Cited by 219Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

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Age-Related Normative Changes in Phasic Orthostatic Blood Pressure in a Large Population Study: Findings From The Irish Longitudinal Study on Ageing (TILDA)

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Finucane, Ciarán, O’Connell, Matthew D.L., Fan, Chie Wei, Savva, George M., Soraghan, Christopher J., Nolan, Hugh, Cronin, Hilary, Kenny, Rose Anne·2014·Circulation

DOI 10.1161/circulationaha.114.009831

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Abstract

BACKGROUND: In this report, we provide the first normative reference data and prevalence estimates of impaired orthostatic blood pressure (BP) stabilization, initial orthostatic hypotension, and orthostatic hypotension based on beat-to-beat blood pressure methods in a population-representative sample. METHODS AND RESULTS: Participants were recruited from a nationally representative cohort study (≥50 years). Beat-to-beat systolic BP, diastolic BP, and heart rate records were analyzed among those who underwent an active stand test (n=4475). Normograms were estimated by use of generalized additive models for location, shape, and scale with Box-Cox power exponential distribution. Prevalence estimates of impaired BP stabilization, initial orthostatic hypotension, and orthostatic hypotension are reported. Orthostatic BP responses in adults aged 50 to 59 years stabilized within 30 seconds of standing, with older groups taking 30 seconds or longer. The total prevalence of impaired BP stabilization was 15.6% (95% confidence interval [CI], 14.1%-17.1%), increasing with age to 41.2% (95% CI, 30.0%-52.4%) in people ≥80 years old. Initial orthostatic hypotension occurred in 32.9% (95% CI, 31.2%-34.6%) of the population aged ≥50 years, with no age gradient evident. The prevalence of orthostatic hypotension was 6.9% (95% CI, 5.9%-7.8%) in the total population, increasing to 18.5% (95% CI, 9.0%-28.0%) in those aged ≥80 years old. CONCLUSIONS: Significant age-related differences exist in the time course of postural BP responses, with abnormal responses taking longer than 30 seconds to stabilize. Impaired BP stabilization is more common as we age, affecting more than two-fifths of the population aged ≥80 years, and may play a future role in the management of falls and syncope.

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Authors: Finucane, C., O’Connell, M. D. L., Fan, C. W., Savva, G. M., Soraghan, C. J., Nolan, H., Cronin, H., & Kenny, R. A.
Affiliations: University of East Anglia (GB)
ORCID: O’Connell, Matthew D.L.
Savva, George M.
Kenny, Rose Anne
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-11-11
Volume: 130
Issue: 20
Pages: 1780-1789
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.114.009831
OpenAlex: W2076099824
Cited by: 219
References: 42
Citations by year: 2026: 7 · 2025: 15 · 2024: 19 · 2023: 12 · 2022: 17 · 2021: 23 · 2020: 21 · 2019: 31 · 2018: 22 · 2017: 20 · 2016: 16 · 2015: 14 · 2014: 2
FWCI: 17.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion, other-oa)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: orthostatic hypotension, age-related changes, normative reference data, beat-to-beat blood pressure, postural blood pressure response, heart rate, older adults, prevalence, falls, syncope
MeSH terms: Aged, Aged, 80 and over, Aging, Blood Pressure, Diastole, Female, Follow-Up Studies, Heart Rate, Humans, Hypotension, Orthostatic, Ireland, Longitudinal Studies, Male, Middle Aged, Posture, Reference Values, Systole, Time Factors, Prevalence

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Age-Related Normative Changes in Phasic Orthostatic Blood Pressure in a Large Population Study: Findings From The Irish Longitudinal Study on Ageing (TILDA)

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