see citing works
Targeting the Unstable Plaque in Acute Coronary Syndromes
Thompson, P. L., Nidorf, S. M., & Eikelboom, J. W. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.07.332 · Cited by 20 · see citing works
Recombinant high-density lipoproteins and their use in cardiovascular diseases
Cao, Y., Xu, L., Han, Y., Wang, Y.-N., Liu, C., & Qi, R. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.08.010 · Cited by 19 · see citing works
A common functional promoter variant links CNR1 gene expression to HDL cholesterol level
Feng, Q., Vickers, K. C., Anderson, M. P., Levin, M. G., Chen, W., Harrison, D. G., & Wilke, R. A. (2013) · Nature Communications · doi:10.1038/ncomms2973 · Cited by 17 · see citing works
Shang, Z., Wang, J., Wang, X., Yan, H., Cui, B., Jia, C., Wang, Q., Cui, X., Li, J., & Ou, T. (2018) · Cancer Management and Research · doi:10.2147/cmar.s165213 · Cited by 16 · see citing works
Papaioannou, I., Simons, J. P., & Owen, J. S. (2012) · Cardiology Research and Practice · doi:10.1155/2012/148796 · Cited by 13 · see citing works
Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI
Chadwick, A. C., & Sahoo, D. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835ed575 · Cited by 13 · see citing works
Koohdani, F., Sadrzadeh-Yeganeh, H., Djalali, M., Eshraghian, M., Zamani, E., Sotoudeh, G., Mansournia, M. A., & Keramat, L. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.3.222 · Cited by 13 · see citing works
Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis
Gulshan, K. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-21547-6_13 · Cited by 12 · see citing works
Therapeutic potential of antisense oligonucleotides for the management of dyslipidemia
Crooke, R. M., & Graham, M. J. (2011) · Clinical Lipidology · doi:10.2217/clp.11.59 · Cited by 11 · see citing works
Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport
Dockendorff, C., Faloon, P. W., Yu, M., Youngsaye, W., Penman, M., Nieland, T. J. F., Nag, P. P., Lewis, T. A., Pu, J., Bennion, M., et al. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500154q · Cited by 12 · see citing works
Herat, L. Y., Matthews, J. R., Rakoczy, E. P., Schlaich, M. P., & Matthews, V. B. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2804083 · Cited by 11 · see citing works
Koohdani, F., Sadrzadeh-Yeganeh, H., Djalali, M., Eshraghian, M., Keramat, L., Mansournia, M. A., & Zamani, E. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.05.024 · Cited by 10 · see citing works
Martin, M. B., López, J. A., Corbacho-Alonso, N., Martínez, P. J., Rodríguez‐Sánchez, E., Mouriño-Álvarez, L., Sastre-Oliva, T., Martín-Rojas, T., Rincón, R., Calvo, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23037-7 · Cited by 10 · see citing works
High-density lipoprotein cholesterol targeting for novel drug discovery: where have we gone wrong?
Escolá‐Gil, J. C., Cedó, L., & Blanco‐Vaca, F. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.871257 · Cited by 10 · see citing works
High-density lipoprotein-based drug discovery for treatment of atherosclerosis
Du, Y., Wang, L., & Hong, B. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1051963 · Cited by 7 · see citing works
Focusing on High-Density Lipoprotein for Coronary Heart Disease Risk Reduction
Davidson, M. H. (2011) · Cardiology Clinics · doi:10.1016/j.ccl.2010.11.005 · Cited by 9 · see citing works
- Authors
- deGoma, E. M., & Rader, D. J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- deGoma, Emil M.
- Venue
- Nature Reviews Cardiology
- Published
- 2011-01-18
- Volume
- 8
- Issue
- 5
- Pages
- 266-277
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- PMC
- PMC3315102
- OpenAlex
- W1984362422
- Cited by
- 149
- References
- 146
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 13 · 2013: 29 · 2012: 29
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k12hl083772-05, UL1TR000003)
- National Heart, Lung, and Blood Institute (K12-HL083772, P50-HL70128, HL22633, K12 HL083772‑01, P01HL022633, P50HL070128)
- National Center for Research Resources (UL1RR024134)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- apolipoprotein A-I, atherothrombotic cardiovascular disease, residual cardiovascular risk, reverse cholesterol transport, cholesteryl ester transfer protein inhibition, GPR109A, nicotinic acid, liver X receptor, lecithin:cholesterol acyltransferase, atheroprotection
- MeSH terms
- Animals, Hypolipidemic Agents, Cardiovascular Diseases, Humans, Cholesterol, HDL, Biomarkers, Apolipoprotein A-I, Treatment Outcome, Molecular Mimicry, Dyslipidemias, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
