Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression
Open accessPublished version of a preprint
Abstract
Background: Scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are preferentially expressed by liver sinusoidal endothelial cells. They mediate the clearance of circulating plasma molecules controlling distant organ homeostasis. Studies suggest that Stab1 and Stab2 may affect atherosclerosis. Although subsets of tissue macrophages also express Stab1, hematopoietic Stab1 deficiency does not modulate atherogenesis. Here, we comprehensively studied how targeting Stab1 and Stab2 affects atherosclerosis. Methods: ApoE-KO mice were interbred with Stab1-KO and Stab2-KO mice and fed a Western diet. For antibody targeting, Ldlr-KO mice were also used. Unbiased plasma proteomics were performed and independently confirmed. Ligand binding studies comprised glutathione-S-transferase–pulldown and endocytosis assays. Plasma proteome effects on monocytes were studied by single-cell RNA sequencing in vivo, and by gene expression analyses of Stabilin ligand–stimulated and plasma-stimulated bone marrow–derived monocytes/macrophages in vitro. Results: Spontaneous and Western diet–associated atherogenesis was significantly reduced in ApoE-Stab1-KO and ApoE-Stab2-KO mice. Similarly, inhibition of Stab1 or Stab2 by monoclonal antibodies significantly reduced Western diet–associated atherosclerosis in ApoE-KO and Ldlr-KO mice. Although neither plasma lipid levels nor circulating immune cell numbers were decisively altered, plasma proteomics revealed a switch in the plasma proteome, consisting of 231 dysregulated proteins comparing wildtype with Stab1/2-single and Stab1/2-double KO, and of 41 proteins comparing ApoE-, ApoE-Stab1-, and ApoE-Stab2-KO. Among this broad spectrum of common, but also disparate scavenger receptor ligand candidates, periostin, reelin, and TGFBi (transforming growth factor, β-induced), known to modulate atherosclerosis, were independently confirmed as novel circulating ligands of Stab1/2. Single-cell RNA sequencing of circulating myeloid cells of ApoE-, ApoE-Stab1-, and ApoE-Stab2-KO mice showed transcriptomic alterations in patrolling (Ccr2 – /Cx3cr1 ++ /Ly6C lo ) and inflammatory (Ccr2 + /Cx3cr1 + /Ly6C hi ) monocytes, including downregulation of proatherogenic transcription factor Egr1. In wildtype bone marrow–derived monocytes/macrophages, ligand exposure alone did not alter Egr1 expression in vitro. However, exposure to plasma from ApoE-Stab1-KO and ApoE-Stab2-KO mice showed a reverted proatherogenic macrophage activation compared with ApoE-KO plasma, including downregulation of Egr1 in vitro. Conclusions: Inhibition of Stab1/Stab2 mediates an anti-inflammatory switch in the plasma proteome, including direct Stabilin ligands. The altered plasma proteome suppresses both patrolling and inflammatory monocytes and, thus, systemically protects against atherogenesis. Altogether, anti-Stab1– and anti-Stab2–targeted therapies provide a novel approach for the future treatment of atherosclerosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
STAB1 and STAB2 are located on different chromosomes (3 and 12), but both encode related scavenger receptors expressed on macrophages and liver sinusoidal endothelial cells that mediate the clearance of aged plasma proteins and other waste molecules.
“STAB1 and STAB2 are located on different chromosomes (3 and 12, respectively), but both encode related scavenger receptors expressed on macrophages and liver sinusoidal endothelial cells that mediate the clearance of aged plasma proteins and other waste molecules21,22.”
From Rare variant associations with plasma protein levels in the UK Biobank (2023) · cites this paper as [22]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works
Pérez-Riverol, Y., Csordas, A., Bai, J.-W., Bernal-Llinares, M., Hewapathirana, S., Kundu, D. J., Inuganti, A., Griss, J., Mayer, G., Eisenacher, M., et al. (2018) · Nucleic Acids Res. · doi:10.1093/nar/gky1106 · Cited by 6,216 · see citing works
Cox, J., Hein, M. Y., Luber, C. A., Paron, I., Nagaraj, N., & Mann, M. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.031591 · Cited by 5,180 · see citing works
Hafemeister, C., & Satija, R. (2019) · Genome Biology · doi:10.1186/s13059-019-1874-1 · Cited by 4,479 · see citing works
DIA-NN: Neural networks and interference correction enable deep proteome coverage in high throughput
Demichev, V., Messner, C., Vernardis, S., Lilley, K., & Ralser, M. (2019) · Nature Methods · doi:10.1038/s41592-019-0638-x · Cited by 2,961 · see citing works
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
Ultrasensitive proteome analysis using paramagnetic bead technology
Hughes, C. S., Föehr, S., Garfield, D. A., Furlong, E. E. M., Steinmetz, L. M., & Krijgsveld, J. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145625 · Cited by 1,194 · see citing works
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Undulating changes in human plasma proteome profiles across the lifespan
Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0673-2 · Cited by 981 · see citing works
Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944 · see citing works
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., Wu, L., Sloan, A. E., McLendon, R. E., Li, X., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3090 · Cited by 940 · see citing works
Binder, C. J., Hörkkö, S., Dewan, A. K., Chang, M.-K., Kieu, E., Goodyear, C. S., Shaw, P. X., Palinski, W., Witztum, J. L., & Silverman, G. J. (2003) · Nature Medicine · doi:10.1038/nm876 · Cited by 735 · see citing works
Kerato-epithelin mutations in four 5q31-linked corneal dystrophies
Munier, F. L., Korvatska, O., Djemaï, A., Paslier, D. L., Zografos, L., Pescia, G., & Schorderet, D. F. (1997) · Nature Genetics · doi:10.1038/ng0397-247 · Cited by 607 · see citing works
Animal models of atherosclerosis
Emini Veseli, B., Perrotta, P., De Meyer, G. R. A., Roth, L., Van der Donckt, C., Martinet, W., & De Meyer, G. R. Y. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.010 · Cited by 548 · see citing works
Plasma protein patterns as comprehensive indicators of health
Williams, S. A., Kivimaki, M., Langenberg, C., Hingorani, A. D., Casas, J. P., Bouchard, C., Jonasson, C., Sarzynski, M. A., Shipley, M. J., Alexander, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0665-2 · Cited by 506 · see citing works
Braun, A., Trigatti, B. L., Post, M. J., Sato, K., Simons, M., Edelberg, J. M., ROSENBERG, R. D., Schrenzel, M. D., & Krieger, M. (2002) · Circulation Research · doi:10.1161/hh0302.104462 · Cited by 491 · see citing works
Binder, C. J., Hartvigsen, K., Chang, M.-K., Miller, M., Broide, D. H., Palinski, W., Curtiss, L. K., Corr, M., & Witztum, J. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20479 · Cited by 451 · see citing works
Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0440-4 · Cited by 442 · see citing works
Moore, K. J., Kunjathoor, V. V., Koehn, S. L., Manning, J. J., Tseng, A. A., Silver, J. M., McKee, M. L., & Freeman, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24061 · Cited by 371 · see citing works
Rahman, K., Vengrenyuk, Y., Ramsey, S., Vila, N. R., Girgis, N., Liu, J.-H., Gusarova, V., Gromada, J., Weinstock, A., Moore, K., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci75005 · Cited by 311 · see citing works
Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues
Politz, O., Gratchev, A. N., McCourt, P., Schledzewski, K., Guillot, P., Johansson, S., Svineng, G., Franke, P., Kannicht, C., Kzhyshkowska, J. G., et al. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620155 · Cited by 310 · see citing works
Self-citationPlasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease
Niu, L., Geyer, P. E., Albrechtsen, N. J. W., Gluud, L. L., Santos, A., Doll, S., Treit, P. V., Holst, J. J., Knop, F. K., Vilsbøll, T., et al. (2019) · Molecular Systems Biology · doi:10.15252/msb.20188793 · Cited by 278 · see citing works
Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses
Chen, Y., Yang, M., Huang, W., Chen, W., Zhao, Y., Schulte, M. L., Volberding, P. J., Gerbec, Z. J., Zimmermann, M. T., Zeighami, A., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315833 · Cited by 274 · see citing works
Instant Clue: A Software Suite for Interactive Data Visualization and Analysis
Nolte, H., MacVicar, T., Tellkamp, F., & Krüger, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-31154-6 · Cited by 240 · see citing works
Self-citationCampbell, F., Bos, F. L., Sieber, S., Arias‐Alpizar, G., Koch, B. E. V., Huwyler, J., Kros, A., & Bussmann, J. (2018) · ACS Nano · doi:10.1021/acsnano.7b06995 · Cited by 233 · see citing works
Kzhyshkowska, J., Mamidi, S., Gratchev, A., Kremmer, E., Schmuttermaier, C., Krusell, L., Haus, G., Utikal, J., Schledzewski, K., Scholtze, J., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2843 · Cited by 216 · see citing works
Self-citationBone Marrow-derived Macrophage Production
Trouplin, V., Boucherit, N., Gorvel, L., Conti, F., Mottola, G., & Ghigo, É. (2013) · Journal of Visualized Experiments · doi:10.3791/50966 · Cited by 211 · see citing works
Kuchibhotla, S., Vanegas, D., Kennedy, D. J., Guy, E. C., Nimako, G., Morton, R. E., & Febbraio, M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm093 · Cited by 210 · see citing works
Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudō, A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40973 · Cited by 199 · see citing works
FEEL-1 and FEEL-2 Are Endocytic Receptors for Advanced Glycation End Products
Tamura, Y., Adachi, H., Osuga, J.-I., Ohashi, K., Yahagi, N., Sekiya, M., Okazaki, H., Tomita, S., Iizuka, Y., Shimano, H., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210211200 · Cited by 197 · see citing works
Schledzewski, K., Géraud, C., Arnold, B., Wang, S., Gröne, H.-J., Kempf, T., Wollert, K. C., Straub, B. K., Schirmacher, P., Demory, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44740 · Cited by 154 · see citing works
Self-citationInhibition of Hyaluronan Synthesis Accelerates Murine Atherosclerosis
