Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management
Open accessAbstract
The Cardiovascular Autonomic Neuropathy (CAN) Subcommittee of the Toronto Consensus Panel on Diabetic Neuropathy worked to update CAN guidelines, with regard to epidemiology, clinical impact, diagnosis, usefulness of CAN testing, and management. CAN is the impairment of cardiovascular autonomic control in the setting of diabetes after exclusion of other causes. The prevalence of confirmed CAN is around 20%, and increases up to 65% with age and diabetes duration. Established risk factors for CAN are glycaemic control in type 1 and a combination of hypertension, dyslipidaemia, obesity, and glycaemic control in type 2 diabetes. CAN is a risk marker of mortality and cardiovascular morbidity, and possibly a progression promoter of diabetic nephropathy. Criteria for CAN diagnosis and staging are: (1) one abnormal cardiovagal test result identifies possible or early CAN; (2) at least two abnormal cardiovagal test results are required for definite or confirmed CAN; and (3) the presence of orthostatic hypotension in addition to abnormal heart rate test results identifies severe or advanced CAN. Progressive stages of CAN are associated with increasingly worse prognosis. CAN assessment is relevant in clinical practice for (1) diagnosis of CAN clinical forms, (2) detection and tailored treatment of CAN clinical correlates (e.g. tachycardia, orthostatic hypotension, non‐dipping, QT interval prolongation), (3) risk stratification for diabetic complications and cardiovascular morbidity and mortality, and (4) modulation of targets of diabetes therapy. Evidence on the cost‐effectiveness of CAN testing is lacking. Apart from the preventive role of intensive glycaemic control in type 1 diabetes, recommendations cannot be made for most therapeutic approaches to CAN. Copyright © 2011 John Wiley & Sons, Ltd.
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Early detection of CAN may enable tailored interventions that prevent progression and reduce risks of CVD, arrhythmias, myocardial dysfunction leading to CHF, CKD, and all-cause mortality.
“Timely detection of CAN may help implementation of tailored interventions to prevent its progression and mitigate the risk of associated complications, including CVD, cardiac arrhythmias, myocardial dysfunction leading to congestive heart failure (CHF), CKD, and all-cause mortality.547,614,617–625”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [622]
The sections on CAN testing for risk stratification and clinical diagnosis (page unavailable in our copy) support detecting CAN to guide tailored treatment and identify risks including cardiovascular events, arrhythmia, heart failure, nephropathy progression, and mortality. The glycaemic-control section reports that intensive treatment can reduce CAN development or progression in specific diabetic populations. The paper does not establish that early detection and tailored interventions prevent or reduce all the listed complications; it describes CAN chiefly as a risk marker for them. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAutonomic neuropathy can increase the risk of exercise-induced injury or adverse events through decreased cardiac responsiveness to exercise, postural hypotension, impaired thermoregulation, impaired night vision due to impaired papillary reaction, and greater susceptibility to hypoglycemia.
“Autonomic neuropathy can increase the risk of exercise-induced injury or adverse events through decreased cardiac responsiveness to exercise, postural hypotension, impaired thermoregulation, impaired night vision due to impaired papillary reaction, and greater susceptibility to hypoglycemia (277).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [277]
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Cites
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119 · see citing works
Glucose control and vascular complications in veterans with type 2 diabetes
Duckworth, W., Abraira, C., Moritz, T., Reda, D., Emanuele, N., Reaven, P. D., Zieve, F. J., Marks, J., Davis, S. N., Hayward, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808431 · Cited by 4,762 · see citing works
Effect of a multifactorial intervention on mortality in type 2 diabetes
Gæde, P., Lund-Andersen, H., Parving, H.-H., & Pedersen, O. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706245 · Cited by 3,489 · cited 1× · see citing works
“with microalbuminuria [56].”
