Cited by 442Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesConnective tissue disorders research

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Bicuspid Aortic Valve: Identifying Knowledge Gaps and Rising to the Challenge From the International Bicuspid Aortic Valve Consortium (BAVCon)

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Michelena, Hector I., Prakash, Siddharth K., Della Corte, Alessandro, Bissell, Malenka M., Anavekar, Nandan, Mathieu, Patrick, Bossé, Yohan, Limongelli, Giuseppe, Bossone, Eduardo, Benson, D.Woodrow, Lancellotti, Patrizio, Isselbacher, Eric M., Enriquez-Sarano, Maurice, Sundt, Thoralf M., Pibarot, Philippe, Evangelista, Artur, Milewicz, Dianna M., Body, Simon C.·2014·Circulation

DOI 10.1161/circulationaha.113.007851PMC PMC4145814

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Abstract

Since its estimated first description >500 years ago by Leonardo da Vinci,2 the bicuspid aortic valve (BAV) has progressively built a reputation; initially, as a curious valvular phenotype with a tendency to develop obstruction and insufficiency. In more contemporary times, however, the BAV is recognized as underlying almost 50% of isolated severe aortic stenosis cases requiring surgery,3 and has been extensively associated with ominous outcomes such as bacterial endocarditis and aortic dissection.4 These associations, coupled with the high prevalence of BAV in humans,5 have prompted investigative efforts into the condition, which although insightful, have generated more questions than answers. This review describes our current knowledge of BAV, but, more importantly, it highlights knowledge gaps and areas where basic and clinical research is warranted. Our review has 2 sections. The first section outlines the multifaceted challenge of BAV, our current understanding of the condition, and barriers that may hamper the advancement of the science. The second section proposes a roadmap to discovery based on current imaging, molecular biology, and genetic tools, recognizing their advantages and limitations.

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Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,487
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Guyton, R. A., O’Gara, P. T., Ruiz, C. E., Skubas, N. J., Sorajja, P., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000031 · Cited by 2,920
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2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease
WRITING GROUP MEMBERS, Hiratzka, L. F., Bakris, G. L., Beckman, J. A., Bersin, R. M., Carr, V. F., Casey, D. E., Eagle, K. A., Hermann, L. K., Isselbacher, E. M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181d4739e · Cited by 2,346
Self-citation
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary
Warnes, C. A., Williams, R. G., Bashore, T. M., CHILD, J. S., Connolly, H. M., Dearani, J. A., del Nido, P. J., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,068
Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene
Dietz, H. C., Cutting, C. R., Pyeritz, R. E., Maslen, C. L., Sakai, L. Y., Corson, G. M., Puffenberger, E. G., Hamosh, A., Nanthakumar, E. J., Curristin, S. M., et al. (1991) · Nature · doi:10.1038/352337a0 · Cited by 2,065
Clinical Methods: The History, Physical, and Laboratory Examinations
Kruse, J. A. (1990) · JAMA · doi:10.1001/jama.1990.03450210108045 · Cited by 2,040
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009)
Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer, Habib, G., Hoen, B., Tornos, P., Thuny, F., Prendergast, B., Vilacosta, I., Moreillon, P., de Jesus Antunes, M., Thilen, U., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp285 · Cited by 2,014
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Loeys, B., Chen, J., Neptune, E., Judge, D. P., Podowski, M., Holm, T. M., Meyers, J. L., Leitch, C. C., Katsanis, N., Sharifi, N., et al. (2005) · Nature Genetics · doi:10.1038/ng1511 · Cited by 1,786
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease
Hiratzka, L. F., Bakris, G. L., Beckman, J. A., Bersin, R. M., Carr, V. F., Casey, D. E., Eagle, K. A., Hermann, L. K., Isselbacher, E. M., Kazerooni, E. A., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.015 · Cited by 1,700
Self-citation
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
A technique for complete replacement of the ascending aorta
Bentall, H. H., & Bono, A. (1968) · Thorax · doi:10.1136/thx.23.4.338 · Cited by 1,490
Clinical Methods: The History, Physical, and Laboratory Examinations
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-7-563_2 · Cited by 1,408
An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta
David, T. E., & Feindel, C. M. (1992) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34942-6 · Cited by 1,304
A classification system for the bicuspid aortic valve from 304 surgical specimens
Sievers, H.-H., & Schmidtke, C. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.01.039 · Cited by 1,222
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146
ACC/AHA guidelines for the management of patients with valvular heart disease
Bonow, R. O., Carabello, B. A., de Leon, A., Edmunds, L. H., Fedderly, B. J., Freed, M. D., Gaasch, W. H., Cr, M., Nishimura, R., O’Gara, P. T., et al. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00454-9 · Cited by 1,132
Frequency by Decades of Unicuspid, Bicuspid, and Tricuspid Aortic Valves in Adults Having Isolated Aortic Valve Replacement for Aortic Stenosis, With or Without Associated Aortic Regurgitation
Roberts, W. C., & Ko, J. M. (2005) · Circulation · doi:10.1161/01.cir.0000155623.48408.c5 · Cited by 1,000
The congenitally bicuspid aortic valve
Roberts, W. C. (1970) · The American Journal of Cardiology · doi:10.1016/0002-9149(70)90761-7 · Cited by 927
Aortic Diameter ≥5.5 cm Is Not a Good Predictor of Type A Aortic Dissection
Pape, L. A., Tsai, T. T., Isselbacher, E. M., Oh, J. K., O’Gara, P. T., Evangelista, A., Fattori, R., Meinhardt, G., Trimarchi, S., Bossone, E., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.702720 · Cited by 848
Self-citation
Incidence of Aortic Complications in Patients With Bicuspid Aortic Valves
Michelena, H. I., Khanna, A. D., Mahoney, D. W., Margaryan, E., Topilsky, Y., Suri, R. M., Eidem, B., Edwards, W. D., Sundt, T. M., & Enriquez-Sarano, M. L. (2011) · JAMA · doi:10.1001/jama.2011.1286 · Cited by 847
Self-citation
Clinical significance of the bicuspid aortic valve
Ward, C. (2000) · Heart · doi:10.1136/heart.83.1.81 · Cited by 803
Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve
Fedak, P. W. M., Verma, S., David, T. E., Leask, R. L., Weisel, R. D., & BUTANY, J. W. (2002) · Circulation · doi:10.1161/01.cir.0000027905.26586.e8 · Cited by 800
Life Expectancy and Causes of Death in the Marfan Syndrome
Murdoch, J. L., Walker, B. A., HALPERN, B. L., Kuzma, J. W., & McKusick, V. A. (1972) · New England Journal of Medicine · doi:10.1056/nejm197204132861502 · Cited by 762
2012 ACCF/AATS/SCAI/STS Expert Consensus Document on Transcatheter Aortic Valve Replacement
Holmes, D. R., Mack, M. J., Kaul, S., Agnihotri, A. K., Alexander, K. P., Bailey, S. R., Calhoon, J., Carabello, B. A., Desai, M. Y., Edwards, F. H., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.001 · Cited by 747
Calcific Aortic Stenosis
Dweck, M. R., Boon, N. A., & Newby, D. E. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.093 · Cited by 692
Bicuspid aortic valve is heritable
Cripe, L., Andelfinger, G., Martin, L. J., Shooner, K., & Benson, D. W. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.050 · Cited by 635
Self-citation
What is the appropriate size criterion for resection of thoracic aortic aneurysms?
