Cited by 1,194Smoking Behavior and CessationGlobal Public Health Policies and EpidemiologyInhalation and Respiratory Drug Delivery

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E-Cigarettes: A Scientific Review

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Grana, Rachel, Benowitz, Neal, Glantz, Stanton A.·2014·Circulation

DOI 10.1161/circulationaha.114.007667PMC PMC4018182

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Abstract

chemicals delivered to users and the air pollution generated by the exhaled aerosol. 19-liquids are flavored, including tobacco, menthol, coffee, fruit, candy, and alcohol flavors, as well as unusual flavors such as cola and Belgian waffle. 3Flavored (conventional) tobacco products are used disproportionately by youth and initiators

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Figure 1. Examples of different electronic cigarette (e-cigarette) products. Reproduced from Grana et al.1CC BY-NC-ND · PubMed Central

Figure 2. Studies screened and selected for inclusion. PRISMA indicates Preferred Reporting Items for Systematic Reviews and Meta-Analyses.CC BY-NC-ND · PubMed Central

Figure 3. Particle number distribution from (A) mainstream aerosol in e-liquid 1 and from (B) conventional cigarette. Reproduced from Fuoco et al55 with permission from the publisher. Copyright © 2013 Elsevier Ltd.CC BY-NC-ND · PubMed Central

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“As the entry point to the body for inhalants, the lungs get a high level of exposure to the chemicals within e-cigarette aerosols ( Grana et al., 2014 ).”
Background
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“Youth are rapidly adopting e-cigarettes (Grana et al., 2014), and the overall occurrence of vaping is increasing, in turn increasing the potential for dermal uptake of nicotine from air.”
Background
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Authors: Grana, R., Benowitz, N., & Glantz, S. A.
Affiliations: University of California, San Francisco (US)
Corresponding author: Glantz, Stanton A.
ORCID: Grana, Rachel
Benowitz, Neal
Glantz, Stanton A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-05-13
Volume: 129
Issue: 19
Pages: 1972-1986
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.114.007667
PMC: PMC4018182
OpenAlex: W2164470169
Cited by: 1,194
References: 112
Citations by year: 2026: 49 · 2025: 51 · 2024: 52 · 2023: 57 · 2022: 67 · 2021: 85 · 2020: 110 · 2019: 97 · 2018: 116 · 2017: 130 · 2016: 170 · 2015: 151 · 2014: 58
FWCI: 113.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: World Health Organization
National Cancer Institute (P50CA180890)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Public Health Policies and Epidemiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: electronic cigarettes, flavored tobacco products, tobacco aroma, youth tobacco use, tobacco product regulation, exhaled aerosols, air pollution
MeSH terms: Electronics, Humans, Risk Factors, Smoking, Smoking Cessation, Treatment Outcome, Tobacco Products

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