Tesfaye, S., Boulton, A. J. M., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., Lauria, G., Malik, R. A., Spallone, V., Vinik, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1303 · Cited by 2,690 · see citing works
Self-citationVinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1553 · Cited by 2,044 · see citing works
Self-citationBoulton, A. J. M., Vinik, A. I., Arezzo, J. C., Bril, V., Feldman, E. L., Freeman, R., Malik, R. A., Maser, R. E., Sosenko, J. M., & Ziegler, D. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.956 · Cited by 1,859 · see citing works
Self-citationGuidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl260 · Cited by 1,638 · see citing works
The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in Diabetes
Ewing, D. J., Martyn, C., Young, R. J., & Clarke, B. F. (1985) · Diabetes Care · doi:10.2337/diacare.8.5.491 · Cited by 1,436 · see citing works
Diabetic cardiovascular autonomic neuropathy
Vinik, A. I., & Ziegler, D. (2007) · Circulation · doi:10.1161/circulationaha.106.634949 · Cited by 1,255 · see citing works
Self-citationThe Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) · Neurology · doi:10.1212/wnl.46.5.1470 · Cited by 1,238 · see citing works
Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus
Buse, J. B., Ginsberg, H. N., Bakris, G. L., Clark, N. G., Costa, F., Eckel, R., Fonseca, V., Gerstein, H. C., Grundy, S., Nesto, R. W., et al. (2007) · Diabetes Care · doi:10.2337/dc07-9917 · Cited by 1,055 · see citing works
Young, L. H., Wackers, F. J. T., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Heller, G. V., Iskandrian, A. E., Wittlin, S. D., Filipchuk, N., et al. (2009) · JAMA · doi:10.1001/jama.2009.476 · Cited by 809 · see citing works
Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects
Wackers, F. J. T., Young, L. H., Inzucchi, S. E., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Wittlin, S. D., Heller, G. V., Filipchuk, N., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1954 · Cited by 791 · see citing works
Maser, R. E., Mitchell, B. D., Vinik, A. I., & Freeman, R. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1895 · Cited by 678 · see citing works
Self-citation19. Department of Internal Medicine
Katô/Chang (1999) · University of California Press eBooks · doi:10.1525/9780520923393-021 · Cited by 647 · see citing works
Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus
Buse, J. B., Ginsberg, H. N., Bakris, G. L., Clark, N. G., Costa, F., Eckel, R. H., Fonseca, V. A., Gerstein, H. C., Grundy, S. M., Nesto, R. W., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.179294 · Cited by 629 · see citing works
Pop-Busui, R., Evans, G. W., Gerstein, H. C., Fonseca, V., Fleg, J. L., Hoogwerf, B. J., Genuth, S., Grimm, R. H., Corson, M. A., Prineas, R., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0125 · Cited by 540 · see citing works
Self-citationHypoglycemia, Diabetes, and Cardiovascular Events
Desouza, C. V., Bolli, G. B., & Fonseca, V. A. (2010) · Diabetes Care · doi:10.2337/dc09-2082 · Cited by 440 · see citing works
Neurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384 · see citing works
Self-citation2007 ESH‐ESC Guidelines for the management of arterial hypertension
Mansia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Blood Pressure · doi:10.1080/08037050701461084 · Cited by 358 · see citing works
EFNS guidelines on the diagnosis and management of orthostatic hypotension
Lahrmann, H., Cortelli, P., Hilz, M., Mathias, C. J., Struhal, W., & Tassinari, M. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01512.x · Cited by 334 · see citing works
England, J. D., Gronseth, G., Franklin, G. M., Carter, G. T., Kinsella, L. J., Cohen, J. A., Asbury, A. K., Szigeti, K., Lupski, J. R., Latov, N., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000336345.70511.0f · Cited by 327 · see citing works
Self-citationAutonomic Symptoms and Diabetic Neuropathy
Low, P. A., Benrud‐Larson, L. M., Sletten, D. M., Opfer‐Gehrking, T. L., Weigand, S. D., O’Brien, P. C., Suárez, G. A., & Dyck, P. J. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2942 · Cited by 320 · see citing works
Self-citationPop-Busui, R., Low, P. A., Waberski, B. H., Martin, C. L., Albers, J. W., Feldman, E. L., Sommer, C., Cleary, P. A., Lachin, J. M., & Herman, W. H. (2009) · Circulation · doi:10.1161/circulationaha.108.837369 · Cited by 310 · see citing works