Nagy, N., Freudenberger, T., Melchior‐Becker, A., Roeck, K., ter Braak, M., Jastrow, H., Kinzig, M., Lucke, S., Suvorava, T., Kojda, G., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.972653 · Cited by 151 · see citing works
Early Growth Response-1 Promotes Atherogenesis
Harja, E., Bucciarelli, L. G., Lu, Y., Stern, D. M., Zou, Y. S., Schmidt, A. M., & Yan, S.-F. (2003) · Circulation Research · doi:10.1161/01.res.0000112405.61577.95 · Cited by 151 · see citing works
Cui, K., Ardell, C. L., Podolnikova, N. P., & Yakubenko, V. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02650 · Cited by 147 · see citing works
Periostin as a Heterofunctional Regulator of Cardiac Development and Disease
Conway, S. J., & Molkentin, J. D. (2008) · Current Genomics · doi:10.2174/138920208786847917 · Cited by 135 · see citing works
Li, R., Oteiza, A., Sørensen, K. K., McCourt, P., Olsen, R. F., Smedsrød, B. H., & Svistounov, D. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2010 · Cited by 127 · see citing works
Rantakari, P., Patten, D. A., Valtonen, J., Karikoski, M., Gerke, H., Dawes, H., Laurila, J., Ohlmeier, S., Elima, K., Hübscher, S. G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604780113 · Cited by 119 · see citing works
αMβ2 Integrin–Mediated Adhesion and Motility of IL-5–Stimulated Eosinophils on Periostin
Johansson, M. W., Annis, D. S., & Mosher, D. F. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0150oc · Cited by 113 · see citing works
Viitala, M., Virtakoivu, R., Tadayon, S., Rannikko, J. H., Jalkanen, S., & Hollmén, M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3016 · Cited by 110 · see citing works
O’Brien, E. R., Bennett, K. L., Garvin, M. R., Zderic, T. W., Hinohara, T., Simpson, J. B., Kimura, T., Nobuyoshi, M., Mizgala, H. F., Purchio, A. F., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.4.576 · Cited by 109 · see citing works
Sha, S. J., Deutsch, G. K., Tian, L., Richardson, K., Coburn, M., Gaudioso, J. L., Marcal, T., Solomon, E., Boumis, A., Bet, A., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.3288 · Cited by 109 · see citing works
The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective
Krolikoski, M., Monslow, J., & Puré, E. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.05.007 · Cited by 105 · see citing works
Tran‐Lundmark, K., Tran, P.-K., Paulsson‐Berne, G., Fridén, V., Soininen, R., Tryggvason, K., Wight, T. N., Kinsella, M. G., Borén, J., & Hedin, U. (2008) · Circulation Research · doi:10.1161/circresaha.108.172833 · Cited by 105 · see citing works
Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: Implication in atherosclerosis
Brochériou, I., Maouche, S., Durand, H., Braunersreuther, V., Naour, G. L., Gratchev, A. N., Koskas, F., Mach, F., Kzhyshkowska, J. G., & Ninio, E. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.11.023 · Cited by 104 · see citing works
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis
Hirose, Y., Saijou, E., Sugano, Y., Takeshita, F., Nishimura, S., Nonaka, H., Chern, E., Sekine, K., Kido, T., Nakamura, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117560109 · Cited by 102 · see citing works
Pachot, A., Blond, J.-L., Mougin, B., & Miossec, P. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.07.001 · Cited by 92 · see citing works
Kzhyshkowska, J. G., Gratchev, A. N., Schmuttermaier, C., Brundiers, H., Krusell, L., Mamidi, S., Zhang, J., Workman, G. A., Sage, E. H., Anderle, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3028 · Cited by 88 · see citing works
Self-citationWeigel, J. A., Raymond, R. C., McGary, C. T., Singh, A., & Weigel, P. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211462200 · Cited by 87 · see citing works
Schwanekamp, J. A., Lorts, A., Vagnozzi, R. J., Vanhoutte, D., & Molkentin, J. D. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306397 · Cited by 86 · see citing works
Scavenger receptors: friend or foe in atherosclerosis?
van Berkel, T. J. C., Out, R., Hoekstra, M., Kuiper, J., Biessen, E. A. L., & Eck, M. V. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000183943.20277.26 · Cited by 85 · see citing works
Kzhyshkowska, J. G., Gratchev, A. N., MARTENS, J. H., Pervushina, O., Mamidi, S., Johansson, S., Schledzewski, K., Hansen, B., He, X., Tang, J., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0504300 · Cited by 83 · see citing works
Self-citationMatsui, R., Xu, S., Maitland, K. A., Mastroianni, R., Leopold, J. A., Handy, D. E., Loscalzo, J., & Cohen, R. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000205850.49390.3b · Cited by 82 · see citing works
Update on the role of Pentraxin 3 in atherosclerosis and cardiovascular diseases
Casula, M., Montecucco, F., Bonaventura, A., Liberale, L., Vecchié, A., Dallegri, F., & Carbone, F. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.10.003 · Cited by 81 · see citing works
Mahmoud, M. M., Mayer, M., Cancel, L. M., Bartosch, A. M. W., Mathews, R., & Tarbell, J. M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa201 · Cited by 76 · see citing works
Ding, Y., Huang, L., Xian, X., Yuhanna, I. S., Wasser, C. R., Frotscher, M., Mineo, C., Shaul, P. W., & Herz, J. (2016) · Science Signaling · doi:10.1126/scisignal.aad5578 · Cited by 72 · see citing works
