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Emerging areas for therapeutic discovery in SLE

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Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Huang, Z., Shen, S., Li, W., Wang, M., Yu, Y., Luo, W., Han, X., Xu, Z., Min, J., Long, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202503192 · Cited by 7

IRF5 Mediates Artery Inflammation in Salt-Sensitive Hypertension by Regulating STAT1 and STAT2 Phosphorylation to Increase ESM1 Transcription: Insights from Bioinformatics and Mechanistic Analysis

Shao, Q., Wang, H., Li, S., Zeng, M., Zhang, S., & Yan, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083722 · Cited by 6

Environmental modulators of vascular physiology and inflammation

Seneviratne, A. N., Majumdar, A., Surendranath, K., & Miller, M. R. (2025) · Experimental Physiology · doi:10.1113/ep092309 · Cited by 5

The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies

Huang, J., Wang, J., Chen, H. H., Guo, F., & Yuan, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1795987 · Cited by 5

Correlative analysis of transcriptome and proteome in Penaeus vannamei reveals key signaling pathways are involved in IFN-like antiviral regulation mediated by interferon regulatory factor (PvIRF)

Liu, Y., He, Y., Cao, J., Lu, H., Zou, R., Zuo, Z., Li, R., Zhang, Y., & Sun, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127138 · Cited by 5

IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice

Mai, L. T., Smans, M., Silva‐Barrios, S., Fabié, A., & Stäger, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03071 · Cited by 5

Interferon Regulatory Factor 5 (IRF5) Gene Haplotypes Are Associated with Premature Coronary Artery Disease. Association of the IRF5 Polymorphisms with Cardiometabolic Parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

Posadas‐Sánchez, R., Cardoso-Saldaña, G. C., Fragoso, J. M., & Vargas‐Alarcón, G. (2021) · Biomolecules · doi:10.3390/biom11030443 · Cited by 5

The role of interferon regulatory factors in atherosclerosis

Wang, Y., Fang, T., Zheng, X., & Huangfu, N. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1606034 · Cited by 4

The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment

Wang, L., Zhang, Y., Yue, J., & Zhou, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094260 · Cited by 4

Periaortic lymphatic vessels protect against thoracic aortic dissection through mobilizing immune response

Pei, Y., Lin, W., Zhang, T., Chu, X., Xu, H., Sun, Y., Xu, M., Xu, Y., Huang, F., Huang, D., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf215 · Cited by 4

The role of integrin-related genes in atherosclerosis complicated by abdominal aortic aneurysm

Hong, D., Ma, L., Jin, L., Tang, L., Chen, L., & Qiu, Z. (2024) · Medicine · doi:10.1097/md.0000000000040293 · Cited by 3

LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis

Yin, X., Chen, X., Wang, T., Yang, J., Yu, J., & Yang, J. (2025) · Epigenetics · doi:10.1080/15592294.2025.2487317 · Cited by 3

Targeted restoration of macrophage mitochondrial function by astaxanthin-geniposide co-assembled nanosystem for atherosclerosis treatment

Luo, X., Zhao, C., Yu, F., Dong, X., Hao, Y., Zhang, H., Liu, B., & Jiang, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.176037 · Cited by 2

Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice

He, S., Huang, L., Chen, Z., Yuan, Z., Zhao, Y., Zeng, L., Zhu, Y., & He, J. (2025) · eLife · doi:10.7554/elife.103413.3 · Cited by 2

Unravelling immune cell complexity in atherosclerosis

Clément, M., & Mallat, Z. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy165 · Cited by 2

IRF5 promotes intestinal inflammation by guiding monocyte differentiation towards a pathogenic CD11c + macrophage phenotypePreprint

Corbin, A., Gomez-Vazquez, M., Khoyratty, T. E., Berthold, D. L., Almuttaqi, H., Attar, M., Arnold, I. C., Powrie, F. M., Sansom, S. N., & Udalova, I. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/601963 · Cited by 2

Advancing therapeutic targeting of the vulnerable plaque

Newman, A. A. C., Cyr, Y., & Moore, K. J. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac060 · Cited by 2

Gut Microbiota-Derived Leucine Promotes Cold-Induced Atherosclerosis by Inhibiting Macrophage EfferocytosisPreprint

Gong, Y., Yan, S. R., Fang, N., Zhang, Y., Zhang, N., Li, L., Wang, Z., Wang, K., Hou, T., Ji, X., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4666347/v1 · Cited by 2

Mechanisms of aging in the cardiovascular system: challenges and opportunities

Zhao, X., Yang, X., Lin, Y., Lei, R., Ding, W., He, X.-Y., Cao, Y. J., Zhang, D., Liu, P., Liang, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1635736 · Cited by 4

PYK2 controls intestinal inflammation via activation of IRF5 in macrophagesPreprint

Ryzhakov, G., Almuttaqi, H., Corbin, A., Khoyratty, T. E., Berthold, D. L., Bullers, S. J., Eames, H. L., Ai, Z., Bonham, S., Fischer, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.24.113076 · Cited by 1

Arsenic Trioxide Ameliorates Atherosclerosis by Inhibiting CD36-Induced Endocytosis and Tlr4/Nf-Κb-Induced Inflammation in Macrophage and Apoe-/- MicePreprint

Zou, X., Li, Z., WAN, X., Sun, S., Wang, S., Qu, N., Zhang, Y., Lu, R., Li, Z., Yang, L. M., et al. (2022) · SSRN Electronic Journal · doi:10.22541/au.170669100.03220590/v1 · Cited by 1

Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in micePreprint

He, S., Huang, L., Chen, Z., Yuan, Z., Zhao, Y., Zeng, L., Zhu, Y., & He, J. (2024) · eLife · doi:10.7554/elife.103413 · Cited by 1

Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture–prone atherosclerotic plaques

Edsfeldt, A., Swart, M., Singh, P., Dib, L. H., Sun, J., Cole, J. E., Park, I., Al-Sharify, D., Persson, A. F., Nitulescu, M., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab920 · Cited by 91

Shear stress and interferon regulatory gactor 5 modulate myeloid cell behaviour in atherosclerosis

Seneviratne, A. N. (2014) · doi:10.25560/45408 · Cited by 1

Macrophage-specific IRF5 deficiency stabilizes atherosclerotic plaques in ApoE−/− mice

Hilgendorf, I., Haerdtner, C., Leipner, J., Dufner, B., Hoppe, N., Wolf, D., Stachon, P., Zirlik, A., & Bode, C. (2020) · European Heart Journal · doi:10.1093/ehjci/ehaa946.3748 · Cited by 2

Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice

Leipner, J., Dederichs, T.-S., von Ehr, A., Rauterberg, S., Ehlert, C. A., Merz, J., Dufner, B., Hoppe, N., Krebs, K., Heidt, T., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101250 · Cited by 31

Hematopoietic Interferon Regulatory Factor 8-Deficiency Accelerates Atherosclerosis in Mice

Döring, Y., Soehnlein, O., Drechsler, M. D., Shagdarsuren, E., Chaudhari, S. M., Meiler, S. U., Hartwig, H., Hristov, M., Koenen, R. R., Hieronymus, T., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.236539 · Cited by 48