Cited by 112Congenital Heart Disease StudiesCongenital heart defects researchCardiovascular Conditions and Treatments

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Congenital Heart Defects and Indices of Placental and Fetal Growth in a Nationwide Study of 924 422 Liveborn Infants

Matthiesen, Niels B., Henriksen, Tine B., Agergaard, Peter, Gaynor, J. William, Bach, Cathrine C., Hjortdal, Vibeke E., Østergaard, John R.·2016·Circulation

DOI 10.1161/circulationaha.116.021793

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Abstract

Background: Congenital heart defects (CHDs) have been associated with placental anomalies. The nature and the consequences of this association remain poorly understood. We aimed to estimate the associations between all major subtypes of CHD and placental weight at birth, and the association between placental weight and measures of both overall and cerebral growth in fetuses with CHD, as well. Methods: We included all 924 422 liveborn Danish singletons, 1997 to 2011. CHD was present in 7569. We compared mean differences in placental weight z score between newborns with CHD and newborns without CHD by multivariable linear regression adjusted for potential confounders. Results: CHD was associated with a mean z score difference of –0.04 (95% confidence interval, –0.07 to –0.02). Some subtypes were associated with smaller placental size at birth: tetralogy of Fallot, –0.45 (95% confidence interval, –0.58 to –0.31); double-outlet right ventricle, –0.48 (95% confidence interval, –0.87 to –0.10); major ventricular septal defects, –0.41 (95% confidence interval, –0.52 to –0.29). Placental weight z score was associated with birth weight and head circumference z scores in all subtypes. In the 3 mentioned subtypes, the mean deviations from the population mean head circumference and birth weight z scores were reduced by up to 66% with adjustment for placental weight z score. Conclusions: Three subtypes of CHD were associated with lower placental weight, and placental weight was associated with measures of both overall growth and cerebral growth in fetuses with all subtypes of CHD. In certain subtypes, the described deviations in fetal growth were reduced by up to two-thirds after adjustment for placental weight z score.

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Authors: Matthiesen, N. B., Henriksen, T. B., Agergaard, P., Gaynor, J. W., Bach, C. C., Hjortdal, V. E., & Østergaard, J. R.
Affiliations: Children's Hospital of Philadelphia (US)
ORCID: Matthiesen, Niels B.
Henriksen, Tine B.
Gaynor, J. William
Hjortdal, Vibeke E.
Østergaard, John R.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-11-15
Volume: 134
Issue: 20
Pages: 1546-1556
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.116.021793
OpenAlex: W2531007892
Cited by: 112
References: 31
Citations by year: 2026: 11 · 2025: 14 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 3
FWCI: 6.87
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Aarhus Universitet
Aarhus Universitets Forskningsfond
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
Keywords: congenital heart disease, placental weight, fetal growth, head circumference, birth weight, tetralogy of Fallot, double outlet right ventricle, ventricular septal defect, placental abnormalities, liveborn infants
MeSH terms: Birth Weight, Female, Heart Defects, Congenital, Humans, Infant, Newborn, Male, Placenta, Pregnancy, Fetal Development

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Congenital Heart Defects and Indices of Placental and Fetal Growth in a Nationwide Study of 924 422 Liveborn Infants

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