The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Transcoronary Concentration Gradients of Circulating MicroRNAs
Abstract
Background—: Circulating levels of microRNA (miR) have been proposed as biomarkers for cardiovascular disease. To identify the heart as a potential source for miRs released into the circulation, we measured concentration gradients across the coronary circulation for muscle-enriched (miR-133a, miR-499, miR-208a), vascular (miR-126, miR-92a), leukocyte-related (miR-155), and platelet-enriched (miR-223) miRs. Methods and Results—: Circulating miRs were measured by TaqMan polymerase chain reaction in EDTA-plasma simultaneously obtained from the aorta and the coronary venous sinus in patients without coronary artery disease (n=7), with stable coronary artery disease (n=31), and with troponin-positive acute coronary syndromes (n=19). Circulating levels of the muscle-enriched miR-499 (>20-fold; P <0.01), miR-133a (11-fold; P <0.01), and miR-208a (5-fold; P <0.01) were significantly elevated in the aorta of troponin-positive acute coronary syndrome patients compared with patients with coronary artery disease. Importantly, there was a significant increase in circulating levels of miR-499 and miR-133a across the coronary circulation in troponin-positive acute coronary syndrome patients, suggestive of a release into the coronary circulation during myocardial injury. Indeed, miR-499 concentration gradients were significantly correlated with the extent of myocardial damage as measured by high-sensitivity troponin T ( r =0.70, P <0.01). In contrast, circulating levels of miR-126 ( P =0.16) decreased during transcoronary passage in patients with evidence of myocardial injury, suggesting consumption during transcoronary passage. Conclusions—: Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. The differential regulation of circulating miRs during the transcoronary passage might provide important insights to exploit their role as cardiac biomarkers. Clinical Trial Registration—: URL: http://www.germanctr.de . Unique identifier: DRKS00000207; in German Clinical Trials Registry.
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Circulating microRNAs as stable blood-based markers for cancer detection
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Universal Definition of Myocardial Infarction
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Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
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Circulating MicroRNAs in Patients With Coronary Artery Disease
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Methodological challenges in utilizing mi RNA s as circulating biomarkers
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Jansen, F., Yang, X., Hoelscher, M., Cattelan, A., Schmitz, T., Proebsting, S., Wenzel, D., Vosen, S., Franklin, B. S., Fleischmann, B. K., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001720 · Cited by 430
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Poller, W., Dimmeler, S., Heymans, S., Zeller, T., Haas, J., Karakas, M., Leistner, D.-M., Jakob, P., Nakagawa, S., Blankenberg, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx165 · Cited by 408
Self-citationRoles and mechanisms of exosomal non-coding RNAs in human health and diseases
Li, C., Ni, Y.-Q., Xu, H., Xiang, Q.-Y., Zhao, Y., Zhan, J.-K., He, J.-Y., Li, S., & Liu, Y.-S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00779-x · Cited by 406
Metadata
- Authors
- De Rosa, S., Fichtlscherer, S., Lehmann, R., Assmus, B., Dimmeler, S., & Zeiher, A. M.
- Venue
- Circulation
- Published
- 2011-11
- Volume
- 124
- Issue
- 18
- Pages
- 1936-1944
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2043469561
- Cited by
- 272
- References
- 30
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Rosa, S., Fichtlscherer, S., Lehmann, R., Assmus, B., Dimmeler, S., & Zeiher, A. M. (2011). Transcoronary Concentration Gradients of Circulating MicroRNAs. Circulation. https://doi.org/10.1161/circulationaha.111.037572
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