The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Physical Activity and Inflammatory Markers Over 10 Years: Follow-Up in Men and Women From the Whitehall II Cohort Study
Open accessAbstract
BACKGROUND: Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. METHODS AND RESULTS: Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower log(e) C-reactive protein (β=-0.07; 95% confidence interval, -0.12 to -0.02) and log(e) interleukin-6 (β=-0.07; 95% confidence interval, -0.10 to -0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower log(e) C-reactive protein (β coefficient=-0.05; 95% confidence interval, -0.10 to -0.001) and log(e) interleukin-6 (β coefficient=-0.06; 95% confidence interval, -0.09 to -0.03) at follow-up. CONCLUSIONS: Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.
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“Under resting conditions, particularly in obese and sedentary populations, elevated circulating IL-6 is primarily derived from adipose tissue macrophages and reflects chronic low-grade inflammation via NF-κB pathway activation, associating with insulin resistance and metabolic abnormalities [29].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [29]
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1 retracted
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600
RetractedFrom inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
A questionnaire for the assessment of leisure time physical activities
Taylor, H. L., Jacobs, D. R., Schucker, B., Knudsen, J., Leon, A. S., & Debacker, G. (1978) · Journal of Chronic Diseases · doi:10.1016/0021-9681(78)90058-9 · Cited by 1,848
(2012) · The Lancet · doi:10.1016/s0140-6736(12)60110-x · Cited by 1,146
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083
Dose Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis
Sattelmair, J., Pertman, J., Ding, E. L., Kohl, H. W., Haskell, W., & Lee, I.-M. (2011) · Circulation · doi:10.1161/circulationaha.110.010710 · Cited by 1,052
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000
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Sabia, S., Dugravot, A., Dartigues, J., Abell, J. G., Elbaz, A., Mika Kivimaki, B., & Singh‐Manoux, A. (2017) · BMJ · doi:10.1136/bmj.j2709 · Cited by 466
Hamer, M., Lavoie, K., & Bacon, S. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092993 · Cited by 392
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
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Metadata
- Authors
- Hamer, M., Sabia, S., Batty, G. D., Shipley, M. J., Tabák, A. G., Singh-Manoux, A., & Kivimaki, M.
- Affiliations
- Semmelweis University (HU)
- From the Department of Epidemiology and Public Health, University College London, London, UK (M.H., S.S., G.D.B., M.J.S., A.G.T., A.S.-M., M.K.); First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary (A.G.T.); and INSERM U1018, Center for Research in Epidemiology and Population Health, Villejuif, France (A.S.-M.).
- Venue
- Circulation
- Published
- 2012-08-21
- Volume
- 126
- Issue
- 8
- Pages
- 928-933
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3890998
- OpenAlex
- W2097528015
- Cited by
- 280
- References
- 28
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 23 · 2023: 19 · 2022: 19 · 2021: 26 · 2020: 19 · 2019: 17 · 2018: 18 · 2017: 22 · 2016: 20 · 2015: 22 · 2014: 19 · 2013: 20 · 2012: 5
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- UCL Discovery (University College London) (submittedVersion)
- Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation (RE/10/005/28296, RG/10/005/28296, RG/07/008/23674)
- European Science Foundation
- Agency for Healthcare Research and Quality (HS06516)
- Medical Research Council
- National Institute on Aging (R01AG034454, R01AG013196)
- National Heart, Lung, and Blood Institute (R01-HL36310, R01HL036310)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- physical activity, inflammation, C-reactive protein, interleukin-6, cardioprotection, Whitehall II cohort, physical activity guidelines adherence, aging, cardiovascular health
- MeSH terms
- Adult, Aging, C-Reactive Protein, Cardiovascular Diseases, Female, Follow-Up Studies, United Kingdom, Humans, Male, Middle Aged, Motor Activity, Prospective Studies, Cohort Studies, Biomarkers, Exercise, Interleukin-6
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