Self-citationNot Available, N. A. (1998) · Diabetologia · doi:10.1007/s001250050924 · Cited by 308 · see citing works
Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy
American Diabetes Association, & American Academy of Neurology (1988) · Diabetes Care · doi:10.2337/diacare.11.7.592 · Cited by 286 · see citing works
Ziegler, D., Schatz, H., Conrad, F., Gries, F. A., Ulrich, H., The DEKAN Study Group, & Reichel, G. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.369 · Cited by 280 · see citing works
Self-citationPrevalence of orthostatic hypotension
Low, P. A. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-007-1001-3 · Cited by 271 · see citing works
Self-citationValensi, P. E., Pariès, J., & Attali, J. R. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00095-7 · Cited by 247 · see citing works
Self-citationRecommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy☆
Spallone, V., Bellavere, F., Scionti, L., Maule, S. V., Quadri, R., Bax, G., Melga, P., Viviani, G. L., Esposito, K., & Morganti, R. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.07.005 · Cited by 243 · see citing works
Self-citationValensi, P. E., Sachs, R.-N., Harfouche, B., Lormeau, B., Pariès, J., Cosson, E., Paycha, F., Leuténegger, M., & Attali, J. R. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.339 · Cited by 236 · see citing works
Self-citationRelationship Between Risk Factors and Mortality in Type 1 Diabetic Patients in Europe
Soedamah‐Muthu, S. S., Chaturvedi, N., Witte, D. R., Stevens, L. K., Porta, M., Fuller, J., & for the EURODIAB Prospective Complications Study Group (2008) · Diabetes Care · doi:10.2337/dc08-0107 · Cited by 236 · see citing works
Carnethon, M. R., Prineas, R. J., Temprosa, M., Zhang, Z.-M., Uwaifo, G., Molitch, M. E., & for the Diabetes Prevention Program Research Group (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1729 · Cited by 220 · see citing works
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function
Adler, G. K., Bonyhay, I., Failing, H., Waring, E., Dotson, S., & Freeman, R. (2009) · Diabetes · doi:10.2337/db08-1153 · Cited by 216 · see citing works
Self-citationZiegler, D., Zentai, C. P., Perz, S., Rathmann, W., Haastert, B., Döring, A., Meisinger, C., & for the KORA Study Group (2008) · Diabetes Care · doi:10.2337/dc07-1615 · Cited by 210 · see citing works
Self-citationPalatini, P., Bénétos, A., Grassi, G. M., Julius, S., Kjeldsen, S. E., Mancia, G., Narkiewicz, K., Parati, G., Pessina, A. C., Ruilope, L. M., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000217838.49842.1e · Cited by 199 · see citing works
England, J. D., Gronseth, G., Franklin, G. M., Carter, G. T., Kinsella, L. J., Cohen, J. A., Asbury, A. K., Szigeti, K., Lupski, J. R., Latov, N., et al. (2009) · PM&R · doi:10.1016/j.pmrj.2008.11.011 · Cited by 192 · see citing works
Self-citationRisk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus
Witte, D. R., Tesfaye, S. H., Chaturvedi, N., Eaton, S. E. M., Kempler, P., Fuller, J., & EURODIAB Prospective Complications Study Group (2004) · Diabetologia · doi:10.1007/s00125-004-1617-y · Cited by 186 · see citing works
Self-citationAstrup, A. S., Tarnow, L., Rossing, P. R., Hansen, B. V., Hilsted, J., & Parving, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1242 · Cited by 181 · see citing works
Self-citationHeart Rate Variability Predicts ESRD and CKD-Related Hospitalization
Brotman, D. J., Bash, L. D., Qayyum, R., Crews, D. C., Whitsel, E. A., Astor, B. C., & Coresh, J. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009111112 · Cited by 163 · see citing works
Assessment of brain SPECT [RETIRED]
(1996) · Neurology · doi:10.1212/wnl.46.1.278 · Cited by 150 · see citing works
QT interval, cardiovascular risk factors and risk of death in diabetes
Veglio, M., Chinaglia, A., & Cavallo‐Perin, P. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03346265 · Cited by 145 · see citing works
The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence
Nordin, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1752-6 · Cited by 143 · see citing works
Spallone, V., Gambardella, S., Maiello, M. R., Barini, A., Frontoni, S., & Menzinger, G. (1994) · Diabetes Care · doi:10.2337/diacare.17.6.578 · Cited by 142 · see citing works
Self-citationSpallone, V., Bernardi, L., Ricordi, L., Pl, S., Maiello, M. R., Calciati, A., Gambardella, S., Fratino, P., & Menzinger, G. (1993) · Diabetes · doi:10.2337/diabetes.42.12.1745 · Cited by 134 · see citing works
