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Cited by 377

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis

Open access
Shah, Zubair, Kampfrath, Thomas, Deiuliis, Jeffrey A., Zhong, Jixin, Pineda, Colleen, Ying, Zhekang, Xu, Xiaohua, Lu, Bo, Moffatt-Bruce, Susan, Durairaj, Rekha, Sun, Qinghua, Mihai, Georgeta, Maiseyeu, Andrei, Rajagopalan, Sanjay·2011·Circulation
DOI 10.1161/circulationaha.111.041418
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Abstract

Background—: Dipeptidyl-peptidase 4 (DPP-4) inhibitors are increasingly used to accomplish glycemic targets in patients with type II diabetes mellitus. Because DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis. Methods and Results—: Male LDLR−/−mice (6 weeks) were fed a high-fat diet or normal chow diet for 4 weeks and then randomized to vehicle or alogliptin, a high-affinity DPP-4 inhibitor (40 mg · kg−1· d−1), for 12 weeks. Metabolic parameters, blood pressure, vascular function, atherosclerosis burden, and indexes of inflammation were obtained in target tissues, including the vasculature, adipose, and bone marrow, with assessment of global and cell-specific inflammatory pathways. In vitro and in vivo assays of DPP-4 inhibition (DPP-4i) on monocyte activation/migration were conducted in both human and murine cells and in a short-term ApoE−/−mouse model. DPP-4i improved markers of insulin resistance and reduced blood pressure. DPP-4i reduced visceral adipose tissue macrophage content (adipose tissue macrophages; CD11b+, CD11c+, Ly6C hi) concomitant with upregulation of CD163. DPP-4 was highly expressed in bone marrow–derived CD11b+cells, with DPP-4i downregulating proinflammatory genes in these cells. DPP-4i decreased aortic plaque with a striking reduction in plaque macrophages. DPP-4i prevented monocyte migration and actin polymerization in in vitro assays via Rac-dependent mechanisms and prevented in vivo migration of labeled monocytes to the aorta in response to exogenous tumor necrosis factor-α and DPP-4. Conclusion—: DPP-4i exerts antiatherosclerotic effects and reduces inflammation via inhibition of monocyte activation/chemotaxis. These findings have important implications for the use of this class of drugs in atherosclerosis.

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Research works printed but not linked: 2

  1. 10.1515/CCLM.2009.062 · doi:10.1515/cclm.2009.062
  2. 10.1016/0022-1759(95)00239-1 · doi:10.1016/0022-1759(95)00239-1

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Metadata

Authors
Shah, Z., Kampfrath, T., Deiuliis, J. A., Zhong, J., Pineda, C., Ying, Z., Xu, X., Lu, B., Moffatt-Bruce, S., Durairaj, R., Sun, Q., Mihai, G., Maiseyeu, A., & Rajagopalan, S.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-11-22
Volume
124
Issue
21
Pages
2338-2349
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.111.041418
OpenAlex
W2016632734
Cited by
377
References
48
FWCI
13.62
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis. https://app.cochat.ai/papers/10.1161/circulationaha.111.041418
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Shah, Z., Kampfrath, T., Deiuliis, J. A., Zhong, J., Pineda, C., Ying, Z., Xu, X., Lu, B., Moffatt-Bruce, S., Durairaj, R., Sun, Q., Mihai, G., Maiseyeu, A., & Rajagopalan, S. (2011). Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis. Circulation. https://doi.org/10.1161/circulationaha.111.041418

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.