Karamariti, E., Zhai, C., Yu, B., Qiao, L., Wang, Z., Potter, C. M. F., Wong, M. M., Simpson, R., Zhang, Z., Wang, X., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310079 · Cited by 70 · see citing works
The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity
Swystun, L., Lai, J. D., Notley, C., Georgescu, I., Paine, A. S., Mewburn, J., Nesbitt, K., Schledzewski, K., Géraud, C., Kzhyshkowska, J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96400 · Cited by 69 · see citing works
Self-citationHuang, W., Febbraio, M., & Silverstein, R. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029092 · Cited by 61 · see citing works
Son, H., Nam, J.-O., Kim, S., & Kim, I.-S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.012 · Cited by 61 · see citing works
Role of hyaluronan in atherosclerosis: Current knowledge and open questions
Fischer, J. W. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.003 · Cited by 60 · see citing works
Ahlfeld, S. K., Wang, J., Gao, Y., Snider, P. L., & Conway, S. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.024 · Cited by 57 · see citing works
Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A. N., Verdiell, M. L., Sticht, C., Schmuttermaier, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8857 · Cited by 57 · see citing works
Self-citationHeparan Sulfate in Perlecan Promotes Mouse Atherosclerosis
Tran‐Lundmark, K., Tran, P.-K., Paulsson‐Berne, G., Fridén, V., Soininen, R., Tryggvason, K., Wight, T. N., Kinsella, M. G., Borén, J., & Hedin, U. (2008) · Circulation Research · doi:10.1161/circresaha.107.172833 · Cited by 56 · see citing works
Quantification of Atherosclerosis in Mice
Centa, M., Ketelhuth, D. F. J., Malin, S., & Gisterå, A. (2019) · Journal of Visualized Experiments · doi:10.3791/59828 · Cited by 55 · see citing works
Martínez‐Pomares, L., Hanitsch, L. G., Stillion, R. J., Keshav, S., & Gordon, S. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700327 · Cited by 48 · see citing works
Kim, H.-J., & Kim, I. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.11.001 · Cited by 46 · see citing works
Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis
Lee, W., Park, S., Yoo, Y., Kim, S., Kim, J., Kim, S., Seo, Y., Park, E., Kim, I., & Bae, J. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1669477 · Cited by 45 · see citing works
Su, C.-T., & Urbán, Z. (2021) · Genes · doi:10.3390/genes12060795 · Cited by 41 · see citing works
Mutation update:TGFBIpathogenic and likely pathogenic variants in corneal dystrophies
Kheir, V., Cortés‐González, V., Zenteno, J. C., & Schorderet, D. F. (2019) · Human Mutation · doi:10.1002/humu.23737 · Cited by 38 · see citing works
TGFBI Promotes Tumor Growth and is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma
Wang, B., Chi, K.-P., Shen, R., Zheng, S., Guo, Y., Li, J., Fei, J., & He, Y. (2019) · Journal of Cancer · doi:10.7150/jca.29958 · Cited by 38 · see citing works
Poulsen, E. T., Runager, K., Nielsen, N. S., Lukassen, M. V., Thomsen, K., Snider, P. L., Simmons, O., Vorum, H., Conway, S. J., & Enghild, J. J. (2017) · FEBS Journal · doi:10.1111/febs.14321 · Cited by 36 · see citing works
LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure
Su, C.-T., Jao, T., Urbán, Z., Huang, Y.-J., See, D. H. W., Tsai, Y., Lin, W., & Huang, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04214-5 · Cited by 36 · see citing works
Dickkopf‐3 Ablation Attenuates the Development of Atherosclerosis in ApoE‐Deficient Mice
Cheng, W., Yang, Y., Zhang, X., Guo, J., Gong, J., Gong, F., She, Z., Huang, Z., Xia, H., & Li, H. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004690 · Cited by 35 · see citing works
Harmon, E. Y., Fronhofer, V., Keller, R. S., Feustel, P. J., Zhu, X., Xu, H., Avram, D., Jones, D., Nagarajan, S., & Lennartz, M. R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001232 · Cited by 34 · see citing works
Nakazawa, N., Yokobori, T., Kaira, K., Turtoï, A., Baatar, S., Gombodorj, N., Handa, T., Tsukagoshi, M., Ubukata, Y., Kimura, A., et al. (2019) · Annals of Surgical Oncology · doi:10.1245/s10434-019-07878-8 · Cited by 34 · see citing works
Albrecht, C., Preusch, M. R., Hofmann, G., Morris-Rosenfeld, S., Blessing, E., Rosenfeld, M. E., Katus, H. A., & Bea, F. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq032 · Cited by 30 · see citing works
Common Variants in the Periostin Gene Influence Development of Atherosclerosis in Young Persons
Hixson, J. E., Shimmin, L. C., Montasser, M. E., Kim, D., Zhong, Y., Ibarguen, H. P., Follis, J. L., Malcom, G. T., Strong, J. P., Howard, T. D., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.224352 · Cited by 30 · see citing works
Liao, J., Guo, X., Wang, M., Dong, C., Gao, M., Wang, H., Kayoumu, A., Shen, Q., Wang, Y., Wang, F., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33019 · Cited by 30 · see citing works
Piek, A., Smit, L., Suthahar, N., Bakker, S. J. L., de Boer, R. A., & Silljé, H. H. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-88107-9 · Cited by 30 · see citing works
