The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Congenital Heart Defects and Indices of Placental and Fetal Growth in a Nationwide Study of 924 422 Liveborn Infants
Abstract
Background: Congenital heart defects (CHDs) have been associated with placental anomalies. The nature and the consequences of this association remain poorly understood. We aimed to estimate the associations between all major subtypes of CHD and placental weight at birth, and the association between placental weight and measures of both overall and cerebral growth in fetuses with CHD, as well. Methods: We included all 924 422 liveborn Danish singletons, 1997 to 2011. CHD was present in 7569. We compared mean differences in placental weight z score between newborns with CHD and newborns without CHD by multivariable linear regression adjusted for potential confounders. Results: CHD was associated with a mean z score difference of –0.04 (95% confidence interval, –0.07 to –0.02). Some subtypes were associated with smaller placental size at birth: tetralogy of Fallot, –0.45 (95% confidence interval, –0.58 to –0.31); double-outlet right ventricle, –0.48 (95% confidence interval, –0.87 to –0.10); major ventricular septal defects, –0.41 (95% confidence interval, –0.52 to –0.29). Placental weight z score was associated with birth weight and head circumference z scores in all subtypes. In the 3 mentioned subtypes, the mean deviations from the population mean head circumference and birth weight z scores were reduced by up to 66% with adjustment for placental weight z score. Conclusions: Three subtypes of CHD were associated with lower placental weight, and placental weight was associated with measures of both overall growth and cerebral growth in fetuses with all subtypes of CHD. In certain subtypes, the described deviations in fetal growth were reduced by up to two-thirds after adjustment for placental weight z score.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As a result of affected antenatal cerebral circulation, birth head circumferences and z-scores are decreased in CHD.31,32”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G., Wood, A. M., & Carpenter, J. R. (2009) · BMJ · doi:10.1136/bmj.b2393 · Cited by 7,299
The incidence of congenital heart disease.
Hoffman, J. I. E., & Kaplan, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01886-7 · Cited by 6,099
The Danish National Patient Register
Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811401482 · Cited by 3,968
The Danish Civil Registration System as a tool in epidemiology
Schmidt, M., Pedersen, L. H., & Sørensen, H. T. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9930-3 · Cited by 3,486
Latest Advances in Understanding Preeclampsia
Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607
Intrauterine growth restriction
Resnik, R. (2002) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(01)01780-x · Cited by 1,022
Quantifying Biases in Causal Models: Classical Confounding vs Collider-Stratification Bias
Greenland, S. (2003) · Epidemiology · doi:10.1097/01.ede.0000042804.12056.6c · Cited by 810
The Danish Medical Birth Registry.
Lb, K., & Olsen, J. (1998) · PubMed · Cited by 803
Limperopoulos, C., Tworetzky, W., McElhinney, D. B., Newburger, J. W., Brown, D. W., Robertson, R. L., Guizard, N., McGrath, E., Geva, J., Annese, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.865568 · Cited by 663
Gilboa, S. M., Salemi, J. L., Nembhard, W. N., Fixler, D. E., & Correa, A. (2010) · Circulation · doi:10.1161/circulationaha.110.947002 · Cited by 610
Sun, L., Macgowan, C. K., Sled, J. G., Yoo, S.-J., Manlhiot, C., Porayette, P., Grosse-Wortmann, L., Jaeggi, E., McCrindle, B. W., Kingdom, J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013051 · Cited by 533
Neurodevelopmental Outcomes After Cardiac Surgery in Infancy
Gaynor, J. W., Stopp, C., Wypij, D., Andropoulos, D. B., Atallah, J., Atz, A. M., Beca, J., Donofrio, M. T., Duncan, K., Ghanayem, N. S., et al. (2015) · Pediatrics · doi:10.1542/peds.2014-3825 · Cited by 518
Self-citationDonofrio, M. T., Bremer, Y. A., Schieken, R. M., Gennings, C., Morton, L. D., Eidem, B. W., Cetta, F., Falkensammer, C. B., Huhta, J. C., & Kleinman, C. S. (2003) · Pediatric Cardiology · doi:10.1007/s00246-002-0404-0 · Cited by 364
United States Birth Weight Reference Corrected For Implausible Gestational Age Estimates
Talge, N. M., Mudd, L. M., Sikorskii, A. E., & Basso, O. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3285 · Cited by 340
Placental programming of chronic diseases, cancer and lifespan: A review
Barker, D. J. P., & Thornburg, K. L. (2013) · Placenta · doi:10.1016/j.placenta.2013.07.063 · Cited by 276
Gaynor, J. W., Wernovsky, G., Jarvik, G. P., Bernbaum, J., Gerdes, M., Zackai, E., Nord, A. S., Clancy, R. R., Nicolson, S. C., & Spray, T. L. (2007) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.10.087 · Cited by 270
Self-citationHead circumference as an index of brain weight in the fetus and newborn
Cooke, R. W. I., Lucas, A., Yudkin, P. L., & Pryse-Davies, J. (1977) · Early Human Development · doi:10.1016/0378-3782(77)90015-9 · Cited by 203