Self-citationPathophysiology in Diabetic Autonomic Neuropathy: Cardiovascular, Hormonal, and Metabolic Studies
Hilsted, J. (1982) · Diabetes · doi:10.2337/diab.31.8.730 · Cited by 122 · see citing works
Self-citationType 2 diabetes mellitus and the risk of sudden cardiac arrest in the community
Siscovick, D. S., Sotoodehnia, N., Rea, T. D., Raghunathan, T. E., Jouven, X., & Lemaître, R. N. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9133-5 · Cited by 106 · see citing works
Whitsel, E. A., Boyko, E. J., & Siscovick, D. S. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.241 · Cited by 101 · see citing works
Prince, C. T., Secrest, A. M., Mackey, R. H., Arena, V. C., Kingsley, L., & Orchard, T. J. (2009) · Diabetes Care · doi:10.2337/dc09-1936 · Cited by 89 · see citing works
Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes
Wheeler, S., Ahroni, J. H., & Boyko, E. J. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00128-6 · Cited by 88 · see citing works
Valensi, P. E., Johnson, N., Maison‐Blanche, P., Extramania, F., Motté, G., & Coumel, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.5.918 · Cited by 75 · see citing works
Self-citationThe consensus statement on the definition of orthostatic hypotension: a revisit after 13 years
Wieling, W., & Schatz, I. J. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832b1145 · Cited by 73 · see citing works
An Overview of the Effect of Weight Loss on Cardiovascular Autonomic Function
Maser, R. E., & Lenhard, M. J. (2007) · Current Diabetes Reviews · doi:10.2174/157339907781368931 · Cited by 73 · see citing works
Lykke, J. A., Tarnow, L., Parving, H. ‐., & Hilsted, J. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802018330 · Cited by 65 · see citing works
Self-citationKadoi, Y. (2010) · Journal of Anesthesia · doi:10.1007/s00540-010-0987-1 · Cited by 56 · see citing works
Dinh, W., Füth, R., Lankisch, M., Bansemir, L., Nickl, W., Scheffold, T., Bufe, A., Krahn, T., & Ziegler, D. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03221.x · Cited by 53 · see citing works
Self-citationProgression of Cardiovascular Autonomic Dysfunction in Patients With Type 2 Diabetes
Ko, S., Park, S.-A., Cho, J., Song, K., Yoon, K., Cha, B., Son, H., Yoo, K., Moon, K., Park, Y., et al. (2008) · Diabetes Care · doi:10.2337/dc08-0682 · Cited by 44 · see citing works
QTc and autonomic neuropathy in diabetes: Effects of acute hyperglycaemia and n-3 PUFA
Santini, V., Ciampittiello, G., Gigli, F., Bracaglia, D., Baroni, A., Cicconetti, E., Verri, C., Gambardella, S., & Frontoni, S. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.09.006 · Cited by 37 · see citing works
Self-citationSpallone, V., Maiello, M. R., Morganti, R., Mandica, S., & Frajese, G. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002162 · Cited by 34 · see citing works
Self-citationIt is not yet the time to stop screening diabetic patients for silent myocardial ischaemia
Valensi, P. E., & Cosson, E. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.01.001 · Cited by 34 · see citing works
Self-citationKempler, P., Tesfaye, S. H., Chaturvedi, N., Stevens, L. K., Webb, D. J., Eaton, S., Kerényi, Z., Tamás, G., Ward, J. D., & Fuller, J. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.3.215.11589 · Cited by 33 · see citing works
Self-citationPharmacologic modulation of autonomic tone: implications for the diabetic patient
Aronson, D. (1997) · Diabetologia · doi:10.1007/s001250050704 · Cited by 29 · see citing works
Flagged first, then by citations
2 of the 67 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- [8]8. Ziegler D, Gries FA, Mühlen H, et al. Prevalence and clinical correlates of car- diovascular autonomic and peripheral diabetic neuropathy in patients attend- ing diabetes centers. Diabetes Metab 1993; 19: 143-151.
- [18]18. Vinik AI, Ziegler D. Diabetic cardiovas- cular autonomic neuropathy. Circula- tion 2007; 115: 387-397.
- [43]43. Desouza CV, Bolli GB, Fonseca V. Hypo- glycemia, diabetes, and cardiovascu- lar events. Diabetes Care 2010; 33: 1389-1394.
- [55]55. NICE-SUGAR Study Investigators, Fin- fer S, Chittock DR, et al. Intensive ver- sus conventional glucose control in crit- ically ill patients. N Engl J Med 2009; 360: 1283-1297.
- [62]62. Freeman R. Clinical practice. Neuro- genic orthostatic hypotension. N Engl J Med 2008; 358: 615-624.