Analysis of gene expression profile identifies potential biomarkers for atherosclerosis
Liu, L., Liu, Y., Liu, C., Zhang, Z., Du, Y., & Zhao, H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5650 · Cited by 29 · see citing works
Lang, K., Kahveci, S., Bonberg, N., Wichert, K., Behrens, T., Hovanec, J., Roghmann, F., Noldus, J., Tam, Y. C., Tannapfel, A., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184483 · Cited by 27 · see citing works
Zhu, X., Ng, H. P., Lai, Y., Craigo, J. K., Nagilla, P., Raghani, P., & Nagarajan, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303075 · Cited by 24 · see citing works
Olsavszky, V., Sticht, C., Schmid, C. D., Winkler, M., Wohlfeil, S. A., Olsavszky, A., Schledzewski, K., Géraud, C., Goerdt, S., Leibing, T., et al. (2020) · Gene · doi:10.1016/j.gene.2020.145284 · Cited by 23 · see citing works
Self-citationKayashima, Y., Makhanova, N., Matsuki, K., Tomita, H., Bennett, B. J., & Maeda, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117478 · Cited by 20 · see citing works
Ling, P., Shan, W., Zhai, G., Qiu, C., Liu, Y., Xu, Y., & Yang, X. (2020) · Brain and Behavior · doi:10.1002/brb3.1773 · Cited by 19 · see citing works
Harris, E. N., Parry, S., Sutton‐Smith, M., Pandey, M. S., Panico, M., Morris, H. R., Haslam, S. M., Dell, A., & Weigel, P. H. (2010) · Glycobiology · doi:10.1093/glycob/cwq057 · Cited by 19 · see citing works
Barretto, K. T., Swanson, C. M., Nguyen, C. L., Annis, D. S., Esnault, S. J., Mosher, D. F., & Johansson, M. W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201320 · Cited by 16 · see citing works
Reduction of Stabilin-2 Contributes to a Protection Against Atherosclerosis
Kayashima, Y., Clanton, C. A., Lewis, A. M., Sun, X., Hiller, S., Huynh, P. K., Wilder, J., Hagaman, J. R., Li, F., Maeda-Smithies, N., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.818662 · Cited by 15 · see citing works
Nahon, J. E., Hoekstra, M., van Hulst, S., Manta, C., Goerdt, S., Geerling, J. J., Géraud, C., & Eck, M. V. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.020 · Cited by 12 · see citing works
Self-citationPIRIE, E. C., Ray, S., Pan, C., Fu, W., Powers, A. F., Polikoff, D., Miller, C. M., Kudrna, K. M., Harris, E. N., Lusis, A. J., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007732 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Nahon JE, Hoekstra M, van Hulst S, Manta C, Goerdt S, Geerling JJ, Geraud C, Van Eck M. Hematopoietic Stabilin-1 deficiency does not influence ath- erosclerosis susceptibility in LDL receptor knockout mice. Atherosclerosis. 2019;281:47-55. doi: 10.1016/j.atherosclerosis.2018.12.020 · DOI
- Cui K, Ardell CL, Podolnikova NP, Yakubenko VP. Distinct migratory proper- ties of M 1 , M 2 , and resident macrophages are regulated by α D β 2 and α M β 2 integrin-mediated adhesion. Front Immunol. 2018;9:2650.
Cited by
Sorted by citations
Rare variant associations with plasma protein levels in the UK Biobank
Dhindsa, R. S., Burren, O. S., Sun, B. B., Prins, B. P., Matelska, D., Wheeler, E., Mitchell, J., Oerton, E., Hristova, V. A., Smith, K. R., et al. (2023) · Nature · doi:10.1038/s41586-023-06547-x · Cited by 193 · see citing works
Nanomedicine for Diagnosis and Treatment of Atherosclerosis
Cheng, J., Huang, H., Chen, Y., & WU, R. T. (2023) · Advanced Science · doi:10.1002/advs.202304294 · Cited by 115 · see citing works
Fu, M., Shu, S., Peng, Z., Liu, X., Chen, X., Zeng, Z., Yang, Y., Cui, H., Zhao, R., Wang, X., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319828 · Cited by 89 · see citing works
Reelin through the years: From brain development to inflammation
Alexander, A., Herz, J., & Calvier, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112669 · Cited by 71 · see citing works
Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
Moss, C. E., Johnston, S. A., Kimble, J. V., Clements, M., Codd, V., Hamby, S. E., Goodall, A. H., Deshmukh, S., Sudbery, I. M., Coca, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114073 · Cited by 71 · see citing works
Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing
Yu, L., Zhang, Y., Liu, C., Wu, X., Wang, S., Sui, W., Zhang, Y., Zhang, C., & Zhang, M. (2023) · The FASEB Journal · doi:10.1096/fj.202201932rr · Cited by 46 · see citing works
Shi, J., Yang, M. M., Yang, S., Fan, F., Zhang, J., Miao, Y., Hua, Y., Zhang, J., Cheng, Y., Liu, S., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155489 · Cited by 30 · see citing works
Lu, Q.-B., Fu, X., Liu, Y., Wang, Z.-C., Liu, S., Li, Y., & Sun, H. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00510-4 · Cited by 29 · see citing works
Innate Immune Pathways in Atherosclerosis—From Signaling to Long-Term Epigenetic Reprogramming
Aronova, A., Tosato, F., Naser, N., & Asare, Y. (2023) · Cells · doi:10.3390/cells12192359 · Cited by 23 · see citing works
Tanshinone IIA alleviates atherosclerosis in LDLR−/− mice by regulating efferocytosis of macrophages
Wang, J., Zhang, Y., Feng, X., Du, M., Li, S., Chang, X., & Liu, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1233709 · Cited by 23 · see citing works
