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2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Abstract
Aim: This executive summary of the hypertrophic cardiomyopathy clinical practice guideline provides recommendations and algorithms for clinicians to diagnose and manage hypertrophic cardiomyopathy in adult and pediatric patients as well as supporting documentation to encourage their use. Methods: A comprehensive literature search was conducted from January 1, 2010, to April 30, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases. Structure: Many recommendations from the earlier hypertrophic cardiomyopathy guidelines have been updated with new evidence or a better understanding of earlier evidence. This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy. For both guideline-directed medical therapy and other recommended drug treatment regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions based on product insert materials.
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Current ESC and ACC guidelines recommend anti-obstructive therapy (beta-blockers or verapamil) to reduce gradient and symptoms in HOCM.
“Current guidelines from the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) recommend anti-obstructive therapy, i.e., beta-blockers or verapamil to reduce gradient and symptoms (6–8).”
From Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (2024) · cites this paper as [6]
Current guidelines do not recommend ACE inhibitors, ARBs and dihydropyridine calcium channel blockers for HOCM.
“Therefore, current guidelines do not recommend these three classes of drugs for HOCM (6, 7).”
From Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (2024) · cites this paper as [6]
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Self-citationHypertrophic subaortic stenosis
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Family screening for hypertrophic cardiomyopathy: Is it time to change practice guidelines?
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Self-citationOutcomes of Restrictive and Hypertrophic Cardiomyopathies After LVAD: An INTERMACS Analysis
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Communicating new knowledge on previously reported genetic variants
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Self-citationYield of Clinical Screening for Hypertrophic Cardiomyopathy in Child First-Degree Relatives
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Vigorous exercise in patients with hypertrophic cardiomyopathy
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Pulmonary hypertension is associated with worse survival in hypertrophic cardiomyopathy
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Utility of genetics for risk stratification in pediatric hypertrophic cardiomyopathy
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Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients
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Concomitant Septal Myectomy at the Time of Aortic Valve Replacement for Severe Aortic Stenosis
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Self-citationCardiovascular collapse after verapamil in supraventricular tachycardia.
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Effectiveness of atrial fibrillation surgery in patients with hypertrophic cardiomyopathy
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Planned vaginal delivery and cardiovascular morbidity in pregnant women with heart disease
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Competitive Sport Participation Among Athletes With Heart Disease
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Outcomes of Contemporary Family Screening in Hypertrophic Cardiomyopathy
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Hypertrophic remodelling in cardiac regulatory myosin light chain ( MYL2 ) founder mutation carriers
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Arrhythmias as Presentation of Genetic Cardiomyopathy
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Self-citationMolecular Diagnosis of Hypertrophic Cardiomyopathy (HCM): In the Heart of Cardiac Disease
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Emerging Medical Treatment for Hypertrophic Cardiomyopathy
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Aficamten and Cardiopulmonary Exercise Test Performance
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Disease Expression and Outcomes in Black and White Adults With Hypertrophic Cardiomyopathy
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Self-citationChildhood Hypertrophic Cardiomyopathy: A Disease of the Cardiac Sarcomere
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Metadata
- Authors
- Writing Committee Members, Ommen, S. R., Mital, S., Burke, M. A., Day, S. M., Deswal, A., Elliott, P., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P., Kimmelstiel, C., Kittleson, M., Link, M. S., Maron, M. S., Martinez, M. W., Miyake, C. Y., Schaff, H. V., Semsarian, C., & Sorajja, P.
- Affiliations
- ACC/AHA Representative.
- American Hospital Association (US)
- ASE Representative.
- HRS Representative.
- SCMR Representative.
- AATS Representative.
- SCAI Representative.
- ORCID
- Venue
- Circulation
- Published
- 2020-12-22
- Volume
- 142
- Issue
- 25
- Pages
- e533-e557
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3113392623
- Cited by
- 336
- References
- 317
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 64 · 2023: 77 · 2022: 70 · 2021: 39 · 2020: 1
- FWCI
- 30.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Keywords
- hypertrophic cardiomyopathy, diagnosis, treatment, guideline-directed medical therapy, risk stratification, genetic screening, family screening, lifestyle modification, surgical treatment, interventional catheterization, medication, pediatric patients, adult patients
- MeSH terms
- Algorithms, American Heart Association, Cardiology, Cardiomyopathy, Hypertrophic, Decision Support Techniques, Humans, Predictive Value of Tests, United States, Treatment Outcome, Evidence-Based Medicine, Consensus, Cardiac Imaging Techniques
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