Cited by 1,194Smoking Behavior and CessationGlobal Public Health Policies and EpidemiologyInhalation and Respiratory Drug Delivery

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E-Cigarettes: A Scientific Review

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Grana, Rachel, Benowitz, Neal, Glantz, Stanton A.·2014·Circulation

DOI 10.1161/circulationaha.114.007667PMC PMC4018182

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Abstract

chemicals delivered to users and the air pollution generated by the exhaled aerosol. 19-liquids are flavored, including tobacco, menthol, coffee, fruit, candy, and alcohol flavors, as well as unusual flavors such as cola and Belgian waffle. 3Flavored (conventional) tobacco products are used disproportionately by youth and initiators

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Characteristics of e-cigarette users and their perceptions of the benefits, harms and risks of e-cigarette use: survey results from a convenience sample in Ottawa, Canada
Volesky, K. D., Maki, A., Scherf, C., Watson, L. M., Cassol, E., & Villeneuve, P. J. (2016) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.36.7.02 · Cited by 36
Hazardous waste status of discarded electronic cigarettes
Krause, M. J., & Townsend, T. G. (2015) · Waste Management · doi:10.1016/j.wasman.2015.02.005 · Cited by 36
Electronic Cigarettes—Attitudes and Use in Germany
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Electronic cigarette chemicals transfer from a vape shop to a nearby business in a multiple-tenant retail building
Khachatoorian, C., Jacob, P., Benowitz, N. L., & Talbot, P. (2018) · Tobacco Control · doi:10.1136/tobaccocontrol-2018-054316 · Cited by 37
Self-citation
Composition and chemical health hazards of the most common electronic cigarette liquids in nine European countries
Girvalaki, C., Tzatzarakis, M. N., Kyriakos, C. N., Vardavas, A. I., Stivaktakis, P. D., Kavvalakis, M. P., Tsatsakis, A. M., & Vardavas, C. I. (2018) · Inhalation Toxicology · doi:10.1080/08958378.2018.1527879 · Cited by 36
“Generally, e-liquids contain humectants (i.e. propylene glycol; glycerine), flavors, nicotine and other additives, with content levels and ratio concentrations varied by product (Grana et al., 2014).”
Background
Use of Multiple Tobacco and Tobacco-Like Products Including Heated Tobacco and E-Cigarettes in Japan: A Cross-Sectional Assessment of the 2017 JASTIS Study
Sugiyama, T., & Tabuchi, T. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17062161 · Cited by 36
Healthcare Professionals’ Beliefs, Attitudes, Knowledge, and Behavior Around Vaping in Pregnancy and Postpartum: A Qualitative Study
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The Future of Substance Abuse Now: Relationships among Adolescent Use of Vaping Devices, Marijuana, and Synthetic Cannabinoids
Tai, H., Swartz, M. D., Marsden, D., & Perry, C. L. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2020.1849305 · Cited by 36
Science and the evolving electronic cigarette
Lopez, A. A., & Eissenberg, T. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.07.006 · Cited by 36
Neuropeptide systems and new treatments for nicotine addiction
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Nicotine delivery efficiency of first- and second-generation e-cigarettes and its impact on relief of craving during the acute phase of use
Rüther, T., Hagedorn, D., Schiela, K., Schettgen, T., Osiander-Fuchs, H., & Schöber, W. (2017) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2017.10.012 · Cited by 41
Knowledge, beliefs, attitude, and practices of E-cigarette use among dental students: A multinational survey
Alhajj, M. N., Al‐Maweri, S. A., Foláyan, M. O., Halboub, E. S., Khader, Y. S., Omar, R., Amran, A. G., Al-Batayneh, O. B., Čelebić, A., Peršić, S., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276191 · Cited by 38
“The E-cigarette was invented by Hon Lik, a Chinese pharmacist, in 2003 as a habit-breaker for tobacco-cigarette smokers to help users gradually quit smoking [1, 3].”
Background
Reported electronic cigarette use among adolescents in the Niagara region of Ontario
Khoury, M., Manlhiot, C., Fan, C. S., Gibson, D., Stearne, K., Chahal, N., Dobbin, S. W., & McCrindle, B. W. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.151169 · Cited by 35
Electronic cigarette use and suicidal behaviors among adolescents
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Secondhand exposure from vaping marijuana: Concentrations, emissions, and exposures determined using both research-grade and low-cost monitors
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“(2015); Grana et al. (2014); Hess et al. (2016); Maloney et al. (2016); Martuzevicius et al. (2018); McAuley et al. (2012); and O’Connell et al. (2015). Useful studies of the “topography” of vaping e-cigarettes (frequency of inhalation, amount of vapor inhaled, length of time the vapor is inhaled and exhaled, etc.) ha…”
BackgroundInfluential
Immediate physiological effects of acute electronic cigarette use in humans: A systematic review and meta-analysis
Larue, F., Tasbih, T., Ribeiro, P. A. B., Lavoie, K., Dolan, E., & Bacon, S. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2021.106684 · Cited by 41
The impact of perinatal nicotine exposure on fetal lung development and subsequent respiratory morbidity
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Examining Metal Contents in Primary and Secondhand Aerosols Released by Electronic Cigarettes
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Cigarette smoking and erectile dysfunction: an updated review with a focus on pathophysiology, e-cigarettes, and smoking cessation
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Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
Bircan, E., Bezirhan, U., Porter, A., Fagan, P., & Orloff, M. S. (2021) · Tobacco Induced Diseases · doi:10.18332/tid/132833 · Cited by 34
The reciprocal relationships of social norms and risk perceptions to cigarette, e-cigarette, and cannabis use: Cross-lagged panel analyses among US young adults in a longitudinal study
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A Longitudinal Study of Predictors for Adolescent Electronic Cigarette Experimentation and Comparison with Conventional Smoking
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Authors: Grana, R., Benowitz, N., & Glantz, S. A.
Affiliations: University of California, San Francisco (US)
Corresponding author: Glantz, Stanton A.
ORCID: Grana, Rachel
Benowitz, Neal
Glantz, Stanton A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-05-13
Volume: 129
Issue: 19
Pages: 1972-1986
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.114.007667
PMC: PMC4018182
OpenAlex: W2164470169
Cited by: 1,194
References: 112
Citations by year: 2026: 49 · 2025: 51 · 2024: 52 · 2023: 57 · 2022: 67 · 2021: 85 · 2020: 110 · 2019: 97 · 2018: 116 · 2017: 130 · 2016: 170 · 2015: 151 · 2014: 58
FWCI: 113.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: World Health Organization
National Cancer Institute (P50CA180890)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Public Health Policies and Epidemiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: electronic cigarettes, flavored tobacco products, tobacco aroma, youth tobacco use, tobacco product regulation, exhaled aerosols, air pollution
MeSH terms: Electronics, Humans, Risk Factors, Smoking, Smoking Cessation, Treatment Outcome, Tobacco Products

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