Coady, M. A., Rizzo, J. A., Hammond, G. L., Mandapati, D., Darr, U. M., Kopf, G. S., & Elefteriades, J. A. (1997) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(97)70360-x · Cited by 613
Natural History of Asymptomatic Patients With Normally Functioning or Minimally Dysfunctional Bicuspid Aortic Valve in the Community
Michelena, H. I., Desjardins, V. A., Aviérinos, J.-F., Russo, A., Nkomo, V. T., Sundt, T. M., Pellikka, P. A., Tajik, A. J., & Enriquez-Sarano, M. L. (2008) · Circulation · doi:10.1161/circulationaha.107.740878 · Cited by 608
Self-citation
Outcomes in Adults With Bicuspid Aortic Valves
Tzemos, N. (2008) · JAMA · doi:10.1001/jama.300.11.1317 · Cited by 604
Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease
Niwa, K., Perloff, J. K., Bhuta, S. M., Laks, H., Drinkwater, D. C., CHILD, J. S., & Miner, P. D. (2001) · Circulation · doi:10.1161/01.cir.103.3.393 · Cited by 572
The Complex Nature of Discordant Severe Calcified Aortic Valve Disease Grading
Clavel, M.-A., Messika-Zeitoun, D., Pibarot, P., Aggarwal, S. R., Malouf, J., Araoz, P. A., Michelena, H. I., Cueff, C., Larose, E., Capoulade, R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1621 · Cited by 569
Self-citation
ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography
Douglas, P. S., Garcia, M. J., Haines, D. E., Lai, W. W., Manning, W. J., Patel, A. R., Picard, M. H., Polk, D. M., Ragosta, M., Ward, R. P., et al. (2011) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2010.12.008 · Cited by 515
Characterizing the young patient with aortic dissection: results from the international registry of aortic dissection (IRAD)
Januzzi, J. L., Isselbacher, E. M., Fattori, R., Cooper, J. V., Smith, D. E., Fang, J., Eagle, K. A., Mehta, R. H., Nienaber, C. A., & Pape, L. A. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.054 · Cited by 511
Self-citation
Structural development of endocardial cushions
Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977) · American Journal of Anatomy · doi:10.1002/aja.1001480108 · Cited by 489
The clinical recognition of congenital heart disease
(1971) · American Heart Journal · doi:10.1016/0002-8703(71)90038-x · Cited by 487
Surgery of the Thoracic Aorta
Kouchoukos, N. T., & Dougenis, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706263362606 · Cited by 468
Aortic root dilatation in young men with normally functioning bicuspid aortic valves
Nistri, S., Sorbo, M. D., Marin, M., Palisi, M., Scognamiglio, R., & Thiene, G. (1999) · Heart · doi:10.1136/hrt.82.1.19 · Cited by 465
Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress in the Ascending Aorta
Barker, A. J., Markl, M., Bürk, J., Lorenz, R., Bock, J., Bauer, S., Schulz‐Menger, J., & von Knobelsdorff‐Brenkenhoff, F. (2012) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.112.973370 · Cited by 454
The effect of valvular heart disease on maternal and fetal outcome of pregnancy
Hameed, A. B., Karaalp, I. S., Tummala, P. P., Wani, O. R., Canetti, M., Akhter, M. W., Goodwin, M., Zapadinsky, N., & Elkayam, U. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01198-0 · Cited by 440
The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape
Schaefer, B., Lewin, M., Stout, K. K., Gill, E. A., Prueitt, A., Byers, P. H., & Otto, C. M. (2008) · Heart · doi:10.1136/hrt.2007.132092 · Cited by 439
Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation
Fedak, P. W. M., de, M. P. L., Verma, S., Nili, N., Kazemian, P., BUTANY, J. W., Strauss, B. H., Weisel, R. D., & David, T. E. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00398-2 · Cited by 436
Ascending Aortic Dilatation Associated With Bicuspid Aortic Valve
Tadros, T. M., KLEIN, M. D., & Shapira, O. M. (2009) · Circulation · doi:10.1161/circulationaha.108.795401 · Cited by 434
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease
Aikawa, E. R., Nahrendorf, M., Sosnovik, D. E., Lok, V. M., Jaffer, F. A., Aikawa, M., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.106.654913 · Cited by 419
Congenitally Bicuspid Aortic Valves: A Surgical Pathology Study of 542 Cases (1991 Through 1996) and a Literature Review of 2,715 Additional Cases
Sabet, H. Y., Edwards, W. D., Tazelaar, H. D., & Daly, R. C. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.1.14 · Cited by 416
Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction
Milewicz, D. M., Guo, D., Tran‐Fadulu, V., Lafont, A. L., Papke, C. L., Inamoto, S., Kwartler, C. S., & Pannu, H. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092303 · Cited by 415
Self-citation
ACC/AHA 2008 Guideline Update on Valvular Heart Disease: Focused Update on Infective Endocarditis
Nishimura, R. A., Carabello, B. A., Faxon, D. P., Freed, M. D., Lytle, B. W., O’Gara, P. T., O’Rourke, R. A., & Shah, P. M. (2008) · Circulation · doi:10.1161/circulationaha.108.190377 · Cited by 411
The Bicuspid Aortic Valve
Braverman, A. C., Güven, H., Beardslee, M. A., Makan, M., Kates, A. M., & Moon, M. R. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.06.002 · Cited by 408
A Prospective Study to Assess the Frequency of Familial Clustering of Congenital Bicuspid Aortic Valve
Huntington, K., Hunter, A. G. W., & Chan, K. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00372-0 · Cited by 407
Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?