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Self-citationCardiac autonomic neuropathy: Risk factors, diagnosis and treatment
Serhiyenko, V. A., & Serhiyenko, A. A. (2018) · World Journal of Diabetes · doi:10.4239/wjd.v9.i1.1 · Cited by 257 · see citing works
Cardiac Autonomic Neuropathy in Diabetes Mellitus
Agashe, S. H., & Petak, S. M. (2018) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-14-4-251 · Cited by 246 · see citing works
Patel, T. P., Rawal, K., Bagchi, A. K., Akolkar, G., Bernardes, N., Dias, D. D. S., Gupta, S. S., & Singal, P. K. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9515-6 · Cited by 240 · see citing works
Diabetic Neuropathies: Diagnosis and Management
Deli, G., Bosnyák, E., Pusch, G., Komoly, S., & Fehér, G. (2013) · Neuroendocrinology · doi:10.1159/000358728 · Cited by 229 · see citing works
Emerging Biomarkers, Tools, and Treatments for Diabetic Polyneuropathy
Bönhof, G. J., Herder, C., Strom, A., Παπάνας, Ν., Roden, M., & Ziegler, D. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00107 · Cited by 227 · see citing works
Self-citationBalcıoğlu, A. S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i1.80 · Cited by 222 · see citing works
Finucane, C., O’Connell, M. D. L., Fan, C. W., Savva, G. M., Soraghan, C. J., Nolan, H., Cronin, H., & Kenny, R. A. (2014) · Circulation · doi:10.1161/circulationaha.114.009831 · Cited by 219 · see citing works
Efficacy of α-lipoic acid in diabetic neuropathy
Παπάνας, Ν., & Ziegler, D. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.972935 · Cited by 197 · see citing works
Self-citationAutonomic Neuropathy in Diabetes Mellitus
Verrotti, A., Prezioso, G., Scattoni, R., & Chiarelli, F. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00205 · Cited by 187 · see citing works
Cardiovascular autonomic neuropathies as complications of diabetes mellitus
Kuehl, M. W., & Stevens, M. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.21 · Cited by 182 · see citing works
Self-citationInteractions between kidney disease and diabetes: dangerous liaisons
Pecoits‐Filho, R., Abensur, H., Betônico, C. D. C. R., Machado, A. D., Parente, E. B., Queiroz, M. S., Salles, J. E. N., Titan, S., & Vencio, S. A. C. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0159-z · Cited by 174 · see citing works
Didangelos, T., Karlafti, E., Kotzakioulafi, E., Margariti, E., Giannoulaki, P., Batanis, G., Tesfaye, S. H., & Kantartzis, K. (2021) · Nutrients · doi:10.3390/nu13020395 · Cited by 174 · see citing works
Self-citationThe Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms
Salvatore, T., Pafundi, P. C., Galiero, R., Albanese, G., Di Martino, A., Caturano, A., Vetrano, E., Rinaldi, L., & Sasso, F. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.695792 · Cited by 165 · see citing works
3. Foundations of Care and Comprehensive Medical Evaluation
American Diabetes Association (2016) · Diabetes Care · doi:10.2337/dc16-s006 · Cited by 159 · see citing works
Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events
Vinik, A. I., CASELLINI, C. M., Parson, H. K., Colberg, S. R., & Névoret, M.-L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00591 · Cited by 156 · see citing works
Barrell, K., & Smith, A. G. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.10.006 · Cited by 141 · see citing works
Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives
Fisher, V. L., & Tahrani, A. A. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s129797 · Cited by 137 · see citing works
Okada, H., Fukui, M., Tanaka, M., Inada, S., Mineoka, Y., Nakanishi, N., Senmaru, T., Sakabe, K., Ushigome, E., Asano, M., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.033 · Cited by 130 · see citing works
Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review
Williams, S. M., Eleftheriadou, A., Alam, U., Cuthbertson, D. J., & Wilding, J. P. H. (2019) · Diabetes Therapy · doi:10.1007/s13300-019-00693-0 · Cited by 128 · see citing works
Fleg, J. L., Evans, G. W., Margolis, K. L., Barzilay, J. I., Basile, J., Bigger, J. T., Cutler, J. A., Grimm, R. H., Pedley, C. F., PETERSON, K. A., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07474 · Cited by 128 · see citing works
Self-citationCardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden
Fedorowski, A., Fanciulli, A., Raj, S. R., Sheldon, R. S., Shibao, C. A., & Sutton, R. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00962-3 · Cited by 128 · see citing works
Pathogenesis of Cardiovascular Disease in Diabetes
