The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM)
Abstract
Background: Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk of sudden cardiac death (SCD) and require a prophylactic implantable cardioverter defibrillator is challenging. In 2014, the European Society of Cardiology proposed a new risk stratification method based on a risk prediction model (HCM Risk-SCD) that estimates the 5-year risk of SCD. The aim was to externally validate the 2014 European Society of Cardiology recommendations in a geographically diverse cohort of patients recruited from the United States, Europe, the Middle East, and Asia. Methods: This was an observational, retrospective, longitudinal cohort study. Results: The cohort consisted of 3703 patients. Seventy three (2%) patients reached the SCD end point within 5 years of follow-up (5-year incidence, 2.4% [95% confidence interval {CI}, 1.9–3.0]). The validation study revealed a calibration slope of 1.02 (95% CI, 0.93–1.12), C-index of 0.70 (95% CI, 0.68–0.72), and D-statistic of 1.17 (95% CI, 1.05–1.29). In a complete case analysis (n= 2147; 44 SCD end points at 5 years), patients with a predicted 5-year risk of <4% (n=1524; 71%) had an observed 5-year SCD incidence of 1.4% (95% CI, 0.8–2.2); patients with a predicted risk of ≥6% (n=297; 14%) had an observed SCD incidence of 8.9% (95% CI, 5.96–13.1) at 5 years. For every 13 (297/23) implantable cardioverter defibrillator implantations in patients with an estimated 5-year SCD risk ≥6%, 1 patient can potentially be saved from SCD. Conclusions: This study confirms that the HCM Risk-SCD model provides accurate prognostic information that can be used to target implantable cardioverter defibrillator therapy in patients at the highest risk of SCD.
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“LVOT obstruction has been identified as a predictor of sudden death in some but not all studies”
From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [103]
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“Family history of sudden death in first degree relatives before age 40-50, long considered a marker of risk, has been validated in one study showing a similar rate of ICD interventions for those implanted for only this risk factor compared with those with other risk factors, 102 as well as in multivariable models of risk.”
From Current management of hypertrophic cardiomyopathy (2025) · cites this paper as [103]
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Cited by
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2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
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Metadata
- Authors
- O’Mahony, C., Jichi, F., Ommen, S. R., Christiaans, I., Arbustini, E., Garcia-Pavia, P., Cecchi, F., Olivotto, I., Kitaoka, H., Gotsman, I., Carr-White, G., Mogensen, J., Antoniades, L., Mohiddin, S. A., Maurer, M. S., Tang, H. C., Geske, J. B., Siontis, K. C., Mahmoud, K. D., Vermeer, A., Wilde, A., Favalli, V., Guttmann, O. P., Gallego-Delgado, M., Dominguez, F., Tanini, I., Kubo, T., Keren, A., Bueser, T., Waters, S., Issa, I. F., Malcolmson, J., Burns, T., Sekhri, N., Hoeger, C. W., Omar, R. Z., & Elliott, P. M.
- Venue
- Circulation
- Published
- 2018-03-06
- Volume
- 137
- Issue
- 10
- Pages
- 1015-1023
- ISSN
- 0009-7322
- 1524-4539
- Cited by
- 201
- References
- 6
- Language
- en
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