Fetal growth is directly related to maternal anthropometry and placental volume
Thame, M. M., Osmond, C., Bennett, F. I., Wilks, R., & Forrester, T. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601909 · Cited by 182
Placental characteristics and birthweight
Salafia, C. M., Zhang, J., CHARLES, A. K., Bresnahan, M. A., Shrout, P. E., Sun, W., & Maas, E. M. (2008) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2008.00935.x · Cited by 150
Maternal and foetal angiogenic imbalance in congenital heart defects
Llurba, E., Sanchez, O., Ferrer, Q., Nicolaides, K. H., Ruiz, A., Domı́nguez, C., Sánchez-de-Toledo, J., Garcia-Garcia, B., Soro, G., Arévalo, S., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht389 · Cited by 136
Jones, H. N., Olbrych, S. K., Smith, K. L., Cnota, J. F., Habli, M. A., Ramos-Gonzales, O., Owens, K. J., Hinton, A. C., POLZIN, W. J., Muglia, L. J., et al. (2015) · Placenta · doi:10.1016/j.placenta.2015.08.003 · Cited by 121
Risk factors in congenital heart disease
Stoll, C. G., Alembik, Y., Roth, M., Dott, B., & de Geeter, B. (1989) · European Journal of Epidemiology · doi:10.1007/bf00144842 · Cited by 99
Intrauterine Growth Restriction
Resnik, R. R. (2002) · Obstetrics and Gynecology · doi:10.1097/00006250-200203000-00020 · Cited by 92
3-D volumetric MRI evaluation of the placenta in fetuses with complex congenital heart disease
Andescavage, N., Yarish, A., Donofrio, M., Bulas, D., Evangelou, I., Vezina, G., McCarter, R., duPlessis, A., & Limperopoulos, C. (2015) · Placenta · doi:10.1016/j.placenta.2015.06.013 · Cited by 89
Matthiesen, N. B., Henriksen, T. B., Gaynor, J. W., Agergaard, P., Bach, C. C., Hjortdal, V. E., & Østergaard, J. R. (2016) · Circulation · doi:10.1161/circulationaha.115.019089 · Cited by 84
Self-citationLinask, K. K. (2013) · Journal of Pregnancy · doi:10.1155/2013/320413 · Cited by 80
Agergaard, P., Hebert, A. H., Bjerre, J. V., Sorensen, K. M., Olesen, C., & Oestergaard, J. R. (2011) · Clinical Epidemiology · doi:10.2147/clep.s15627 · Cited by 74
Self-citationCongenital Heart Defects and Developmental and Other Psychiatric Disorders
Olsen, M., Sørensen, H. T., Hjortdal, V. E., Christensen, T. D., & Pedersen, L. H. (2011) · Circulation · doi:10.1161/circulationaha.110.002832 · Cited by 57
Self-citationAgergaard, P., Olesen, C., Østergaard, J. R., Christiansen, M., & Sørensen, K. M. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34250 · Cited by 46
Self-citationAnalysis of placental weight centiles is useful to estimate cause of fetal growth restriction
Hasegawa, J., Arakawa, K., Nakamura, M., Matsuoka, R., Ichizuka, K., Otsuki, K., Sekizawa, A., & Okai, T. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01600.x · Cited by 34
Jørgensen, F. S. (1998) · PubMed · Cited by 26
Flagged first, then by citations
Research works printed but not linked: 1
- Jørgensen FS. [Ultrasonography of pregnant women in Denmark 1999-2000. Description of the development since 1980-1990]. Ugeskr Laeger. 2003;165:4409–4415.
Cited by
Sorted by citations
Mechanisms of early placental development in mouse and humans
Hemberger, M., Hanna, C. W., & Dean, W. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0169-4 · Cited by 515
Placentation defects are highly prevalent in embryonic lethal mouse mutants
Pérez-García, V., Fineberg, E., Wilson, R. J., Murray, A., Icoresi-Mazzeo, C., Tudor, C. L., Sienerth, A. R., White, J. K., Tuck, E. J., Ryder, E. J., et al. (2018) · Nature · doi:10.1038/nature26002 · Cited by 371
Neurodevelopmental Abnormalities and Congenital Heart Disease
Morton, P. D., Ishibashi, N., & Jonas, R. A. (2017) · Circulation Research · doi:10.1161/circresaha.116.309048 · Cited by 211
Rychik, J. R., Goff, D. A., McKay, E. M., Mott, A. R., Tian, Z., Licht, D. J., & Gaynor, J. W. (2018) · Pediatric Cardiology · doi:10.1007/s00246-018-1876-x · Cited by 144
Self-citationRussell, M. W. W., Chung, W. K., Kaltman, J. R., & Miller, T. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.006906 · Cited by 128
Metadata
- Authors
- Matthiesen, N. B., Henriksen, T. B., Agergaard, P., Gaynor, J. W., Bach, C. C., Hjortdal, V. E., & Østergaard, J. R.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- Circulation
- Published
- 2016-11-15
- Volume
- 134
- Issue
- 20
- Pages
- 1546-1556
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2531007892
- Cited by
- 112
- References
- 31
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 3
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Aarhus Universitet
- Aarhus Universitets Forskningsfond
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
- Keywords
- congenital heart disease, placental weight, fetal growth, head circumference, birth weight, tetralogy of Fallot, double outlet right ventricle, ventricular septal defect, placental abnormalities, liveborn infants
- MeSH terms
- Birth Weight, Female, Heart Defects, Congenital, Humans, Infant, Newborn, Male, Placenta, Pregnancy, Fetal Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