Haas, A. V., & McDonnell, M. E. (2018) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.10.010 · Cited by 125 · see citing works
Bajaj, M. S., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Early, K. B., ChallaSivaKanaka, S., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc26-s005 · Cited by 178 · see citing works
9. Microvascular Complications and Foot Care
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc15-s012 · Cited by 123 · see citing works
Russell, J. W., & Zilliox, L. A. (2014) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000455884.29545.d2 · Cited by 121 · see citing works
Exercise improves cardiac autonomic function in obesity and diabetes
Voulgari, C., Pagoni, S., Vinik, A. I., & Poirier, P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.005 · Cited by 118 · see citing works
Markus, M. R. P., Rospleszcz, S., Ittermann, T., Baumeister, S. E., Schipf, S., Siewert‐Markus, U., Lorbeer, R., Storz, C., Ptushkina, V., Peters, A., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0948-4 · Cited by 120 · see citing works
Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
Fedorowski, A., Ricci, F., Hamrefors, V., Sandau, K. E., Chung, T., Muldowney, J. A. S., Gopinathannair, R., & Olshansky, B. (2022) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010573 · Cited by 120 · see citing works
Jun, J. E., Jin, S., Baek, J.-H., Oh, S. W., Hur, K. Y., Lee, M., Lee, M., & Kim, J. H. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0233-0 · Cited by 111 · see citing works
Aune, D., Schlesinger, S., Norat, T., & Ríboli, E. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.02.011 · Cited by 111 · see citing works
Adrenergic signaling in heart failure and cardiovascular aging
Santulli, G., & Iaccarino, G. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.03.022 · Cited by 109 · see citing works
Type 1 diabetes and cardiovascular disease
Schnell, O., Cappuccio, F. P., Genovese, S., Standl, E., Valensi, P. E., & Ceriello, A. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-156 · Cited by 107 · see citing works
Self-citationImportance of resting heart rate
Olshansky, B., Ricci, F., & Fedorowski, A. (2022) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2022.05.006 · Cited by 108 · see citing works
Andersen, S. T., Witte, D. R., Fleischer, J., Andersen, H., Lauritzen, T., Jørgensen, M. E., Jensen, T. S., Pop-Busui, R., & Charles, M. (2018) · Diabetes Care · doi:10.2337/dc18-1411 · Cited by 99 · see citing works
Self-citationPop-Busui, R., Braffett, B. H., Zinman, B., Martin, C., White, N. H., Herman, W. H., Genuth, S., Gubitosi-Klug, R., & the DCCT/EDIC Research Group (2017) · Diabetes Care · doi:10.2337/dc16-1397 · Cited by 116 · see citing works
Self-citationManagement of diabetic neuropathy
Cernea, S., & Raz, I. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154867 · Cited by 102 · see citing works
What Do We Know and We Do Not Know About Cardiovascular Autonomic Neuropathy in Diabetes
Pop‐Busui, R. (2012) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-012-9367-6 · Cited by 102 · see citing works
Self-citationJaiswal, M., Martin, C. L., Brown, M. B., Callaghan, B. C., Albers, J. W., Feldman, E. L., & Pop‐Busui, R. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.07.013 · Cited by 95 · see citing works
Self-citationDuque, A. P., Mediano, M. F. F., Lorenzo, A. D., & Rodrigues, L. F. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i6.855 · Cited by 93 · see citing works
Physical activity and dietary interventions in diabetic neuropathy: a systematic review
Zilliox, L. A., & Russell, J. W. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00607-x · Cited by 92 · see citing works
Jaiswal, M., Divers, J., Urbina, E. M., Dabelea, D., Bell, R. A., Pettitt, D. J., Imperatore, G., Pihoker, C., Dolan, L. M., Liese, A. D., et al. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12633 · Cited by 90 · see citing works
Self-citationGreco, C., Gennaro, F. D., D’Amato, C., Morganti, R., Corradini, D., Sun, A., Longo, S., Lauro, D., Pierangeli, G., Cortelli, P., et al. (2016) · Diabetic Medicine · doi:10.1111/dme.13310 · Cited by 93 · see citing works
Self-citationCapece, U., Moffa, S., Improta, I., Giuseppe, G. D., Nista, E. C., CEFALO, C. M. A., Cinti, F., Pontecorvi, A., Gasbarrini, A., Giaccari, A., et al. (2022) · Nutrients · doi:10.3390/nu15010018 · Cited by 96 · see citing works
Tahrani, A. A., Dubb, K., Raymond, N. T., Begum, S., Altaf, Q. A., Sadiqi, H., Piya, M. K., & Stevens, M. J. (2014) · Diabetologia · doi:10.1007/s00125-014-3211-2 · Cited by 89 · see citing works