Borger, M. A., Preston, M. A., Ivanov, J., Fedak, P. W. M., Davierwala, P. M., Armstrong, S. M., & David, T. E. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.07.009 · Cited by 389
Aortic Dilation in Bicuspid Aortic Valve Disease
Bissell, M. M., Hess, A. T., Biasiolli, L., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000528 · Cited by 380
Self-citation
Histologic abnormalities of the ascending aorta and pulmonary trunk in patients with bicuspid aortic valve disease: Clinical relevance to the ross procedure
de, M. P. L., Moshkovitz, Y., BUTANY, J. W., & David, T. E. (1999) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(99)70002-4 · Cited by 377
Bicuspid Aortic Valves Are Associated With Aortic Dilatation Out of Proportion to Coexistent Valvular Lesions
Keane, M. G., Wiegers, S. E., Plappert, T. J., Pochettino, A. A., Bavaria, J. E., & Sutton, M. G. S. J. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-35 · Cited by 376
Valve Configuration Determines Long-Term Results After Repair of the Bicuspid Aortic Valve
Aicher, D., Kunihara, T., Issa, O. A., Brittner, B., Gräber, S., & Schäfers, H. (2011) · Circulation · doi:10.1161/circulationaha.109.934679 · Cited by 370
Cell Biology of Cardiac Cushion Development
Person, A. D., Klewer, S. E., & Runyan, R. B. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)43005-3 · Cited by 369
Aortic Dilatation and Dissection in Turner Syndrome
Matura, L. A., Ho, V. B., Rosing, D. R., & Bondy, C. A. (2007) · Circulation · doi:10.1161/circulationaha.106.685487 · Cited by 366
Abnormal Extracellular Matrix Protein Transport Associated With Increased Apoptosis of Vascular Smooth Muscle Cells in Marfan Syndrome and Bicuspid Aortic Valve Thoracic Aortic Aneurysm
Nataatmadja, M. I., West, M., West, J., SUMMERS, K. M., Walker, P. J., Nagata, M., & Watanabe, T. (2003) · Circulation · doi:10.1161/01.cir.0000087660.82721.15 · Cited by 352
Cellular mechanics and gene expression in blood vessels
Lehoux, S., & Tedgui, A. (2003) · Journal of Biomechanics · doi:10.1016/s0021-9290(02)00441-4 · Cited by 336
Abnormal Aortic Valve Development in Mice Lacking Endothelial Nitric Oxide Synthase
Lee, T. C., Zhao, Y. D., Courtman, D. W., & Stewart, D. J. (2000) · Circulation · doi:10.1161/01.cir.101.20.2345 · Cited by 328
An echocardiographic survey of primary school children for bicuspid aortic valve
Basso, C., Boschello, M., Perrone, C., Mecenero, A., Cera, A., Bicego, D., Thiene, G., & Dominicis, E. D. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.11.031 · Cited by 324
Natural History of Ascending Aortic Aneurysms in the Setting of an Unreplaced Bicuspid Aortic Valve
Davies, R. R., Kaple, R., Mandapati, D., Gallo, A. E., Botta, D. M., Elefteriades, J. A., & Coady, M. A. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.10.074 · Cited by 323
Mechanisms Underlying Aortic Dilatation in Congenital Aortic Valve Malformation
Bonderman, D., Gharehbaghi-Schnell, E., Wollenek, G., Maurer, G., Baumgartner, H., & Lang, I. M. (1999) · Circulation · doi:10.1161/01.cir.99.16.2138 · Cited by 316
Clinical Problem Solving
Miccio, A. W. (2002) · American Journal of Speech-Language Pathology · doi:10.1044/1058-0360(2002/023 · Cited by 314
Failure to Prevent Progressive Dilation of Ascending Aorta by Aortic Valve Replacement in Patients With Bicuspid Aortic Valve: Comparison With Tricuspid Aortic Valve
Yasuda, H., Nakatani, S., Stugaard, M., Tsujita-Kuroda, Y., Bando, K., Kobayashi, J., Yamagishi, M., Kitakaze, M., Kitamura, S., & Miyatake, K. (2003) · Circulation · doi:10.1161/01.cir.0000087449.03964.fb · Cited by 289
ACC/AHA Guidelines for the Management of Patients With Valvular Heart Disease. Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease).
Bonow, R. O., Carabello, B. A., de Leon, A. C., Edmunds, L. H., Fedderly, B. J., Freed, M. D., Gaasch, W. H., McKay, C. R., Nishimura, R. A., O’Gara, P. T., et al. (1998) · PubMed · Cited by 289
Dissection of the aorta associated with congenital malformation of the aortic valve
Roberts, C. S., & Roberts, W. C. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80188-3 · Cited by 283
Coarctation of the aorta of the adult type II. A statistical study and historical retrospect of 200 recorded cases, with autopsy, of stenosis or obliteration of the descending arch in subjects above the age of two years
Abbott, M. E. S. (1928) · American Heart Journal · doi:10.1016/s0002-8703(28)90386-5 · Cited by 281
The congenitally bicuspid aortic valve: how does it function? Why does it fail?