Swystun, L. L., Michels, A., & Lillicrap, D. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.04.014 · Cited by 21 · see citing works
Huang, K., Wu, H., Xu, X., Wu, L., Li, Q., & Han, L. (2023) · Aging · doi:10.18632/aging.204901 · Cited by 16 · see citing works
Krzistetzko, J., Géraud, C., Dormann, C., Riedel, A., & Leibing, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310969 · Cited by 15 · see citing works
Self-citationMechanism of efferocytosis in atherosclerosis
Shu, L.-X., Cao, L.-L., Guo, X., Wang, Z., & Wang, S. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02439-3 · Cited by 14 · see citing works
Holte, C. F., Szafranska, K., Kruse, L. D., Simón-Santamaría, J., Li, R., Svistounov, D., & McCourt, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-46462-9 · Cited by 13 · see citing works
Toba, H., & Takai, S. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00565.2024 · Cited by 13 · see citing works
Vo, T.-T. T., Kong, G., Kim, C., Juang, U., Gwon, S., Jung, W., Nguyen, H., Kim, S., & Park, J. (2023) · Toxicological Research · doi:10.1007/s43188-023-00176-2 · Cited by 11 · see citing works
Babakr, A. T. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2897 · Cited by 11 · see citing works
Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review
Bekheit, M., Kamera, B. S., Colacino, L., Dropmann, A., Delibegović, M., Almadhoob, F., Hanafy, N. A. N., Bermano, G., & Hammad, S. (2024) · EXCLI journal · doi:10.17179/excli2024-7718 · Cited by 11 · see citing works
Self-citationEarly growth response-1, a dynamic conduit in cardiovascular disease
Khachigian, L. M. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1487668 · Cited by 10 · see citing works
Macrophage-endothelial cell crosstalk drives atherosclerotic plaque formation and progression
Zhang, C., Zhang, Y., Yu, Y., Zhou, M., Zhang, J., Fu, K., & Li, Y. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177879 · Cited by 10 · see citing works
Meng, S., Wang, Z., Liu, X., Shen, K., Gu, Y., Yu, B., & Wang, L. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111114 · Cited by 10 · see citing works
Yin, J., Luo, J., Wang, L., Liu, L., & Liu, L. (2025) · Cancer Science · doi:10.1111/cas.70044 · Cited by 10 · see citing works
Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy
Prince, S., Viitala, M., Sjöroos, R., Bendes, Á. Á., Rannikko, J. H., Patten, D. A., di Benedetto, I., Turpin, R., Ylitalo, A., Tyni, L., et al. (2025) · Theranostics · doi:10.7150/thno.110544 · Cited by 9 · see citing works
Leibing, T., Riedel, A., Xi, Y., Adrian, M., Krzistetzko, J., Kirkamm, C., Dormann, C., Schledzewski, K., Goerdt, S., & Géraud, C. (2023) · Aging Cell · doi:10.1111/acel.13914 · Cited by 9 · see citing works
Self-citationWang, Y., Ge, J., Dou, M., Cheng, X., Chen, X., Ma, L., & Xie, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113803 · Cited by 7 · see citing works
Akram, M. A., Khodja, A., Dalibalta, S., & Majdalawieh, A. F. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673348217241119063941 · Cited by 7 · see citing works
Huang, Z., Shen, S., Li, W., Wang, M., Yu, Y., Luo, W., Han, X., Xu, Z., Min, J., Long, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202503192 · Cited by 7 · see citing works
Biomechanics-mediated endocytosis in atherosclerosis
Wang, J., Xu, J., Liu, T., Yu, C., Xu, F., Wang, G., Li, S., & Dai, X. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1337679 · Cited by 7 · see citing works
Mao, Q., Deng, M., Zhao, J., Zhou, D., Chen, M., Liu, Q., Xu, S., & Zhao, X. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156213 · Cited by 7 · see citing works
Ge, Y., Liu, X., Chen, H., Li, G., Xing, X., Liu, J., Zhang, C., Zhuge, Y., & Wang, F. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1140856 · Cited by 6 · see citing works
Ravi, S., Martin, L. C., Krishnan, M., Kumaresan, M., Manikandan, B., & Ramar, M. (2023) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2023.105362 · Cited by 6 · see citing works
Bibliometric analysis of monoclonal antibodies for atherosclerosis
Ma, J., Zhao, K., Zhu, Y., Wen, X., Huang, J., Wei, X., & Zhao, Z. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2266926 · Cited by 5 · see citing works
Bai, B., Xie, S., Wang, Y., Wu, F., Chen, Y., Bian, J., & Gao, X. H. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1463061 · Cited by 5 · see citing works
Zhang, Y., Chai, Z., Chen, M., Li, S., Zhuang, W., Hu, W. W., & Chen, M. (2025) · Precision medicine and engineering. · doi:10.1016/j.preme.2025.100046 · Cited by 5 · see citing works
Male osteoporosis: the impact of lifestyle, from nutrition to physical activity
Defeudis, G., Cardinali, L., Eftekhariranjbar, S., Massari, M. C., & Migliaccio, S. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02517-w · Cited by 5 · see citing works
Vicedomini, R., Righetti, N., Polit, L., Condémi, S., Longo, L., & Carbone, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.30.466563 · Cited by 5 · see citing works
Stabilin-1 in Tumor-Associated Macrophages: A Potential Therapeutic Target in Cancer Immunotherapy