Self-citationDiabetic heart disease: A clinical update
Rajbhandari, J., Fernandez, C. J., Agarwal, M., Yeap, B. X. Y., & Pappachan, J. M. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i4.383 · Cited by 89 · see citing works
Association Between Cardiovascular Autonomic Neuropathy and Left Ventricular Dysfunction
Pop-Busui, R., Cleary, P. A., Braffett, B. H., Martin, C. L., Herman, W. H., Low, P. A., Lima, J. A. C., & Bluemke, D. A. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.10.028 · Cited by 88 · see citing works
Self-citationManagement of Orthostatic Hypotension
Palma, J., & Kaufmann, H. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000816 · Cited by 90 · see citing works
Cardiovascular autonomic neuropathy in diabetes: an update with a focus on management
Eleftheriadou, A., Spallone, V., Tahrani, A. A., & Alam, U. (2024) · Diabetologia · doi:10.1007/s00125-024-06242-0 · Cited by 89 · see citing works
Self-citationCardiac Autonomic Neuropathy in Type 1 and 2 Diabetes: Epidemiology, Pathophysiology, and Management
Williams, S., Raheim, S. A., Khan, M. I., Rubab, U., Kanagala, P., Zhao, S. S., Worthington, A., Brown, E. E., & Alam, U. (2022) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.09.002 · Cited by 94 · see citing works
Identifying Common Genetic Risk Factors of Diabetic Neuropathies
Witzel, I., Jelinek, H. F., Khalaf, K. A., Lee, S., Khandoker, A. H., & AlSafar, H. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00088 · Cited by 88 · see citing works
Heart Rate Variability and Incident Stroke
Fyfe‐Johnson, A. L., Muller, C. J., Alonso, Á., Folsom, A. R., Gottesman, R. F., Rosamond, W. D., Whitsel, E. A., Agarwal, S. K., & MacLehose, R. F. (2016) · Stroke · doi:10.1161/strokeaha.116.012662 · Cited by 85 · see citing works
Truini, A., Spallone, V., Morganti, R., Tamburin, S., Zanette, G., Schenone, A., De Michelis, C., Tugnoli, V., Simioni, V., Manganelli, F., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001378 · Cited by 85 · see citing works
Self-citationAksu, T., Brignole, M., Calò, L., Debruyne, P., Biase, L. D., Deharo, J., Fanciulli, A., Fedorowski, A., Kułakowski, P., Morillo, C. A., et al. (2024) · EP Europace · doi:10.1093/europace/euae206 · Cited by 83 · see citing works
A simple new non‐invasive sweat indicator test for the diagnosis of diabetic neuropathy
Παπάνας, Ν., Boulton, A. J. M., Malik, R. A., Manes, C., Schnell, O., Spallone, V., Tentolouris, N., Tesfaye, S. H., Valensi, P. E., Ziegler, D., et al. (2012) · Diabetic Medicine · doi:10.1111/dme.12000 · Cited by 83 · see citing works
Self-citationCardiac Autonomic Neuropathy: Why Should Cardiologists Care about That?
Bissinger, A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/5374176 · Cited by 86 · see citing works
Lin, Y. K., Fisher, S. J., & Pop‐Busui, R. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13290 · Cited by 82 · see citing works
Self-citationCatechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats
Addepalli, V., & Suryavanshi, S. V. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.179 · Cited by 79 · see citing works
Corneal confocal microscopy for the diagnosis of diabetic autonomic neuropathy
Tavakoli, M., Begum, P., McLaughlin, J. T., & Malik, R. A. (2014) · Muscle & Nerve · doi:10.1002/mus.24553 · Cited by 78 · see citing works
Zoppini, G., Cacciatori, V., Raimondo, D., Gemma, M., Trombetta, M., Dauriz, M., Brangani, C., Pichiri, I., Negri, C., Stoico, V., et al. (2015) · Diabetes Care · doi:10.2337/dc15-0081 · Cited by 74 · see citing works
Herder, C., Schamarek, I., Nowotny, B., Carstensen‐Kirberg, M., Straßburger, K., Nowotny, P., Kannenberg, J. M., Strom, A., Püttgen, S., Müssig, K., et al. (2016) · Heart · doi:10.1136/heartjnl-2015-309181 · Cited by 77 · see citing works
Self-citationMoon, J. S., Kang, S., Choi, J. H., Lee, K. A., Moon, J. H., Chon, S., Kim, D. J., Kim, H. J., Seo, J. A., Kim, M. K., et al. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0249 · Cited by 76 · see citing works
Blood Pressure Variability and Autonomic Dysfunction
Spallone, V. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1108-z · Cited by 73 · see citing works
Self-citationDiabetes and cardiovascular disease: inter-relation of risk factors and treatment
Sharma, A., Mittal, S., Aggarwal, R., & Chauhan, M. K. (2020) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00151-w · Cited by 71 · see citing works