Robicsek, F., Thubrikar, M. J., Cook, J. W., & Fowler, B. L. (2004) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(03)01249-9 · Cited by 281
4D Flow CMR in Assessment of Valve-Related Ascending Aortic Disease
Hope, M. D., Hope, T. A., Crook, S. E. S., et al. (2011) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.05.004 · Cited by 275
Surgical Pathology of Pure Aortic Insufficiency: A Study of 225 Gases
Olson, L. J., Subramanian, R., & Edwards, W. D. (1984) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65618-3 · Cited by 274
Valvular Heart Disease and Pregnancy
Elkayam, U., & Bitar, F. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.085 · Cited by 262
Morphology of bicuspid aortic valve in children and adolescents
Fernandes, S. M., Sanders, S. P., Khairy, P., Jenkins, K. J., Gauvreau, K., Lang, P. J., SIMONDS, H. M., & Colan, S. D. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.063 · Cited by 255
The Ross Procedure
Takkenberg, J. J. M., Klieverik, L. M. A., Schoof, P. H., van Suylen, R. J., van Herwerden, L. A., Zondervan, P. E., Roos‐Hesselink, J. W., Eijkemans, M. J. C., Yacoub, M. H., & Bogers, A. J. J. C. (2008) · Circulation · doi:10.1161/circulationaha.107.726349 · Cited by 255
Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves
Beppu, S., Suzuki, S., Matsuda, H., Ohmori, F., Nagata, S., & Miyatake, K. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90799-i · Cited by 234
The aortopathy of bicuspid aortic valve disease has distinctive patterns and usually involves the transverse aortic arch
Fazel, S. S., Mallidi, H. R., Lee, R. S., et al. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.01.022 · Cited by 234
Bicuspid Aortic Valves With Different Spatial Orientations of the Leaflets Are Distinct Etiological Entities
Fernández, B., Durán, A. C., Fernández-Gallego, T., Fernández, M. C., Such, M., Arqué, J. M., & Sans-Coma, V. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.044 · Cited by 230
Development of the heart: (3) Formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks
Anderson, R. H., Webb, S., Brown, N. A., Lamers, W. H., & Moorman, A. F. M. (2003) · Heart · doi:10.1136/heart.89.9.1110 · Cited by 230
Aortic dilatation patterns and rates in adults with bicuspid aortic valves: a comparative study with Marfan syndrome and degenerative aortopathy
Détaint, D., Michelena, H. I., Nkomo, V. T., Vahanian, A. S., Jondeau, G., & Enriquez-Sarano, M. L. (2013) · Heart · doi:10.1136/heartjnl-2013-304920 · Cited by 229
Self-citation
Early and intermediate-term outcomes of pregnancy with congenital aortic stenosis
Silversides, C. K., Colman, J. M., Sermer, M., Farine, D., & Siu, S. C. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00340-0 · Cited by 224
Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves
Svensson, L. G., Kim, K. H., Lytle, B. W., & Cosgrove, D. M. (2003) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00608-1 · Cited by 223
Association Between Bicuspid Aortic Valve Phenotype and Patterns of Valvular Dysfunction and Bicuspid Aortopathy
Kang, J., Song, H., Yang, D. H., Baek, S., Kim, D., Song, J., Kang, D.-H., Lim, T.-H., & Song, J.-K. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2012.11.007 · Cited by 213
The prevalence of bicuspid aortic valve in newborns by echocardiographic screening
Tutar, E., Ekici, F., Atalay, S., & Naçar, N. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.10.036 · Cited by 213
Valvuloplasty for aortic insufficiency
Cosgrove, D. M., Rosenkranz, E. R., Hendren, W. G., et al. (1991) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(20)31429-x · Cited by 213
Familial thoracic aortic dilation and bicommissural aortic valve: A prospective analysis of natural history and inheritance
Loscalzo, M. L., Goh, D. L. M., Loeys, B., Kent, K. C., Spevak, P. J., & Dietz, H. C. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31872 · Cited by 212
Risk factors for aortic complications in adults with coarctation of the aorta
Oliver, J. M., Gallego, P., Gonzalez, A. E., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.037 · Cited by 208
The Structure of the Aortic Valve in Clinically Isolated Aortic Stenosis
Roberts, W. C. (1970) · Circulation · doi:10.1161/01.cir.42.1.91 · Cited by 205
Aortic complications after bicuspid aortic valve replacement: long-term results
Russo, C., Mazzetti, S., Garatti, A., Ribera, E., Milazzo, A., Bruschi, G., Lanfranconi, M., Colombo, T., & Vitali, E. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04261-3 · Cited by 205
Left Heart Growth, Function, and Reintervention After Balloon Aortic Valvuloplasty for Neonatal Aortic Stenosis
McElhinney, D. B., Lock, J. E., Keane, J. F., Moran, A. M., & Colan, S. D. (2005) · Circulation · doi:10.1161/01.cir.0000153809.88286.2e · Cited by 204
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves
Ikonomidis, J. S., Jones, J. A., Barbour, J. R., Stroud, R. E., Clark, L. L., Kaplan, B. S., Ahmed, Z. S., Bavaria, J. E., Gorman, J. H., Spinale, F. G., et al. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.10.083 · Cited by 200
Frequency of Bicuspid Aortic Valve in Young Male Conscripts by Echocardiogram
Nistri, S., Basso, C., Marzari, C., Mormino, P., & Thiene, G. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.04.051 · Cited by 195
Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations
Martin, L. J., Ramachandran, V., Cripe, L. H., Hinton, R. B., Andelfinger, G., Tabangin, M. E., Shooner, K. A., Keddache, M. A., & Benson, D. W. (2007) · Human Genetics · doi:10.1007/s00439-006-0316-9 · Cited by 187
Self-citation
Transcatheter Aortic Valve Implantation in Patients With Bicuspid Aortic Valve Stenosis
Wijesinghe, N., Ye, J., Rodés‐Cabau, J., et al. (2010) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2010.08.016 · Cited by 185
T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valves
Wallby, L., Janerot-Sjöberg, B., Steffensen, T., & Broqvist, M. (2002) · Heart · doi:10.1136/heart.88.4.348 · Cited by 185
Cardiovascular and Vascular Disease of the Aorta
Svensson, L. G., & Crawford, E. S. (1997) · Medical Entomology and Zoology · Cited by 182
Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves
Jain, R., Engleka, K. A., Rentschler, S., Manderfield, L. J., Li, L., Yuan, L., & Epstein, J. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44244 · Cited by 177
The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve
Kappetein, A. P., Groot, A. C. G., Zwinderman, A. H., Rohmer, J., Poelmann, R. E., & Huysmans, H. A. (1991) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)33931-5 · Cited by 176
Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: Focus on cell–matrix signaling
Corte, A. D., Quarto, C., Bancone, C., Castaldo, C., Meglio, F. D., Nurzyńska, D., Santo, L. S. D., FEO, M. D., Scardone, M., Montagnani, S., et al. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.09.009 · Cited by 172
Pattern of Ascending Aortic Dimensions Predicts the Growth Rate of the Aorta in Patients With Bicuspid Aortic Valve
Corte, A. D., Bancone, C., Buonocore, M., Dialetto, G., Covino, F. E., Manduca, S., Scognamiglio, G., D’Oria, V., & FEO, M. D. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2013.07.009 · Cited by 169
Cardiovascular Problems in Pregnant Women with the Marfan Syndrome
Elkayam, U., Ostrzega, E., Shotan, A., et al. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-2-199507150-00007 · Cited by 168
Small ventricular septal defects in adults
Neumayer, U. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1083 · Cited by 167
Aortic valve and aortic arch pathology after coarctation repair
Roos‐Hesselink, J. W., Schölzel, B. E., Heijdra, R. J., Spitaels, S. E. C., Meijboom, F. J., Boersma, E., Bogers, A. J. J. C., & Simoons, M. L. (2003) · Heart · doi:10.1136/heart.89.9.1074 · Cited by 167
Wall shear stress and flow patterns in the ascending aorta in patients with bicuspid aortic valves differ significantly from tricuspid aortic valves: a prospective study
Meierhofer, C., Schneider, E., Lyko, C., Hutter, A., Martinoff, S. A., Markl, M., Hager, A., Hess, J., Stern, H. C., & Fratz, S. (2012) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jes273 · Cited by 166
The Bicuspid Aortic Valve
Lewin, M., & Otto, C. M. (2005) · Circulation · doi:10.1161/01.cir.0000157137.59691.0b · Cited by 165
Accuracy of 2-dimensional echocardiographic diagnosis of congenitally bicuspid aortic valve: Echocardiographic-anatomic correlation in 115 patients
Brandenburg, R. O., Tajik, A. J., Edwards, W. D., et al. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90659-8 · Cited by 163
Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease
Padang, R., Bagnall, R. D., Richmond, D., Bannon, P. G., & Semsarian, C. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.05.009 · Cited by 156
Bicuspid Aortic Valve--A Silent Danger: Analysis of 50 Cases of Infective Endocarditis
Lamas, C. D. C., & Eykyn, S. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313646 · Cited by 155
Mortality ratios, life expectancy, and causes of death in patients with Turner's syndrome.