Gurung, J. L., Tamang, R. L., Madduri, L. S. V., Bennett, R. G., Harris, E. N., Denton, P. W., & McVicker, B. L. (2025) · Biology · doi:10.3390/biology14091198 · Cited by 4 · see citing works
Pan, Q., Chen, C., & Yang, Y. (2023) · Current Medical Science · doi:10.1007/s11596-023-2818-2 · Cited by 4 · see citing works
Ma, Y.-H., Yang, Y., Li, J., Yao, B.-C., Chen, Q., Wang, L., Guo, Z., & Guo, S. (2023) · Medicine · doi:10.1097/md.0000000000036133 · Cited by 4 · see citing works
Deficiency of Stabilin-1 in the Context of Hepatic Melanoma Metastasis
Wohlfeil, S. A., Olsavszky, A., Irkens, A. L., Häfele, V., Dietsch, B., Straub, N., Goerdt, S., & Géraud, C. (2024) · Cancers · doi:10.3390/cancers16020441 · Cited by 3 · see citing works
Self-citationOmics research in atherosclerosis
Tian, K.-J., Yu, Y., Chen, G., Deng, N.-H., Tian, Z., Bai, R., Zhang, F., & Jiang, Z.-S. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05139-1 · Cited by 2 · see citing works
Identification of multiple novel procoagulant plasma ligands for stabilin-2
Underwood, M. I., Leprevost, F. D. V., Basrur, V., Nesvizhskii, A. I., Rawley, O., Golden, K. L., Emmer, B. T., Lillicrap, D., & Desch, K. C. (2025) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2025.01.023 · Cited by 2 · see citing works
Shou, X., Wang, Y., Zhou, Z., Liu, J., Zhang, D., Yang, Z., & Liu, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-20826-9 · Cited by 2 · see citing works
Willumsen, N., Henriksen, K., Bager, C. L., Selnø, A. T. H., Mohamed, K. E., Leeming, D. J., Skarsfeldt, M. A., Nissen, N. I., Pedersen, R. S., Thorlacius‐Ussing, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-24463-0 · Cited by 2 · see citing works
Liu, Y., Li, Y., Wang, Q., Wu, M., Zhang, Z., Liang, X., Yang, X., He, X., Tang, J. M., Li, C., et al. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s541504 · Cited by 2 · see citing works
Possenriede, L., Sendtner, G. W., Falahat, P., Scheidt, U., Miranda, J., Schmitz, J., Bräsen, J. H., & von Vietinghoff, S. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00914.2025 · Cited by 2 · see citing works
Wang, N., Ni, C., Jiang, Q., Shi, X., & Guo, R. (2026) · Precision medicine and engineering. · doi:10.1016/j.preme.2026.100065 · Cited by 2 · see citing works
Proteomic signatures as biomarkers of atherosclerosis burden
Zhang, L., Omarov, M., Xu, L., Das, B., Luo, H., Hauck, S. M., Petrera, A., Yu, Z., Goonewardena, S. N., Zeggini, E., et al. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag140 · Cited by 2 · see citing works
Krzistetzko, J., Géraud, C., Dormann, C., Riedel, A., & Leibing, T. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13857 · Cited by 2 · see citing works
Self-citationScavenger receptors: key players in the immunological puzzle of lupus
Hahn, S., Chitre, M., Shepard, D., Rashid, R., & Ramirez‐Ortiz, Z. G. (2025) · Frontiers in Lupus · doi:10.3389/flupu.2025.1679564 · Cited by 1 · see citing works
Molecular crosstalk between MASLD and IVDD revealed through integrated biomarker discovery analysis
Wang, G., Liu, Y., & Shen, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1703972 · Cited by 1 · see citing works
Spatially Resolved Heterogeneity of Lymphatic Vasculature in the Adult Lung—Brief Report
Crossey, E., Carty, S., Garza, I., Perez, M., Shao, F., Abdullatif, S. A., Campbell, J. D., Mizgerd, J. P., Fine, A., & Jones, M. R. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.126.324437 · Cited by 1 · see citing works
Kailasam, S., Fayek, B., Bedaiwy, M. A., & Terry, J. (2026) · Placenta · doi:10.1016/j.placenta.2026.05.025 · Cited by 1 · see citing works
Nguyen, M. B., Chen, A., Lyons, Q. P., Ninh, V. K., McCabe, M. C., Luo, C., Bridgelal, B. D., Uhre, C., Cheng, J., Reimold, K. E., et al. (2026) · Advanced Science · doi:10.1002/advs.78446 · Cited by 1 · see citing works
Stabilin-1 levels are related to dysregulated lipid metabolism and atherosclerotic plaque burden
Giannousi, E., Georgiadou, C., Vlachogiannis, N. I., Kassi, E. N., Aggeli, I.-K. S., Sfikakis, P. P., Tentolouris, N., Protogerou, A. D., Kararigas, G., & Chatzigeorgiou, A. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00786.2025 · Cited by 1 · see citing works
Shu, X., Li, F., Chen, J., Wu, X., Tao, L., Amuti, A., Chen, S., Quan, J., Liu, J. F., Maimati, Y., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70624 · Cited by 1 · see citing works
Li, Q., Zhang, F., Li, X., & Wang, Q. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1546073 · Cited by 1 · see citing works
Dai, Y., Jiang, Y., Cao, C., Xu, Y., Lai, S., Zhu, W., Gao, M., Li, F., He, S., & Xu, J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406794122 · Cited by 1 · see citing works
Ding, Y., Niu, X., Guo, P., & Wang, B. (2025) · Journal of Immunology Research · doi:10.1155/jimr/9987367 · Cited by 1 · see citing works
Lv, Z., Zhao, B., Hu, L., Pan, J., Li, X., Li, M., Wu, C., & Mao, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3268699/v1 · Cited by 1 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.15.608116
Lin, M., Guo, J., Tang, W., Tao, H., Gu, Z., Zhou, F., Jiang, Y., Zhang, R., Jia, D., Sun, Y., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5112749