Jaiswal, M., McKeon, K., Comment, N., Henderson, J., Swanson, S., Plunkett, C. D., Nelson, P. W., & Pop‐Busui, R. (2014) · Diabetes Care · doi:10.2337/dc14-0445 · Cited by 69 · see citing works
Self-citationDiabetes mellitus and risk of sudden cardiac death: a systematic review and meta-analysis
Zaccardi, F., Khan, H., & Laukkanen, J. A. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.105 · Cited by 69 · see citing works
Mathew, A. V., Jaiswal, M., Ang, L. P., Michailidis, G. C., Pennathur, S., & Pop‐Busui, R. (2019) · Diabetes · doi:10.2337/db19-0145 · Cited by 68 · see citing works
Self-citationDidangelos, T., Karlafti, E., Kotzakioulafi, E., Kontoninas, Z., Margaritidis, C., Giannoulaki, P., & Kantartzis, K. (2020) · Nutrients · doi:10.3390/nu12113254 · Cited by 70 · see citing works
The prevalence of cardiac autonomic neuropathy in prediabetes: a systematic review
Eleftheriadou, A., Williams, S., Nevitt, S. J., Brown, E. E., Roylance, R., Wilding, J. P. H., Cuthbertson, D. J., & Alam, U. (2020) · Diabetologia · doi:10.1007/s00125-020-05316-z · Cited by 71 · see citing works
Diabetic Autonomic Imbalance and Glycemic Variability
Fleischer, J. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600526 · Cited by 69 · see citing works
Corneal Confocal Microscopy: A New Technique for Early Detection of Diabetic Neuropathy
Παπάνας, Ν., & Ziegler, D. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0390-z · Cited by 67 · see citing works
Self-citationBudoff, M. J., Alpert, B. S., Chirinos, J. A., Fernhall, B., Hamburg, N. M., Kario, K., Kullo, I. J., Matsushita, K., Miyoshi, T., Tanaka, H., et al. (2021) · American Journal of Hypertension · doi:10.1093/ajh/hpab178 · Cited by 67 · see citing works
Self-citationCharles, M., Fleischer, J., Witte, D. R., Ejskjær, N., Borch‐Johnsen, K., Lauritzen, T., & Sandbæk, A. (2012) · Diabetologia · doi:10.1007/s00125-012-2744-5 · Cited by 65 · see citing works
Prediabetic Neuropathy: Does It Exist?
Παπάνας, Ν., & Ziegler, D. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0278-3 · Cited by 66 · see citing works
Self-citationDiabetes-Induced Cardiac Autonomic Neuropathy: Impact on Heart Function and Prognosis
Sudo, S. Z., Montagnoli, T. L., Rocha, B., Santos, A. D., de Sá, M. P. L., & Zapata‐Sudo, G. (2022) · Biomedicines · doi:10.3390/biomedicines10123258 · Cited by 62 · see citing works
Pop‐Busui, R., Hotaling, J., Braffett, B. H., Cleary, P. A., Dunn, R. L., Martin, C. L., Jacobson, A. M., Wessells, H., & Sarma, A. V. (2015) · The Journal of Urology · doi:10.1016/j.juro.2014.12.097 · Cited by 61 · see citing works
Self-citationHilz, M. J., Liu, M., Koehn, J., Wang, R., Ammon, F., Flanagan, S. R., & Hösl, K. M. (2016) · BMC Neurology · doi:10.1186/s12883-016-0584-5 · Cited by 59 · see citing works
Diabetic cardiovascular autonomic neuropathy: clinical implications
Karayannis, G., Giamouzis, G., Cokkinos, D. V., Skoularigis, J. S., & Triposkiadis, F. K. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.53 · Cited by 58 · see citing works
- Authors
- Spallone, V., Ziegler, D., Freeman, R., Bernardi, L., Frontoni, S., Pop‐Busui, R., Stevens, M., Kempler, P., Hilsted, J., Tesfaye, S., Low, P., Valensi, P., & Neuropathy, O. B. O. T. T. C. P. O. D.
- Affiliations
- University of Rome Tor Vergata (IT)
- Düsseldorf University Hospital (DE)
- Beth Israel Deaconess Medical Center (US)
- University of Pavia (IT)
- University of Michigan (US)
- University of Birmingham (GB)
- Copenhagen University Hospital (DK)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Mayo Clinic (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Spallone, Vincenza
- ORCID
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2011-10
- Volume
- 27
- Issue
- 7
- Pages
- 639-653
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- OpenAlex
- W2086516175
- Cited by
- 957
- References
- 67
- Citations by year
- 2026: 65 · 2025: 67 · 2024: 78 · 2023: 63 · 2022: 71 · 2021: 86 · 2020: 93 · 2019: 62 · 2018: 78 · 2017: 54 · 2016: 61 · 2015: 60 · 2014: 52 · 2013: 34 · 2012: 24
- FWCI
- 37.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- cardiac autonomic neuropathy, diabetes mellitus, orthostatic hypotension, glycemic control, cardiovascular morbidity and mortality, diabetic nephropathy progression, risk stratification, type 1 diabetes, type 2 diabetes
- MeSH terms
- Autonomic Nervous System, Blood Glucose, Cardiovascular Diseases, Diabetic Neuropathies, Humans, Prognosis, Disease Management
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