Price, W. H., Clayton, J. F., Collyer, S., Mey, R. D., & Wilson, J. (1986) · Journal of Epidemiology & Community Health · doi:10.1136/jech.40.2.97 · Cited by 154
Bicuspid Aortic Valve Morphology and Interventions in the Young
Fernandes, S. M., Khairy, P., Sanders, S. P., & Colan, S. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.090 · Cited by 152
Pathogenesis of aortic stenosis and its relation to age.
Pomerance, A. (1972) · Heart · doi:10.1136/hrt.34.6.569 · Cited by 150
Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve
Bauer, M. F., Pašić, M., Meyer, R., et al. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03650-0 · Cited by 147
Midterm results of balloon dilation of congenital aortic stenosis: Predictors of success
Moore, P., Egito, E. S. T., Mowrey, H., Perry, S. B., Lock, J. E., & Keane, J. F. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00608-7 · Cited by 146
Congenital Aortic Stenosis
Sissman, N. J., Neill, C. A., Spencer, F. C., et al. (1959) · Circulation · doi:10.1161/01.cir.19.3.458 · Cited by 144
Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: Preliminary results
Cotrufo, M. F., Corte, A. D., Santo, L. S. D., Quarto, C., FEO, M. D., Romano, G., Amarelli, C., Scardone, M., Meglio, F. D., Guerra, G., et al. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.01.016 · Cited by 141
Feasibility and Outcomes of Transcatheter Aortic Valve Implantation in High-Risk Patients With Stenotic Bicuspid Aortic Valves
Himbert, D., Pontnau, F., Messika–Zeitoun, D., Descoutures, F., Détaint, D., Cueff, C., Sordi, M., Laissy, J., Alkhoder, S., Brochet, É., et al. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.064 · Cited by 139
Pathology and pathogenesis of infective endocarditis in native heart valves
Thiene, G., & Basso, C. (2006) · Cardiovascular Pathology · doi:10.1016/j.carpath.2006.05.009 · Cited by 139
Long-Term Risk of Aortic Events Following Aortic Valve Replacement in Patients With Bicuspid Aortic Valves
McKellar, S. H., Michelena, H. I., Li, Z., Schaff, H. V., & Sundt, T. M. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.07.043 · Cited by 133
Self-citation
Insertion-Deletion Polymorphism of the ACE Gene Modulates Reversibility of Endothelial Dysfunction With ACE Inhibition
Prasad, A., Narayanan, S. N., Husain, S., Padder, F. A., Waclawiw, M. A., Epstein, N., & Quyyumi, A. A. (2000) · Circulation · doi:10.1161/01.cir.102.1.35 · Cited by 133
Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation
Girdauskas, E., Disha, K., Raisin, H. H., Secknus, M. A., Borger, M. A., & Kuntze, T. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs137 · Cited by 133
Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves
Boyum, J., Fellinger, E. K., Schmoker, J. D., Trombley, L. M., McPartland, K. J., Ittleman, F. P., & Howard, A. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.11.049 · Cited by 132
Frequency of Congenitally Bicuspid Aortic Valves in Patients ≥80 Years of Age Undergoing Aortic Valve Replacement for Aortic Stenosis (With or Without Aortic Regurgitation) and Implications for Transcatheter Aortic Valve Implantation
Roberts, W. C., Janning, K. G., Ko, J. M., Filardo, G., & Matter, G. J. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.01.390 · Cited by 128
Biomechanical implications of the congenital bicuspid aortic valve: A finite element study of aortic root function from in vivo data
Conti, C. A., Corte, A. D., Votta, E., Viscovo, L. D., Bancone, C., Santo, L. S. D., & Redaelli, A. C. L. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.01.016 · Cited by 122
Congenitally bicuspid aortic valve causing severe, pure aortic regurgitation without superimposed infective endocarditis
Roberts, W. C., Morrow, A. G., Mclntosh, C. L., Jones, M., & Epstein, S. E. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90385-4 · Cited by 121
Shone's anomaly: Operative results and late outcome
Bolling, S. F., Iannettoni, M. D., Dick, M., Rosenthal, A., & Bove, E. L. (1990) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(90)90861-y · Cited by 120
The Bentall procedure: Is it the gold standard? A series of 597 consecutive cases
Etz, C. D., Bischoff, M. S., Bodian, C., et al. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.07.033 · Cited by 119
Lipid Lowering on Progression of Mild to Moderate Aortic Stenosis: Meta-analysis of the Randomized Placebo-Controlled Clinical Trials on 2344 Patients
Teo, K. K., Corsi, D. J., Tam, J. W., Dumesnil, J. G., & Chan, K. L. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.03.012 · Cited by 118
Is aortic wall degeneration related to bicuspid aortic valve anatomy in patients with valvular disease?
Russo, C., Cannata, A., Lanfranconi, M., et al. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.11.072 · Cited by 117
Inconsistent echocardiographic grading of aortic stenosis: is the left ventricular outflow tract important?