Brown, P. A. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102007
Wen, Y., Huang, Z., Hong, X., Jiang, Q., Han, L., Wang, Q., Wang, J., Shang, X., Wu, Z., & Huang, T. (2025) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.10069
Xuan, Z., Yang, H., Duan, L., Wu, X., Hu, M., & Shan, W. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000004296
Exploring the Role of SPARC in Atherosclerosis: Mechanisms and Potential Implications
Luo, X., Luo, X., Tang, S., Chen, Y., Xia, R., & Wang, X. (2025) · Current Atherosclerosis Reports · doi:10.1007/s11883-025-01362-3
Lu, Q.-B., Fu, X., Liu, Y., Wang, Z.-C., Liu, S.-Y., Li, Y.-C., & Sun, H.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26643922
Lu, Q.-B., Fu, X., Liu, Y., Wang, Z.-C., Liu, S.-Y., Li, Y.-C., & Sun, H.-J. (2024) · Figshare · doi:10.6084/m9.figshare.26643919
ST2 Signaling Regulates Innate Immune Responses in Kidney InjuryPreprint
Sabapathy, V., Costlow, G., Acharya, S., Upchurch, C. M., Pelletier, O. B., Mekhri, B., Bullock, T. N. J., Leitinger, N., Arandjelovic, S., & Sharma, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.24.701541
Microenvironment-Targeted Nanomedicine for Diagnosis and Treatment of Atherosclerosis
Wang, D., Yuan, L., Zheng, D., Li, M., Wang, Y., Zhu, Z., Wang, T., & Liu, K. (2026) · Tissue Engineering Part B Reviews · doi:10.1177/19373368251399414
Wang, Q., Zhou, J., Li, X., Zhao, C., Cheng, L., Wang, L., Chen, J., Chen, C., Li, C., & Su, C. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101379
Zhong, X., Wang, Z., Huang, S., Tang, B., Wu, H., You, Q., Liu, Y., Xu, W., Li, Q., Zhang, C. J., et al. (2026) · Current Atherosclerosis Reports · doi:10.1007/s11883-026-01420-4
Qian, J., Zhang, J., Wang, J., Xu, S., Li, Y., Kong, C., & Zhou, Q. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1838380
Hyaluronan (HA) Receptors: Discovery, Function & Pathology
Bopp, A. E., Pratt, L. B., Schroder, C. J., Staab, J. D., Hatcher, G. D., McWilliams, J. T., Wilhelm, M. C., Texel, A. C., & Harris, E. N. (2026) · Proteoglycan Research · doi:10.1002/pgr2.70049
Li, J., Zeng, Y., Chen, F., Hu, J., Guo, Z., & Peng, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1880488
Remodeling macrophage efferocytosis and phenotype via targeted nanoimmunotherapy for atherosclerosis
He, Z., Luo, Y., Li, Y., Yang, S., Fan, Y., Zhang, Y., Liu, S., Zhou, Z., Cao, C., Shi, H., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.08.006
Nanoparticle-Enabled Plasma Proteomics of Experimental Atherosclerosis in Mice
Delwarde, C., Matamalas, J. T., Chelvanambi, S., Kasai, T., Shlayen, G., Pestana, D. V. S., Zamani, M., Aikawa, E. R., Aikawa, M., & Singh, S. A. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101649
Göl, D., Talaz, E. İ., Mese-tayfur, S., Elmas, M. A., Gioiello, A., Galli, F., Özer, N. K., Sözen, E., & Gök, Ö. (2026) · ACS Omega · doi:10.1021/acsomega.6c01032
Xiao, Q., Hou, R., Zhang, M., Wang, X., Wei, J., Tang, Y., Ma, S., Pan, X., & Zhu, X. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118476
Procoagulant plasma in three individuals with stabilin-2 deficiencyPreprint
Adam, R., Jordan, A., Valovka, T., Seidl, C., Kreidl, K., Dempfle, C.-E. H., Garczarczyk‐Asim, D., Siegemund, A., Nittka, S., Müller, R., et al. (2026) · medRxiv · doi:10.64898/2026.10.04.26363616
Self-citation
- Authors
- Manta, C.-P., Leibing, T., Friedrich, M., Nolte, H., Adrian, M., Schledzewski, K., Krzistetzko, J., Kirkamm, C., David Schmid, C., Xi, Y., Stojanovic, A., Tonack, S., de la Torre, C., Hammad, S., Offermanns, S., Krüger, M., Cerwenka, A., Platten, M., Goerdt, S., & Géraud, C.
- Affiliations
- Heidelberg University (DE)
- German Cancer Research Center (DE)
- University of Cologne (DE)
- Department of Dermatology, Venereology, and Allergology (C.-P.M., T.L., M.A., K.S., J.K., C.K., C.D.S., Y.X., S.G., C.G.), University Medical Center and Medical Faculty Mannheim, Heidelberg University, Germany.
- Max Planck Institute for Heart and Lung Research (DE)
- Centre for Medical Research (ZMF) (C.d.l.T.), University Medical Center and Medical Faculty Mannheim, Heidelberg University, Germany.
- Corresponding author
- Géraud, Cyrill
- ORCID
- Venue
- Circulation
- Published
- 2022-12-06
- Volume
- 146
- Issue
- 23
- Pages
- 1783-1799
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W4308060355
- Cited by
- 84
- References
- 91
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 19 · 2023: 22 · 2021: 1
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Circulation (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- stabilin-1, stabilin-2, scavenger receptors, atherosclerosis, plasma proteome, periostin, reelin, TGFBI, monocytes, macrophages, myeloid cells, CCR2, CX3CR1, patrolling, ApoE-deficient mice, Western diet, ligand binding, liver sinusoidal endothelial cells
- MeSH terms
- Mice, Knockout, ApoE, Animals, Ligands, Macrophages, Mice, Inbred C57BL, Monocytes, Cell Adhesion Molecules, Neuronal, Proteome, Endothelial Cells, Atherosclerosis, Receptors, Scavenger, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