Michelena, H. I., Margaryan, E., Miller, F. A., Eleid, M. F., Maalouf, J. F., Suri, R. M., Messika–Zeitoun, D., Pellikka, P. A., & Enriquez-Sarano, M. L. (2013) · Heart · doi:10.1136/heartjnl-2012-302881 · Cited by 113
Self-citation
Comparison of the Structure of the Aortic Valve and Ascending Aorta in Adults Having Aortic Valve Replacement for Aortic Stenosis Versus for Pure Aortic Regurgitation and Resection of the Ascending Aorta for Aneurysm
Roberts, W. C., Vowels, T. J., Ko, J. M., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.972406 · Cited by 111
Task Force 3: Valvular heart disease
Bonow, R. O., Cheitlin, M. D., Crawford, M. H., & Douglas, P. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.010 · Cited by 110
Echocardiography reveals a high incidence of bicuspid aortic valve in Turner syndrome
Miller, M. J., Geffner, M. E., Lippe, B. M., Itami, R. M., Kaplan, S. A., DiSessa, T. G., Isabel-Jones, J. B., & Friedman, W. F. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80284-4 · Cited by 106
Features and predictors of ascending aortic dilatation in association with a congenital bicuspid aortic valve
Novaro, G. M., Tiong, I., Pearce, G. L., Grimm, R. A., Smedira, N. G., & Griffin, B. P. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00480-6 · Cited by 105
A Critical Review of the American College of Cardiology/American Heart Association Practice Guidelines on Bicuspid Aortic Valve With Dilated Ascending Aorta
Guntheroth, W. G. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.106 · Cited by 102
Development of the Heart
Schoenwolf, G. C., Bleyl, S. B., Brauer, P. R., & Francis‐West, P. H. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-06811-9.10012-0 · Cited by 102
Echocardiographic Recognition of the Congenital Bicuspid Aortic Valve
Nanda, N. C., Gramiak, R., MANNING, J. A., et al. (1974) · Circulation · doi:10.1161/01.cir.49.5.870 · Cited by 100
Bicuspid Aortic Valves Are Associated With Aortic Dilatation Out of Proportion to Coexistent Valvular Lesions
Keane, M. G., Wiegers, S. E., Plappert, T. J., Pochettino, A. A., Bavaria, J. E., & Sutton, M. G. S. J. (2000) · Circulation · doi:10.1161/circ.102.suppl_3.iii-35 · Cited by 100
Ascending aorta diameters measured by echocardiography using both leading edge-to-leading edge and inner edge-to-inner edge conventions in healthy volunteers
Muraru, D., Maffessanti, F., Kocabay, G., et al. (2013) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jet173 · Cited by 99
Bicuspid aortic valves in hearts with other congenital heart disease.
Duran, A. C., Frescura, C., Sans-Coma, V., Angelini, A., Basso, C., & Thiene, G. (1995) · PubMed · Cited by 98
Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography.
PACHULSKI, R. T., & Chan, K. L. (1993) · Heart · doi:10.1136/hrt.69.3.237 · Cited by 97
Frequency of Cardiovascular Events in Women With a Congenitally Bicuspid Aortic Valve in a Single Community and Effect of Pregnancy on Events
McKellar, S. H., MacDonald, R. J., Michelena, H. I., Connolly, H. M., & Sundt, T. M. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.08.061 · Cited by 96
Self-citation
Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve: involvement and clinical relevance of smooth muscle cell apoptosis and expression of cell death-initiating proteins
Schmid, F., Bielenberg, K., Schneider, A., et al. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(02)00833-3 · Cited by 96
Familial Aorto-Cervicocephalic Arterial Dissections and Congenitally Bicuspid Aortic Valve
Schievink, W. I., & Mokri, B. (1995) · Stroke · doi:10.1161/01.str.26.10.1935 · Cited by 95
Case-controlled study to assess risk factors for aortic stenosis in congenitally bicuspid aortic valve
Chan, K., Ghani, M., Woodend, K., & Burwash, I. G. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01820-3 · Cited by 93
Occam's Razor versus Saint's Triad
Hilliard, A. A., Weinberger, S. E., Tierney, L. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmcps031794 · Cited by 91
Type A aortic dissection in patients with bicuspid aortic valves: clinical and pathological comparison with tricuspid aortic valves
Eleid, M. F., Forde, I. C., Edwards, W. D., Maleszewski, J. J., Suri, R. M., Schaff, H. V., Enriquez-Sarano, M. L., & Michelena, H. I. (2013) · Heart · doi:10.1136/heartjnl-2013-304606 · Cited by 91
Self-citation
Tissue microarray detection of matrix metalloproteinases, in diseased tricuspid and bicuspid aortic valves with or without pathology of the ascending aorta
Koullias, G. J. (2004) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2004.07.050 · Cited by 87
Twenty-Five Year Experience With Balloon Aortic Valvuloplasty for Congenital Aortic Stenosis
Maskatia, S. A., Ing, F. F., Justino, H., Crystal, M. A., Mullins, C. E., Mattamal, R. J., Smith, E. O., & Petit, C. J. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.05.040 · Cited by 85
Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: A survey of 100 cardiac surgeons
Verma, S., Yanagawa, B., Kalra, S., Ruel, M., Peterson, M. D., Yamashita, M. H., Fagan, A., Currie, M. E., White, C. W., Sang, S. L. W., et al. (2013) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2013.06.037 · Cited by 84
Association of left dominant coronary arterial system with congenital bicuspid aortic valve
Hutchins, G. M., Nazarian, I. H., & Bulkley, B. H. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90985-2 · Cited by 79
Role of balloon dilatation of the aortic valve in pregnant patients with severe aortic stenosis.
BANNING, A. P., Pearson, J. F., & Hall, R. J. C. (1993) · Heart · doi:10.1136/hrt.70.6.544 · Cited by 79
Congenitally bicuspid aortic valve in multiple family members
Glick, B. N., & Roberts, W. C. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90018-3 · Cited by 76
Clinical characteristics and outcome of infective endocarditis in adults with bicuspid aortic valves: a multicentre observational study
Tribouilloy, C. M., Ruşinaru, D., Sorel, C., Thuny, F., Casalta, J.-P., Ribéri, A., Jeu, A., Gouriet, F., Collart, F., Caus, T., et al. (2010) · Heart · doi:10.1136/hrt.2009.189050 · Cited by 76
Reversal of dominance of the coronary arterial system in isolated aortic stenosis and bicuspid aortic valve.
Higgins, C. B., & Wexler, L. (1975) · Circulation · doi:10.1161/01.cir.52.2.292 · Cited by 75
Morphology and Function of the Bicuspid Aortic Valve With and Without Coarctation of the Aorta in the Young
Ciotti, G., Vlahos, A. P., & Silverman, N. H. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.05.035 · Cited by 75
Genetic Insights into Bicuspid Aortic Valve Formation
Laforest, B., & Nemer, M. J. (2012) · Cardiology Research and Practice · doi:10.1155/2012/180297 · Cited by 72
Imaging Biomarkers of Aortic Disease
Hope, M. D., Wrenn, J., Sigovan, M., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.072 · Cited by 70
Bicuspid aortic valve.
Yener, N., Oktar, G. L., Erer, D., et al. (2002) · PubMed · Cited by 67
Risk Factors Associated With Reoperation and Mortality in 252 Patients After Aortic Valve Replacement for Congenitally Bicuspid Aortic Valve Disease
Goland, S., Czer, L. S. C., Robertis, M. A. D., et al. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.10.047 · Cited by 66
Management of the Valve and Ascending Aorta in Adults with Bicuspid Aortic Valve Disease
Borger, M. A., & David, T. E. (2005) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2005.02.005 · Cited by 66
Comparison of Feasibility and Accuracy of Transthoracic Echocardiography Versus Computed Tomography in Patients With Known Ascending Aortic Aneurysm
Tamborini, G., Galli, C. A., Maltagliati, A. C., Andreini, D., Pontone, G., Quaglia, C., Ballerini, G., & Pepi, M. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.04.043 · Cited by 65
Outcome of Isolated Bicuspid Aortic Valve in Childhood
Mahle, W. T., Sutherland, J. L., & Frías, P. A. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.03.004 · Cited by 64
Steady‐state free‐precession (SSFP) cine MRI in distinguishing normal and bicuspid aortic valves
Gleeson, T. G., Mwangi, I., Horgan, S. J., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21547 · Cited by 64
Aortic dissection in children and young adults: diagnosis, patients at risk, and outcomes
Zalzstein, E., Hamilton, R. M., Zucker, N., et al. (2003) · Cardiology in the Young · doi:10.1017/s1047951103000696 · Cited by 61
Reliability of transthoracic echocardiography in the assessment of aortic valve morphology: pathological correlation in 178 patients.
Chan, K. L., Stinson, W. A., & Veinot, J. P. (1999) · PubMed · Cited by 59
Percutaneous Transcatheter Heart Valve Implantation in a Bicuspid Aortic Valve
Chiam, P. T. L., Chao, V. T. T., Tan, S.-Y., et al. (2010) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2009.11.024 · Cited by 59
Balloon aortic valvuloplasty in the young adult with congenital aortic stenosis
Rosenfeld, H., Landzberg, M. J., Perry, S. B., Colan, S. D., Keane, J. F., & Lock, J. E. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90292-5 · Cited by 57
Clinical factors useful in predicting aortic valve structure in patients >40 years of age with isolated valvular aortic stenosis
Mautner, G. C., Mautner, S. L., Cannon, R. O., et al. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90159-a · Cited by 57
Open commissurotomy for critical isolated aortic stenosis in neonates
Alexiou, C., Langley, S. M., Dalrymple-Hay, M. J. R., et al. (2001) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)02232-3 · Cited by 56
Impaired Splicing of Fibronectin Is Associated With Thoracic Aortic Aneurysm Formation in Patients With Bicuspid Aortic Valve
Paloschi, V., Kurtovic, S., Folkersen, L., Gomez, D. A., Wågsäter, D., Roy, J., Petrini, J., Eriksson, M. J., Caidahl, K., Hamsten, A., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.218461 · Cited by 56
Early cell changes and TGFβ pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis
Forte, A., Corte, A. D., Grossi, M., Bancone, C., Provenzano, R., Finicelli, M., FEO, M. D., Santo, L. S. D., Nappi, G., Cotrufo, M. F., et al. (2012) · Clinical Science · doi:10.1042/cs20120324 · Cited by 55
Aortopathy and bicuspid aortic valve: haemodynamic burden is main contributor to aortic dilatation
Kim, Y., Sun, B. J., Park, G., Han, S., Kim, D., Song, J., Kang, D., & Song, J. (2012) · Heart · doi:10.1136/heartjnl-2012-302828 · Cited by 55
Surgical treatment of ischemic mitral regurgitation might not influence ventricular remodeling
Enomoto, Y., Gorman, J. H., Moainie, S. L., Guy, T. S., Jackson, B. M., Parish, L. M., Plappert, T. A., Zeeshan, A., John-Sutton, M. G. S., & Gorman, R. C. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.09.035 · Cited by 53
Bicuspid aortic valves undergo excessive strain during opening: A simulation study
Katayama, S., Umetani, N., Hisada, T., & Sugiura, S. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.05.032 · Cited by 53
Aortic Dissection in Childhood and Adolescence: An Analysis of Occurrences Over a 10‐Year Interval in New York State
Fikar, C. R., & Fikar, R. (2009) · Clinical Cardiology · doi:10.1002/clc.20383 · Cited by 50
Frequency and significance of coronary arterial dominance in isolated aortic stenosis
Murphy, E. S., Rösch, J., & Rahimtoola, S. H. (1977) · The American Journal of Cardiology · doi:10.1016/s0002-9149(77)80158-6 · Cited by 49
Including aortic valve morphology in computational fluid dynamics simulations: Initial findings and application to aortic coarctation
Wendell, D. C., Samyn, M. M., Cava, J. R., et al. (2012) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2012.07.015 · Cited by 49
Aortic medial changes associated with bicuspid aortic valve: myth or reality?
Parai, J. L., Masters, R. G., Walley, V. M., et al. (1999) · PubMed · Cited by 49
Valvular Heart Surgery During Pregnancy
Sullivan, H. J. (1995) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)46534-5 · Cited by 49
Sensitivity and specificity of transesophageal echocardiography for determination of aortic valve morphology
ESPINAL, M. A., Fuisz, A., Nanda, N. C., et al. (2000) · American Heart Journal · doi:10.1067/mhj.2000.103843 · Cited by 48
The Aortic Root: Comparison of Measurements From ECG-gated CT Angiography With Transthoracic Echocardiography
Ocak, İ., Lacomis, J. M., Deible, C. R., et al. (2009) · Journal of Thoracic Imaging · doi:10.1097/rti.0b013e31819f9369 · Cited by 46
Left coronary artery anatomy in patients with bicuspid aortic valves.
Johnson, A., Detwiler, J., & Higgins, C. B. (1978) · Heart · doi:10.1136/hrt.40.5.489 · Cited by 45
Abnormal architecture of the ventricles in hearts with an overriding aortic valve and a perimembranous ventricular septal defect (“Eisenmenger VSD”)
Oppenheimer-Dekker, A., Groot, A. C. G., Bartelings, M. M., Wenink, A. C. G., Moene, R. J., & van der Harten, J. J. (1985) · International Journal of Cardiology · doi:10.1016/0167-5273(85)90032-4 · Cited by 44
Cardiac magnetic resonance imaging is more diagnostic than 2-dimensional echocardiography in determining the presence of bicuspid aortic valve
Malaisrie, S. C., Carr, J., Mikati, I. A., et al. (2011) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2011.09.068 · Cited by 40
Elastic Properties of Aortic Wall in Patients With Bicuspid Aortic Valve by Magnetic Resonance Imaging
Aquaro, G. D., Ait-Alì, L., Basso, M. L., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.03.005 · Cited by 38
Erratum: Corrigendum: Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
Guo, D., Pannu, H., Tran‐Fadulu, V., et al. (2008) · Nature Genetics · doi:10.1038/ng0208-255c · Cited by 38
Two-Dimensional Echocardiographic Features of Bicuspid Aortic Valve
Fowles, R. E., Martin, R. P., Abrams, J. M., et al. (1979) · CHEST Journal · doi:10.1378/chest.75.4.434 · Cited by 36
The diagnosis of a non-stenotic bicuspid aortic valve.
Leech, G. J., Mills, P. G., & Leatham, A. (1978) · Heart · doi:10.1136/hrt.40.9.941 · Cited by 33
Williams-Beuren syndrome: cardiovascular abnormalities in 20 patients diagnosed with fluorescence in situ hybridization
Sugayama, S. M. M., Moisés, R. L., Wagënfur, J., et al. (2003) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2003001300003 · Cited by 33
Morphological assessment of the aortic valve using coronary computed tomography angiography, cardiovascular magnetic resonance, and transthoracic echocardiography: comparison with intraoperative findings
Lee, S. C., Ko, S. M., Song, M. G., Shin, J. K., Chee, H. K., & Hwang, H. K. (2012) · International journal of cardiac imaging · doi:10.1007/s10554-012-0066-9 · Cited by 31
Heterogeneous distribution of soluble guanylate cyclase in the pulmonary vasculature of the fetal lamb
D’Angelis, C. A., Nickerson, P. A., Steinhorn, R. H., & Morin, F. C. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199801)250:1 · Cited by 28
Multimodality Imaging of Aortic Dimensions: Comparison of Transthoracic Echocardiography with Multidetector Row Computed Tomography
Tsang, J. F., Lytwyn, M., Farag, A., Zeglinski, M. R., Wallace, K., daSilva, M., Bohonis, S., Walker, J. R., Tam, J. W., Strzelczyk, J., et al. (2012) · Echocardiography · doi:10.1111/j.1540-8175.2012.01666.x · Cited by 27
Bicuspid Aortic Valve: Spectrum of Imaging Findings at Cardiac MDCT and Cardiovascular MRI
Ko, S. M., Song, M. G., & Hwang, H. K. (2011) · American Journal of Roentgenology · doi:10.2214/ajr.10.6084 · Cited by 27
Congenital bicuspid aortic valve: analysis of 63 surgical cases.
Yotsumoto, G., Moriyama, Y., Toyohira, H., et al. (1998) · PubMed · Cited by 26
Umbilical artery flow velocity during maternal cardiopulmonary bypass
Goldstein, I., Jakobi, P., Gutterman, E., et al. (1995) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00673-9 · Cited by 26
Replacement of the ascending aorta in bicuspid aortic valve disease: Where do we draw the line?
Sundt, T. M. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2010.08.053 · Cited by 25
Self-citation
Correlation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study
Lee, C., Tai, B., Lim, G.-H., Chan, M. Y., Low, A. F.-H., Tan, K. C. B., Chia, B. L., & Tan, H. C. (2010) · International journal of cardiac imaging · doi:10.1007/s10554-010-9777-y · Cited by 20
The presence of bicuspid aortic valve does not predict ventricular septal defect type
Hor, K. N., Border, W. L., Cripe, L. H., et al. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32609 · Cited by 19
Outcome of Surgical Commissurotomy for Aortic Valve Stenosis in Early Infancy
Rehnström, P., Malm, T. K., Jögi, P., et al. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.03.098 · Cited by 18
The many faces of bicuspid aortic valve disease
Cedars, A. M., & Braverman, A. C. (2012) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2012.08.006 · Cited by 17
Dilatación aórtica en válvula aórtica bicúspide
Carro, A., Teixidó‐Turà, G., & Evangelista, A. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2012.04.025 · Cited by 16
Self-citation
Valvular Disease of the Heart
Caird, F. I. (1982) · Springer eBooks · doi:10.1007/978-3-642-68214-8_5 · Cited by 15

Research works printed but not linked: 1

Einstein AOn the method of theoretical physics: The Herbert Spencer lecture delivered at Oxford 10 June 1933. Oxford University Press; 1933.

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Authors: Michelena, H. I., Prakash, S. K., Della Corte, A., Bissell, M. M., Anavekar, N., Mathieu, P., Bossé, Y., Limongelli, G., Bossone, E., Benson, D. W., Lancellotti, P., Isselbacher, E. M., Enriquez-Sarano, M., Sundt, T. M., Pibarot, P., Evangelista, A., Milewicz, D. M., & Body, S. C.
Affiliations: From the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (H.I.M., N.A., M.E.-S.); Division of Medical Genetics; Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX (S.K.P., D.M.M.); Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy (A.D.C.); Department of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (M.M.B.); Institut Universitaire de Cardiologie et de...
Mayo Clinic (US)
Children's Hospital of Wisconsin (US)
ORCID: Prakash, Siddharth K.
Bissell, Malenka M.
Mathieu, Patrick
Bossé, Yohan
Limongelli, Giuseppe
Bossone, Eduardo
Benson, D.Woodrow
Lancellotti, Patrizio
Isselbacher, Eric M.
Enriquez-Sarano, Maurice
Sundt, Thoralf M.
Evangelista, Artur
Milewicz, Dianna M.
Body, Simon C.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-06-24
Volume: 129
Issue: 25
Pages: 2691-2704
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.113.007851
PMC: PMC4145814
OpenAlex: W2023616993
Cited by: 442
References: 214
Citations by year: 2026: 28 · 2025: 27 · 2024: 32 · 2023: 36 · 2022: 46 · 2021: 59 · 2020: 39 · 2019: 32 · 2018: 35 · 2017: 44 · 2016: 35 · 2015: 17 · 2014: 8
FWCI: 23.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Corpus Université Laval (Université Laval) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Open Repository and Bibliography (University of Liège) (submittedVersion)
Funders: British Heart Foundation (FS/10/43/28415)
National Institutes of Health (UL1TR000371, UL1TR000170)
National Heart, Lung, and Blood Institute (R01HL114823)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Keywords: bicuspid aortic valve, aortic stenosis, aortic valve obstruction, aortic regurgitation, bacterial endocarditis, aortic dissection, congenital heart disease, aortic valve imaging, genetic susceptibility, research gaps
MeSH terms: Bicuspid Aortic Valve Disease, Aortic Valve, Diagnostic Imaging, Cardiac Surgical Procedures, Heart Valve Diseases, Humans, Health Knowledge, Attitudes, Practice

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Bicuspid Aortic Valve: Identifying Knowledge Gaps and Rising to the Challenge From the International Bicuspid Aortic Valve Consortium (BAVCon)

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